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Topic: Partial thromboplastin time

	Partial thromboplastin time - Wikipedia, the free encyclopedia
		The partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT or APTT) is a performance indicator measuring the efficacy of both the intrinsic and the common coagulation pathways.
		The time is measured until a thrombus (clot) forms.
		The test is termed "partial" due to the absence of tissue factor from the reaction mixture.
	en.wikipedia.org /wiki/Partial_thromboplastin_time (322 words)

	Partial thromboplastin time Encyclopedia of Medicine - Find Articles
		Measuring the partial thromboplastin time helps to assess which specific clotting factors may be missing or defective.
		The PTT test allows a doctor to check that there is enough heparin in the blood to prevent clotting, but not so much as to cause bleeding.
		The partial thromboplastin time is the time it takes for a clot to form, measured in seconds.
	www.findarticles.com /p/articles/mi_g2601/is_0010/ai_2601001029 (903 words)

	Medicare: Partial Thromboplastin Time (Site not responding. Last check: 2007-10-09)
		The partial thromboplastin time (PTT) test is an in-vitro laboratory test used to assess the intrinsic coagulation pathway.
		The PTT is not useful in determining the effects of coumadin on a patient's coagulation.
		If the partial thromboplastin time (PTT) is being done to monitor heparin therapy, then the correct ICD-9 code to use is E934.2, as the primary diagnosis, and the reason the patient is on the heparin (i.e., phlebitis, etc.) should appear as a secondary diagnosis code.
	library.umsmed.edu /medi-thrombo.html (662 words)

	Activated Partial Thromboplastin Time
		This measures the integrity of the intrinsic and common pathways of coagulation, whereas the prothrombin time (PT) measures the integrity of the extrinsic and common pathways of coagulation.
		PTT prolongations are caused by either factor deficiencies (especially of factors VIII, IX, XI, and/or XII), or inhibitors (most commonly, lupus anticoagulants, or therapeutic anticoagulants such as heparin, hirudin, or argatroban).
		Methodology PTT reagent (phospholipid with an intrinsic pathway activator such as silica, celite, kaolin, ellagic acid) and calcium are added to patient plasma, and the time until clot formation is measured in seconds.
	www.massgeneral.org /pathology/coagbook/co003400.htm (2445 words)

	Partial Thromboplastin Time - [Medical Test]
		Partial thromboplastin time (PTT) is a blood test that measures the time it takes blood to clot.
		The activated partial thromboplastin time (APTT) test is used after taking blood-thinners to determine the most effective dosage of medication that prevents blood clots.
		Prothrombin time is often measured along with partial thromboplastin time to evaluate bleeding abnormalities.
	www.bchealthguide.org /kbase/topic/medtest/hw203152/descrip.htm (224 words)

	NEW YORK STATE MEDICARE POLICY: Partial Thromboplastin Time
		The partial thromboplastin time (PTT) test is an in vitro laboratory test used to assess the extrinsic coagulation pathway.
		Certain disease states may also affect a patient's coagulation and require a PTT test: liver disease, disseminated intravascular coagulation, other acquired and congenital coagulopathies and thrombotic states, malabsorption, etc. The assessment of a patient's coagulation may need to be evaluated prior to undergoing surgical procedures.
		The PTT test is not useful in determining the effect of coumadin on a patient's coagulation, and should not be ordered routinely with a PT test.
	www.urmc.rochester.edu /Path/Medicare/ptt.htm (846 words)

	Partial Thromboplastin Time in Dogs
		PTT is also determined before procedures in which there is a concern about blood clotting, such as a liver biopsy.
		Normal PTT time in dogs and cats is less than 20 seconds, but this can vary from lab to lab.
		In order to perform a partial thromboplastin time, your veterinarian must draw a blood sample, which is placed in a special glass tube.
	www.petplace.com /dogs/partial-thromboplastin-time-in-dogs/page1.aspx (691 words)

	Prothrombin Time
		Prothrombin time is an important coagulation test because it measures the presence and activity of five different blood clotting factors (factors I, II, V, VII, and X).
		An abnormal prothrombin time is often caused by liver disease or injury or by treatment with the medication warfarin (Coumadin), which is used to prevent the formation of blood clots.
		PTT is often measured along with PT to evaluate bleeding abnormalities.
	www.webmd.com /hw/health_guide_atoz/hw203083.asp (1178 words)

	Partial Thromboplastin Time
		A long PTT or APTT can be caused by liver disease, kidney disease (such as nephrotic syndrome), or treatment with medications such as heparin or warfarin (Coumadin) that are used to prevent the formation of blood clots.
		A long PTT may be caused by conditions such as antiphospholipid antibody syndrome and lupus anticoagulant syndrome that can cause abnormal clotting or blood clot formation.
		PTT can be increased when aspirin is used during heparin therapy, so the PTT value needs to be closely monitored.
	www.webmd.com /hw/lab_tests/hw203152.asp (1040 words)

	Partial Thromboplastin Time Mixing Study (Site not responding. Last check: 2007-10-09)
		The PTT mixing study is indicated when the PTT is prolonged in the absence of heparin therapy.
		Patient plasma is mixed with normal plasma and the PTT is repeated.
		The results of the PTT mixing study are used to direct further studies in consultation with the ordering physician.
	peir.path.uab.edu /coag/article_101.shtml (166 words)

	Preparation of lyophilized partial thromboplastin time reagent composed of synthetic phospholipids: usefulness for ...
		in the coagulation time as the incubation time increased from
		Effect of synthetic phospholipids on the response of the activated partial thromboplastin time to heparin.
		Response of the activated partial thromboplastin time (APTT) to heparin is influenced by coagulometers.
	www.clinchem.org /cgi/content/full/43/7/1215 (3662 words)

	Partial Thromboplastin Time (PTT) - Health Encyclopedia
		It is useful in the evaluation of disorders of both excessive clotting and excessive bleeding.
		This test may be used in the evaluation of a wide variety of disorders.
		Note: this test is often performed on people who may have bleeding problems; if so, the risk of bleeding and hematoma are slightly greater than for people without bleeding problems.
	www.wnbc.com /encyclopedia/6864718/detail.html (881 words)

	Partial thromboplastin time
		It has largely replaced the older PTT, which was unable to incorporate variables in surface/contact time.
		now measures the clotting time of plasma, from the activation of factor XII by a reagent (a negatively charged activator such as silica and a phospholipid) through the formation of a fibrin clot.
		Heparin is most often administered as an initial intravenous bolus followed by a continuous intravenous infusion.
	www.rnceus.com /coag/coagptt.html (340 words)

	Partial Thromboplastin Time (PTT), Activated
		The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood.
		Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant.
		Prothrombin time and activated partial thromboplastin time can be performed on the first tube.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/cg003300.htm (1275 words)

	Prothrombin time
		The normal prothrombin time is 11-15 seconds, although there is some variation depending on the source of the thromboplastin used in the test.
		The prothrombin time of patients receiving warfarin therapy will also be prolonged-usually in the range of one and one half to two times the normal PT time.
		A PT time that exceeds approximately two and a half times the control value (usually 30 seconds or longer) is grounds for concern, as abnormal bleeding may occur.
	www.healthatoz.com /healthatoz/Atoz/ency/prothrombin_time.jsp (826 words)

	Partial Thromboplastin Time - [Medical Test] - Quest Diagnostics Patient Health Library
		The partial thromboplastin time (PTT) and activated partial thromboplastin time (APTT) may be normal in people who have inherited bleeding disorders with only mild symptoms.
		The APTT is used to monitor treatment of people who are receiving heparin or other blood-thinning medication to prevent the formation of blood clots.
		A test called the heparin neutralization assay may be done to determine whether this is the case.
	www.questdiagnostics.com /kbase/topic/medtest/hw203152/consider.htm (179 words)

	Partial Thromboplastin Time (PTT), Lupus Anticoagulant
		The sample should be mixed immediately by gentle inversion at least 6 times to ensure adequate mixing of the anticoagulant with the blood.
		To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
		Lupus anticoagulants are nonspecific antibodies that extend the clotting time of phospholipid defendant clotting assays such as the aPTT.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/cf003700.htm (1065 words)

	INR - Page 5
		This test measures the time it takes for a patient to generate thromboplastin.
		It is known as the “partial thromboplastin” test because of the absence of certain factors along the coagulation cascade.
		A test in which three small scratches are made on the patient’s skin and then the time it takes for the bleeding to stop is recorded.
	heart.healthcentersonline.com /bloodtest/prothrombintime5.cfm (409 words)

	PTT (Partial Thromboplastin Time)
		PTT detects nearly all abnormalities in clotting, due to deficiencies in clotting factors or circulating anticoagulants.
		It is frequently used to monitor heparin therapy.
		A modification of the test, "Activated PTT," or APTT, is basically the same as PTT, but is slightly more sensitive.
	www.brooksidepress.org /Products/Military_OBGYN/Lab/PTT.htm (114 words)

	Healthopedia.com - Partial Thromboplastin Time (PTT, Activated Partial Thromboplastin Time, APTT)
		The partial thromboplastin time (PTT) test helps measure the ability of the blood to clot normally.
		It is very similar to the prothrombin time (PT) test.
		The PTT and PT test each measure the function of some of these proteins.
	www.healthopedia.com /partial-thromboplastin-time (355 words)

	Partial Thromboplastin Time - [Medical Test] - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-10-09)
		Conditions such as antiphospholipid antibody syndrome or lupus anticoagulant syndrome develop when the immune system produces antibodies that attack certain blood clotting factors, causing the blood to clot easily in veins and arteries.
		The activated partial thromboplastin time (APTT) test is used to determine the most effective dosage of some medications, such as heparin, that prevent blood clots.
		If the test is done for this purpose, an APTT may initially be repeated every few hours.
	www.questdiagnostics.com /kbase/topic/medtest/hw203152/whydone.htm (178 words)

	Partial Thromboplastin Time Information on Healthline
		It is usually done in combination with other tests, such as the prothrombin test, which evaluate the factors of the extrinsic
		Normal APTT results are usually between 25–40 seconds; PTT results are between 60–70 seconds.
		APTT results for a patient on heparin should be 1.5–2.5 times normal values.
	www.healthline.com /galecontent/partial-thromboplastin-time (804 words)

	Activated Partial Thromboplastin Time (APTT), Testing at Millenova Immunology Laboratories
		Activated Partial Thromboplastin Time (APPT) is a useful and effective method for screening patients with a bleeding tendency, for evaluating the effect of therapy in procoagulant disorders and as the basis for several specific coagulant factor assay procedures.
		Calcium is then added to trigger further reactions and the time required for clot formation is measured.
		Kelsey PR, Stevenson KJ, Pollan L. The diagnosis of lupus anticoagulants by the activated partial thromboplastin time.
	millenova.com /tests/aptt.asp (345 words)

	A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism -- Tripodi et ...
		A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism -- Tripodi et al.
		A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
		Plasma Circulating Levels of Soluble P-Selectin and Thrombospondin-1 (TSP1) Are Elevated in Patients with Cancer and a Shortened Activated Partial Thromboplastin Time (APTT) without Clinical Evidence of Thrombosis: An Inexpensive and Simple Test (APTT) To Be Considered for Its Clinical Value.
	www.bloodjournal.org /cgi/content/abstract/104/12/3631 (336 words)

	aPTT: Test Sample
		The activated partial thromboplastin time (aPTT, often called PTT) test is a measure of the functionality of the intrinsic and common pathways of the coagulation cascade.
		If there is an inherited or acquired deficiency in one or more of the factors, or if the factors are functioning abnormally, then stable clot formation will be inhibited and excessive bleeding and/or clotting may occur.
		The aPTT test measures the length of time (in seconds) that it takes for clotting to occur when reagents are added to plasma (liquid portion of the blood) in a test tube.
	www.labtestsonline.org /understanding/analytes/aptt/sample.html (304 words)

	partial thromboplastin time - available resources from Patient UK
		partial thromboplastin time - available resources from Patient UK partial thromboplastin time
		partial thromboplastin time - also known as or related to ptt.
		(partial thromboplastin time), ptt, ptt., activated partial thromboplastin time, aptt.
	www.patient.co.uk /leaflets/partial_thromboplastin_time.htm (162 words)

	Dr. Rose's Peripheral Brain--PARTIAL THROMBOPLASTIN TIME
		In fact, refers to groups of coagulation factors which in combination with Ca can produce Va and convert prothrombin; so "extrinsic thromboplastin" = factors of the extrinsic pathway; "intrinsic thromboplastin" = factors of the intrinsic pathway + PF-3; the former is tested in the PT assay; the latter is tested with the PTT.
		and record time till 1st appearance of fibrin threads
		Increases with Heparin, deficiencies of factors VIII and IX (but also X, XI, XII) and 10% of SLE pts (circulating anticoagulants)
	faculty.washington.edu /momus/PB/ptt.htm (98 words)

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