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Topic: Phenylbutazone

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	The Use of Phenylbutazone (Bute) in Horses
		Phenylbutazone is indicated for the treatment of a wide range of musculoskeletal disorders, including muscular sprain and strain, muscular overuse (including both muscular damage and strain/damage of the tendons attaching muscles to bone), tendonitis, acute joint injury/strain/sprain, and arthritic conditions.
		Phenylbutazone or its metabolites may be detected in plasma and particularly in urine for longer periods (up to 7 days or longer) after administration of a course of phenylbutazone therapy.
		Phenylbutazone may be a cause of heart disease, high blood pressure, blurred vision, bleeding in the back of the eye, detachment of a retina, hearing loss, high blood sugar, thyroid disease, agitation, confusion, or lethargy.
	horseproducts.stablemade.com /_Articles/Phenylbutazone.htm (2584 words)

	Phenylbutazone *
		Phenylbutazone may cause decreased renal blood flow and sodium and water retention, and should be used cautiously in animals with preexisting renal disease or CHF.
		Phenylbutazone should therefore be used in pregnancy only when the potential benefits of therapy outweigh the risks associated with it.
		Phenylbutazone is contraindicated in patients demonstrating previous hypersensitivity reactions to it, and should be used very cautiously in patients that have a history of allergies to other drugs.
	www.elephantcare.org /Drugs/phenylbu.htm (1851 words)

	1800PetMeds.com - Phenylbutazone 1 gram Tab
		Phenylbutazone is used for the relief of pain and inflammation caused by arthritis.
		Phenylbutazone is an anti-inflammatory drug used to treat pain and inflammation associated with fractures, arthritis and painful injuries to the limbs and joints.
		Phenylbutazone 100mg tablet is FDA approved for use in dogs.
	www.1800petmeds.com /pdetail.asp?SK=10141&SP=horse (509 words)

	phenylbutazone - Arthritis and Arthritic Conditions, Medications, Symptoms, and Treatment on MedicineNet.com
		PRESCRIBED FOR: Phenylbutazone is used for the treatment of inflammation and pain that results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis.
		Phenylbutazone is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding.
		Phenylbutazone is not a commonly used NSAID because of a unique potential for severe bone marrow toxicity, which results in dangerously low white blood cell counts.
	www.medicinenet.com /phenylbutazone/article.htm (592 words)

	Phenylbutazone NSAID Veterinary Medicine for Horses and Dogs
		Phenylbutazone may be given intravenously or orally; pain relief and fever reduction usually starts within one to two hours.
		Phenylbutazone is occasionally used in dogs for the longer-term management of chronic pain particularly due to osteoarthritis.
		Phenylbutazone should be avoided or used with caution in pregnant or nursing animals.
	www.wedgewoodpharmacy.com /monographs/phenylbutazone.asp (976 words)

	Final Diagnosis -- Case 268
		PHENYLBUTAZONE: is a NSAID which was discontinued for human use because of its harmful side effects.
		Phenylbutazone is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 2 hours after ingestion.
		Phenylbutazone is widely distributed throughout body fluids and tissues; it diffuses into the synovial fluid, crosses the placenta, and small amounts enter the CNS and breast milk.
	path.upmc.edu /cases/case268/dx.html (495 words)

	FR Doc 03-4741
		Phenylbutazone Phenylbutazone became available for use in humans for the treatment of rheumatoid arthritis and gout in 1949 (Ref. 1), but is no longer approved, and thus not marketed, for any human use in the United States.
		Phenylbutazone is known for its ulcerogenic, nephrotoxic, and hemotoxic effects in horses, dogs, rats, and humans (Refs.
		This evidence indicates that the extralabel use of phenylbutazone in female dairy cattle 20 months of age or older will likely result in the presence, at slaughter, of residues that are toxic to humans, including being carcinogenic, at levels that have not been shown to be safe.
	www.fda.gov /OHRMS/DOCKETS/98fr/03-4741.htm (1355 words)

	Phenylbutazone Tablets
		Phenylbutazone is indicated for the treatment of a wide range of musculoskeletal disorders, including muscular sprain and strain, muscular overuse (including both muscular damage and strain/damage of the tendons attaching muscles to bone), tendonitis, acute joint injury/strain/sprain, and arthritic conditions.
		INDICATIONS Phenylbutazone is indicated for the treatment of a wide range of musculoskeletal disorders, including muscular sprain and strain, muscular overuse (including both muscular damage and strain/damage of the tendons attaching muscles to bone), tendonitis, acute joint injury/strain/sprain, and arthritic conditions.
		Phenylbutazone or its metabolites may be detected in plasma and particularly in urine for longer periods (up to 7 days or longer) after administration of a course of phenylbutazone therapy.
	www.allivet.com /ProductDetails.asp?ProductCode=25719 (1355 words)

	Medi-Vet - Phenylbutazone Product Information
		PHENYLBUTAZONE is used for the relief of inflammatory conditions associated with the musculoskeletal system in horses.
		Phenylbutazone is a white crystalline solid, slightly soluble in water, and soluble in some organic solvents.
		The anti-inflammatory activity of phenylbutazone has been shown in lower animals1 and in man.2 The greatest amount of data on efficacy is in man.3-6 Studies in horses have reported useful anti-inflammatory activity.7-10 Metabolic studies in horses have shown that the drug is well absorbed when administered orally with a balling gun.
	www.medi-vet.com /Phenylbutazone.aspx (714 words)

	Phenylbutazone - Wikipedia, the free encyclopedia
		Despite its name, phenylbutazone is chemically unrelated to the class of chemicals known as benzones (common examples include oxybenzone, dioxybenzone, avobenzone, and sulisobenzone), which are used as active ingredients in sunscreen formulations for protection against UVB rays.
		Phenylbutazone should not be used in combination with blood thinners (e.g., Coumadin), as it amplifies the anticoagulant effects of these drugs; with other NSAIDs (all NSAIDs are additive); or in horses with known kidney or liver problems.
		Phenylbutazone should be used cautiously in pregnant or nursing mares, as it may be toxic to the embryo and can be transferred via the umbilical cord and by milk.
	en.wikipedia.org /wiki/Phenylbutazone (905 words)

	Patent 6,022,563
		Paste and granulized formulations of phenylbutazone are available to prevent those administering the drug from having to crush tablets, but the granulized and past formulations still sustain the same problems associated with tablets, namely, rejection, inconvenience, and inconsistent dosages.
		Phenylbutazone is widely understood to be an effective veterinary anti-inflammatory and analgesic agent in treating inflammation in horses and other animals.
		A suitable weight proportion of phenylbutazone to achieve the advantages of the invention may be in the range of 50% to 90% and preferably in the range of 70% to 90% of the total formulation weight.
	www.pharmcast.com /Patents/020800OG/6022563_phenylbutazone.htm (2492 words)

	NTP: Abstract for TR-367 - Phenylbutazone
		Phenylbutazone produced a positive response in the mouse lymphoma assay in both the presence and absence of activation.
		Phenylbutazone induced chromosomal aberrations in CHO cells in the presence, but not the absence, of exogenous metabolic activation; no induction of sister chromatid exchanges was observed in CHO cells in the presence or absence of activation.
		Phenylbutazone was also nephrotoxic to rats, as shown by the dose-related increase in the severity of age-related nephropathy, necrosis of the renal papilla, and mineralization of the collecting ducts in the papilla.
	ntp.niehs.nih.gov /index.cfm?objectid=0708CAA4-0E21-4DD3-A165B607853F9C9B (1097 words)

	Pharmaceutical Technology - Nantong Jinghua Pharmaceutical - Active Pharmaceutical Ingredients (API) and Chemical ...
		Phenylbutazone is a crystalline powder, practically insoluble in water, soluble in ether and sparingly soluble in alcohol.
		Phenylbutazone dissolves in alkaline solutions and is used for the treatment of rheumatic and rheumatoid arthritis, gout and similar conditions.
		Phenylbutazone is used for the treatment of rheumatic and rheumatoid arthritis.
	www.pharmaceutical-technology.com /contractors/materials/nantong (702 words)

	Phenylbutazone (Bute) Use in Horses
		Phenylbutazone (Bute) is an analgesic (relieves pain) and anti-inflammatory medication, commonly used for the treatment of lameness in horses.
		Phenylbutazone is available in many preparations for horses, including 1-gram tablets, oral paste syringes (containing 6 grams or 12 grams/syringe), an injectable (200 mg/ml in 100-ml vials) and oral powder.
		Both phenylbutazone and its active ingredient, oxyphenbutazone, are highly bound to plasma proteins and, therefore, caution is advised when using this medication in horses with hypoproteinemia (low blood protein) and gastrointestinal ulceration.
	www.omafra.gov.on.ca /english/livestock/horses/facts/info_pheny.htm (990 words)

	Extralabel use of phenylbutazone banned in dairy cattle - April 15, 2003
		Phenylbutazone became available for use in humans for the treatment of rheumatoid arthritis and gout in 1949.
		Phenylbutazone is known to induce blood dyscrasias, including aplastic anemia, leukopenia, agranulocytosis, and thrombocytopenia, and can result in death.
		The USDA found zero violations for phenylbutazone residues in 2002 and 2001, one in 2000, and zero in 1999 and 1998.
	www.kaufmanzoning.net /horsemeat/Bute04152003.htm (525 words)

	Specific Nonsteroidal Anti-inflammatory Drugs - The Merck Veterinary Manual
		The main subgroups of enolic acids are the pyrazolones (phenylbutazone, oxyphenbutazone, and ramifenazone) and the oxicams (meloxicam, piroxicam, and tenoxicam).
		Phenylbutazone is metabolized by the liver to several active and inactive metabolites, which are excreted in urine.
		Because the therapeutic index for phenylbutazone is relatively narrow, dosage should be adjusted to the minimum possible to maintain comfort and avoid toxicity.
	www.merckvetmanual.com /mvm/htm/bc/191606.htm (2606 words)

	Phenylbutazone (IARC Summary & Evaluation, Supplement7, 1987) (Site not responding. Last check: 2007-11-07)
		Phenylbutazone did not induce dominant lethality or micronuclei or chromosomal anomalies in bone-marrow cells of mice treated in vivo.
		Phenylbutazone was not mutagenic to bacteria [ref: 6].
		Phenylbutazone is not classifiable as to its carcinogenicity to humans (Group 3).
	www.inchem.org /documents/iarc/suppl7/phenylbutazone.html (408 words)

	PROVET HEALTHCARE INFORMATION - Phenylbutazone - Warnings (Site not responding. Last check: 2007-11-07)
		You should seek the advice of your veterinarian if your pet is ill as only he or she can correctly advise on the diagnosis and recommend the treatment that is most appropriate for your pet.
		Phenylbutazone is a commonly prescribed drug in veterinary practice but there are some circumstances when it should not be prescribed
		Phenylbutazone should be avoided, or used with great care and at a reduced dose rate in :
	www.provet.co.uk /health/diseases/cdwphenylbutazone.htm (148 words)

	warfarin/phenylbutazone case
		C-warfarin to albumin in the presence and absence of phenylbutazone.
		On day 22 of the study, phenylbutazone was discontinued while warfarin and vitamin K were continued.
		The effects of phenylbutazone on the binding of warfarin to human serum albumin.
	www.umdnj.edu /~howland/warf_phenyl.htm (469 words)

	Phenylbutazone (Site not responding. Last check: 2007-11-07)
		Phenylbutazone is the common name for 4-n-butyl-1,2-diphenyl-3,5-pyrazolidinedione which has the molecular formula C
		Phenylbutazone is another analgesic, thus it has the same effects as earlier, including anti-inflammatory and anti-arthritic.
		It is an anti-inflammatory drug licensed for both human and veterinary medicine, which when used in horses can be used to treat osteoarthritis, arthritis, bursitis, posterior weakness or paralysis, rheumatism, inflammation of the skin and other soft tissues.
	www.hull.ac.uk /chemistry/horseDoping/phenylbutazone.htm (114 words)

	Phenylbutazone use surveyed, caution advised - November 1, 2001
		Phenylbutazone residues were found in 13 of 2,243 cull cows (a 0.05 percent failure rate) over six months.
		At press time, meat industry officials were urging the government to ban phenylbutazone outright in food-producing animals, but the FDA was not considering withdrawing its approval.
		Because phenylbutazone can be detected in the urine of treated animals for extended periods after treatment, FARAD estimates the slaughter withdrawal interval for IV, extralabel phenylbutazone administration in cattle (up to 4.4 mg/kg) to be 45 days and the milk withholding interval to be 120 hours.
	www.avma.org /onlnews/javma/nov01/s110101g.asp (522 words)

	Apo-Phenylbutazone - Drugs - Medbroadcast
		Phenylbutazone belongs to the family of medicines known as nonsteroidal anti-inflammatory drugs or NSAIDs.
		Phenylbutazone is used forthe treatment of ankylosing spondylitis, a type of rheumatoid arthritis that involves inflammation of the joints between the vertebrae of the spine.
		Phenylbutazone is not approved for use by children 14 years of age or younger.
	www.medbroadcast.com /drug_info_details.asp?brand_name_id=1526 (656 words)

	Phenylbutazone Tablets or Paste For Horses
		If there is not a significant clinical effect in five (5) days, a re-evaluation of the diagnosis and treatment should be made.
		Paste: Administer 1 to 2 g of phenylbutazone per 500 lbs.
		Response to PHENYLBUTAZONE therapy is prompt, usually occurring within 24 hours.
	www.bullwrinklerx.com /horses_equine/phenylbutazone.htm (225 words)

	.# Phenylbutazone - 100% BEST Pharmacy Pills!
		Exercise in part, by a Phenylbutazone a Phenylbutazone clinical pharmacology of Phenylbutazone.
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		Bind to ensure that Phenylbutazone by nerves and the response to as.
	toile.com /ext/go?http://search-meds.com/~du/@1175/Phenylbutazone.html (503 words)

	Equiphen® "BUTE" Rx Apple Flavored Paste-12 gram paste
		Equiphen Paste (Phenylbutazone) is a synthetic, non-hormonal, anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions.
		The apparent analgesic effect is probably related mainly to the anti-inflammatory properties of the compound.
		Oral dose of 1 to 2 grams of phenylbutazone per 500 lbs.
	www.agri-med.com /site/255063/product/EQUIPHEN-12 (380 words)

	TIME.com: For Creaky Joints -- Jun. 16, 1952 -- Page 1 (Site not responding. Last check: 2007-11-07)
		Geigy chemists hit upon phenylbutazone, which worked well as a solvent and then paid a big bonus: it turned out to have remarkable painkilling qualities of its own.
		Unlike cortisone, phenylbutazone is not a hormone, and it does not seem to arrest the disease process in arthritis.
		And phenylbutazone also has some annoying side effects: one patient out of four has suffered nausea, hives or water retention.
	www.time.com /time/magazine/article/0,9171,859741,00.html (687 words)

	Phenylbutazone Drug Information
		Studies in animals have not shown that fenoprofen, floctafenine, flurbiprofen, ibuprofen, ketoprofen, nabumetone, phenylbutazone, piroxicam, tiaprofenic acid, or tolmetin causes birth defects.
		With phenylbutazone, blood problems may also be more likely to occur in the elderly.
		Also, phenylbutazone should be used for the shortest time possible because of the chance of serious side effects, especially in patients who are 40 years of age or older.
	www.drugs.com /cons/Phenylbutazone.html (7756 words)

	Bute use in miniature horses
		Phenylbutazone may cause decreased renal blood flow and sodium and water retention, and should be used cautiously in animals with preexisting renal disease or CHF (CONGESTIVE HEART FAILURE).
		The primary concerns with phenylbutazone therapy in humans include its bone marrow effects (agranulocytosis, aplastic anemia), renal and cardiovascular effects (fluid retention to acute renal failure), and GI effects (perforated ulcers).
		...acute overdosage with phenylbutazone include, a prompt respiratory or metabolic acidosis with compensatory hyperventilation, seizures, coma, and acute hypotensive crisis.
	www.ramblinroseranch.com /bute.htm (2508 words)

	Subject: FDA PROHIBITS EXTRALABEL USE OF PHENYLBUTAZONE
		Phenylbutazone in female dairy cattle 20 months of age and older.
		Phenylbutazone became available for use in humans for the treatment of
		phenylbutazone on farms and identified tissue residues in culled dairy
	lawrence.osu.edu /ag/butazone.htm (400 words)

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