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Topic: Pharmacological


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  Pharmacological chaperone - Wikipedia, the free encyclopedia
Pharmacological chaperones present an attractive alternative to transplantation due its low risk and an alternative to enzyme replacement therapy due to lowered expense and oral availability.
The mutated protein is unstable (in the thermodynamic sense) and in retrotranslocation to the cytoplasm is degraded by the proteasome.
Ironically, most pharmacological chaperones are inhibitors of the enzyme targeted; due to differing conditions in the target's destination (pH, metal ions, etc) the inhibitor is ejected, and the enzyme functions; or, the relatively high concentration of substrate outcompetes the inhibitor; or a combination of both effects enables the enzyme to function.
en.wikipedia.org /wiki/Pharmacological_chaperone   (338 words)

  
 Recommendations for Pharmacological Treatment of Acute Stress Reactions // National Center for Post-Traumatic Stress ...   (Site not responding. Last check: 2007-10-09)
Pharmacological treatment for acute traumatic stress reactions (within one month of the trauma) is generally reserved for individuals who already have received individual or group debriefing and/or brief crisis-oriented psychotherapy.
Pharmacological agents for the treatment of trauma-related arousal include benzodiazepines and antiadrenergic agents such as clonidine, guanfacine and propranolol.
Other pharmacological agents may also be helpful in treating insomnia in persons suffering from acute traumatic stress.
www.ncptsd.va.gov /facts/disasters/fs_medication_disaster.html   (1071 words)

  
 The importance of pharmacological synergy in psychoactive herbal medicines - Herbal Synergy Review Alternative Medicine ...   (Site not responding. Last check: 2007-10-09)
Determining the pharmacological mechanisms of herbal medicines presents certain challenges distinct from the study of synthetic drugs.
A single drug may have several pharmacological actions, but it is only those that occur in concentrations reached by standard doses that are considered relevant.
Pharmacological synergy should also be investigated to explain the actions of an herbal medicine.
www.findarticles.com /p/articles/mi_m0FDN/is_2_7/ai_85522985   (790 words)

  
 Alcohol's pharmacological properties, not smell or taste, reinforce its effects
New research indicates that alcohol's reinforcing properties during rodent infancy can be due to its pharmacological effects, independent of taste or smell.
"If an infant is exposed to the odor of alcohol in the environment, or the combined taste, odor and pharmacological effects of alcohol during fetal development or breast feeding, it is important to determine how this experience affects preference for alcohol and levels of alcohol consumption later in life.
This study demonstrates that the pharmacological effects of alcohol, independent of orosensory cues, contribute to the reinforcing properties of ethanol in the developing fetus/infant."
www.eurekalert.org /pub_releases/2003-10/ace-app100703.php   (786 words)

  
 Endotext.com - Diabetes, Oral Pharmacological Agents for Type 2 Diabetes: Sulfonylureas, Meglitinides, Metformin, ...
In response to the enormity of the growing problem, efforts to identify and develop new pharmacological agents for type 2 diabetes have increased dramatically in recent years.
Pharmacological therapies that inhibit carbohydrate breakdown in the gut (
However, based on the growing sophistication of 21st Century research approaches (141-144) along with the realization of the consequences of failure (1,145), there is ample support for the optimistic viewpoint that the current selection of orally active treatment options will continue to expand.
www.endotext.org /diabetes/diabetes16/diabetes16.htm   (7172 words)

  
 A Review of Pharmacological and Educational Approaches for Tobacco Cessation
Pharmacological interventions consist of bupropion (Zyban, Wellbutrin), nicotine patch, gum, nasal spray, lozenge and inhaler.
This article recognizes the potential benefits of using pharmacological agents combined with educational approaches to help combat the apparent health problems associated with the by-products of tobacco.
Smoking cessation interventions can be more successful when the health care professional understands that a combined approach making use of available pharmacological agents along with existing alternatives that include behavioral and education approaches may be the most effective.
ijahsp.nova.edu /articles/vol3num3/monson.htm   (4840 words)

  
 2107.03 Special Considerations for Asserted Therapeutic or Pharmacological Utilities - 2100 Patentability
As a general matter, evidence of pharmacological or other biological activity of a compound will be relevant to an asserted therapeutic use if there is a reasonable correlation between the activity in question and the asserted utility.
Courts have routinely found evidence of structural similarity to a compound known to have a particular therapeutic or pharmacological utility as being supportive of an assertion of therapeutic utility for a new compound.
If reasonably correlated to the particular therapeutic or pharmacological utility, data generated using in vitro assays, or from testing in an animal model or a combination thereof almost invariably will be sufficient to establish therapeutic or pharmacological utility for a compound, composition or process.
www.uspto.gov /web/offices/pac/mpep/documents/2100_2107_03.htm   (1989 words)

  
 Internet Alcohol Recovery Center   (Site not responding. Last check: 2007-10-09)
The same pharmacological principles apply to legal prescription drugs as to illegal drugs, such as heroin or cocaine, or to non-prescription drugs, such as ethanol or nicotine.
This lecture will stress the pharmacological aspects of drug addiction and drug abuse because all physicians who prescribe drugs should be familiar with the pharmacological principles underlying abuse and addiction.
It is necessary to apply an understanding of these pharmacological principles in prescribing medication for all patients and especially in properly prescribing those medications with the capability of producing dependence.
www.uphs.upenn.edu /recovery/consumers/library/OBrianCharles.htm   (5449 words)

  
 Title: Pharmacological Management of Pain
While this chapter reviews pharmacological management of organic pain, the reader should not suppose that this is the only important component of comprehensive pain management.
While we cannot be certain of the effects of the first dose in an opioid naïve patient, patients develop pharmacological tolerance to the respiratory depressant effects of opioids over the same time course as other side effects.
Medications should be chosen appropriately, administered using the pharmacological principles that guide their usage and patients monitored closely for undesired side effects.
www.galter.northwestern.edu /Geriatrics/chapters/pharmacological_management_pain.cfm   (4692 words)

  
 Pharmacological Reviews -- Pharmacological Reviews Instructions to Authors
Papers published in Pharmacological Reviews are generally invited by the Editor after consideration of recommendations from the Associate Editors.
A completed copy of the Authorship Responsibility, Financial Disclosure, and Copyright Transfer form signed by all authors must be included with the manuscript at the time of submission [Fill-In PDF Version of Authorship Responsibility, Financial Disclosure and Copyright Transfer Form].
The corresponding author is responsible for obtaining permission from the copyright owner to reproduce or modify figures and tables and to reproduce text (in whole or in part) from previous publications; permissions must allow electronic reproduction as well as print.
pharmrev.aspetjournals.org /misc/ifora.shtml   (1938 words)

  
 NIH Guide: PHARMACOLOGICAL APPROACHES TO ENHANCE NEUROMODULATION IN REHABILITATION
Pharmacological compounds could further enhance the benefits of rehabilitative therapies through several possible mechanisms.
Applicants are encouraged to provide a mechanistic basis for the use of pharmacological interventions in a rehabilitative context and to discuss the potential for incorporation into clinical settings.
A major priority in the NIDCD strategic plan is the development and improvement of devices, pharmacologic agents, and strategies for habilitation/rehabilitation of human communication disorders.
grants.nih.gov /grants/guide/rfa-files/RFA-HD-02-023.html   (2679 words)

  
 Pharmacological Intervention and Migraine
The primary reason a patient sees a physician for migraine is to secure effective pharmacological intervention for the treatment of acute symptoms.(16) Fortunately, there is a wide range of drugs available.
Appreciating the clinical evolution of the migrainous process is the key to a rational pharmacological approach.
For this reason, early pharmacological intervention is emphasized as a critical factor to ensure therapeutic success.
www.primarycarenet.org /pcs/pharm.htm   (710 words)

  
 Pharmacological Actions, 2006. Documentation
The files are independent of other MeSH files in XML format but use some of the same techniques for representing data, such as referring to Descriptors by the element and its sub-elements, so users may find it helpful to consult Introduction to XML MeSH.
The two files consist of mappings between Pharmacological Action Descriptors, on the one hand, and substances having a particular action, on the other.
This file also differs from the file by-substance in that it is expanded to include: (a) selected headings which are ancestors of PAs in the MeSH Tree hierarchy, and, (b) substances having PAs that are descendents of the PA in the list.
www.nlm.nih.gov /mesh/pa2006abt.html   (394 words)

  
 A Pharmacological Study of Ayahuasca in Healthy Volunteers
Although ayahuasca is not as widely used by the general public as amphetamine derivatives of the MDMA type are, it has a achieved a certain popularity and is beginning to attract media attention in Spain; in Summer 1997 a weekly general interest magazine labelled it a "fashionable drug" on the Spanish island of Ibiza.
Our study aims to be the first controlled pharmacological study of ayahuasca in humans undertaken in a Western country and with local volunteers who are familiar with its consumption.
The compound is remarkable within the hallucinogen family because of its pharmacological characteristics; when administered parenterally it produces extremely strong effects which are felt almost immediately (intravenously) or within around ten minutes (intramuscularly), to disappear within the space of about half an hour or forty-five minutes.
maps.org /news-letters/v08n3/08312rib.html   (2527 words)

  
 eMJA: McColl , Pharmacological therapies for the treatment of osteoarthritis
The recommendations continue to emphasise the role of paracetamol as the initial pharmacological treatment of mild to moderate osteoarthritis.
This contention is certainly supported by a randomised controlled clinical trial, which found no difference in the efficacy of paracetamol (4 g daily) and ibuprofen (1.2 g or 2.4 g daily) in patients with osteoarthritis.
If a patient's condition fails to respond to paracetamol and non-pharmacological therapies, then rational planning for further therapy must include a risk assessment of his or her comorbidity (Box).
www.mja.com.au /public/rheumatology/mccoll/mccoll.html   (3062 words)

  
 Panic Disorder and Pharmacological Treatment Options
The increased interest can be attributed at least in part to reconceptualization of anxiety disorders by the American Psychiatric Association, improvements in psychological and pharmacological therapies, and an increased understanding of the biological mechanisms causing panic and anxiety [Warren, 1991].
Until the 1980s, panic disorder patients rarely received specific, regimented treatments of either the pharmacological or behavioral nature, and the treatments that were administered often proved ineffective.
As further evidence, cognitive procedures that prevent panic disorder patients from misinterpreting the sensations induced by pharmacological challenge tests were shown to block panic attacks induced in the laboratory [Clark, 1991; Sanderson, 1990].
elvis.engr.wisc.edu /UER/uer97/author3/content.html   (5414 words)

  
 Com Pharmacological
Pharmacological Treatment - There is insufficient evidence to assist clinicians in a rational approach to antispastic treatment for SCI.
Gabapentin may be useful in the management of spasticity associated with SCI (Gruenthal, et al 1997), and specifically for some features of spasticity (Priebe, et al 1997).
Valproic acid has been demonstrated to greatly diminish the frequency of myoclonic jerks with minimal side effects in a patient who failed or was intolerant to baclofen, dantrolene, and diazepam (Andary, et al 1997).
calder.med.miami.edu /providers/MEDICINE/comphar.html   (1201 words)

  
 NIH Pharmacological Sciences Training Program   (Site not responding. Last check: 2007-10-09)
The pharmacological sciences have been defined as: “research on the biological phenomena and related chemical and molecular processes involved in the actions of therapeutic drugs and their metabolites".
According to this broad definition, the pharmacological sciences incorporates not only the discipline of pharmacology, but cell biology, physiology, biochemistry, molecular biology, chemistry, medicinal chemistry, and toxicology, pharmacognosy, and pharmaceutics, as well.
Because of the outstanding depth and breadth of expertise in pharmacological sciences at UIC, provided by the assembled training faculty of 42, representing 5 departments (Biochemistry and Molecular Genetics, Biopharmaceutical Sciences, Medicinal Chemistry and Pharmacognosy, Pharmacology, and Physiology and Biophysics), we are able to offer students training that spans this multidisciplinary spectrum.
www.uic.edu /depts/mcph/PSTP1.htm   (319 words)

  
 Concise Dictionary of Pharmacological Agents - Properties and Synonyms
There is an alphabetic, fully cross-indexed listing of pharmacologically active agents and their properties, containing details of some 4000 individual chemical agents including medical drugs in current use, experimental agents and toxins used as investigation tools.
Over 10,000 alternative names are indexed, including chemical names, abbreviated chemical names, official pharmacological names, proprietary names and research code numbers.
A key feature is that the properties of the agents are categorized, according to mechanism and use, into 300 classes for each of which there are descriptive articles for which key literature and review references are provided.
www.knovel.com /knovel2/Toc.jsp?BookID=1047   (148 words)

  
 Pharmacological Treatment of Dementia
This report is a systematic evaluation of the evidence for pharmacological interventions for the treatment of dementia in the domains of cognition, global function, behavior/mood, quality of life/activities of daily living (ADL) and caregiver burden.
Interventions were restricted to pharmacological agents, including food supplements (as defined by the FDA) administered for at least 1 day.
The articles were grouped according to the pharmacological agent used in the intervention.
www.ahrq.gov /clinic/epcsums/demphsum.htm   (5144 words)

  
 Pharmacological Challenges in Anxiety Disorders
The pharmacological challenge strategy involves administering a test agent under controlled conditions to elucidate some aspect of biological or behavioral function in the organism being studied.
It is based on the assumption that true functional abnormalities may not be evident in the basal state because of the action of compensatory mechanisms.
Unfortunately, the pharmacological and behavioral effects of caffeine are neither selective nor potent, which limits its utility as a probe for anxiety disorders.
www.acnp.org /G4/GN401000126/CH124.html   (7325 words)

  
 British Journal of Pharmacology - Abstract of article: Molecular cloning, expression and pharmacological ...
Molecular cloning, expression and pharmacological characterization of the canine cholecystokinin 1 receptor
This protein was 89% identical to the human and 85% identical to the rat CCK1 receptor.
The data obtained will facilitate the interpretation of numerous pharmacological experiments that have been performed using canine tissue to elucidate the actions of CCK and gastrin.
www.nature.com /bjp/journal/v145/n3/abs/0706196a.html   (332 words)

  
 Pharmacological Treatment of Dementia: Structured Abstract
Data were extracted on type of dementia, severity of disease, setting, regimen of pharmacological agents, study duration, main outcome measures, adverse effects, and results.
Efficacy: In 186 RCTs evaluating 97 drugs, with findings that varied with the dementia population and the specific outcomes in the various domains, specific pharmacological agents showed consistent effects of benefit on global assessment, cognition (general and specific), behavior/mood, and quality of life/activities of daily living (ADL).
Ischemic VaD: A total of 20 pharmacological interventions in 29 studies were applied to vascular dementias.
www.ahrq.gov /clinic/tp/dempharmtp.htm   (377 words)

  
 Insomnia - Pharmacological Therapies   (Site not responding. Last check: 2007-10-09)
Prior to pharmacological treatment, it is important to improve sleep hygiene and treat any contributing underlying medical conditions (e.g.
Benzodiazepines have been successfully used for short term insomnia, although there are no systematic studies on long-term use and rare studies in palliative care.
This mirror version is provided subject to copyright restrictions for educational use within the Inter-Instutional Collaborating Network on End-of-Life Care (IICN).
www.mywhatever.com /cifwriter/library/eperc/fastfact/ff105.html   (631 words)

  
 Pharmacological Action Terms
Most chemical and drug MeSH headings and Supplementary Concept Records (SCRs) are assigned one or more headings that describe the pharmacological action (PA) of the substance.
Since 1996, indexers add the appropriate pharmacological action MeSH heading as well as the specific chemical MeSH heading to a citation when the action of the chemical is being discussed in the article.
Use of a term with the Pharmacologic Action [pa] field tag instructs PubMed to OR together terms from a list made up of a PA term and the drug/substance terms known to have that action.
www.nlm.nih.gov /bsd/disted/mesh/paterms.html   (329 words)

  
 The Department Pharmacological & Physiological Science || Saint Louis University School of Medicine   (Site not responding. Last check: 2007-10-09)
This course involves participation in small group exercises in problem solving, laboratory exercises, computer tutorials and critical analysis of the current scientific literature of special topics that are related to the didactic material covered in the co-requisite PPYG-511 course.
Course involves participation in small group exercises in problem solving, laboratory exercises, computer tutorials and critical analysis of the current scientific literature of selected topics that are related to the didactic material covered in the co-requisite PPYG-513 course.
Graduate students in the Program in Pharmacological and Physiological Science or the Training Program in Pharmacological Sciences are encouraged to obtain formal teaching experience by participating as lecturers in BLA-293: Drugs We Use and Abuse.
medschool.slu.edu /pharmphys/index.phtml?page=advancedprogram&...   (1527 words)

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