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Topic: Peroxysome

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	Botany online: Membranes - Compartments - Significance - Peroxysomes - Glyoxysomes
		Peroxysomes are usually found in the vicinity of chloroplasts and mitochondria, glyoxysomes occur only near mitochondria.
		Especially during growth are a lot of carbohydrates required for the synthesis of new cell walls.
		The activities in peroxysomes and glyoxysomes show how important compartmentalization is for the regulation of metabolic pathways.
	www.biologie.uni-hamburg.de /b-online/e23/23c.htm (302 words)

	Peroxysome : causes, symptômes, traitements, dans l'encyclopédie Vulgaris-Médical
		Les peroxysomes sont particulièrement fréquents dans les cellules hépatiques (du foie) et des reins et tout particulièrement des tubes rénaux.
		Les peroxysomes jouent un rôle dans la dégradation du peroxyde d'hydrogène (oxygéné) mais également dans la régulation énergétique de la cellule, la synthèse des acides aminés qui sont les éléments de base constituant une protéine et enfin dans l'oxydation des acides gras.
		Les peroxysomes ont la capacité de se reproduire d'eux-mêmes en se scindant simplement en deux.
	www.vulgaris-medical.com /encyclopedie/peroxysome-3599.html (444 words)

	Pipecolic acidemia
		Pipecolicacidemia formerly described patients with accumulated pipecolic acid in the blood and/or urine.
		Pipecolic acid is an intermediate compound in the lysine metabolism that is synthethised by the pipecolic oxidase in peroxysomes.
		Recent findings show that the vast majority of pipecolicacidemias are actually due to general peroxysome storage disorders.
	www.orpha.net /static/GB/pipecolic_acidemia.html (1608 words)

	Help document for LOCtree subcellular localization predictions
		These keywords are assigned to the query protein U. See figure for further explanation of the entropy-based algorithm used by LOCkey to infer subcellular localization.
		LOCkey assigne proteins to one of 10 subcellular classes: Extra-cellular,Nuclear,Cytoplasm,Mitochondria,Chloroplast,ER, Golgi, Peroxysome, Lysosome and Vacuole.
		Proteins are assigned to one of 10 subcellular classes: Extra-cellular,Nuclear,Cytoplasm,Mitochondria,Chloroplast,ER, Golgi, Peroxysome, Lysosome and Vacuole.
	cubic.bioc.columbia.edu /services/loctree/methods.html (1039 words)

	PVC additieven
		Dit soortverschil wordt weerspiegeld in het besluit van de Europese Commissie van 25 Juli 1990 dat stelt dat DEHP niet als een kankerverwekkende of irriterende substantie mag geclassificeerd of bestempeld worden.
		Een recent uitgebreid overzicht en een IARC concensus rapport concluderen dat effecten als gevolg van peroxysome proliferatie bij knaagdieren voor de mens niet relevant zijn.
		Enkel 2 ftalaten, dibutylftalaat (DBP, ook van nature in selder en lavas aanwezig!) en butylbenzylftalaat (BBP) dat hoofdzakelijk in drukinkten worden gebruikt, toonden een zeer zwakke oestrogene activiteit (1 miljoenste van de kracht van het natuurlijke vrouwelijke hormoon oestradiol) in SOMMIGE in vitro testen, maar toonden geen effect in andere testen [21] [22] [23] [24].
	www.ping.be /~ping5859/nl/nl_pvc_add.html (1199 words)

	[No title] (Site not responding. Last check: 2007-10-28)
		In the rat, the peroxysome proliferator activated receptor (PPAR) inducer clofibrate can moderately influence the hormone (testosterone) level and, after single perinatal treatment, irreversibly affects sexual behavior through the mechanism of hormonal imprinting.
		The thymic glucocorticoid and estrogen receptors weren't significantly influenced.
		The experiments call the attention to the universality of false imprinting by molecules able to bind to the steroid/thyroid receptor superfamily, and point to the different sensitivity to different ligands.
	www.elsevier.com /cdweb/journals/00319384/articles/58/6/003193849502065.abstract.en (72 words)

	[No title] (Site not responding. Last check: 2007-10-28)
		These peroxysomes consume almost half the oxygen of a cell converting it to H
		To protect the rest of the cells from this aggressive chemical it is conveniently contained within these membrane bounded spherical vesicles.
		Peroxysomes are both involved in the synthesis and breakdown of various classes of lipids and bile acids.
	www.peghole.com /mare/cell/multi/b/b1.html (118 words)

	SAV, an archaebacterial gene with extensive homology to a family of highly conserved eukaryotic ATPases.
		The new archaebacterial ORF, called SAV (S. acidocaldarius VCP-like) exhibited the usual signature of all members of the family, a highly conserved domain of about 200 amino acids, which is duplicated.
		Thus, apart from the VCP-like proteins, SAV also appeared similar, although less clearly, to other ATPases, members of the family, involved in vesicle-mediated transport (NSF, Sec18p), peroxysome assembly (PAS1p), and gene expression in yeast (SUG1p) and in human immunodeficiency virus (TBP-1).
		Finally, the discovery of the archaebacterial gene could enlighten not only the evolutionary relationships between the members of this complex ATPase family, but also the cellular function of these proteins, that is presently obscure.
	www.aegis.com /aidsline/1994/apr/M9440235.html (493 words)

	RedOrbit - Health - Calorie Restriction Increases Life Span: A Molecular Mechanism
		In mammals, Sirt1, an ortholog of Sir2, controls the metabolism of white adipose tissue.
		Lowering of adiposity appears to be one mechanism whereby calorie restriction affects life span.
		Seventy years ago, in a remarkable series of experiments lasting nearly 4 years, McCay et al.1 determined the effect of retarded growth of rats on the length of life span and on the ultimate body size.
	www.redorbit.com /news/health/405872/calorie_restriction_increases_life_span_a_molecular_mechanism/index.html?source=r_health (2177 words)

	EVER
		i381 - Peroxysome proliferator-activated receptor gamma agonist 15-deoxy-delta 12,14 prostaglandin J2 suppresses murine model of experimental autoimmune uveitis
		Peroxysome proliferator-activated receptor (PPAR) gamma agonist 15-deoxy-delta 12,14 prostaglandin J2 (15PGJ2) suppresses immune responses in previous studies.
		Our data, together with other immunosuppressive properties of 15PGJ2 on RPE cells, suggest that 15PGJ 2 may be a useful candidate for control of intraocular inflammation.
	www.ever.be /view_abstract.php?abs_id=563 (268 words)

	Directory of open access journals
		Recently, lipoprotein-lowering agents have been found to be effective for PBC.
		The aim of this study was to examine the safety and efficacy of fenofibrate, a member of the fibrate class of hypolipidemic and anti-inflammatory agent via peroxysome proliferatory-activated receptor alpha, in patients with aPBC.
		METHODS: Fenofibrate was administered for twelve weeks in nine patients with aPBC who failed to respond to UDCA.
	www.doaj.org /doaj?func=abstract&id=90613&recNo=26&toc=1 (283 words)

	Linoleic acid increases lectin-like oxidized LDL receptor-1 (LOX-1) expression in human aortic endothelial ... (Site not responding. Last check: 2007-10-28)
		This could be related to the very low basal activity of elongase and desaturase enzymes in endothelial cells, thus preventing arachidonic acid formation from LA in these cells (17).
		They include disruption of endothelial cell integrity with alterations of functions of gap-junctions proteins (18), cell morphology (19), membrane-bound enzymes (20), peroxysome (21), and induction of apoptotic cell death (22).
		Last but not least, accumulating evidences suggest that increase in intracellular oxidative stress and calcium levels (10,23) could be the main mechanisms by which LA exerts its harmful effects on endothelial cells.
	www.highbeam.com /library/docfree.asp?DOCID=1G1:132227844&ctrlInfo=Round18:Mode18c:DocG:Result&ao= (4732 words)

	Identification of a functional peroxysome proliferator-activated receptor responsive element within the murine ...
		Identification of a functional peroxysome proliferator-activated receptor responsive element within the murine perilipin gene -- NAGAI et al., 10.1210/en.2003-1180 -- Endocrinology
		Articles by NAGAI, S. Articles by KOIKE, T. Submitted on September 8, 2003
		Identification of a functional peroxysome proliferator-activated receptor responsive element within the murine perilipin gene
	endo.endojournals.org /cgi/content/short/en.2003-1180v1 (614 words)

	Adipocyte membrane phospholipids and PPAR-gamma expression in obese women: relationship to hyperinsulinemia -- Zeghari ...
		Thiazolidinediones in the treatment of insulin resistance and type II diabetes.
		Schoonjans, K, Staels B, and Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression.
		Identification of high-affinity binding sites for the insulin sensitizer Rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxysomal proliferator-activated receptor gamma.
	ajpendo.physiology.org /cgi/content/full/279/4/E736 (4174 words)

	Molecular Recognition of Agonist Ligands by RXRs -- Egea et al. 16 (5): 987 -- Molecular Endocrinology
		Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR 1998 Structure and specificity of nuclear receptor-coactivator interactions.
		Xu EH, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Stermbach DD, Lehman JM, Wisely GB, Willson TM, Kmiewer SA, Milburn MV 1999 Molecular recognition of fatty acids by peroxysome proliferator-activated receptors.
		Vivat V, Zechel C, Wurtz J-M, Bourguet W, Kagechika H, Umemiya H, Shudo K, Moras D, Gronemeyer H, Chambon P 1997 A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.
	mend.endojournals.org /cgi/content/full/16/5/987 (5639 words)

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