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Topic: Pathogenesis

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Haemophilus influenzae

Berehove

	Influenza Report 2006 \| Pathogenesis and Immunology
		Although a frequent disease, the specific inflammatory patterns or regulation of immune response and the pathogenesis of cytopathic effects in human influenza is incompletely understood.
		The pathogenesis is characterized by the rapid replication and distribution of the virus within the lungs, causing local and systemic inflammation and cytokine release.
		Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses.
	www.influenzareport.com /ir/pathogen.htm (7289 words)

	Medmicro Chapter 45
		Pathogenesis is the process by which an infection leads to disease.
		Pathogenesis is the process by which virus infection leads to disease.
		Pathogenesis at the cellular level can be viewed as a process that occurs in progressive stages leading to cellular disease.
	gsbs.utmb.edu /microbook/ch045.htm (3478 words)

	Lipton v. Pathogenesis Corp.
		PathoGenesis Corporation ("PathoGenesis" or "the Company"), founded in 1991, is a pharmaceutical company that develops and markets medicines to treat chronic infectious diseases.
		On March 22, 1999, PathoGenesis issued a mid-quarter press release stating that "some first quarter 1999 sales were accelerated into the fourth quarter of 1998 as patients and wholesalers increased their normal orders." PathoGenesis announced that 1Q99 results would not be as strong as previously predicted and would be approximately $10 million.
		PathoGenesis' alleged desires to obtain favorable financing and to expand abroad are in themselves ordinary and appropriate corporate objectives.
	www.law.com /regionals/ca/opinions/mar/0035268.shtml (4421 words)

	Pseudomonas Genome Database: A database for Pseudomonas aeruginosa and other Pseudomonas species genomes
		406:959-964) the year 2000 in a collaboration among the Cystic Fibrosis Foundation, the University of Washington Genome Center and PathoGenesis Corporation.
		Genome annotation was carried out by PathoGenesis scientists and by scientists in the Pseudomonas aeruginosa Community Annotation Project (PseudoCAP).
		As researchers begin to use this genome sequence to make new discoveries about this bacterium, the genome annotation is now being continually updated and the database content and functionality is being expanded to facilitate accelerated discovery of P.aeruginosa drug targets and vaccine candidates.
	www.pseudomonas.com (393 words)

	PathoGenesis Corp. Gains U.K. Approval of TOBI (Site not responding. Last check: 2007-10-26)
		PathoGenesis intends to market TOBI through its own sales force in the U.K. and several other E.U. countries, while working through distributors in the remaining countries.
		PathoGenesis previously announced distributor agreements in Germany, the Nordic countries, Greece and Cyprus.
		PathoGenesis' stock is traded on the Nasdaq National Market System under the symbol PGNS.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/12-15-1999/0001096892&EDATE= (409 words)

	Hospital Practice: New Perspectives on Pneumococcal Meningitis (Site not responding. Last check: 2007-10-26)
		Bench research has helped to elucidate the pathogenesis and pathophysiology of pneumococcal meningitis and may lead to new therapeutic strategies.
		While research efforts have enhanced our understanding of the pathogenesis and pathophysiology of this disease, the resultant therapeutic implications have yet to be fully realized.
		Guidelines for the diagnosis and therapy of patients with suspected and confirmed pneumococcal meningitis will continue to evolve in response to changing resistance patterns, the availability of new antibiotics and vaccines, and a better understanding of the role of adjunctive therapy.
	www.hosppract.com /issues/2001/02/cearon.htm (2758 words)

	NIH Guide: MECHANISMS OF AIDS PATHOGENESIS
		Although the research necessary to test a proposed pathogenesis hypothesis may be possible within a single laboratory, highly competitive applications may require separate components at the same or different institutions specializing in different scientific disciplines (e.g., molecular biology, biochemistry, cellular biology, cellular immunology, genetics and biophysics).
		Clues to HIV pathogenesis also may be discovered from analyses of lentivirus-infected non-human primates in which there is little or no apparent disease, e.g., HIV-infected chimpanzees and African green monkeys infected with African Green Monkey (AGM) lentiviruses.
		This RFA is intended to foster applications for integrated, multi-disciplinary pathogenesis research linking in vitro studies to in vivo disease and focusing specifically on these three scientific areas.
	grants.nih.gov /Grants/guide/rfa-files/RFA-AI-94-018.html (3372 words)

	PathoGenesis Corp. Announces Two-Year Data on TOBI (Site not responding. Last check: 2007-10-26)
		While TOBI therapy resulted in treatment benefits for all age groups, patients who were 13 to 17 years old demonstrated a larger treatment effect of 14.3 percent in relative lung function improvement above the baseline after two years.
		Seattle-based PathoGenesis Corp. is a pharmaceutical company that develops drugs to treat chronic infectious diseases -- lung infections, in particular -- where there is a significant need for improved therapy.
		In addition, PathoGenesis is further developing TOBI and other drug candidates to treat serious chronic lung infections, including those common in cystic fibrosis, bronchiectasis and tuberculosis patients.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-14-1999/0000962331&EDATE= (541 words)

	The Seattle Times: Business & Technology: Chiron trims Seattle operations; Pathogenesis work shifts to California (Site not responding. Last check: 2007-10-26)
		Some observers are critical of how Chiron has handled Pathogenesis, a company that developed an aerosol drug for cystic fibrosis called Tobi.
		At the time it was acquired, Pathogenesis was not profitable, but growing, and had some anti-microbial drugs showing promise in animal testing.
		Many former Pathogenesis people have moved on to other local biotech companies or nonprofit research centers.
	seattletimes.nwsource.com /html/businesstechnology/2001920950_chiron06.html (467 words)

	RFA-DK-98-017: HEPATITIS C: NATURAL HISTORY, PATHOGENESIS, THERAPY AND PREVENTION
		Another goal could be the development of a readily available cell culture system that is fully permissive for viral replication thus promoting the identification of infectious molecular clones in the support of the analysis of the viral structure.
		Studies are needed to investigate mechanisms of augmented liver matrix formation and hepatic fibrosis formation induced by hepatitis C. Studies are also needed to better define means of staging of fibrosis in chronic hepatitis C using liver biopsy tissue as well as noninvasive means such blood tests or imaging procedures.
		Also studies are needed to determine the mechanism(s) by which alcohol enhances virus-induced cytopathology in hepatocytes, and whether chronic alcohol consumption sensitizes hepatocytes to the fibrogenic effects of cytokines, especially in the presence of HCV infection.
	grants.nih.gov /grants/guide/rfa-files/RFA-DK-98-017.html (2973 words)

	Search Results for pathogenesis - Encyclopædia Britannica (Site not responding. Last check: 2007-10-26)
		Pathogenesis is the stage of disease in which the pathogen is in intimate association with living host tissue.
		It also contributes to the pathogenesis of four human tumours: the African form of Burkitt lymphoma,...
		Notes explaining the structure, genome, replication, and pathogenesis of the three sub categories of this virus.
	www.britannica.com /search?query=pathogenesis&submit=Find&source=MWTEXT (393 words)

	Technical: Pathology \| CDC Hantaviruses
		Functional impairment of vascular endothelium is central to the pathogenesis of HPS.
		However, the pathogenesis of HPS is complex, and a myocardial depressant may contribute significantly to the mortality of this disease.
		It is unclear how the shock syndrome relates to factors such as viral distribution and immunologic and pharmacological mediators of capillary permeability.
	www.cdc.gov /ncidod/diseases/hanta/hps/noframes/phys/patho.htm (261 words)

	Bacterial Pathogenesis
		Pathogenesis is a multi-factorial process which depends on the immune status of the host, the nature of the species or strain (virulence factors) and the number of organisms in the initial exposure.
		A limited number of bacterial species are responsible for the majority of infectious diseases in healthy individuals.
		Shiga toxins (chromosomally encoded) are involved in the pathogenesis of shigellosis, whilst shiga-like toxins (phage encoded) are primarily produced by enterohemorraghic E.
	pathmicro.med.sc.edu /fox/bact-path.htm (2143 words)

	Pathogenesis
		Thus, increasing our knowledge of these many processes and steps (collectively called pathogenesis) is essential to the development of more effective prevention and treatment methods.
		Together these research projects will provide critical knowledge on normal breast cell activities, and the ways in which these are disrupted in breast cancer, with the ultimate goal of developing ways to restore normal function to, or interfere with abnormal function of, these cells.
		The FISH technique we will use in the research laboratory may itself form the basis of future tests to classify breast tumors with respect to the activity of these and other genes and so aid in earlier detection and clinical management of disease progression.
	www.ucop.edu /srphome/bcrp/compendium/1996/patho.html (9230 words)

	Molecular Pathogenesis Program
		The Microbiology and Molecular Pathogenesis Program (M2P2) provides graduate students and postdoctoral fellows with first-rate training to prepare them for careers in research as competitive, independent investigators.
		The program faculty's research interests span a wide range of questions regarding host-microbe interactions and related topics in pathogenesis, which allows the entering trainee considerable breadth of choice of experimental systems, approaches and research topics.
		For admissions information, application material and general questions, please contact either the Microbiology and Molecular Pathogenesis Program directly (Email: Molecular.Pathogenesis@Dartmouth.EDU) or visit the MCB web site or for more specific information contact specific faculty members (faculty e-mails can be found on the faculty page).
	www.dartmouth.edu /~molpath (158 words)

	The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors -- Koch et al. 87 (12): ...
		The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors -- Koch et al.
		The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors
		To elucidate the pathogenesis of adrenocortical tumors, the
	jcem.endojournals.org /cgi/content/full/87/12/5367 (9449 words)

	tab001tgf: Comparison of disease pathogenesis of Ebola virus infection in animal models and humans (Site not responding. Last check: 2007-10-26)
		(1999) Pathogenesis of experimental Ebola virus infection in guinea pigs.
		(2003) Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
		(2003) Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.
	www-ermm.cbcu.cam.ac.uk /04008324h.htm (824 words)

	Molecular Pathogenesis
		Immunologists in the MP program also study medically relevant problems such as the mechanisms of HIV pathogenesis, allergic disease, autoimmunity, and lymphomagenesis.
		Other MP laboratories are investigating telomere maintenance, protein misfolding, bacterial virulence, and genomic instability while striving to understand human afflictions as diverse as diabetes, cholesterol toxicity, cancer, and aging.
		Our goals are to identify human host factors required for HIV replication and pathogenesis and to engineer mice permissive for HIV infection and replication.
	saturn.med.nyu.edu /research/mp (2130 words)

	Molecular Microbial Pathogenesis
		Microbial Pathogenesis is the study of the molecular mechanisms used by microbes to cause disease in humans and animals.
		Opportunities for research training in Microbial Pathogenesis at VCU are provided by an interactive group of well funded investigators from several departments including Microbiology and Immunology.
		Research activities are enhanced by state of the art facilities at MCV for DNA sequence analysis, molecular biology supplies, and electron microscopy.
	www.vcu.edu /micro/micpathogen.htm (474 words)

	Deep Vein Thrombosis, epidemiology, pathogenesis and risk factors MEDSTUDENTS- INTERNAL MEDICINE (Site not responding. Last check: 2007-10-26)
		Deep vein thrombosis (DVT) is a common but elusive illness that can result in suffering and death if not recognized and treated effectively.Death can occur when the venous thrombi break off and form pulmonary emboli, which pass to and obstruct the arteries of the lung.
		Three mechanisms are involved in the pathogenesis of venous thrombosis, they are: venous stasis, injury to the venous wall, and hypercoagulable states.
		Venous stasis predisposes the patients to venous thrombosis mainly by impairing the clearance of activated coagulation factors from the local where thrombus is formed, and vascular damage contributes to the genesis of venous thrombosis through either direct trauma, or activation of endothelial cells by cytokines.
	www.medstudents.com.br /medint/medint4.htm (613 words)

	THE PATHOGENESIS OF ORAL LICHEN PLANUS -- Sugerman et al. 13 (4): 350 -- Critical Reviews in Oral Biology & Medicine
		THE PATHOGENESIS OF ORAL LICHEN PLANUS -- Sugerman et al.
		in the pathogenesis of oral lichen planus (OLP).
		in the pathogenesis of OLP and propose a unifying hypothesis
	crobm.iadrjournals.org /cgi/content/abstract/13/4/350 (284 words)

	IAS Conference - Paris 2003
		The Scientific Programme of the 2nd IAS Conference on HIV Pathogenesis and Treatment is planned to provide new insights into HIV disease that can lead to new research directions, help speed translational research and move advances into clinical practice.
		IAS 2005 aims to bring together participants from around the world by providing an environment for researchers and clinicians to address current issues in HIV research, prevention and treatment.
		The 2nd IAS Conference on HIV Pathogenesis and Treatment will be held at Le Palais des Congrès, just at the City Centre of Paris.
	www.ias2003.org /start.aspx (392 words)

	Varicella-Zoster Virus Pathogenesis and Immunobiology: New Concepts Emerging from Investigations with the SCIDhu Mouse ...
		Varicella-Zoster Virus Pathogenesis and Immunobiology: New Concepts Emerging from Investigations with the SCIDhu Mouse Model -- Ku et al.
		A model of the pathogenesis of primary VZV infection.
		The right panel is a diagram depicting proposed events in the pathogenesis of VZV infection of skin.
	jvi.asm.org /cgi/content/full/79/5/2651 (5293 words)

	Pathogenesis of Group A Streptococcal Infections -- Cunningham 13 (3): 470 -- Clinical Microbiology Reviews (Site not responding. Last check: 2007-10-26)
		report on its features and pathogenesis (3, 290, 379, 498).
		Several virulence factors of group A streptococci are likely to be involved in the pathogenesis of toxic shock, invasion of
		Two theories have been proposed for the role of internalization of group A streptococci in disease pathogenesis.
	cmr.asm.org /cgi/content/full/13/3/470 (9759 words)

	Workplan of the Pathogenesis and Applied Genomics Committee. The UNICEF-UNDP-World Bank-WHO Special Programme for ...
		The Pathogenesis and Applied Genomics Committee, a component of the Steering Committee on Basic and Strategic Research (STR), promotes application of post genome activities in research on the pathogenesis of African trypanosomiasis, Chagas disease, dengue fever, lymphatic filariasis, leishmaniasis, leprosy, malaria, onchocerciasis, schistosomiasis, and tuberculosis.
		Significant genome data were accumulated through successful collaborations between scientists from developed and developing countries and emphasis was put on rapid availability of this information in the public domain databases.
		The Pathogenesis and Applied Genomics Committee promotes novel approaches that take advantage of recent advances in molecular biology, immunology, gene technology and genomic structure to elucidate important host-parasite/virus relationships.
	www.who.int /tdr/grants/workplans/pathogen.htm (429 words)

	PATHOGENESIS CORPORATION - Legal Case Documents
		Pathogenesis Corp, et al JRYDMD JRYDMD U.S. District Court U.S. District Court -- Western Washington (Seattle) CIVIL DOCKET FOR CASE #: 99-CV-439 Green v.
		Pathogenesis Corp, et al JRYDMD JRYDMD U.S. District Court U.S. District Court -- Western Washington (Seattle) CIVIL DOCKET FOR CASE #: 99-CV-419 Lipton v.
		PGNS is, essentially, a one-product company entirely dependent upon the success of its formulation of the antibiotic Tobramycin ("TOBI"), an inhaled antibiotic used to treat cystic fibrosis.
	www.legalcasedocs.com /120/246/258.html (836 words)

	Second International AIDS Society Conference on HIV Pathogenesis and Treatment
		Brian Conway, MD, comments and provides relevant illustrations to an expert debate on the relative importance of evidence-based and principle-driven approaches to the optimal management of HIV infection.
		The message: expanding antiretroviral drug access in the developing world is a moral, ethical, and economic imperative following 20 years of advances in the study and treatment of HIV disease in the United States and Europe.
		The scaling up of anti-HIV initiatives was the theme of the opening session of the Second IAS Conference on HIV Pathogenesis and Treatment.
	www.medscape.com /viewprogram/2536 (1354 words)

	Mechanisms of Bacterial Pathogenesis
		These "N-methylphenylalanine pili" have been established as virulence determinants in pathogenesis of Pseudomonas aeruginosa lung infection in cystic fibrosis patients.
		These type of fimbriae occur in Neisseria gonorrhoeae and their receptor is thought to be an oligosaccharide.
		Heterotrophic bacteria, in general, produce a wide variety of extracellular enzymes including proteases, lipases, glycohydrolases, nucleases, etc., which are not clearly shown to have a direct role in invasion or pathogenesis.
	textbookofbacteriology.net /pathogenesis.html (6644 words)

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