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Phenelzine - Wikipedia, the free encyclopedia Phenelzine is a derivative of hydrazine, which is phenylethylamine-like moiety and similar to normal substrates of MAO. Phenelzine is administered orally as phenelzine sulphate and it is rapidly absorbed form the gastro-intestinal tract. Phenelzine is acetylated in the liver and its metabolites are excreted in the urine. en.wikipedia.org /wiki/Nardil   (356 words)

Phenelzine Phenelzine is sometimes used to treat people with depression who do not respond to other antidepressant drug therapy. In a case report of a woman treated with phenelzine for depression, addition of ginseng (not further identified) was associated with hypomania (a mild form of mania), which the patient had not previously experienced. Phenelzine can alter metabolism of a chemical called tyramine that is present in certain foods, leading to diarrhea, flushing, sweating, pounding chest, dangerous changes in blood pressure, and other symptoms. www.publix.com /wellness/notes/Display.do?id=Drug&childId=Phenelzine   (738 words)

Parkinsn's List Drug DataBase phenelzine / Nardil Phenelzine is a nonselective MAOI and desensitizes ›and œadrenergic and serotonin receptors. Phenelzine should be used with caution in patients with hepatic disease or severe heart failure, and is not recommended for use in patients with severe hepatic disease. Phenelzine should be used with caution in patients with asthma or bronchitis because of possible changes in the blockade of sympathetic neurotransmission and dramatic pressor effects from œ-adrenergic bronchodilators. www.parkinsons-information-exchange-network-online.com /drugdb/102.html   (3209 words)

Phenelzine ( Nardil )   (Site not responding. Last check: 2007-10-08) Phenelzine sulfate is a potent inhibitor of monoamine oxidase (MAO). Phenelzine sulfate should not be used in patients who are hypersensitive to the drug, with phaeochromocytoma, congestive heart failure, a history of liver disease, or with abnormal liver function tests. Phenelzine sulfate is a potent inhibitor of monoamine oxidase. www.psyweb.com /Drughtm/phenel.html   (3138 words)

Antidepressant Medications Anti-depressant Drugs Antidepressant: phenelzine, Nardil Phenelzine is a potent monoamine oxidase (MAO) inhibitor. Phenelzine should not be used in combination with dextromethorphan or with CNS depressants such as alcohol and certain narcotics. Phenelzine is a potent inhibitor of monoamine oxidase. www.support4hope.com /medications/antidepressants/phenelzine_nardil.htm   (771 words)

Nardil on MediResource TM - Health Simplified Severe reactions during phenelzine therapy may also be caused by eating foods with a high concentration of tyramine or dopamine. Phenelzine should not be used in combination with dextromethorphan (a cough suppressant in many cough medicines) or with sedating drugs such as alcohol and certain narcotics. Phenelzine should not be taken at the same time or in rapid succession to other MAO inhibitors or other antidepressant drugs such as: amitriptyline, amitriptyline and perphenazine, amoxapine, carbamazepine, clomipramine, cyclobenzaprine, desipramine, doxepin, imipramine, maprotiline, nortriptyline, protriptyline, trimipramine. www.mediresource.com /e/health/drug_detail.asp?brand_name_id=456&dowhat=accept_disclaimer   (826 words)

Phenelzine, Nardil, Parnate Pharmacology - HealthyPlace.com Phenelzine (Nardil) is used in the treatment of depressed patients clinically characterized as "atypical", "nonendogenous" or "neurotic". Phenelzine should not be administered together with or in rapid succession to other MAO inhibitors (see Table I), because Hypertensive Crises and convulsive seizures, fever, marked sweating, excitation, delirium, tremor, coma and circulatory collapse may occur. Phenelzine should not be used in combination with buspirone HCl, since several cases of elevated blood pressure have been reported in patients taking MAO inhibitors who were then given buspirone HCl. www.healthyplace.com /medications/nardil.htm   (1687 words)

Tyramine-Containing Foods Abstract: The concentration of p-tyramine in the rat striatum was increased significantly by intraperitoneal injection of phenelzine (5 or 100 mg/kg). Following intraperitoneal injection of 100 mg/kg phenelzine, the initial concentration of phenelzine in the striatum appears to be high enough to inhibit aromatic L-amino acid decarboxylase. It is suggested that the multiple enzyme inhibition caused by administration of high doses of phenelzine accounts for its unusual effects on striatal p-tyramine levels compared with other MAO inhibitors, i.e., its initial lack of effect on p-tyramine levels followed later by very large increases in p-tyramine levels. home.caregroup.org /clinical/altmed/interactions/Nutrients/Tyramine-Contai.htm   (3014 words)

Phenelzine and Phenelzine Sulphate (IARC Summary & Evaluation, Volume 24, 1980)   (Site not responding. Last check: 2007-10-08) Phenelzine sulphate was tested in mice by oral administration: it significantly increased the incidence of lung and blood vessel tumours in females. Phenelzine sulphate is a monoamine oxidase inhibitor with limited use in the treatment of depressive states. In view of the evidence in experimental animals, the mutagenicity of phenelzine sulphate and a single case report of angiosarcoma of the liver in a patient taking phenelzine sulphate, further studies on the carcinogenicity of this compound are warranted. www.inchem.org /documents/iarc/vol24/phenelzinesul.html   (154 words)

Phenelzine Sulfate   (Site not responding. Last check: 2007-10-08) Phenelzine inhibits the activity of monoamine oxidase, an enzyme that renders certain brain chemicals (epinephrine, norepinephrine, and dopamine) inactive. Phenelzine may pass into breast milk; caution is advised. Phenelzine is not recommended for children 16 years of age and under. www.wholehealthmd.com /refshelf/drugs_view/1,1524,493,00.html   (525 words)

Phenelzine Sulphate (Suppl7)   (Site not responding. Last check: 2007-10-08) A liver angiosarcoma was reported in one person who had taken phenelzine sulphate for six years preceding tumour diagnosis [ref: 1]. Phenelzine sulphate was administered to mice in drinking-water for life. Phenelzine sulphate is not classifiable as to its carcinogenicity to humans (Group 3). monographs.iarc.fr /htdocs/monographs/suppl7/phenelzinesul.html   (109 words)

phenelzine of Augusta, Georgia Phenelzine is a monoamine oxidase inhibitor (MAOI) in the class of drugs called antidepressants. Phenelzine is used to treat symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Phenelzine is in the FDA pregnancy category C. This means that it is not known whether phenelzine will harm an unborn baby. www.universityhealth.org /16788.cfm   (1496 words)

MedlinePlus Drug Information: Phenelzine Children younger than 18 years of age should not normally take phenelzine.If your child’s doctor has prescribed phenelzine for your child, you should watch his or her behavior very carefully, especially at the beginning of treatment and any time his or her dose is increased or decreased. Phenelzine, a monoamine oxidase (MAO) inhibitor, and an antidepressant, is used to treat depression. MAO inhibitors [phenelzine (Nardil) or tranylcypromine (Parnate)] are also used occasionally to treat eating disorders, cocaine addiction, headaches, and panic attacks. www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682089.html   (1022 words)

Phenelzine, Nardil, Monoamine Oxidase Inhibitors, MAOIs, Antidepressants, Depression Prescription Drugs, Medications   (Site not responding. Last check: 2007-10-08) Phenelzine (Nardil) mechanism of action:parkinsons-information-exchange-network:"Phenelzine inhibits monoamine oxidase by binding to it irreversibly. Phenelzine (Nardil) contraindications, warnings and precautions:Red Oak Psychiatry:" Contraindicated in patients with hypersensitivity to the drug, congestive heart failure, pheochromocytoma, hypertension, significant renal impairment, cerebrovascular defects, liver disease, or cardiovascular disease. Why Phenelzine (Nardil) should Not be prescribed:healthsquare:"You should not take this d rug if you have pheochromocytoma (a tumor of the adrenal gland), congestive heart failure, or a history of liver disease, or if you have had an allergic reaction to it. www.buyxanaxonline.com /drugs/anti.depressants/monoamine.oxidase.inhibitors.maoi.phenelzine.nardil.htm   (2452 words)

Science News: Stepping out of social phobias - treatment with phenelzine   (Site not responding. Last check: 2007-10-08) Preliminary findings, according to study director Cheryl A. Shea, indicate that phenelzine, a drug that increases the amounts available of several neurotransmitters, and psychological training both provide relief from symptoms of social phobia. Phenelzine appears to be effective wiot about 80 percent of social phobics, says psychiatrist Michael R. Liebowitz of the New York State Psychiatric Institute, who has conducted several phenelzine studies. Short-term phenelzine therapy may not wipe out social fears entirely, adds Liebowitz, but it allows patients to talk to other people, develop skills and build close relationships, often for the first time. www.findarticles.com /p/articles/mi_m1200/is_n21_v133/ai_6739441   (404 words)

Phenelzine Phenelzine should not be started until at least 2 weeks after a tricyclic (or related antidepressant)or a selective serotonin re-uptake inhibitor (SSRI) or related antidepressant has been stopped (5 weeks for fluoxetine). There may be a large increase in blood pressure when phenelzine is taken with tyramine-rich foods. There may be a decrease in blood pressure when phenelzine is taken with alcohol and altremine. www.tiscali.co.uk /lifestyle/healthfitness/health_advice/netdoctor/archive/100004001_2.html   (432 words)

Phenelzine - Patient UK Phenelzine is used to treat depression, especially when the patient is excitable or suffering from phobias (fears). Make sure you know how you react to phenelzine before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert or able to see properly. Phenelzine can cause some people to sweat more than they usually do. www.patient.co.uk /showdoc/30002839   (946 words)

Prophylactic efficacy of phenelzine and imipramine in chronic atypical depression: likelihood of recurrence on ...   (Site not responding. Last check: 2007-10-08) Prophylactic efficacy of phenelzine and imipramine in chronic atypical depression: likelihood of recurrence on discontinuation after 6 months' remission -- Stewart et al. Prophylactic efficacy of phenelzine and imipramine in chronic atypical depression: likelihood of recurrence on discontinuation after 6 months' remission phenelzine is withdrawn 6 months after initial improvement. ajp.psychiatryonline.org /cgi/content/abstract/154/1/31   (435 words)

The Anxiety Community - Treatment - Medication: Nardil By inhibiting monoamine oxidase (MAO) enzymes, phenelzine slows down the metabolism of neurotransmitters such as epinephrine, norepinephrine, serotonin, and dopamine, and thus keeps them longer in the brain. Clinical trails suggest phenelzine is at least as effective as other commonly used drugs for conditions such as Social Anxiety, and real-world testimonials suggest it is even better. Even though, phenelzine is usually indicated only for patients who have failed to respond to safer drugs, such as SSRIs. anxietyhelp.org /treatment/medication/nardil.html   (3982 words)

Numark | Phenelzine In a case report of a woman treated with phenelzine for Phenelzine can alter metabolism of a chemical called tyramine that is present in certain foods, leading to diarrhoea, flushing, sweating, pounding chest, dangerous changes in blood pressure, and other symptoms. Numark Plc is not responsible or liable for any action taken by following the use of any content on this website, including any links provided to external websites and any product sold and promoted on the sites. www.numarkpharmacists.com /hn/Drug/Phenelzine.htm   (733 words)

Cognitive behavioural group therapy and phenelzine were both effective in social phobia -- Thyer 2 (3): 80 -- ... Cognitive behavioural group therapy and phenelzine were both effective in social phobia -- Thyer 2 (3): 80 -- Evidence-Based Mental Health Cognitive behavioural group therapy and phenelzine were both effective in social phobia Cognitive behavioral group therapy vs phenelzine therapy for social phobia. ebmh.bmjjournals.com /cgi/content/full/2/3/80   (631 words)

NJ CFS Center News - Fall 1995 - pg 2 We started the trial when Dr. Joseph Chu, who was then a medical student, realized that CFS like symptoms followed treatment of high blood pressure with a pill that altered firing of a part of the brain known as the locus coeruleus. Since the antidepressant phenelzine returned locus coeruleus firing to normal, Dr. Chu reasoned that phenelzine might be helpful in the treatment of CFS. Since only low doses of phenelzine are required to alter locus firing, we elected to do the treatment trial with doses that would probably have no antidepressant effect. www.umdnj.edu /cfsweb/CFS/NewsLetter/cfsnewslet95_2.html   (855 words)

Nardil Online, Description, Chemistry, Ingredients - Phenelzine - RxList Monographs The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%. Nardil® (phenelzine sulfate) is a potent inhibitor of monoamine oxidase (MAO). Each Nardil tablet for oral administration contains phenelzine sulfate equivalent to 15 mg of phenelzine base. rxlist.com /cgi/generic2/phenelzine.htm   (241 words)

Different Effects of Phenelzine Treatment on EEG Topography in Waking and Sleep in Depressed Patients   (Site not responding. Last check: 2007-10-08) A novel approach to investigate the relationship between depression and changes in sleep-wake regulatory mechanisms used the monoamine oxidase inhibitor (MAOI) phenelzine that is known to suppress rapid-eye-movement (REM) sleep. These data indicate that in contrast to wakefulness the effects of phenelzine treatment on the EEG in non-REM sleep were small. Rank correlation analyses revealed no association between the antidepressant treatment response and the changes in sleep and EEG power spectra during administration of phenelzine. www.nature.com /cgi-taf/dynapage.taf?file=/npp/journal/v27/n3/abs/1395912a.html   (282 words)

Psychiatric Drugs - Nardil (Phenelzine) Phenelzine comes as a tablet and is taken orally. If you are pregnant or planning to become pregnant, talk to your doctor about possible risks to your pregnancy. For breastfeeding mothers, it is not know whether or not phenelzine is excreted in breast milk. psychiatricdrugs.org /meds/nardil.html   (510 words)

Phenelzine - Drugs & Vitamins - Drug Library - DrugDigest Phenelzine increases the level of certain chemicals in the brain that help fight depression and other mood problems, including certain anxiety disorders. Notify your health care professional if you are scheduled to have any surgery, procedure or medical testing (including myelography). Keep out of the reach of children in a container that small children cannot open. www.drugdigest.org /DD/DVH/HowToTake/0,3919,536|Phenelzine,00.html   (919 words)

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