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Pemoline - Wikipedia, the free encyclopedia It is marketed under the brand name "Cylert." Pemoline is a Schedule IV drug under the Convention on Psychotropic Substances[1]. Pemoline has some advantages over other stimulants in that it doesn't reduce the appetite or cause dry mouth. However, in some patients Pemoline is suspected of causing liver damage, so regular liver tests should be done. www.wikipedia.org /wiki/Pemoline   (96 words)

Cylert Online, Description, Chemistry, Ingredients - Pemoline - RxList Monographs Pemoline is structurally dissimilar to the amphetamines and methylphenidate. Pemoline is a white, tasteless, odorless powder, relatively insoluble (less than 1 mg/mL) in water, chloroform, ether, acetone, and benzene; its solubility in 95% ethyl alcohol is 2.2 mg/mL. CYLERT (pemoline) is supplied as tablets containing 18.75 mg, 37.5 mg or 75 mg of pemoline for oral administration. www.rxlist.com /cgi/generic/pemoline.htm   (440 words)

Pemoline Synthesis 0.5 Pemoline is a CNS stimulant of the lesser known chemical family of oxazolines. Pemoline is about five times as strong a CNS stimulant as caffeine, slightly stronger than methylpgenidate (Ritalin) and but is not as strong as methamphetamine [2]. The melting point of Pemoline is 256-257°C, and is soluble to an extent of 50 ug/ml in water, the figures for Pemoline Magnesium being >300°C and 70 ug/ml respectively. www.intellicandy.com /oldschool/chemcandy/pemoline.html   (977 words)

pemoline - Mental Health Disorders on MedicineNet.com Pemoline and methylphenidate both have the ability to stimulate the brain, probably by affecting neurotransmitters, the chemicals in the brain that nerves use to communicate with each other. Pemoline was approved for use by the FDA in 1975. Reports suggest that pemoline may decrease the effectiveness of drugs that are used to manage seizures such as phenytoin (Dilantin) or carbamazepine (Tegretol). www.medicinenet.com /pemoline/article.htm   (605 words)

Antidepressant Medications Anti-depressant Drugs Antidepressant: pemoline, Cylert Pemoline is a CNS stimulant, which, although structurally different from the amphetamines and methylphenidate, possesses pharmacological activity similar to that of other known stimulants. Although studies indicate that pemoline may act in animals through dopaminergic mechanisms, the exact mechanism and site of action of the drug in man is not known. Pemoline is not recommended for children less than 6 years since its safety and efficacy in this age group have not been established. support4hope.com /medications/antidepressants/pemoline_cylert.htm   (655 words)

Cylert, Pemoline Pharmacology - HealthyPlace.com Pemoline is contraindicated in patients with known hypersensitivity or idiosyncrasy to the drug. The decision to prescribe pemoline (pemoline) should depend on the physician's assessment of the chronicity and severity of the child's symptoms and their appropriateness for his/her age. Pemoline should be given with caution to emotionally unstable patients who may increase the dosage on their own initiative. healthyplace.com /medications/pemoline.asp   (1156 words)

Cylert (pemoline) June 1999 labeling Pemoline is rapidly absorbed from the gastrointestinal tract. CYLERT (pemoline) therapy should be part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. CYLERT (pemoline) is administered as a single oral dose each morning. www.fda.gov /medwatch/safety/1999/cylert19.htm   (2450 words)

Pemoline - Resources from the U.S. Government   (Site not responding. Last check: 2007-10-25) Pemoline is effective for treatment of daytime sleepiness in narcolepsy (Option). There may be a role for stimulants such as modafanil, pemoline, methylphenidate, and amphetamines in defined settings. Chapter 9: Fatigue: Clarifying the Research Questions: Psychostimulants, such as methylphenidate, pemoline, and dextroamphetamine, have been studied for use as a treatment of opioid-related somnolence and cognitive... drugs.mongabay.com /resources/Pemoline.html   (1290 words)

Drug Directory: Pemoline   (Site not responding. Last check: 2007-10-25) Before taking pemoline, you will be required to discuss with your doctor the risks and benefits of this medicine and to sign an informed consent stating that you understand these risks and benefits. Pemoline is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Symptoms of a pemoline overdose include agitation, vomiting, tremors (shaking), muscle twitches, seizures, confusion, hallucinations, sweating, flushing, headache, fast or irregular heartbeat, large pupils, and dryness of the mouth and eyes. netpediatrics.com /drugs/p-27.htm   (894 words)

Pemoline ( Cylert , Volital )   (Site not responding. Last check: 2007-10-25) In this context a dose response study was carried out to investigate the effects of pemoline, a dopamimetic agent, on overnight work and to assess potential residual effects on subsequent sleep. Pemoline increased subjective alertness and performance on all but two tasks, compared with placebo. The onset of activity was seen 4.5 h after drug ingestion and alerting effects of 30 and 40 mg pemoline persisted beyond the work period, disturbing morning recovery sleep. www.biopsychiatry.com /pemoline.htm   (265 words)

Published Warnings for Pemoline (CYLERT®) CYLERT (pemoline) has a pharmacological activity similar to that of other known central nervous system stimulants; however, it has minimal sympathomimetic effects. Although studies indicate that pemoline (CYLERT) may act in animals through dopaminergic mechanisims, the exact mechanism and site of action of the drug in man is not known. The decision to prescribe CYLERT (pemoline) should depend on the physician's assessment of the chronicity and severity of the child's symptoms and their appropriateness for his/her age. www.pemoline.net   (1057 words)

Pemoline therapy resulting in liver transplantation -- Adcock et al. 32 (4): 422 -- The Annals of Pharmacotherapy Pemoline therapy was discontinued, but the patient's liver function continued to decline. DISCUSSION: Pemoline, an agent used in ADHD treatment, has been associated with hepatotoxicity with the majority of cases occurring in pediatric patients. Prior to initiating therapy, baseline liver function tests should be obtained and closely monitored, and parents and patients should be educated on the signs and symptoms of liver toxicity. www.theannals.com /cgi/content/abstract/32/4/422   (212 words)

Cylert Indications, Dosage, Storage, Stability - Pemoline - RxList Monographs CYLERT (pemoline) therapy should be proof of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted. Using the recommended schedule of dosage titration, significant benefit may not be evident until the third or fourth week of drug administration. www.rxlist.com /cgi/generic/pemoline_ids.htm   (330 words)

Healthopedia.com Drugs Information - Pemoline : Side Effects (Cylert, Cylert Chewable) Pemoline may cause some serious side effects, including liver problems. Also, medicines like pemoline, when used for a long time, have been reported to slow the growth rate of children. Pemoline may also cause unwanted effects on behavior in children with severe mental illness. www.healthopedia.com /drugs/detailed/pemoline/side-effects.html   (525 words)

Psych Central - Cylert (Pemoline) Pemoline is a stimulant used to treat attention-deficit disorder. Pemoline may be prescribed for other condtions as well. Pemoline works in the brain and has been shown to decrease fatigue, increase alertness, and increase mood. www.grohol.com /meds/cylert.html   (642 words)

Pemoline.com | All you need to know about pemoline This site is unique in that it provides you with real experiences from people who are using or who have used pemoline. Pemoline is used to treat attention-deficit disorder in children over the age of six. These forums are a valuable community meeting place for members who wish to give and receive support and information on Pemoline. www.pemoline.com   (327 words)

Journal of the American Academy of Child and Adolescent Psychiatry : A study of compliance with FDA recommendations for ...   (Site not responding. Last check: 2007-10-25) Pemoline (Cylert[R]), one of the drugs available for the treatment of ADHD, was approved by the Food and Drug Administration (FDA) in 1975. At the time of approval, delayed hypersensitivity reactions involving the liver were noted to occur in 1% to 2% of patients receiving pemoline, leading to recommendations in the precautions section to monitor liver transaminase levels periodically. Read 'Journal of the American Academy of Child and Adolescent Psychiatry: A study of compliance with FDA recommendations for pemoline. static.highbeam.com /j/journaloftheamericanacademyofchildandadolescentpsy/july012002/astudyofcompliancewithfdarecommendationsforpemolin/index.html   (314 words)

Pemoline - Side Effects of Pemoline   (Site not responding. Last check: 2007-10-25) Pemoline If you are a looking Pemoline for a way to get your child off of Pemoline medications such as Adderall, Adderall, Dexedrine or Pemoline Cylert, then you’ve come to the Pemoline right place. While we believe there is a time and place for the administration of Pemoline in certain cases, we agree with many critics of psychotropics that these medications are administered far too frequently without proper testing and without adhering to the precautions on the prescribing inserts provided with the medications. Ritalin, Pemoline,, Ritalin, Pemoline, Cylert, Ritalin, Pemoline, Cylert, Ritalin, Pemoline, Cylert, Ritalin, Pemoline, Cylert, Ritalin, Pemoline, Cylert, www.sharpermindcenters.com /ADD/Pemoline.htm   (198 words)

MedlinePlus Drug Information: Pemoline To avoid insomnia and to provide its greatest benefits during waking hours, pemoline should be taken in the morning. Continue to give pemoline even if the child appears to be better. Although side effects from pemoline are not common, they can occur. www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682313.html   (567 words)

Public Citizen | Publications - Letter to FDA urging the immediate recall of all outstanding supplies of generic ... On March 28th of this year, we petitioned the FDA to immediately ban the attention deficit drug Cylert (pemoline--Abbott) and all generic versions of pemoline because of clear evidence that the drug causes liver failure and that it has no unique advantage over other drugs used to treat this condition. It is reckless and insensitive to the health and lives of children and adults using this drug for the FDA and the involved drug companies to fail to institute an immediate recall of these dangerous products. We urge you to immediately tell these companies to recall all outstanding supplies of pemoline and to urge patients and parents of patients to immediately see their physicians about alternative treatments. www.citizen.org /publications/release.cfm?ID=7405&secID=1687&catID=126   (369 words)

MedlinePlus Drug Information: Pemoline (Systemic)   (Site not responding. Last check: 2007-10-25) However, studies in animals given large doses of pemoline have shown that pemoline causes an increase in stillbirths and decreased survival of the offspring after birth. Pemoline may make behavior worse in children with serious mental illness. The dose of pemoline will be different for different patients. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202444.html   (1478 words)

Healthopedia.com Drugs Information - Pemoline (Cylert, Cylert Chewable) Pemoline increases attention and decreases restlessness in children who are overactive, cannot concentrate for very long or are easily distracted, and are emotionally unstable. This medicine is used as part of a total treatment program that also includes social, educational, and psychological treatment. In addition, you will be asked to sign an informed consent form stating that you understand and agree to accept the risk of liver problems. www.healthopedia.com /drugs/detailed/pemoline   (318 words)

Pemoline If you have an allergy to pemoline or any other part of the medicine. Pemoline stimulates the brain in adults to increase alertness. Pemoline has a stabilizing effect in children with attention deficit disorder. www.umm.edu /altmed/ConsDrugs/Pemolinecd.html   (693 words)

Product Information on Pemoline The date Pemoline was approved as stated in the FDA approval letter to the applicant. The group or category of approved drugs Pemoline is in. The full name of the firm holding legal responsibility for the new application of Pemoline. newdruginformation.com /Pemoline_8.htm   (126 words)

PEMOLINE (2-IMINO-5-PHENYL-4-OXAZOLIDINONE) Pemoline, an oxazolidine compound, is a central nervous system stimulant used in the treatment of children with attention-deficit/hyperactivity disorder such as inattention, hyperactivity and impulsivity as well as adults with narcolepsy in case of no response of psychotherapy. Pemoline is a white to off-white crystalline powder; insoluble in water; melting point 245 C; administered orally. We are pleased to receive your any questions or remarks. www.chemicalland21.com /lifescience/phar/PEMOLINE.htm   (95 words)

Alternative health - Public Citizen Petitions FDA to Take Pemoline Off the Market Pemoline originally appealed to clinicians because it allowed pemoline prescriptions were filled in the United States. failure due to pemoline, 11 of which resulted in death or liver www.pahealthsystems.com /archive254-2005-3-347836.html   (573 words)

Case 2: An Irresistible Urge to Sleep -- Answer   (Site not responding. Last check: 2007-10-25) Pemoline is a stimulant medication that blocks dopamine uptake. It has been associated with fulminant hepatic failure in some patients. Pemoline would be helpful for daytime sleepiness, not cataplexy. www.medscape.com /content/2004/00/48/04/480459/ans13.html   (38 words)

Pemoline   (Site not responding. Last check: 2007-10-25) The word "pemoline" uses 8 letters: E E I L M N O P. Words within pemoline not shown as it has more than seven letters. All words formed from pemoline by changing one letter www.morewords.com /word/pemoline   (180 words)

PR Newswire : Copley Announces Launch Of Pemoline, Its First Controlled Drug. @ HighBeam Research   (Site not responding. Last check: 2007-10-25) Start / P / PR Newswire / June 14, 1999 / Copley Announces Launch Of Pemoline, Its First Controlled Drug. Copley is the first multi-source pharmaceutical company to receive FDA approval of an Abbreviated New Drug Application (ANDA) for Pemoline and the first to begin shipments. Read 'PR Newswire: Copley Announces Launch Of Pemoline, Its First Controlled Drug.' with a FREE Trial for instant access » static.highbeam.com /p/prnewswire/june141999/copleyannounceslaunchofpemolineitsfirstcontrolledd/index.html   (212 words)

HON Mother & Child Glossary, Childhood Mental Health: Attention Deficit Hyperactivity Disorder Three medications in the class of drugs known as stimulants seem to be the most effective in both children and adults. These are methylphenidate (Ritalin), dextroamphetamine (Dexedrine or Dextrostat), and pemoline (Cylert). For many people, these medicines dramatically reduce their hyperactivity and improve their ability to focus, work, and learn. www.hon.ch /Dossier/MotherChild/child_mentalhealth/attention_deficiency.html   (615 words)

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