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Topic: Pentamidine

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	drugs
		Treatment of the early phase of the disease is with either pentamidine in West Africa or suramin in East Africa and for the late stage of the disease with organic arsenicals (Arsobal, Melarsoprol, Mel B).
		Pentamidine (Lomidine) is used only for the early phase of the disease, since it does not cross the blood-brain barrier.
		The recommended dose for treatment is 4 mg of pentamidine base per kg of body weight given intramuscularly in a total of 7 injections daily or on alternating days.
	www.icp.ucl.ac.be /~opperd/parasites/drugs1.htm (811 words)

	Pentamidine
		Pentamidine isethionate is a drug given for prevention and treatment of Pneumocystis carinii pneumonia, a type of pneumonia often seen in people with HIV infection.
		PCP pneumonia is more effectively treated with trimethoprim combined with sulfamethoxazole (marketed in fixed combination as Bactrim[?]), but pentamidine is used as a second or third-line treatment if Bactrim treatment cannot be tolerated.
		Pentamidine is administered intravenously once a day for 14 to 21 days for treatment, or in an aerosolized form given by nebuliser once monthly for prevention of PCP in those at risk.
	www.ebroadcast.com.au /lookup/encyclopedia/pe/Pentamidine.html (143 words)

	[No title]
		Pentamidine isethionate was approved by the FDA on June 15, 1989, for use in the treatment of Pneumocystic jiroveci (formerly Pneumocystis carinii) pneumonia (PCP) in AIDS patients.
		Pentamidine isethionate is indicated as secondary prophylaxis in the treatment of PCP in patients who have already had at least one episode of the illness and in immunocompromised patients.
		Pentamidine isethionate is soluble in glycerol, with solubility increasing upon warming; slightly soluble in alcohol; and insoluble in ether, acetone, chloroform, and liquid petroleum.
	aidsinfo.nih.gov /DrugsNew/DrugDetailT.aspx?int_id=25 (1901 words)

	Aidsmap \| Pentamidine
		Pentamidine is an approved anti-fungal and anti-protozoal drug used for the treatment and prevention of Pneumocystis pneumonia (PCP).
		The effectiveness of aerosolised pentamidine prophylaxis seems to be significantly dependent on the size of the aerosol particles generated by the nebulising machine, as finer particles penetrate deeper into the lungs than large particles.
		Effect of aerosolized pentamidine prophylaxis on the diagnosis of Pneumocystis carinii pneumonia in patients infected with the human immunodeficiency virus.
	www.aidsmap.com /en/docs/09A66BF4-313E-47B9-AC86-CC2FAB06EB4C.asp (498 words)

	Pentamidine (8:30.92) - 385029
		Pentamidine given by oral inhalation is one of several alternatives that can be used in adults, adolescents, and children who cannot tolerate co-trimoxazole (the drug of choice).
		pentamidine is an alternative and may be a drug of choice in patients who fail to respond to antimony compounds.
		Manufacturer states that parenteral pentamidine should be used with caution in patients with renal impairment and that safety and efficacy of alternative dosage regimens have not been established in these patients.
	www.ashp.org /mngrphs/essentials/a385029e.htm (3760 words)

	pentamidine - Drug Finder - MSN Health & Fitness (Site not responding. Last check: )
		Pentamidine is in the FDA pregnancy category C. This means that it is not known whether pentamidine will harm an unborn baby.
		Pentamidine for inhalation may be administered via the Respigard II nebulizer as part of a home health regimen by a nurse, respiratory therapist or other healthcare practitioner.
		Pentamidine should be administered in a clinical setting where a healthcare provider can monitor vital signs (blood pressure, heart rates) and where an emergency situation can be handled immediately.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100105357 (1035 words)

	Nebulised Pentamidine - 2nd edition - Information for children and families - Family factsheets - GOSH and ICH
		Nebulised pentamidine is a drug given to children to prevent a type of chest infection called Pneumocystis Carinii pneumonia.
		The symptoms of this infection are a raised temperature, rapid breathing and a dry cough.
		Pentamidine is possibly harmful to the unborn child, although this has not been proved.
	www.gosh.nhs.uk /factsheets/families/F040252/index.html (672 words)

	Pentamidine(Systemic) - [Medication] (Site not responding. Last check: )
		Pentamidine is to be administered only by or under the immediate supervision of your doctor.
		Children—Although pentamidine has not been widely used in children, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Pentamidine can lower the number of white blood cells in your blood, increasing the chance of your getting certain infections.
	www.luhs.org /health/kbase/htm/mdx-/drde/2024/49/mdx-drde202449.htm (1507 words)

	Pentamidine - Wikipedia, the free encyclopedia
		Pentamidine isethionate is an antimicrobial medication primarily given for prevention and treatment of Pneumocystis jiroveci pneumonia, also formerly known as Pneumocystis carinii pneumonia (PCP), a severe interstitial type of pneumonia often seen in patients with HIV infection.
		Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia.
		Clinical evidence suggests that pentamidine is often better tolerated than co-trimoxazole because a high dose of co-trimoxazole is needed, which is associated with a high incidence and severity of side effects such as hepatitis, bone-marrow-damage, renal-damage, and life threatening skin disease (Lyell-syndrome).
	en.wikipedia.org /wiki/Pentamidine (702 words)

	Pentamidine
		Pentamidine is usually administered parenterally by intravenous or intramuscular injection.
		Adverse reactions of coughing was noted in adverse reactions were successfully treated by administration of an aerosolized bronchodilator prior to aerosolization of pentamidine or by lowering the gas flow rate to the pentamidine aerosol delivery device.
		In general, the procedure for aerosolization calls for 600 mg of lypholized pentamidine to be reconstituted with 6 ml of sterile water.
	www.nemc.org /RespCare/pentamid.htm (1260 words)

	pentamidine Side Effects, Interactions and Information - Drugs.com
		Pentamidine is in the FDA pregnancy category C. This means that it is not known whether pentamidine will harm an unborn baby.
		Pentamidine for inhalation may be administered via the Respigard II nebulizer as part of a home health regimen by a nurse, respiratory therapist or other healthcare practitioner.
		Pentamidine should be administered in a clinical setting where a healthcare provider can monitor vital signs (blood pressure, heart rates) and where an emergency situation can be handled immediately.
	www.drugs.com /MTM/pentamidine.html (1069 words)

	MedlinePlus Drug Information: Pentamidine Inhalation
		Pentamidine is an anti-infective agent that helps to treat or prevent pneumonia caused by the organism Pneumocystis carinii.
		Pentamidine comes as a solution to be inhaled using a nebulizer.
		Your doctor may suggest slowing the aerosol stream or may prescribe a bronchodilator (medication that opens the airways) to use before your pentamidine inhalation.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601208.html (666 words)

	:: Healthline Aerosol Medicine -- Ref List Pentamidine
		Fluticasone propionate and pentamidine isethionate reduce airway hyperreactivity, pulmonary eosinophilia and pulmonary dendritic cell response in a guinea pig model of asthma.
		Effect of aerosolized pentamidine prophylaxis on the diagnosis of Pneumocystis carinii pneumonia by induced sputum examination in patients infected with the human immunodeficiency virus.
		Aerosol pentamidine for secondary prophylaxis of AIDS-related Pneumocystis carinii pneumonia.
	www.healthlinemed.com /ref-pentam.htm (1956 words)

	PENTAMIDINE
		Pentamidine (sold as NebuPent®, Pentam®, and Pentacarinat®) is a treatment for pneumocystis pneumonia (PCP).
		Pentamidine is normally not the first choice for treatment of PCP.
		Pentamidine is a drug that is usually inhaled in an aerosol form to prevent PCP.
	www.aids.org /Factsheets/537-Pentamidine.html (776 words)

	AEGiS-MMWR: Notice to Readers Pentamidine Methanesulfonate to be Distributed by CDC
		Pentamidine is used to treat patients with Pneumocystis carinii pneumonia (PCP) who have failed to respond or who have had adverse reactions to trimethoprim/sulfamethoxazole.
		The change from one pentamidine salt to another is necessary because CDC has been unable to obtain assurances that the manufacturer of the isethionate salt can meet the increasing U.S. demand for pentamidine.
		Pentamidine isethionate is labeled to reflect the weight of salt present (pentamidine base moiety plus isethionate salt moieties), whereas pentamidine methanesulfonate is labeled according to the weight of only the pentamidine base present.
	www.aegis.com /pubs/mmwr/1984/MM3317.html (753 words)

	A prospective study of the effect of IV pentamidine therapy on ventricular arrhythmias and QTc prolongation in ... (Site not responding. Last check: )
		The aim of this study was to prospectively examine in a controlled manner the effect of IV pentamidine therapy, on the QT interval and the incidence of ventricular arrhythmias.
		The mean QTc in the pentamidine group decreased during therapy as compared to pretherapy with the difference approaching significance for days 2, 4, and 6 with pentamidine (p [is less than] 0.06).
		In the absence of QTc prolongation, pentamidine therapy was not associated with a significant increase in PVCs, NSVT, or sustained VT as compared to pretherapy recordings or as compared to therapy with TMP-SMX.
	www.findarticles.com /p/articles/mi_m0984/is_n3_v112/ai_19831782 (529 words)

	Pentamidine
		Pentamidine is prescribed to transplant patients in order to treat or prevent the development of a serious type of pneumonia known as pneumocystis carinii pneumonia.
		Pentamidine is injected into the body, and works best when there is a constant amount of it in the bloodstream.
		Pentamidine must be taken for the entire duration of treatment in order to achieve the best results.
	cms.clevelandclinic.org /transplant/body.cfm?id=259 (319 words)

	PENTAMIDINE Faq
		Pentamidine is used in the prevention and treatment of pneumocystis carinii pneumonia (PCP).
		Pentamidine is used when a person has experienced adverse effects or toxicity to other drugs, such as trimethoprim-sulfamethoxazole TMP/SMX (Bactrim, Septra and others) or dapsone.
		For the prevention of PCP, pentamidine is given by inhalation which involves breathing in the drug through a device called a nebulizer which changes the drug into a mist that coats your lungs.
	www.tthhivclinic.com /pentam.htm (503 words)

	Pentamidine advanced consumer information \| Drugs.com
		Pentamidine is to be administered only by or under the immediate supervision of your doctor.
		Children—Although pentamidine has not been widely used in children, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Pentamidine can lower the number of white blood cells in your blood, increasing the chance of your getting certain infections.
	www.drugs.com /cons/Pentamidine.html (1829 words)

	Pharmaceutical compositions containing pentamidine - Patent 5204113
		Pentamidine has also been found to be effective in the treatment of PCP infection in AIDS patients when administered by intravenous infusion or intramuscular injection although this treatment is often accompanied by severe side-effects, e.g.
		Pharmaceutically acceptable salts of pentamidine which may be mentioned are the isethionate, the naphthoate and the mesylate.
		According to another aspect of the invention, there is provided the use of pentamidine, or a pharmaceutically acceptable salt thereof, as active ingredient in the manufacture of a medicament for use in the treatment of PCP, characterized in that the medicament contains pentamidine in powdered form.
	www.freepatentsonline.com /5204113.html (3145 words)

	Consumer Reports Health - Pentamidine Isethionate Injection
		If you are receiving pentamidine intravenously (in your vein), your health care provider will tell you to store it at room temperature in a clean, dry place.
		If you are receiving pentamidine intramuscularly (in your muscle), your health care provider will tell you how to store it properly.
		If you are receiving pentamidine in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.consumerreports.org /health/drug-reports/pentamidine-isethionate-injection.htm (1005 words)

	Pentamidine (Systemic)
		Pentamidine (pen-TAM-i-deen) is used to treatPneumocystis carinii (noo-moe-SISS-tis) pneumonia (PCP), a very serious kind of pneumonia.
		Although pentamidine has not been widely used in children, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		To help clear up your infection completely, pentamidine must be given for the full time of treatment, even if you begin to feel better after a few days.
	allnutritionals.com /drugs/p/pentamidine-systemic.shtml (1547 words)

	pentamidine - Ask.com Web Search
		Pentamidine isethionate is an antimicrobial medication primarily given for prevention and treatment of Pneumocystis jiroveci pneumonia, also
		The diamidine pentamidine is used to treat leishmaniasis,...
		In Vitro Activities of Pentamidine, Pyrimethamine, Trimethoprim, and...
	search.ask.com /web?q=pentamidine (229 words)

	Pentamidine-induced acute renal failure
		The mechanism by which pentamidine produces acute renal failure is unclear, but a direct nephrotoxic effect is probably involved, leading to acute tubular necrosis.
		HYPERKALEMIA — An elevation in the plasma potassium concentration, often leading to overt hyperkalemia, is an extremely common complication of pentamidine therapy, typically being out of proportion to the degree of renal insufficiency [1,6,7].
		Pentamidine appears to act by decreasing the number of open sodium channels in the luminal membrane of the principal cells in the cortical collecting tubule, a mechanism similar to the potassium-sparing diuretics such as amiloride and triamterene.
	www.uptodate.com /patients/content/topic.do?topicKey=renlfail/2684 (635 words)

	pentamidine - Hartford, Connecticut CT
		Pentamidine is a type of antibiotic that fights protozoa in the body.
		Pentamidine may also be used for purposes other than those listed in this medication guide.
		You may not be able to take pentamidine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
	www.saintfranciscare.com /110679.cfm (893 words)

	Pentamidine Information - Geriatric Services of America
		This medication should only be taken in accordance with your doctor's instructions, as prescribed for your respiratory disease.
		Free under Medicare Part B: If you suffer from lung disease, and are on Medicare, you may be entitled to pentamidine at no cost.
		Pentamidine, and its brand name equivalents are, are available through Geriatric Services of America, and covered under Medicare Part B. Fill out the below contact form, and a GSA representative will assist you in obtaining the medication, treatment, and relief that you're entitled to.
	www.geriatricservices.com /information/pentamidine.asp (136 words)

	ConsuMed - Pentamidine Injecties
		Pentamidine Injecties is uitsluitend op recept verkrijgbaar (= UR-geneesmiddel).
		Overgevoeligheid of allergie voor Pentamidine Injecties of voor een of meer van de bestanddelen.
		Pentamidine Injecties is alleen op doktersrecept verkrijgbaar en wordt daarom vergoed volgens de daarvoor geldende regels van de overheid en uw zorgverzekeraar.
	www.consumed.nl /medicijnen/5425/Pentamidine_Injecties (939 words)

	Viloxazine interferes in liquid chromatographic assay of pentamidine.
		Unusually high plasma concentrations of pentamidine in patients receiving viloxazine concurrently with aerosolized pentamidine as prophylaxis against Pneumocystis carinii led us to suspect an interference by the antidepressant or its hydroxylated metabolites in the chromatographic assay of pentamidine.
		METHODS: Pentamidine was assayed by chromatography of the liquid phase according to the method of Conte and al.
		Interference is greatest when the blood sample is obtained close to the time at which viloxazine peaks in the serum (Tmax = 2-3h) and gives rise to concentrations (expressed as pentamidine equivalent) similar to those observed after the administration of pentamidine by the intravenous or intramuscular route.
	gateway.nlm.nih.gov /MeetingAbstracts/102192819.html (335 words)

	(ATN) Aerosol Pentamidine Gets "Treatment IND" Approval
		Aerosol pentamidine was already in widespread use before this treatment IND. Several different doses had been used.
		And the U.S. approval may contribute to efforts to make aerosol pentamidine available in Canada, where lack of access has been a major problem.
		LyphoMed has agreed to continue trials of aerosol pentamidine for 24 months, even after full FDA approval, so some patients will receive free treatment through this study.
	www.aegis.com /pubs/atn/1989/atn07402.html (648 words)

	Pentamidine (Inhalation, Oral/nebulization Route) - MayoClinic.com
		Pentamidine is used to try to prevent Pneumocystis carinii pneumonia (PCP), a very serious type of pneumonia.
		However, pentamidine inhalation is recommended in children 5 years of age and older who cannot tolerate other medicines.
		If you are also using the inhalation form of a bronchodilator (medicine used to help relieve breathing problems), use the pentamidine inhalation at least 5 to 10 minutes after the bronchodilator, unless otherwise directed by your doctor.
	www.mayoclinic.com /health/drug-information/DR601083 (1007 words)

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