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	Signal peptide - Wikipedia, the free encyclopedia
		A signal peptide is a short (3-60 amino acids long) peptide chain that directs the post-translational transport of a protein.
		Signal peptides may also be called targeting signals, signal sequences, transit peptides, or localization signals.
		The signal peptide that directs to the mitochondrial matrix has a sequence consisting of an alternating pattern with a few hydrophobic amino acids and a few plus-charged amino acids form.
	en.wikipedia.org /wiki/Signal_peptide (367 words)

	A Novel Mutation of the Signal Peptide of the Preproparathyroid Hormone Gene Associated with Autosomal Recessive ...
		-1 and +1) in the signal peptide of the prepro-PTH gene that
		A, Amino acids 1–25 comprise the signal peptide; residues 26–31 constitute the pro sequence, and the remaining 84 amino acids are mature PTH (not shown).
		Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.
	jcem.endojournals.org /cgi/content/full/84/10/3792 (3752 words)

	MVS Solutions - SIVmac239 Immunogenic Plasmids and AIDS DNA Vaccine Containing the Same
		Preferably, a signal peptide of glycoprotein is used as a signal sequence of secretory protein.
		Preferably, the DNA sequence encoding a signal peptide of glycoprotein is used as the DNA sequence encoding a signal peptide of secretory protein.
		Preferably, the DNA sequence encoding a signal peptide of glycoprotein is used as a signal sequence of secretory protein.
	www.mvssolutions.com /PBC_03-048366.html (15604 words)

	The signal peptide sequence of a lytic transglycosylase of Neisseria meningitidis is involved in regulation of gene ...
		The signal peptide sequence of a lytic transglycosylase of Neisseria meningitidis is involved in regulation of gene expression -- Serruto and Galeotti 150 (5): 1427 -- Microbiology
		The signal peptide sequence of a lytic transglycosylase of Neisseria meningitidis is involved in regulation of gene expression
		The 60 nucleotides encoding the signal peptide of the Neisseria
	mic.sgmjournals.org /cgi/content/full/150/5/1427 (5331 words)

	[No title]
		RB10043 (32476218) hypothetical protein-signal peptide and transmembrane predictio -
		RB10386 (32476405) hypothetical protein-signal peptide and transmembrane predictio -
		RB11545 (32477037) hypothetical protein-signal peptide and transmembrane predictio -
	cmgm.stanford.edu /~merino/Pirellula_sp/indice_alpha.html (1937 words)

	Signal Peptide Peptidase antibody (ab16080) datasheet (Site not responding. Last check: 2007-10-31)
		This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein.
		Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.
		Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
	www.abcam.com /?datasheet=16080 (514 words)

	In Vivo Analysis of Sequence Requirements for Processing and Degradation of the Colicin A Lysis Protein Signal Peptide ...
		for the stability of the wild-type signal peptide.
		Degradation of a signal peptide by protease IV and oligopeptidase A. Bacteriol.
		The stable BRP signal peptide causes lethality but is unable to provoke the translocation of cloacin DF13 across the cytoplasmic membrane of Escherichia coli.
	jb.asm.org /cgi/content/full/180/12/3026 (3993 words)

	Signal Peptide-Dependent Protein Transport in Bacillus subtilis: a Genome-Based Survey of the Secretome -- Tjalsma et ...
		From the prediction of signal peptides and transmembrane regions, the percentage of the proteome that is transported from
		Based on the predictions of signal peptides and various retention signals, it is hypothesized that at least four different protein transport pathways exist in B.
		signal peptide peptidase, encoded by the sppA gene) (123, 125,
	mmbr.asm.org /cgi/content/full/64/3/515 (8953 words)

	Secretion of Cartilage Oligomeric Matrix Protein Is Affected by the Signal Peptide -- Holden et al. 280 (17): 17172 -- ...
		signal peptide is recognized and bound by the cytosolic signal
		In each case, the total value for wild type COMP targeted by the COMP signal peptide was assigned a value of 1 and the values for the remaining constructs were adjusted relatively.
		to the amino terminus of the signal peptide.
	www.jbc.org /cgi/content/full/280/17/17172 (6282 words)

	From The Cover: An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter -- ...
		of the signal peptide led to mis-folding of EspP in the periplasm
		Truncation of the signal peptide causes incomplete folding of EspP in the OM.
		the signal peptide mutant remains trapped in the periplasm.
	www.pnas.org /cgi/content/full/102/1/221 (4621 words)

	A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition -- Michaëlsson et al. ...
		Hsp60 signal peptide targets GFP into mitochondria and the methionine residue at position 11 is not crucial for mitochondrial translocation.
		K562 cells were transfected with either a chimeric construct consisting of the wild-type full-length hsp60 signal peptide (residues 1–26) directly upstream and in frame of GFP (top panel, green), or a mutated variant of the full-length hsp60 signal peptide where the methionine at position 11 was replaced with a glycine (bottom panel, green).
		Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach.
	www.jem.org /cgi/content/full/196/11/1403 (7084 words)

	Biochemical Properties of a Putative Signal Peptide Peptidase from the Hyperthermophilic Archaeon Thermococcus ...
		Signal peptide peptidases are enzymes considered to cleave the
		Mechanism of signal peptide cleavage in the biosynthesis of the major lipoprotein of the Escherichia coli outer membrane.
		Molecular cloning and sequencing of the sppA gene and characterization of the encoded protease IV, a signal peptide peptidase, of Escherichia coli.
	jb.asm.org /cgi/content/full/187/20/7072 (4555 words)

	Genome Biology \| Full text \| Signal peptide cleavage site prediction
		The signal peptide is often used to localize proteins to specific regions within the cell, so knowledge of a specific signal peptide for a protein can provide a clue to its likely location.
		There are links to background information as well as links to PDF files of the original articles for a detailed description of the methods used for signal peptide identification.
		This version incorporates a new signal peptide prediction method based on hidden Markov models which allows improved discrimination between signal peptides and uncleaved signal anchors for eukaryotic data.
	genomebiology.com /2000/1/3/reports/2054 (459 words)

	A Common Autoimmunity Predisposing Signal Peptide Variant of the Cytotoxic T-lymphocyte Antigen 4 Results in ...
		A common T17A polymorphism in the signal peptide of the cytotoxic T-lymphocyte antigen 4 (CTLA-4), a T-cell receptor that
		Because the signal peptide is co-translationally cleaved in the endoplasmic reticulum (ER) and is not a part of the mature
		We assessed signal peptide cleavage by performing the translation reactions for each allele in the presence of the signal peptidase inhibitor, N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone.
	www.jbc.org /cgi/content/full/277/48/46478 (6113 words)

	Signal peptide - periplasmic protein - BioForum
		maybe your protein does not have a signal peptide because it have an interaction with a protein carrier which get itself the signal peptide.
		I'm not sure but maybe the peptide signal is clived in a maturation process which occurs after the fixation in the membrane (but this idea is less possible cause the signal would exist in the gene).
		If you have used the protein extracte from the perilasm them, you will have see a signal peptide, as duirng the transmembrane transport the signal peptide is cleaved off.
	www.protocol-online.org /forums/index.php?showtopic=5429 (234 words)

	Genome Biology \| Full text \| How is the human signal peptide recognized?
		The crystal structure of human SRP54M from the signal recognition particle (SRP) reveals a homodimer interaction, which may be a model for the way signal sequences on nascent proteins recognize and activate the SRP.
		The signal recognition particle (SRP) machinery performs three jobs in the cell: it captures an actively transcribing ribosome; links it to the endoplasmic reticulum (ER) membrane; and then threads the nascent protein chain into the ER for processing and transport.
		In this paper, the authors describe the atomic-resolution structure of the M domain of human SRP54, a protein believed to bind the signal peptide directly.
	genomebiology.com /2000/1/1/reports/020 (554 words)

	InterPro: IPR006639 Peptidase A22, presenilin signal peptide
		SPP and potential eukaryotic homologs represent a family of aspartic proteases that promote intramembrane proteolysis to release biologically important peptides.
		Signal peptide peptidase (SPP) catalyses intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein.
		In humans, SPP activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognised by the immune system, and are required in the processing of the hepatitis C virus core protein.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR006639 (3034 words)

	SignalP server
		SignalP V2.0 comprises two signal peptide prediction methods, SignalP-NN (based on neural networks, corresponding to SignalP V1.1) and SignalP-HMM (based on hidden Markov models).
		SignalP-HMM provides not only a prediction of the presence of a signal peptide and the position of the cleavage site, but also an approximate assignment of n-, h- and c-regions within the signal peptide.
		Prediction of signal peptides and signal anchors by a hidden Markov model.
	www.cbs.dtu.dk /services/SignalP-2.0 (659 words)

	BioMed Central \| Abstract \| SPdb - a signal peptide database
		The signal peptide plays an important role in protein targeting and protein translocation in both prokaryotic and eukaryotic cells.
		Understanding how signal peptides function is crucial in predicting where proteins are translocated.
		To support this understanding, we present SPdb signal peptide database http://proline.bic.nus.edu.sg/spdb, a repository of experimentally determined and computationally predicted signal peptides.
	www.biomedcentral.com /1471-2105/6/249/abstract (241 words)

	Ten amino acid signal peptide - BioForum
		Can enybody tell me a signal peptide less than 10 amino acid.
		I want to clone IL-18 which has no signal peptide of its own.
		Once I searched on pubmed and found that there are many signal sequences, and there was also artificial signal peptides which is, in fact, a combination of signals that have high efficiency!
	www.protocol-online.org /forums/index.php?showtopic=7166 (165 words)

	Lost in translation: the signal hypothesis -- Leslie 170 (3): 338 -- The Journal of Cell Biology
		Lost in translation: the signal hypothesis -- Leslie 170 (3): 338 -- The Journal of Cell Biology
		signal hypothesis in 1975, with the signal peptide as a dotted
		enzyme that removes the signal is part of the ER membrane.
	www.jcb.org /cgi/content/full/170/3/338 (600 words)

	Support Vector Machine Prediction Of Signal Peptide Cleavage Site - Vert (ResearchIndex)
		Performance comparison of generalized PSSM in in signal..
		0.6: Prediction of signal peptides and signal anchors by a hidden..
		Support vector machine prediction of signal peptide cleavage site using a new class of kernels for strings.
	citeseer.ist.psu.edu /529909.html (577 words)

	Colgate University Biology Department - Ken Belanger
		Molecules, Cells, and Genes (Biol 212) is required of all Biology, Environmental Biology, and Molecular Biology concentrators and provides an in-depth introduction to eukaryotic cell function at the biochemical, macromolecular, and cellular levels.
		In lecture and lab, students are introduced to and asked to explore such topics as bioenergetics, enzyme kinetics, genes and regulation of gene expression, the cell cycle and the cytoskeleton, intracellular signaling and transport, and organelle structure and function.
		Belanger, K.D., Wyman, A., Sudol, M., Singla, S., and Quatrano, R. A signal* peptide screen in Fucus distichus embryos reveals expression of glucanase, EGF domain-containing, and LRR receptor kinase-like polypeptides during asymmetric cell growth.
	departments.colgate.edu /biology/People/KBelanger/KBelanger.html (1891 words)

	SignalP 3.0 Server
		SignalP 3.0 server predicts the presence and location of signal peptide cleavage sites in amino acid sequences from different organisms: Gram-positive prokaryotes, Gram-negative prokaryotes, and eukaryotes.
		The method incorporates a prediction of cleavage sites and a signal peptide/non-signal peptide prediction based on a combination of several artificial neural networks and hidden Markov models.
		This file is last modified Monday 4th of April 2005 10:00:29 GMT
	www.cbs.dtu.dk /services/SignalP (266 words)

	[No title]
		S 28 0.887 0.82 YES mean S 1-40 0.378 0.47 NO # Most likely cleavage site between pos.
		S 1 0.106 0.82 NO mean S 1-20 0.054 0.47 NO SignalP-HMM result: >C. Prediction: Non-secretory protein Signal peptide probability: 0.000 Signal anchor probability: 0.000 Max cleavage site probability: 0.000 at 21 ------------------------------------------------------------------------ >C. albicans fungus_CA5137_IPF1032_ 556 aa - similar to probable membrane protein _S.
		S 25 0.132 0.82 NO mean S 1-34 0.061 0.47 NO SignalP-HMM result: >C. Prediction: Non-secretory protein Signal peptide probability: 0.001 Si
	info.med.yale.edu /intmed/infdis/candida/i.txt (9387 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #6681894 - Chemically synthesized radiolabeled signal peptide: design, preparation, and biological evaluation of an iodinated analog of preproparathyroid hormone
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Chemically synthesized radiolabeled signal peptide: design, preparation, and biological evaluation of an iodinated analog of preproparathyroid hormone
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=6681894 (141 words)

	Nutritional Supplements Directory - Amino Acid - Amino Acid Peptide
		blocks peptides for research and clinical practices or GMP.
		Manufacturer of bulk peptides and related organic chemicals as active ingredients
		Peptides, amino acids, resins, antibody and proteins for use in research, giving
	www.aminoacid.nutritional-supplements-directory.com /aminoacidpeptide (228 words)

	Structural Genomics of Bacterial Secretion Systems
		Using networks trained on gram- data is the sequence a signal peptide?
		4.1.2 -Peptide signal detection ouput for B.pertussis Ptl components
		4.1.4 -Peptide signal detection ouput for E.coli Tra components
	www.biochem.wustl.edu /~StrucGen/sec4_signalp.htm (1904 words)

	Center for Infectious Diseases and Vaccinology: Publications
		Sojikul P, Buehner N, Mason HS (2003) A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells.
		Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.
		The Role of the PKR-Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range.
	www.biodesign.asu.edu /centers/idv/publications (1245 words)

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