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Topic: Paramyxovirus

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In the News (Fri 20 Jul 18)

  A Novel Paramyxovirus? | CDC EID
This notable homology suggests that Angrem52 is actually a paramyxovirus M gene (Figure 1A).
Paramyxovirus genes are separated by cis-acting elements in the genome.
The carboxy-terminus of the predicted V protein is cysteine-rich, as expected for a paramyxovirus V protein (Figure 1D).
www.cdc.gov /Ncidod/EID/vol11no01/04-0653.htm   (2381 words)

 .:IBiS Graduate Program :: Faculty :: Robert A. Lamb:.
Paramyxovirus membrane fusion: lessons from the F and HN atomic structures.
Paramyxovirus fusion: real-time measurement of parainfluenza virus 5 virus-cell fusion.
Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: The multifunctional V protein blocks both interferon-_ induction and interferon signalling.
www.biochem.northwestern.edu /ibis/faculty/lamb.htm   (921 words)

 More About Paramyxovirus
Paramyxovirus infection occurs in pigeons as an acute disease, taking an epidemic course.
The paramyxovirus is related to the Newcastle disease pathogen, but not identical.
Visibly affected birds should be excluded from emergency vaccination and removed from the flock, since by shedding the virus they put the remainder of the flock at risk until vaccine protection is acquired.
www.rense.com /general35/about.htm   (336 words)

The Paramyxovirus of pigeons is closely related to the virus of atypical fowl pest (Newcastle Disease).
A pigeon suspected of Paramyxovirus is put into an unaccustomed position, for example it is placed on its side, or is frightened by the clapping of one's hands.
If Paramyxovirus is suspected, precautionary measures should be taken which slow down or prevent the spread of the infection, until the position has been clarified.
www.wingswest.net /pigeons/health/paramyxo.html   (783 words)

 Ophidio Paramyxovirus (OPMV) / Reovirus in Australian Reptile Collections.
That the FDLV is a paramyxovirus was indicated by demonstrating it possessed a single-stranded RNA genome and had a sedimentation value of 50S (Jacobson, 2000).
Histopathological changes in reptiles suffering Paramyxovirus are now well documented in the scientific literature as is the progress of OPMV infections in snakes in the laboratory situation.
Paramyxovirus as identified in reptiles is believed to be from an undescribed genus.
www.smuggled.com /OPMV6.htm   (18845 words)

 Paramyxovirus and Reptiles
The answer, such as it is, is that there are reptilian paramyxoviruses, just as there are reptilian herpesviruses, adenoviruses, and other types of organisms.
Ahne W, Batts WN, Kurath G, Winton JR Viral genomic RNA of Fer-de-Lance virus (FDLV), a paramyxovirus highly pathogenic for reptiles, was reverse transcribed and cloned.
Tests have been developed for exposure to paramyxovirus of snakes, mycoplasma of tortoises and crocodilians, herpesvirus infection of marine turtles and tortoises, cryptosporidium of snakes, and spirorchid trematodes of sea turtles.
www.anapsid.org /paramyxovirus.html   (1309 words)

 CIDRAP >> Paramyxovirus implicated in SARS as cases reach 264
Paramyxovirus implicated in SARS as cases reach 264
The WHO statement said the Paramyxovirus family includes many well-known viruses associated with respiratory infections, including respiratory syncytial virus, mumps, and measles.
At a CDC news conference today, Gerberding called the evidence from more than one lab that the pathogen may be a paramyxovirus "an encouraging step forward." She added, "But seeing something in a nasal swab isn't the same thing as identifying it as the cause.
www.cidrap.umn.edu /cidrap/content/hot/sars/news/sarsreport.html   (901 words)

 Robert A. Lamb
Our laboratory is investigating the molecular structure and the mechanism of replication of influenza A, B, and C viruses and the paramyxovirus family of viruses, often using as a prototype parainfluenza virus 5 (PIV5), formerly called SV5.
Influenza A and B viruses cause important diseases in humans and animals, with tremendous socioeconomic consequences, for influenza continues to occur in regular epidemics and occasional pandemics and is a leading cause of morbidity and mortality.
Recently, we have found that activation of the paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail.
www.hhmi.org /research/investigators/lamb.html   (1833 words)

 On the trail of a microscopic menace - smh.com.au
If a paramyxovirus is the cause of SARS, it is expected that tests could be developed quickly to identify those who are infected.
The paramyxovirus family includes an extremely wide variety of viruses that affect both animals and humans.
The organisation says that, if a paramyxovirus is confirmed as the cause, it "will be in a much better position to recommend a treatment".
www.smh.com.au /articles/2003/03/21/1047749939219.html   (450 words)

 A Functional Antigenomic Promoter for the Paramyxovirus Simian Virus 5 Requires Proper Spacing between an Essential ...
During replication, paramyxovirus RNA synthesis is tightly coupled to encapsidation of the nascent RNA chain by the viral
Paramyxovirus DI RNAs have proven to be useful models for the analysis of cis-acting sequences that are necessary for replication
Parks, G. Mapping of a region of the paramyxovirus L protein required for the formation of a stable complex with the viral phosphoprotein P. Virol.
jvi.asm.org /cgi/content/full/72/1/10   (8835 words)

 Paramyxovirus-derived rnp invention
[0002] Paramyxovirus is a virus comprising negative-strand RNA as the genome.
Sendai virus is a non-segmented type negative-strand RNA virus belonging to the genus Paramyxovirus, and is a type of murine parainfluenza virus.
[0012] (1) A complex comprising (a) a negative-strand single-stranded RNA derived from a paramyxovirus, wherein said RNA is modified so as not express at least one of the envelope proteins of paramyxoviruses, and (b) proteins encoded by and binding to said negative-strand single-stranded RNA.
www.freshpatents.com /Paramyxovirus-derived-rnp-dt20070111ptan20070009949.php   (2414 words)

 Paramyxoviridae - MicrobeWiki
The paramyxovirus is non-segmented and contains a molecule of linear, negative-sense, single-stranded RNA.
Paramyxovirus virions consist of an envelope, a nucleocapsid, and a matrix protein.
Paramyxovirus replication is very similar to that of other viruses in this group.
microbewiki.kenyon.edu /index.php/Paramyxoviridae   (429 words)

 HealthGene - Avian Paramyxovirus.
Viruses of the family Paramyxoviridae have also been shown to cause CNS infections in domestic and large exotic felines, although none of the viruses in this group are known to be primarily feline viruses.
Diagnosis for avian paramyxovirus infection often relies on histopathological analysis, however this process can be time consuming and costly.
A highly sensitive PCR-based assay for the paramyxovirus is now available, which can accurately detect the presence of paramyxovirus infection in a timely and efficient manner.
www.healthgene.com /vet/a116.asp   (251 words)

 BioPortfolio News : Paramyxovirus vector for gene transfer to the cardiovascular system
Products of genes introduced by intranasalor intramuscular administration of the paramyxovirus vector were detected inblood at high levels.
The administration of a vector for the expression of theanti-inflammatory cytokine IL-10 inhibited collagen deposition in lung ofpulmonary fibrosis model animal.
Thus, the vector of the present invention issuitable for gene transfer to the cardiovascular system.If you would like to purchase a copy of this patent, please call MicroPatent at 800-648-6787.
www.bioportfolio.com /June_06/08_06_2006/Paramyxovirus_vector_for_gene.html   (109 words)

 Paramyxovirus definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
Paramyxovirus: One of a group of RNA viruses that are responsible predominantly for acute respiratory diseases and are usually transmitted in an airborne manner.
The paramyxoviruses replicate, unlike the influenza virus, in the cytoplasm (not in the nucleus) of the host cell.
The word "paramyxovirus" is a compound of "para-" + "-myxo-" + "virus.
www.medterms.com /script/main/art.asp?articlekey=22713   (248 words)

 HHMI News: Viral Harpoon Reveals Ancestry of Measles, Mumps Viruses
The scientists crystallized the fusion protein of a paramyxovirus that infects monkeys and used x-ray crystallography to determine the proteins three-dimensional structure.
Although the scientists studied the fusion protein of only one paramyxovirus, they are confident that the structural finding applies to the entire paramyxovirus family.
Specifically, determining the three-dimensional structure of the fusion protein sheds new light on the key event in paramyxovirus infection when the virus unfolds itself to reveal a spikelike protein that is launched into the gel-like outer membrane of the target cell.
www.hhmi.org /news/lamb.html   (663 words)

 RKI Isolation and molecular characterization of a novel cytopathogenic paramyxovirus from tree shrews
A cytopathic infectious agent was isolated from the kidneys of an apparently healthy tree shrew (Tupaia belangeri) that had been captured in the area around Bangkok.
Paramyxovirus-like pleomorphic enveloped particles and helical nucleocapsids were observed by electron microscopy and accordingly the infectious agent was termed Tupaia paramyxovirus (TPMV).
Highest homologies were detected between TPMV and Hendra virus (equine morbillivirus), which recently emerged in Australia, causing outbreaks of fatal respiratory and neurological disease in horses and humans.
www.rki.de /nn_225898/SharedDocs/Publikationen/DE/1999/T/Tidona__CA,templateId=render,layoutVariant=StandardMitAbstract.html?realTID=renderPlain   (235 words)

 EPAH: Paramyxovirus
Paramyxovirus was first recognized as a disease in pigeons in 1975.1 It spread through Europe by 1983 and by 1984, was present on the east coast and in Canada.
Paramyxovirus (PMV-1) is related to another type of Paramyxovirus known as Newcastle's Disease.
Paramyxovirus can be a devastating disease in an unprotected, large flock.
www.epah.net /birds/Paramyxovirus-p.html   (1227 words)

 Paramyxovirus Infection in Snakes
Diagnosis of paramyxovirus infection in snakes has involved a variety of techniques including routine histology, immunohistochemistry, fluorescent antibody staining, hemagglutination inhibition, and virus isolation with molecular characterization.
The goal of this research project is to develop sensitive and specific molecular methods to diagnose paramyxovirus infection in snakes.
The first objective is to develop molecular probes for the post mortem diagnosis paramyxovirus infection in formalin-fixed, paraffin embedded tissue specimens.
www.vet.uga.edu /VPP/Undergrad/Sand/index.php   (595 words)

 [No title]
Severe acute respiratory syndrome - worldwide --------------------------------------------- We are able to confirm that the patient whose NPA [nasophayngeal aspirate] was found to contain paramyxovirus is a health care worker with SARS who was exposed to the index patient in the medical ward associated with the outbreak at the Prince of Wales Hospital in Hong Kong.
We also thank Dr Doerr and colleagues for submitting their first hand report of the electron microscopy identification of paramyxovirus particles from plasma in one of the cases of SARS undergoing hospital treatment in Germany.
As their report states this may be indicative of a viremia (circulation of the virus in the blood stream consistent with an acute infection with the virus).
www.promedmail.org /pls/promed/f?p=2400:1001:1718422751363262853::::F2400_P1001_BACK_PAGE,F2400_P1001_ARCHIVE_NUMBER,F2400_P1001_USE_ARCHIVE:1001,20030319.0688,Y   (1500 words)

 UK Parakeet Fanciers In Panic Over New Budgie Virus
Hello Jeff - We may have a new paramyxovirus outbreak infecting Budgerigars aka (variety of small parrot.) There has been no confirmation as to whether this is a brand new paramyxovirus disease or older one, perhaps, newcastle or avian influenza.
There are at least 9 types of paramyxovirus and in many of these there are a large number of subtypes, all of which can infect birds.
The classical type affecting budgerigars is type 5 (also known as Kinitachi virus) which caused high mortality in aviaries in Japan in the mid 1970s; there was also a small outbreak of this in the UK in 1993.
www.rense.com /general38/para.htm   (993 words)

A new clinicopathological disorder associated with a paramyxovirus infection in pigs and humans has been identified as Nipah virus disease in Malaysia.
This new Malaysian paramyxovirus first isolated by a Malaysian scientist in University of Malaya was referred to the Centers for Disease Control and Prevention (CDC), Fort Collins.
The story of this peculiar new virus in Malaysia was indeed warfare with the unknown, human tragedy and most of all it posed a serious threat to the very survival of the swine industry.
www.jphpk.gov.my /Malay/je3.html   (608 words)

 Emedicine Search Results for Measles
The mumps virus is a paramyxovirus that shares various epidemiological characteristics with other well-known viral pediatric dis...
Lymph nodes, in conjunction with the spleen, tonsils, adenoids, and Peyer patches, are highly organized centers of immune cells...
Mumps - Mumps is a single-stranded RNA virus and a member of the family Paramyxoviridae, genus Paramyxovirus.
www.emedicine.com /cgi-bin/foxweb.exe/searchengine@/em/searchengine?boolean=and&book=all&maxhits=100&HiddenURL=&query=Measles   (451 words)

The linear arrangement of genes (6) are separated by repeated sequences, a polyadenylation signal at the end of the gene, the intergenic sequence GAA followed by a translation start signal at the beginning of the next gene.
However, the overall strategy very similar to influenza, although unlike influenza, Paramyxovirus replication is resistant to actinomycin D. A large excess of nucleocapsids are produced in infected cells, which form characteristic cytoplasmic inclusion bodies.
Cause acute respiratory infections of man ranging from relatively mild influenza-like illness to bronchitis, croup (narrowing of airways which can result in respiratory distress) and pneumonia; common infection of children.
www.tulane.edu /~dmsander/WWW/335/Paramyxoviruses.html   (790 words)

 SARS Is NOT Naturally-Occuring
The multiple press releases related to the identification of a coronavirus continue to be promising, (especially if there has been genetic sequencing of the virus), yet again caution needs to be exerted until further confirmation that this agent is in fact the etiologic agent of SARS.
[Two of the laboratories that originally suggested that SARS was associated with infection by an unspecified paramyxovirus have now come into line with the CDC verdict that the etiologic agent has the characteristics of a member of the genus _Coronavirus_ of the family _Coronaviridae_.
Until the full details of the scientific evidence become available, however, the final verdict will remain in doubt in view of the earlier contrary reports from Canada that the recently characterized human metapneumovirus may be the etiologic agent.
www.rense.com /general36/aas.htm   (2071 words)

 Role of the Hemagglutinin-Neuraminidase Protein in the Mechanism of Paramyxovirus-Cell Membrane Fusion -- Takimoto et ...
Paramyxovirus infects cells by initially attaching to a sialic
Luque, L. E., Russell, C. Spring-Loaded Heptad Repeat Residues Regulate the Expression and Activation of Paramyxovirus Fusion Protein.
Connolly, S. A., Leser, G. P., Yin, H.-S., Jardetzky, T. S., Lamb, R. Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy.
jvi.asm.org /cgi/content/abstract/76/24/13028   (803 words)

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