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Topic: Pergonal

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Ovulation

Louise Brown

Hamster

2001

	Apthorp Infertility Pharmacy:- Products
		Pergonal and hCG are given in a sequential manner for the induction of ovulation and pregnancy in the anovulatory infertile patient when the cause of anovulation is functional and not due to primary ovarian failure (inability of the ovaries to respond to any hormonal stimulation, often due to a postmenopausal condition).
		Pergonal and hCG may also be used to stimulate the development of multiple follicles in ovulatory patients participating in an IVF program.
		Pergonal with concomitant hCG is indicated for the stimulation of spermatogenesis (sperm development) in men who have primary or secondary hypogonadotropic hypogonadism (inadequate testicular function).
	www.apthorp.com /products.html (1495 words)

	[No title]
		John- ston noted that although a 1992 regulation required an inac- tive ingredient in a generic drug to be in the same concentra- tion as in the pioneer drug, that regulation was not in effect when the ANDA for Repronex was filed in 1990.
		In concluding that the FSH in Repronex is the "same as" or "identical" to that in Pergonal, the FDA determined that their protein backbones and amino acid sequences are identical.
		With regard to inactive ingredients, the Act di- rects the FDA to approve an ANDA for a generic drug unless the agency finds the inactive ingredients are "unsafe for use" or the composition of the drug is unsafe "because of the type or quantity" of the inactive ingredients.
	pacer.cadc.uscourts.gov /common/opinions/199810/97-5188a.txt (6809 words)

	Pegonal (Menotropins)
		Pergonal is a natural purified product extracted from the urine of post-menopausal women.
		It consists of two hormones, FSH (follicle stimulating hormone) and LH (luteinizing hormone) which are gonadotropin or sex hormones originating in the pituitary gland.
		Pergonal is a potent drug with potential for adverse side effects.
	www.stronghealth.com /services/womenshealth/ivf/currentpatients/ovulationinduction/pergonal.cfm (372 words)

	Pergonal - InfertilityPhysician.com (Site not responding. Last check: 2007-09-10)
		I use the term "Pergonal" in a generic fashion since the list is too long to mention every one by name each time.
		Pergonal is a drug that is used to either induce or correct abnormalities of ovulation in women where other methods have been ineffective.
		The Pergonal injections are started on the 3rd day of your menstrual cycle (count the first day of full flow as day 1).
	www.infertilityphysician.com /ovulation/pergonal.html (857 words)

	IndiaParenting.com - Treatment of Female Infertility - Drug: Human Menopausal Gonadotrophins (H.M.G. or Pergonal)
		Pergonal is a combination of human F.S.H. and L.H..
		Pergonal is expensive and it has a greater potential for causing complications than have other ovulation inducing drugs.
		As the treatment program is complex, doctors generally carry out a Pergonal counseling session with a couple, in order to ensure that they fully understand the intricacies of treatment and how to avoid the possible problems.
	www.indiaparenting.com /fertility/data/fert05_05.shtml (741 words)

	IVF Phoenix Medications
		Pergonal, Follistim, and Clomiphene Citrate are medications indicated for women who are infertile.
		Pergonal consists of 75 IU of FSH (follicle stimulating hormone) and 75 IU of LH (luteinizing hormone) per ampule and is given by injection.
		The action of hCG is similar to that of LH in that it stimulates the eggs/oocytes to mature and be released from the ovary.
	www.ivfphoenix.com /fertility/Medications.htm (2776 words)

	infertility - sperm ovulation and fertility problems
		Pergonal® (also called menotropins) manufactured by Serono is used to induce ovulation and pregnancy in women whose cause of infertility is no ovulation.
		Pergonal® may also be used to stimulate the growth and development of multiple follicles for an invitro fertilization program.
		Pergonal® is an injection that should be given either intramuscular (IM) or subcutaneous (SC) at the same time every day, normally for not more than 12 days.
	www.familymeds.com /familymeds/infertility.html (1301 words)

	pergonal drug information, pergonal side effects
		Pergonal is expensive and it has a greater potential for...
		Pergonal® is a fertility medicine used to stimulate ovarian follicles in infertility...
		Pergonal® (menotropins for injection) is available as ampoules, each containing 75 IU of FSH and 75 IU of LH plus 10 mg...
	www.drugs.com /drug/pergonal (433 words)

	Infertility Fertility Drugs and Medications - Franklin Drug Center
		Pergonal® and hCG may also be used to stimulate the development of multiple follicles in ovulatory patients participating in an in vitro fertilization program.
		Your physician may have prescribed Pergonal® and Profasi® for you despite the fact that you are already ovulating normally.
		When doctors use Pergonal® and Profasi® in conjunction with this procedure, they are trying to stimulate the ovary to a greater extent than what occurs naturally in order to create several mature eggs in a particular month.
	www.franklindrugcenter.com /Pergonal.htm (470 words)

	Pergonal Dilution Instructions
		Pergonal 37 1/2 IU = Mix one powder vial with one liquid vial (2cc); administer 1 cc
		Pergonal 50 IU = Mix one powder vial with 1 1/2 cc of liquid vial; administer 1 cc
		Pergonal 187 IU = Mix one powder vial with one liquid vial (2cc); draw out 1 cc medication; add 1 cc to second and third powder vial; administer 1 cc
	www.stronghealth.com /services/womenshealth/ivf/currentpatients/ovulationinduction/pergonaldilution.cfm (182 words)

	Dr. Randine Lewis on Assisting Reproductive Techniques - How to Make a Family
		Pergonal (menotropins for injection, USP), by Serono Laboratories is a purified preparation of gonadotropins extracted from the urine of postmenopausal women.
		Pergonal administered for seven to twelve days produces ovarian follicular growth in women who do not have primary ovarian failure.
		Pergonal and hCG given in a sequential manner are indicated for the induction of ovulation and pregnancy in the anovulatory infertile patient, in whom the cause of anovulation is functional and is not due to primary ovarian failure.
	www.howtomakeafamily.com /experts/lewis/assisting_reproductive_technique2.htm (2556 words)

	The Fertility Solution
		Pergonal is a very potent drug, and its effect on a given individual's reproductive system is highly unpredictable.
		Each month a patient takes Pergonal, her system's response to the drug must be closely monitored with blood tests, ultrasound scans, and mucus examinations, necessitating several visits to the fertility specialist's office.
		Pergonal administration is continued until the sonography reveals a sufficient ovarian response, at which point I give the patient an HCG injection to facilitate release of the egg.
	www.fertilitysolution.com /chapter4.html (8787 words)

	Jones Institute: Fertility Drugs, Medications to Treat Infertility (Site not responding. Last check: 2007-09-10)
		FSH is naturally produced by the pituitary gland upon stimulation by gonadotropin releasing hormone, which is produced by the hypothalamus.
		The earliest member of this class of drugs is Pergonal, which is a combination of FSH and luteinizing hormone (LH).
		Pergonal is extracted from the urine of post menopausal women and is therefore "natural".
	www.jonesinstitute.org /infertility_medications.html (844 words)

	IVF Phoenix - Medications (Site not responding. Last check: 2007-09-10)
		Pergonal and Humegon consists of 75 IU of FSH (Follicle Stimulating Hormone) and 75 IU of LH (Luteinizing Hormone) per ampule by intramuscular injection.
		Clean data is not available for Pergonal and Metrodin for risk of ovarian cancer, but some data does suggest an increase.
		When this is used with Pergonal or Metrodin in superovulation, it may potentiate the ovarian hyperstimulation syndrome.
	www.fertilethoughts.net /faq/ivfphoenix/medication.htm (1754 words)

	Pergonal - Talk Medical
		Likewise, Pergonal are used to stimulate the production of sperm in men who have functioning testes but in whom hormonal stimulation is deficient.
		· Do not use Pergonal without first taking to your doctor if you ·might be pregnant; ·have a thyroid problem; ·have cancer or a tumor of the breast, ovary, uterus, hypothalamus, or pituitary gland; ·have undiagnosed vaginal bleeding; ·have ovarian cysts or enlargement; or ·have any other serious or chronic medical illness.
		Do not use Pergonal without first talking to your doctor if you are breast-feeding a baby.
	www.talkmedical.com /medications/4775/Pergonal (799 words)

	Jacob Manteuffel
		Pergonal is a fertility drug designed to increase a woman’s chance of pregnancy.
		In vitro fertilization (IVF) is a laboratory procedure by which fertilization between the egg and sperm is done in a test tube and the resulting zygote is implanted into the uterus of the woman.
		The conditional prediction, which is likely the same for both studies, was: If fertility drugs cause ovarian cancer, then there will be a higher incidence of ovarian cancer in women who take fertility drugs than in women who do not take fertility drugs.
	www.msu.edu /user/manteuff/PSL480Essay2.html (757 words)

	FSH Follicle Stimulating Hormone Gonal-F Follistim Repronex
		The first FSH commercial gonadotropin in the United States, Pergonal, was released by Serono Laboratories.
		Pergonal is derived from the urine of post-menopausal women and purified for injection.
		Pergonal has to be administered by intramuscular injection while the newer medications are given subcutaneously with much less discomfort Both human and genetically derived products are difficult to obtain and manufacture and are therefore expensive.
	www.infertilityspecialist.com /fertility_drug_fsh.html (447 words)

	Septuplets pose health threat
		The truth is, this birth was not at all miraculous; it was the pitiful offspring of the coupling of science run amok and human arrogance.
		According to Pergonal's own literature, it is natural for Pergonal injections to cause hyperstimulation of the ovaries, resulting in multiple gestations 20 to 40 percent of the time.
		Her babies, born 12 weeks early, all weighed between 1 pound, 1 ounce and 1 pound, 13 ounces - even less than the two to three pounds of the McCaugheys, who were also born extremely premature (as is the case in virtually all multiple births).
	www.usc.edu /student-affairs/dt/V135/N59/01-septup.59v.html (947 words)

	Pergonal (Marketed Products) - Serum Institute of India (Site not responding. Last check: 2007-09-10)
		Pergonal with concomitant Profasi therapy is indicated for the stimulation of spermatogenesis in men who have primary or secondary hypogonadotrophic hypogonadism.
		Up to 5 ampoules of Pergonal® may be dissolved in 1 ml solvent.
		In the absence of a response the dose of Pergonal
	www.seruminstitute.com /content/products/product_pergonal.htm (847 words)

	The Fertility Solution
		Rather than using Clomiphene, Pergonal or HCG for a lengthy period of time we turn to the IVF procedure.
		Pergonal, HCG and Metrodin, however, need close monitoring with serial vaginal ultrasound examinations and with blood estradiol determinations.
		The stimulated IVF cycles use a combination of Lupron, Metrodin, Pergonal, and HCG to stimulate several eggs during the first part of the menstrual cycle, which are subsequently retrieved through vaginal aspiration.
	www.fertilitysolution.com /treatment2.html (1326 words)

	Update Summer 1999 - InfertilityPhysician.com (Site not responding. Last check: 2007-09-10)
		Pergonal was a mixture of FSH and LH.
		Because this was a biologic extract, it contained a great deal of extraneous protein material and, therefore, had to be dissolved in a fairly large volume of water.
		Pergonal had to be given deep into the muscle of the buttock.
	www.infertilityphysician.com /ovulation/update.html (565 words)

	TTC Dreams - Infertility Procedures and Costs
		Pergonal is usually taken for nine to ten days.
		On the fourth day of Pergonal your blood must be drawn in the morning for a rapid estrogen level and an ultrasound will be performed.
		Between day 8 and 10 of Pergonal you will be told to take an hCG shot instead of Pergonal.
	www.ttcdreams.com /ifpc2.html (699 words)

	Infertility and Fertility Drugs and Medications - Chicago IVF
		Pergonal, Humegon, Repronex and Fertinex - These compounds are human hormones produced by the pituitary gland (LH and FSH) and are used to stimulate ovarian follicular development.
		Pergonal and Humegon are given intramuscularly while Follistim, Fertinex, Gonal-F and Repronex are given subcutaneously.
		Injections usually begin on day 2 or 3 of the menstrual cycle and continue for several days until the developing follicles are mature.
	www.chicago-ivf.com /Treatment/Medications.aspx (1594 words)

	Pergonal news articles (Site not responding. Last check: 2007-09-10)
		The cost for the injectible drugs (Humegon, Pergonal, Repronex, Fertinex, Follistim and Gonal-F) is high - for one cycle, depending on the drug used, retail...
		The Browns started their family after consulting a fertility specialist and using the drug Pergonal.
		The Browns started their family after consulting a fertility specialist and usingthe drug Pergonal.
	www.mongabay.com /drugs/drugs/Pergonal.html (238 words)

	Dr Jacky Boivin: Abstract (Site not responding. Last check: 2007-09-10)
		In that regard, this study evaluated the effectiveness of a daily monitoring form in measuring the psychological and physical symptomatology associated with Pergonal treatments.
		For this study, 20 infertile women who were planning to begin a regimen of Pergonal treatment and met the selection criteria were interviewed and asked to complete a battery of standardized psychological questionnaires measuring personal and interpersonal functioning.
		During treatment cycles patients reported more severe psychological symptomatology (e.g., nervousness, depression, pessimism) during their menstruation, whereas physical complaints (e.g., fatigue, nausea, headaches) were more prevalent during the luteal phase of the cycle.
	www.cf.ac.uk /psych/home/boivin/conf/posters/annmeet91.html (401 words)

	Infertility and Adoption by Fertile Thoughts - medications
		Pergonal, Metrodin, and Clomiphene Citrate are medications indicated for women who are infertile.
		It is also used to trigger ovulation in women treated with Pergonal, Metrodin, or clomiphene citrate.
		When used with Pergonal or Metrodin, it may cause or increase ovarian hyperstimulation syndrome.
	www3.fertilethoughts.com /forums/view.php?pg=medications (2944 words)

	PCOS-MEDICATION Messages for December, 2002: Re: What is Pergonal? (Site not responding. Last check: 2007-09-10)
		Pergonal® is a natural product containing both human FSH and LH, 75 or 150 international units of each per ampule, plus 10 mg lactose.
		This material is extracted from the urine of post-menopausal women, carefully purified and then freeze-dried in sterile glass ampules where it is sealed until use.
		Pergonal® is used in the treatment of both male and female infertility, but this booklet wil1 deal only with the use of Pergonal® for women.
	forums.obgyn.net /pcos-medication/PCOS-MEDICATION.0212/0159.html (259 words)

	Miracle Babies: Chapter 14 The Road to Successful Ovulation
		Tammy had received Pergonal before, but her doctor had used started with three ampoules of Pergonal each day and each cycle had to be canceled when she developed too many eggs.
		She had previously used progesterone vaginal suppositories after Pergonal therapy and developed a vaginal irritation.
		Frequently, superovulation (Humegon, Metrodin, Pergonal) is combined with intrauterine insemination for male factor infertility or unexplained infertility.
	www.ivf.com /ch14mbpg2.html (2998 words)

	[No title] (Site not responding. Last check: 2007-09-10)
		The name of your medicine is PERGONAL It is a freeze-dried powder available in packs of 1 or 10 ampoules.
		PERGONAL is a combination of hormones which is used to treat infertility caused by certain conditions in both men and women, which are as follows:
		PERGONAL is given as a course of either daily injections or injections every other day.
	www.itri.brighton.ac.uk /projects/pills/corpus/Serono:Pergonal (1010 words)

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