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Topic: Phenethylamines

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  Phenethylamine - Wikipedia, the free encyclopedia   (Site not responding. Last check: 2007-10-07)
Phenethylamine is a colorless liquid that forms a solid carbonate salt with carbon dioxide (CO) upon exposure to air.
Substituted phenethylamines are a broad and diverse class of compounds that include alkaloids, neurotransmitters, hormones, stimulants, hallucinogens, entactogens, anorectics, bronchodilators, and antidepressants.
The phenethylamine structure can also be found as part of more complex ring systems like in the ergoline system of LSD or the morphinan system of morphine.
en.wikipedia.org /wiki/Phenethylamine   (429 words)

 MAPS - Volume 4 Number 1 Spring 1993 - Phenethylamines, Free Radicals, and Antioxidants
Phenethylamines are a class of compounds chemically, and functionally, related to adrenaline -- the fight or flight neurotransmitter made from the amino acid tyrosine.
Phenethylamines all contain a benzene (C6H6) ring linked to an ethylamine (-CH2-CH2-NH2) group, and include: amphetamine (a stimulant), ephedrine (a naturally-occurring decongestant), and methylenedioxymethamphetamine (MDMA, a psychotherapeutic agent that facilitates communication).
Phenethylamines are stored in highest concentrations in the brain and nervous system.
www.maps.org /news-letters/v04n1/04134pea.html   (902 words)

 Escaline - Wikipedia, the free encyclopedia   (Site not responding. Last check: 2007-10-07)
Escaline is a psychedelic hallucinogenic drug and entheogen of the phenethylamine class of compounds.
In his book PIHKAL (Phenethylamines I Have Known and Loved), Shulgin lists the dosage range as 40 to 60 mg, consumed orally.
Escaline is the phenethylamine analog of 3C-E and the 4-ethoxy analog of mescaline.
www.lighthousepoint.us /project/wikipedia/index.php/Escaline   (183 words)

 PiHKAL #142 PEA   (Site not responding. Last check: 2007-10-07)
This, the simplest of all phenethylamines, has always been the darling of the psychopharmacologists in that it is structurally clean, it is naturally present in various human fluids and tissues, and because of its close chemical relationship to amphetamine and to the neurotransmitters.
Phenethylamine is intrinsically a stimulant, although it doesn't last long enough to express this property.
Thus, just as there is a "family" of compounds based on the foundation of phenethylamine itself, there is an equally varied and rich "families" of other compounds that might be based on some phenethylamine with a small modification to its backbone.
www.drugsinfo.net /pihkal/pihkal142.html   (1802 words)

 Category:Phenethylamines - Wikipedia, the free encyclopedia
Substitutions to the phenethylamine molecule give rise to a group of compounds collectively known as phenethylamines.
Some of the phenethylamines not categorized as hallucinogenic may, in fact, be hallucinogens; information on the effects and properties of many of these may be lacking.
This page was last modified 05:10, 3 May 2005.
en.wikipedia.org /wiki/Category:Phenethylamines   (76 words)

 Phalaris Grass | Ask Dr. Shulgin Online
The most significant phenethylamine (significant at least from the psychoactive point of view) to be found in cacti is the alkaloid mescaline.
There are over a dozen other phenethylamines known to be present in the cactus world, but none of them have been established as being active in man, at least as pure compounds.
There are a number of psychoactive cacti that contain both phenethylamines and tetrahydroisoquinolines and which are devoid of mescaline, so it is possible that some phenethylamine in admixture with other alkaloids might account for the cactus activity.
www.cognitiveliberty.org /shulgin/adsarchive/phalariscacti.htm   (200 words)

 2c c   (Site not responding. Last check: 2007-10-07)
In his book PIHKAL (Phenethylamines I Have Known and Loved), Shulgin lists the dosage range as 20 to 40 mg.
Not much information is known about the toxicity of 2C-C. According to Shulgin, the psychoactive effects of 2C-C typically last 4-8 hours.
Many users report that 2C-C is gentler and more sedating that other closely related psychedelic phenethylamines.
www.yourencyclopedia.net /2c_c.html   (181 words)

 Drugs and drink - 2CB, 2C-i, phenethylamines
Part of the phenethylamine class, it is structurally similar to mescaline and MDMA.
Another phenethylamine developed by Shulgin, 2C-i is thought to be stronger than 2CB and the effects to last longer (eight hours or more).
According to Erowid:  "2C-T-7 is a psychedelic phenethylamine developed by Alexander Shulgin around 1980.
www.thesite.org /youthnet/jsp/polopoly.jsp?d=210&a=11917   (764 words)

 2C-E - Pictures   (Site not responding. Last check: 2007-10-07)
It is commonly active in the 10 - 25 mg range, taken orally, and highly dose-sensitive.
Many have reported that the effects of 2C-E are similar to those of the other phenethylamines, only much more intense.
Vivid hallucinations similar to those experienced while under the influence of LSD are common, and many reports would indicate that the effects of this particular chemical may be overly intense for those not well experienced with psychedelics.
www.greatestinfo.org /2C-E   (181 words)

 DEA Resources, Microgram Journal, A Rapid and Simple GC/MS Screening Method for 4-Methoxyphenol in Illicitly Prepared ...
At present, the phenethylamines amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), and 3,4- methylenedioxymethamphetamine (MDMA) are particularly popular amongst members of certain social environments.
The production and use of unusual phenethylamines is sometimes accidental, but is often an intentional response to laws controlling illicit drugs of abuse.
Most of the common phenethylamine drugs - and virtually all of the more popular ones - are illegal, which leads clandestine chemists to engage in their illicit manufacture.
www.usdoj.gov /dea/programs/forensicsci/microgram/journal071203/mj071203_pg5.html   (1651 words)

 [No title]
The first half of PIHKAL (Phenethylamines I Have Known and Loved), by Alexander and Ann Shulgin (Transform Press), is a thinly-veiled biography of one of our greatest "white shamans," a chemist in this instance, and of his seduction by his second wife, Ann.
He has specialized in what are largely analogs of the mescaline molecule (the simplest of the "one ring phenethylamines"), all of which are fairly easy to synthesize, in contrast to the four-ring indolic psychedelics such as LSD, psilocybin, harmaline and ibogaine.
Phenethylamines are particularly fascinating in that they are only partially indolic, meaning they can be constructed reasonably easily, unlike the case with LSD, ibogaine, harmaline, psilocybin, DMT and other classic psychedelics.
www.island.org /ive/3/pihkal3.html   (1058 words)

 Reading - Psychotropic Chemistry   (Site not responding. Last check: 2007-10-07)
The Shulgins' classic story of "Phenethylamines I Have Known and Loved" has to be owned by anyone who's into psychoalchemy.
The first 2/3 of the book tells the story of the evolution of Sasha and Ann's relationship, all the while filling us in as to who these people are, what they believe, and how they came to believe it.
The great majority of, though by no means all, known psychedelics are either phenethylamines (the classic example being mescaline) or tryptamines (the classic example being LSD).
www.etfrc.com /psychoalchemy.htm   (232 words)

 [No title]   (Site not responding. Last check: 2007-10-07)
"If all the phenethylamines were to be ranked as to their acceptability and intrinsic richness, 2C-T-7 would be right up there near the top," he wrote of his 1986 invention.
Nowadays he often refers to them by the terms "phenethylamines" or "tryptamines," concerned as he is by the connotations of hippie excess attached to the word "psychedelic." Shulgin does not design drugs for the commercial market.
PIHKAL: A Chemical Love Story (the acronym stands for Phenethylamines I Have Known and Loved) was a unique book by any standard, weaving together lab procedure, highly personalized accounts of each compound's creation, and Sasha and Ann's own love story, as told in the alternating voices of two not-quite-fictional characters named Shura and Alice Borodin.
www.partyvibe.com /articles/text_versions/2c-t-27s_bad_trip.TXT   (6057 words)

 E is for Ecstasy, Chapter 3   (Site not responding. Last check: 2007-10-07)
Thanks to his remarkable personality - combining openness without proselytising about his liberal and controversial views - he has earned the respect of influential people and is able to carry on with his research today, with the full approval of the US government.
His approach to psychedelics is similar to that of a botanist: he specialises in the phenethylamines, and delights in recording the subtle differences between each member of that family of drugs.
MDMA is but one of 179 psychoactive drugs which he describes in detail, and, although its effects are less dramatic than many, MDMA is perhaps the one which comes closest to fulfilling his ambition of finding a therapeutic drug.
www.ecstasy.org /books/e4x/e4x.ch.03.html   (1886 words)

 Avant Labs -> phenethylamine legality
In a recent correspondence with a supplier, information was shared stating that phenethylamines of the 2c variety are illegal.
The name even sounds a lot like an amphetamine (never heard of "Ethamphetamine") There is even an undergound book about this very subject called, "Phenethylamines I have Known and Loved" by some name like Uncle Fester (as in Adams Family, probably).
The book you mention is "PIHKAL: Phenethylamines I have known and loved" by Alexander and Ann Shulgin.
forum.avantlabs.com /topic15951.html   (535 words)

 Analysis of Underivatized Amphetamines and Related Phenethylamines with High-Performance Liquid ...   (Site not responding. Last check: 2007-10-07)
Amphetamine, methamphetamine, illicit designer phenethylamines (MDA, MDEA, MDMA, MBDB, and BDMPEA), and other phenethylamines (benzyl-1-phenylethylamine, cathinone, ephedrine, fenfluramine, norfenfluramine, phentermine, 1-phenylethylamine, phenylpropanolamine, and propylhexedrine) were extracted from serum using a solid-phase extraction procedure.
A linear response was observed for all drugs in the range from 5 to 500 µg/L. The method was applied for routine determination of amphetamine, MDMA, MDA, and MDEA in one run.
Solid-phase extraction used assured simultaneous isolation of various groups of basic drugs of forensic interest (opiates, cocaines, phenethylamines, and benzodiazepines) from biofluids.
www.jatox.com /abstracts/2000/march/77-bogusz.htm   (290 words)

 Expert Opinions on Ecstasy   (Site not responding. Last check: 2007-10-07)
Although he didn't discover the drug, he rescued it from obscurity by writing the first scientific papers about it in the 1970s.
Indeed, Ecstasy (MDMA) is just one of hundreds of phenethylamines whose effects he's spent the best part of his career investigating.
The results from 179 of these experiments have been compiled in a book Shulgin and his wife co-authored and published in 1991 called Pihkal (Phenethylamines I Have Known and Loved), which has been Refused Classification by The Office of Film and Literature Classification, and is not available in Australia.
www.abc.net.au /quantum/poison/ecstasy/shulgin.htm   (129 words)

 yeast   (Site not responding. Last check: 2007-10-07)
I chose to start with tryptamines and phenethylamines as they are simple molecules, almost identical to their biosynthetic precursors: the ubiquitous amino acids tryptophan and tyrosine.
The bulk of the work is involved in identifying the appropriate reading frame for the cloned mrna to cdna fragment which codes a single enzyme for a specific chemical transformation, again two such genes in the case of tryptophan to N-methyltryptamine --and in choosing appropriate marker genes to identify the transformed vs. wild type cells.
Somewhere between three and possibly five unkown genes will have to be characterized and inserted for a yeast to produce substituted phenethylamines from tyrosine (not including the known decarboxylation enzyme gene) so it is a more difficult transformation to attempt by far.
www.pervertedlogic.com /lucifer_m/yeast.htm   (1932 words)

 0210 PIHKAL - Shulgin   (Site not responding. Last check: 2007-10-07)
This world-famous and notorious book describes synthesis, dose, and duration of the effects and experiences of 179 designer drugs (Phenethylamines) in its second part.
The first part of Ann and Alexander Shulgin their book is an autobiographical novel in which they describe their experiences with these and some other (LSD and Mescaline) synthetics.
Here are some of the Phenethylamines and amphetamines described: 2CB, 2CT2, 2CT7, DOB, DOM, FLEA, MDA, MDE, MDMA and TMA-2.
www.de-sjamaan.nl /en/0210_PIHKAL_-_Shulgin.html   (82 words)

 British Journal of Pharmacology - Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the ...   (Site not responding. Last check: 2007-10-07)
The affinities of the nonphenethylamine reference compounds UK14,304, p-aminoclonidine and clonidine were not affected to the same extent by the mutations as those of the phenethylamines (Tables 1 and 2).
The R-enantiomers of the phenethylamines (adrenaline, noradrenaline, octopamine and norphenephrine) appeared to be more potent and efficacious on the wild-type receptor than the S-enantiomers, which was expected according to previous studies (Airriess et al.
In contrast, clearly, the efficacies of phenethylamines possessing an OH in the meta-position (R-adrenaline, R-noradrenaline, R-norphenephrine and dopamine) have suffered.
www.nature.com /bjp/journal/v140/n2/full/0705439a.html   (7069 words)

 PiHKAL #27 2C-G
I had always thought of the phenethylamines as being somewhat weaker than the corresponding amphetamines.
It is equally valid to think of the phenethylamines as the prototypes, and that the amphetamines are somewhat stronger than the corresponding phenethylamines.
It is simply a historic fact, that in most of my exploring, the amphetamine was made and evaluated first, and so tended to slip into the role of the prototype.
meltingpot.fortunecity.com /macau/656/techdrug/pihkal/pihkal027.html   (1768 words)

 Simple Plant Isoquinolines $40.00
One part is the large collection of psychoactive compounds known as the phenethylamines.
This simple one-ring alkaloid was discovered in the North American dumpling cactus Peyote (Anhalonium williamsii) in the late nineteenth century, and is now known to be a component of over fifty other cacti.
Over a dozen other cactus phenethylamines have been isolated and identified, and there are perhaps a hundred synthetic analogues that are now also known to be psychedelic in action.
www.fsbookco.com /SimplePlantIsoquinolines.html   (659 words)

 Ask Dr. Alexander "Sasha" Shulgin Online - 2C-B
This entire research world started with mescaline, which is a phenethylamine.
As the research progressed into more complex and more potent phenethylamines, it was noted that the amphetamine analogues were more potent and more aggressive.
As further progress was made, it became obvious that the phenethylamines that corresponded to these amphetamines were indeed less potent but much more friendly and gentle.
www.cognitiveliberty.org /shulgin/adsarchive/2cb.htm   (542 words)

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