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| | eMedicine - Gout : Article Excerpt by: Mark L Francis, MD |
 | | When bare areas of the urate crystals are exposed, they can bind immunoglobulin G (IgG). |
 | | Such binding stimulates neutrophils to engulf and phagocytose the crystals. |
 | | Once this occurs, there is a brisk influx of neutrophils associated with elevated levels of interleukin-1, interleukin-6, interleukin-8, tumor necrosis factor-alpha, prostaglandin E2, leukotriene B4, kinins, C5a, and other inflammatory mediators. |
| www.emedicine.com /med/byname/gout.htm (602 words) |
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