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Topic: Phosphatidylinositol (3,5)-bisphosphate

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Odor-Stimulated Phosphatidylinositol 3-Kinase in Lobster Olfactory Receptor Cells -- Zhainazarov et al. 85 (6): 2537 -- Journal of Neurophysiology Direct Activation of the Epithelial Na+ Channel by Phosphatidylinositol 3,4,5-Trisphosphate and Phosphatidylinositol 3,4-Bisphosphate Produced by Phosphoinositide 3-OH Kinase Effects of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate on a Na -gated nonselective cation channel. Toker A. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. jn.physiology.org /cgi/content/full/85/6/2537

Phosphatidylinositol 4,5-Bisphosphate Induces Actin Stress-fiber Formation and Inhibits Membrane Ruffling in CV1 Cells -- Yamamoto et al. 152 (5): 867 -- The Journal of Cell Biology Phosphatidylinositol 4,5-Bisphosphate Induces Actin Stress-fiber Formation and Inhibits Membrane Ruffling in CV1 Cells -- Yamamoto et al. Jones, D.H., Morris, J.B., Morgan, C.P., Kondo, H., Irvine, R.F., and Cockcroft, S. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment. Lassing, I., and Lindberg, U. Specific interaction between phosphatidylinositol 4,5 bisphosphate and profilactin. www.jcb.org /cgi/content/full/152/5/867

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p -- Bonangelino et al. 156 (6): 1015 -- The Journal of Cell Biology Acquisition of Unprecedented Phosphatidylinositol 3,5-Bisphosphate Rise in Hyperosmotically Stressed 3T3-L1 Adipocytes, Mediated by ArPIKfyve-PIKfyve Pathway Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. www.jcb.org /cgi/content/full/156/6/1015

Domain Formation in Phosphatidylinositol Monophosphate/Phosphatidylcholine Mixed Vesicles -- Redfern and Gericke 86 (5): 2980 -- Biophysical Journal Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C-kinase substrate is due to nonspecific electrostatic interactions. Phosphatidylinositol phosphate 5-kinase I ß recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. www.biophysj.org /cgi/content/full/86/5/2980

Phosphatidylinositol 4,5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol -- Kinuta et al. 99 (5): 2842 -- Proceedings of the National Academy of Sciences Phosphatidylinositol 4,5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol -- Kinuta et al. Phosphatidylinositol 4,5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type I{gamma} www.pnas.org /cgi/content/full/99/5/2842

A Crucial Role for the p110{delta} Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation -- Clayton et al. 196 (6): 753 -- The Journal of Experimental Medicine The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo. , a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. www.jem.org /cgi/content/full/196/6/753

PIP2 and Bipolar Disorder -- Neurotransmitter.net A critical component of the PI pathway is phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)), which is hydrolyzed to second messengers and has a direct role in synaptic vesicle function. One gene involved in PI metabolism that maps to a region of interest is 10p12-linked PIP5K2A, a member of the phosphatidylinositol 4-phosphate 5-kinase family. Lithium increases cell survival by inducing brain-derived neurotrophic factor and thereby stimulating activity in anti-apoptotic pathways, including the phosphatidylinositol 3-kinase/Akt and the mitogen-activated protein kinase pathways. www.neurotransmitter.net /bipolarpip2.html

Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis -- Zhou et al. 111 (2): 283 -- Journal of Cell Science Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils. Yamauchi, K., Holt, K. and Pessin, J. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. jcs.biologists.org /cgi/content/refs/111/2/283

Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase {beta}-/- Mice -- Lamia et al. 24 (11): 5080 -- Molecular and Cellular Biology Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase ß mcb.asm.org /cgi/content/full/24/11/5080

ERRB--Unit on Molecular Signal Transduction (2000) A pleckstrin homology domain specific for phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2 as being important in exocytosis. Várnai P, Rother K, Balla T (1999) Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin-homology domain visualized in single living cells. These enzymes are type-III PI 4-kinases, and although both catalyze the same reaction, namely the synthesis of phosphatidylinositol (PI) 4-phosphate, they show distinct subcellular distributions and assume non-redundant functions. dir2.nichd.nih.gov /nichd/ERRB/ERRBtext/molsigtrans_text.htm

EC 3.1.3.36 phosphatase; triphosphoinositide phosphomonoesterase; diphosphoinositide phosphatase; inositol 1,4,5-triphosphate 5-phosphomonoesterase; inositol triphosphate 5-phosphomonoesterase; phosphatidylinositol-bisphosphatase; phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphatase; polyphosphoinositol lipid 5-phosphatase; phosphatidyl-inositol-bisphosphate phosphatase Woscholski, R. and Parker, P.J. Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. www.chem.qmw.ac.uk /iubmb/enzyme/EC3/1/3/36.html   (163 words)

Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations Energy Citations Database (ECD) Document #6213494 - A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. www.osti.gov /energycitations/product.biblio.jsp?osti_id=6213494   (163 words)

jullookup.txt Enzyme: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase E 3.1.4.3 Class: Hydrolases Subclass: Acting on ester bonds Enzyme: 1-phosphatidylinositol phosphodiesterase E 3.1.4.11 Class: Hydrolases Subclass: Acting on ester bonds Enzyme: Serine/threonine specific protein phosphatase E 3.1.3.25 Class: Hydrolases Subclass: Acting on ester bonds bioinfo.mbb.yale.edu /partslist/func/data/jullookup.txt   (163 words)

Pfam 18.0 : PX Among these proteins are: the phox proteins p40phox (see INTERPRO:IPR000919) and p47phox (see INTERPRO:IPR001655), the Cpk class of phosphatidylinositol 3-kinase, phospholipase D, Saccharomyces cerevisiae Bem1 and Schizosaccharomyces pombe Scd2, S. cerevisiae GTPase-activating protein Bem3, sorting nexins and the murine adapter protein Fish. Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. The PX (phox) domain MEDLINE:8931154 occurs in a variety of eukaryotic proteins associated with intracellular signaling pathways.PX domains are important phosphoinositide-binding modules that have varying lipid-binding specificities MEDLINE:11884510. pfam.wustl.edu /cgi-bin/getdesc?name=PX   (366 words)

76th National Meeting of the Chemical Society of Japan 1A110 Synthesis of natural phosphatidylinositol 3,4-bisphosphate and its analogue ( Ehime University, Faculty of Engineering) WATANABE,Yutaka ; TAKAO,Hiroyuki ; HONDA,Yosuke 1A109 Synthesis of natural phosphatidylinositol 5-phosphate ( Ehime University, Faculty of Engineering) WATANABE,Yutaka ; ISHIKAWA,Hideki ; FUJIMOTO,Takahiro 3A202 Searching for the Denaturant of Hemocyte from discolored Pinctada fucata ( Ehime Univ.; Ehime Pre. www.chemistry.or.jp /nenkai/76haru/prog-76e.html   (366 words)

Regulation of cytosolic free calcium concentration by extracellular nucleotides in human hepatocytes -- Schöfl et al. 276 (1): 164 -- AJP - Gastrointestinal and Liver Physiology Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca -mobilizing hormones. Sensitivity of the response of cytosolic calcium in quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides. Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization. ajpgi.physiology.org /cgi/content/full/276/1/G164   (366 words)

Phospholipase D page The phospholipase C system which generates diacylglycerol and IP3 from phosphatidylinositol 4,5-bisphosphate has been extensively studied in recent years. These include the protein kinase C regulator diacylglycerol, the calcium signal inositol 1,4,5-trisphosphate, probably phosphatidic acid, and phosphorylated forms of phosphatidylinositol. Diacylglycerol generation was also activated by a protein kinase C activator, PMA. www.biochem.emory.edu /labs/dlambe/phosdpage.html   (697 words)

Alan Dawson : Publications Irvine, R.F., Letcher, A.J., Lander, D.J., Drobak, B.K., Dawson, A.P. and Musgrave, A. (1989) Phosphatidylinositol (4,5) bisphosphate and phosphatidylinositol (4) phosphate in plant-tissues. Tregar, R.T., Dawson, A.P. and Irvine, R.F. (1991) Quantal release of Ca2+ from intracellular stores by InsP3 - Tests of the concept of control of Ca2+ release by intraluminal Ca2+. Dawson, A.P. (1985) GTP enhances inositol trisphosphate-stimulated Ca2+ release from rat-liver microsomes. www.uea.ac.uk /bio/people/faculty/Updatehtml/APDpub.html   (2358 words)

Positive Charge at Position 549Is Essential for Phosphatidylinositol 4,5-Bisphosphate-hydrolyzing but Not Phosphatidylinositol-hydrolyzing Activities of Human Phospholipase C delta 1 -- Wang et al. 271 (40): 24505 -- Journal of Biological Chemistry Positive Charge at Position 549 Is Essential for Phosphatidylinositol 4,5-Bisphosphate-hydrolyzing but Not Phosphatidylinositol-hydrolyzing Activities of Human Phospholipase C Positive Charge at Position 549Is Essential for Phosphatidylinositol 4,5-Bisphosphate-hydrolyzing but Not Phosphatidylinositol-hydrolyzing Activities of Human Phospholipase C delta 1 -- Wang et al. Taken together, these results suggest that positive charge at position 549 of PLC www.jbc.org /cgi/content/abstract/271/40/24505   (2358 words)

Exclusion of exogenous phosphatidylinositol-3,4,5-trisphosphate from neutrophil-polarizing pseudopodia: stabilization of the uropod and cell polarity -- Tian et al. 4 (10): 982 -- EMBO Reports Ellson, C.D., Anderson, K.E., Morgan, G., Chilvers, E.R., Lipp, P., Stephens, L.R. and Hawkins, P.T. Phosphatidylinositol 3-phosphate is generated in the phagosomal membranes. for the exclusion effect as two phosphatidylinositol bisphosphate Hallett, M.B. Controlling the molecular motor of neutrophil chemotaxis. emboreports.npgjournals.com /cgi/content/full/4/10/982   (2358 words)

Hypo-osmotic Stress Activates Plc1p-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Inositol Hexakisphosphate Accumulation in Yeast -- Perera et al. 279 (7): 5216 -- Journal of Biological Chemistry Hypo-osmotic Stress Activates Plc1p-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Inositol Hexakisphosphate Accumulation in Yeast -- Perera et al. Articles by Perera, N. Articles by Dove, S. Hypo-osmotic Stress Activates Plc1p-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Inositol Hexakisphosphate Accumulation in Yeast cells that were hypo-osmotically stressed for 2 min, and Fig. www.jbc.org /cgi/content/full/279/7/5216   (2358 words)

IngentaConnect Oxidants Depress the Synthesis of Phosphatidylinositol 4,5-Bispho... Keywords: phosphatidylinositol 4-kinase ; phosphatidylinositol 4-phosphate 5-kinase ; phosphatidylinositol 4,5-bisphosphate ; oxidants ; sulfhydryl groups ; rat heart sarcolemma Oxidants Depress the Synthesis of Phosphatidylinositol 4,5-Bisphosphate in Heart Sarcolemma The results suggest that functionally critical thiol groups may be associated with PtdIns 4-kinase and PtdIns 4-P 5-kinase and that changes of their redox state by ROS can impair their activities, which may be an important factor in the oxidant-induced cardiac dysfunction. api.ingentaconnect.com /content/ap/bb/2000/00000382/00000001/art02012   (2358 words)

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling -- JANMEY 78 (3): 763 -- Physiological Reviews C TRUMEL, P. Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human phosphatidylinositol (3,4)-bisphosphate. A hallmark of programmed cell death is an alteration of the cytoskeleton frequently resulting in membrane blebbing (122, 127, 229, 230). Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. physrev.physiology.org /cgi/content/full/78/3/763   (7091 words)

Program in Neuroscience - Faculty PLC hydrolyzes the lipid phosphatidylinositol 4,5-bisphosphate (PIP2) to produce two second messengers that activate protein kinase C (PKC). For example, single molecule enzymology studies are being conducted with a phospholipase C enzyme (PLC) of known structure by combining laser tweezers and microelectrophoresis. Electrostatics, Reductions of Dimensionality and the Calcium/Phospholipid Second Messenger System www.hsc.stonybrook.edu /SOM/neurobiology/mclaughlin.cfm   (672 words)

A Cell-Specific, Prenylation-Independent Mechanism Regulates Targeting of Type II RACs -- Lavy et al. 14 (10): 2431 -- THE PLANT CELL Kost, B., Lemichez, E., Spielhofer, P., Hong, Y., Tolias, K., Carpenter, C., and Chua, N.H. Rac homologues and compartmentalized phosphatidylinositol 4,5-bisphosphate act in a common pathway to regulate polar pollen tube growth. Bokoch, G.M. Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins. Ono, E., Wong, H.L., Kawasaki, T., Hasegawa, M., Kodama, O., and Shimamoto, K. Essential role of the small GTPase Rac in disease resistance of rice. www.plantcell.org /cgi/content/full/14/10/2431   (672 words)

Vered Chalifa-Caspi, Ph.D. - Curriculum Vitae Pertile, P., Liscovitch, M., Chalifa, V., and L.C. Cantley (1995) Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells. Danin, M., Chalifa, V., M—hn, H., Schmidt, U.S. and M. Liscovitch (1993) Brain membrane-bound phospholipase D. In Lipid Metabolism and Signaling Systems. Auslander M., Yudkovski Y., Caspi, V., Ophir, R., Tom M. Multi-gene evaluation of hepatic transcript expression in the sentinel fish lithognathus mormyrus exposed to a battery of pollutants. bioinfo.bgu.ac.il /bsu/staff/vered/cv.htm   (917 words)

Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism -- Serajee et al. 40 (11): 119 -- Journal of Medical Genetics inositol ring from polyphosphates such as inositol 1,4-bisphosphate Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. INPP1 enzyme removes the phosphate group at position 1 of the jmg.bmjjournals.com /cgi/content/full/40/11/e119   (2864 words)

Evening Primrose Oil The level of phosphatidylinositol-4, 5-bisphosphate in spleen lymphocytes was unaffected by diet. The fish or olive oil diets, and to a lesser extent the safflower or evening primrose oil diets, decreased the adhesion of both freshly prepared and Con A-stimulated lymphocytes to macrophage monolayers. Morphological analyses showed that evening primrose oil diminished endothelial lesions caused by the atherogenic diet, reducing area of the arterial wall (from 6.9 +/- 0.2 to 4.7 +/- 0.2 microm2 x 10(6)) and the degree of neointimal proliferation (from 0.6 +/- 0.02 to 0.4 +/- 0.09 microm2 x 10(6)). www.bphata.com /EPO.htm   (2864 words)

Biophysical Journal: Membrane Position of a Basic Aromatic Peptide that Sequesters Phosphatidylinositol 4,5 Bisphosphate Determined by Site-Directed Spin Labeling and High-Resolution NMR EPR measurements using a spin-labeled derivative of PI(4,5)P^sub 2^ indicate that the MARCKS-ED binds ~3 molecules of PI(4,5)P^sub 2^, and site-directed spin labeling of the MARCKS-ED peptide suggests that neither specific van der Waals contacts nor hydrogen bonds are required for the pcptide-PI(4,5)P^sub 2^ interaction (Rauch et al., 2002). SDSL is used to position the peptide in the membrane interface and suggests that the interactions with PI(4,5)P^sub 2^ are electrostatic in origin. Site-directed spin labeling of the SCAMP-E peptide indicates that the position and structure of membrane bound SCAMP-E are not altered by the presence of PI(4,5)P^sub 2^, and that the peptide backbone is positioned within the lipid interface below the level of the lipid phosphates. www.findarticles.com /p/articles/mi_qa3938/is_200411/ai_n9463099   (1209 words)

Diabetes: Intracellular mechanisms involved in D-glucose-mediated amplification of agonist-induced Ca2+ response and EDRF formation in vascular endothelial cells - endothelium-derived relaxing factor EDRF, endothelium-derived relaxing factor; NO, nitric oxide; ER, endoplasmic reticulum; [IP.sub.3], inositol 1,4,5-trisphosphate; [IP.sub.4], inositol 1,3,4,5-tetrakisphosphate; BHQ, 2,5-di-(tert-butyl)-hydroquinone; FCS, fetal calf serum; DMEM, Dulbecco's minimum essential medium; BSA, bovine serum albumin; PBS, phosphate-buffered saline; HPLC, high-performance liquid chromatography; [PIP.sub.2], phosphatidylinositol 4,5-bisphosphate; TBA, tetrabutylammonium; NS, not significant; RIA, radioimmunoassay. (43.)Cohen RA: Dysfunction of vascular endothelium in diabetes mellitus. (27.)Graier WF, Schmidt K, Kukovetz WR: Is the bradykinin-induced [Ca.sup.2+] influx and the formation of endothelium-derived relaxing factor mediated by a G protein? www.findarticles.com /p/articles/mi_m0922/is_n8_v43/ai_15692198/pg_5   (1209 words)

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