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Topic: Phencyclidine

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	Phencyclidine - Wikipedia, the free encyclopedia
		Phencyclidine (a contraction of the chemical name phenylcyclohexylpiperidine), abbreviated PCP, is a dissociative drug formerly used as an anesthetic agent, exhibiting hallucinogenic and neurotoxic effects.
		PCP was commercially developed in the 1950s by the Parke-Davis pharmaceutical company.
		In Thomas Harris' novel Hannibal, it is described that one of Hannibal Lecter's victims, Mason Verger, performed self-mutilation whilst under the influence of phencyclidine and other drugs that Lecter drugged him with.
	en.wikipedia.org /wiki/Phencyclidine (1785 words)

	U.S. Patent: 5155212 - Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent ...
		Phencyclidine is metabolized into two major metabolites, 4-phenyl 4 piperidinocyclohexanol and 1 (1 phenylcyclohexyl) 4-hydroxypiperidine, each of which is excreted mostly in the urine along with the corresponding glucuronide conjugates.
		All phencyclidine derivatives that have a terminal amino group, such as amino, hydrazinyl, hydrazido or the like, are coupled to carboxyfluorescein by the active ester method or the mixed anhydride method, preferably the active ester method, and coupled to fluorescein isothiocyanate, DTAF or alkoxy DTAF by simply mixing the two materials in solution.
		Phencyclidine calibrators comprising phencyclidine in normal human urine at concentrations of 0.0, 25.0, 60.0, 120.0, 250.0, and 500.0 nanograms per milliliter, with 0.1% sodium azide as a preservative are useful.
	www.everypatent.com /comp/pat5155212.html (11003 words)

	Phencyclidine
		Phencyclidine (PCP) was developed in the 1950s as an intravenous anesthetic but, due to the side effects of confusion and delirium, its development for human medical use was discontinued.
		Phencyclidine is illicitly marketed under a number of street names including Angel Dust, Hog, Lovely, Wack, Embalming Fluid, and Rocket Fuel, which reflect the range of bizarre and volatile effects.
		Phencyclidine is addictive and its use often leads to psychological dependence, craving, and compulsive Phencyclidine-seeking behavior.
	www.drugs.com /phencyclidine.html (816 words)

	Pass A Drug Test for Phencyclidine & PCP
		Phencyclidine (PCP, Angel Dust) is a cheap and popular drug often concentrated in selected socioeconomic groups.
		Phencyclidine is easily manufactured from relatively common chemical precursors, is relatively potent, and long lasting.
		Phencyclidine is rapidly absorbed from the lung and easily crosses the blood/brain barrier.
	www.alwaystestclean.com /drug_definitions/phencyclidine.htm (622 words)

	Lycaeum > Leda > Phencyclidine: pharmacology and toxicology
		Phencyclidine (PCP), (1-(1-phenylcyclohexyl)-piperidine) is a white crystalline powder, molecular weight 243.38.
		At a conference on environmental mutagens it was reported that PCP has been found to be teratogenic; "Users of phencyclidine had increased rates of fetal loss, decreased fertility, extensive chromosome breakage, and increased presence of a small chromosome that resembled the Philadelphia chromosome.
		Phencyclidine (PCP) was introduced in 1960 as an analgesic and general anesthetic for man, but too many severe adverse effects developed, including hallucinations, manic depressive and schizophrinic-like symptoms.
	leda.lycaeum.org /?ID=12989 (3028 words)

	Erowid PCP Vault : Info #1
		Phencyclidine is thought to stimulate alpha-adrenergic receptors and to potentiate the pressor response to epinephrine, norepinephrine, and serotonin.
		Phencyclidine abusers feel the onset of drug effect in 2 to 5 minutes when it is smoked, compared with 30 to 60 minutes when ingested orally.
		Patients ingesting small amounts of phencyclidine present prominent body image distortions (enlarging limbs, detached head) on a background of sensory blockade described as a "numbness", depersonalization, "sheer nothingness" or "endless isolation".
	www.erowid.org /chemicals/pcp/pcp_info1.shtml (1796 words)

	PHENCYCLIDINE (Site not responding. Last check: 2007-10-21)
		In some respects, PCP acts like an hallucinogen; and, it is frequen PCP (phencyclidine) is classified as a hallucinogen and has many of the same effects as LSD, but can be much more dangerous.
		In the 1950's, PCP Phencyclidine (a contraction of the chemical name phenylcyclohexylpiperidine; also called PCPwhilst under the influence of phencyclidine and other drugs thUnion Theope that uses phencyclidine on some of its agents in order to make them more invulnerable.
		For smoking, Phencyclidine is typically sprayed onAt high doses of Phencyclidine, there is a drop in blood pressure, pulse rate, and respiration.
	www.republika.pl /daneen/phencyclidine/index.htm (303 words)

	Drugs and Human Performance FACT SHEETS - Phencyclidine (PCP)
		Adams B, Moghaddam B. Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine.
		Phencyclidine intoxication: Clinical experience in 27 cases confirmed by urine assay.
		Phencyclidine and violent deaths in St. Louis, Missouri: A survey of medical examiner’s cases from 1977 through 1986.
	www.nhtsa.dot.gov /people/injury/research/job185drugs/phencyclidine.htm (1557 words)

	PHENCYCLIDINE (Site not responding. Last check: 2007-10-21)
		PCP or Phencyclidine, is a single drug that forms a distinct category of its own, because the effects it produces are unlike those of any category.
		The formal chemical name for this drug is Phenyl Cyclohexyl Piperidine, from which the initials PCP are derived.
		"Phencyclidine" is simply a contracted form of the actual chemical name.
	www.sayno.com /pcp.html (482 words)

	Phencyclidine and related disorders - Definition, Description, Causes and symptoms, Demographics, Diagnosis, ... (Site not responding. Last check: 2007-10-21)
		Phencyclidine (PCP) is a street drug known as "angel dust" that causes physiological changes to the nervous and circulatory system, disturbances in thinking and behavior, and can cause hallucinations, psychotic disorder, mood disorder, and anxiety disorder.
		Phencyclidine (PCP) is the best known of several related drugs including ketamine, cyclohexamine, and dizocilpine.
		PCP was first synthesized by a pharmaceutical company in the 1950s and sold under the brand names Sernyl and Sernylan until 1967.
	www.minddisorders.com /Ob-Ps/Phencyclidine-and-related-disorders.html (1831 words)

	Phencyclidine Drug Tests - $5.95... For the Drug PCP.
		Ten percent of the specimens employed were either at -25% or +25% level of the cut-off concentration of 25 ng/mL Phencyclidine.
		The PCP One Step Phencyclidine Test Device was tested in duplicate using the fifteen neat and spiked urine samples.
		The pH of an aliquoted negative urine pool was adjusted to a pH range of 5 to 9 in 1 pH unit increments and spiked with Phencyclidine to 12.5 ng/mL and 37.5ng/mL.
	www.drugtestsuccess.com /instantdrugtest-1p-pcp2.htm (348 words)

	PHENCYCLIDINE (Street Names: PCP, Angel Dust, Supergrass, Boat, Tic Tac, Zoom, Shermans)
		After a decline in abuse during the late 1980s and 1990s, phencyclidine (PCP) has re-emerged as a drug of abuse.
		Once marketed as an anesthetic in the United States under the trade names, Sernyl and Sernylan, PCP is no longer produced or used for medical purposes in the United States.
		Phencyclidine, 1-(1-phencyclohexyl) piperdine, is a white crystalline powder that is readily soluble in water.
	www.deadiversion.usdoj.gov /drugs_concern/pcp.htm (721 words)

	Expomed Drug Testing For The Detection of Phencyclindine (PCP) in Urine. (Site not responding. Last check: 2007-10-21)
		Phencyclidine, commonly known as PCP or "angel dust," is used primarily as a recreational drug for its hallucinogenic effects.
		PCP is commonly taken orally, by inhalation, by insufflation, or intravenously, and is well absorbed following all routes of administration, concentrating fastest in fatty tissues and the brain.
		The Phencyclidine Test is a one step rapid, qualitative immunoassay for the detection of Phencyclidine in urine.
	www.expomed.com /drugtest/phencycl.htm (239 words)

	InfoFacts - PCP (Phencyclidine)
		PCP (phencyclidine) was developed in the 1950s as an intravenous anesthetic.
		Its use in humans was discontinued in 1965, because patients often became agitated, delusional, and irrational while recovering from its anesthetic effects.
		The National Institute on Drug Abuse (NIDA) is part of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services.
	www.nida.nih.gov /Infofax/pcp.html (942 words)

	eMedicine - Toxicity, Phencyclidine : Article by Robert S Helman, MD
		Background: Phencyclidine, 1-(1-phenylcyclohexyl) piperidine (PCP), is a dissociative anesthetic that was originally synthesized for intravenous use in 1957 and was marketed under the trade name Sernylan.
		According to data from the Drug Abuse Warning Network (DAWN), which examines the number of emergency department records that mention drug use in the diagnosis, for the third and fourth quarters of 2003, PCP was involved in 4,581 of all drug-related ED visits nationwide (n= 627,923), nearly 0.75% of all drug-related ED visits.
		Shepherd SM, Jagoda AS: Phencyclidine and the hallucinogens.
	www.emedicine.com /med/topic1813.htm (4703 words)

	Phencyclidine antibody [6E7] (ab23358) datasheet (Site not responding. Last check: 2007-10-21)
		Phencyclidine modulates secretogranin II[sg II] expression in prefrontal cortex tissue in the absence of afferent inputs.
		The nature of these changes is dependent upon the duration of exposure to and/or withdrawal from phencyclidine.
		It is used as an anesthetic by veterinarians and is illicitly taken for its hallucinogen effects.
	www.abcam.com /?datasheet=23358 (274 words)

	Phencyclidine Information
		PCP (phencyclidine) was first used in the 1950s as an anesthetic for surgery.
		But because it produced such highly undesirable side effects as convulsions during operations and post-operative hallucinations, its use was quickly discontinued.
		Importing, exporting, trafficking, and possession for the purposes of trafficking are all indictable offences and carry a maximum penalty of life imprisonment.
	www.bacteria.nl /phencycl.html (975 words)

	Medical Dictionary: Phencyclidine - WrongDiagnosis.com - WrongDiagnosis.com
		Phencyclidine: Phencyclidine (PCP) was developed as an anesthetic for humans in 1959.
		Its use was discontinued due to extreme side effects that included delirium, confusion, visual disturbances, hallucinations and violence.
		Phencyclidine : this drug is both a legitimate prescription anesthetic and a notoriously abused street drug also known as "angel dust."
	www.wrongdiagnosis.com /medical/phencyclidine_printer.htm (242 words)

	eMedicine - Toxicity, Phencyclidine : Article by Nicole S Johnson, MD
		Background: Phencyclidine (PCP) was originally developed for use as a general anesthetic for surgery under the trade name Sernyl in the 1950s.
		Users of PCP often appear to be having a psychotic episode and may or may not report to the physician that they have taken the drug.
		Physical: Based on a study by McCarron et al in which 1,000 patients presenting with acute phencyclidine intoxication were evaluated, clinical effects ranged from lethargy and coma to extreme agitation and psychosis.
	www.emedicine.com /emerg/topic420.htm (3010 words)

	Phencyclidine (PCP)
		Phencyclidine (commonly known as PCP or "angel dust") is a synthetic arylcyclohexylamine with a complex and unusual pharmacology that has captured the interest of researchers, clinicians, recreational drug users, and illegal drug dealers alike.
		Although human therapeutic use in the United States has ended and illicit use has waned over the past decade, scientific interest remains high, focused on the use of PCP as a probe for certain neurotransmitter systems (see Excitatory Amino Acid Neurotransmission) and as a model for certain psychiatric disorders (see Functional Brain-Imaging Studies in Schizophrenia.
		Serum concentrations in several case series of intoxicated patients have ranged from 0 to 800 ng/ml, whereas subjects arrested for public intoxication or driving under the influence have had concentrations from 7 to 240 ng/ml.
	www.acnp.org /g4/GN401000171/CH167.html (5919 words)

	Neuroscience for Kids - PCP
		Diaz believes that the reported violent behavior is not due to the pharmacological effect of PCP, but rather is the result of the way people under the influence of PCP perceive things and are subsequently treated by law enforcement personnel.
		These complex effects on multiple chemical systems in the brain most likely underlie the behavioral effects of PCP.
		Phencyclidine - the National Institute on Drug Abuse
	faculty.washington.edu /chudler/pcp.html (555 words)

	Phencyclidine \| TutorGig.co.uk Encyclopedia (Site not responding. Last check: 2007-10-21)
		For other uses of the term "angel dust", see Angel Dust.
		'Phencyclidine' (also called 'PCP', 'sherm', 'angel dust', or 'Ashy Larry') is a dissociative psychedelic drug formerly used as an anaesthetic agent.
		Sigma and Phencyclidine: Like Compounds As Molecular Probes in Biology
	www.tutorgig.co.uk /ed/Phencyclidine (1077 words)

	Drug Testing: Encyclopedia of Everyday Law (Site not responding. Last check: 2007-10-21)
		Random testing involves unannounced, "suspicionless," and/or non-routine testing that may be indiscriminately applied to some, but not all, employees.
		Basic tests screen for amphetamines (speed, meth, ecstasy, crank, etc.), cannabinoids (marijuana, hashish), cocaine (coke or crack), opiates (heroin, morphine, opium, codeine), or phencyclidine (PCP).
		Extended tests might screen for barbiturates, benzodiazepines, ethanol, hallucinogens, inhalants, or anabolic steroids.
	law.enotes.com /everyday-law-encyclopedia/90012 (2551 words)

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