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Topic: Phosphodiesterase

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Phosphodiester bond

Pyrophosphate

DNA

Phosphodiesterase inhibitor

Hydrolysis

Carboxylic acid

Ester

Adenylyl cyclase

Purine

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Adenosine triphosphate

Cyclic adenosine monophosphate

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	BioMed Central \| Full text \| EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony ...
		Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
		Under normal physiological conditions, cyclic AMP is rapidly degraded by a family of enzymes known as cyclic nucleotide phosphodiesterases (PDE).
		As the proportion of colonies expressing alkaline phosphatase remained fairly constant throughout, it seems likely that the increase differentiation is due to an increase in the recruitment of precursor cells rather than a direct effect on differentiation.
	www.biomedcentral.com /1471-2210/4/10 (3975 words)

	Phosphorylation of an inhibitory subunit of cGMP phosphodiesterase in Rana catesbeiana rod photoreceptors. II. A ...
		Phosphorylation of an inhibitory subunit of cGMP phosphodiesterase in Rana catesbeiana rod photoreceptors.
		The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to gamma Subunit of the Photoreceptor cGMP Phosphodiesterase
		The Catalytic and GAF Domains of the Rod cGMP Phosphodiesterase (PDE6) Heterodimer Are Regulated by Distinct Regions of Its Inhibitory gamma Subunit
	www.jbc.org /cgi/content/abstract/269/21/15016 (932 words)

	Worthington Phosphodiesterase I
		ADP-ribosylated proteins are cleaved at the pyrophosphate linkages by venom phosphodiesterase to yield phosphoribosyl-AMP (Hayaishi 1976).
		Frischauf, A., and Eckstein, F.: Purification of a Phosphodiesterase from Botrhrops atrox Venomby Affiinity Chromatography, Eur J Biochem 32, 479, 1973
		Kinetics of the Hydrolysis of Thymidine-5'(5-Bromo-4-Chloroindol-3-YL) Phosphate by Snake Venom Phosphodiesterase, Biochim Biophys Acta 185, 143, 1969
	www.worthington-biochem.com /VPH/default.html (992 words)

	International Journal of Impotence Research - Abstract of article: Phosphodiesterase 11: a brief review of structure, ...
		Phosphodiesterase 11: a brief review of structure, expression and function
		Phosphodiesterase 11 (PDE11) is the latest isoform of the phosphodiesterase family to be identified.
		A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia
	www.nature.com /doifinder/10.1038/sj.ijir.3901441 (228 words)

	Phosphodiesterase type 5 inhibitor : by Ray Sahelian, M.D.
		Phosphodiesterase type 5 inhibitor : by Ray Sahelian, M.D. Phosphodiesterase Inhibitors by Ray Sahelian, M.D. phosphodiesterase (PDE) is an enzyme that catalyzes the hydrolysis of phosphodiester bonds.
		Phosphodiesterases are responsible for the degradation of the cyclic nucleotides cAMP and cGMP.
		The early use of phosphodiesterase type 5 inhibitors in patients with hypertension, hyperlipidaemia or diabetes with concomitant ED and treating these risk factors may improve corporeal blood flow and lead to long-term preservation of cavernosal function.
	www.raysahelian.com /phosphodiesterase.html (672 words)

	Cough \| Full text \| Phosphodiesterase 3 inhibition and cough in elderly asthmatics
		Phosphodiesterase 3 inhibition and cough in elderly asthmatics
		Recently, considerable attention has been focused on the potential use of selective inhibitors of cyclic nucleotide phosphodiesterases (PDEs) in the treatment of respiratory diseases as PDE isoenzymes may play an important role in the regulation of airway caliber and bronchial smooth muscle function [3].
		We have demonstrated that a phosphodiesterase 3 inhibitor, cilostazol, reduces bronchial hyperresponsiveness to inhaled methacholine in elderly patients with stable asthma [10].
	www.coughjournal.com /content/1/1/11 (2704 words)

	A study of phosphodiesterase in the fission yeast Schizosaccharomyces pombe
		The data indicated that the phosphodiesterase exists as a dimer and the different forms could be due to post-translational modifications.
		S. pombe cAMP phosphodiesterase activity was inhibited by a tyrosine specific phosphatase and a phosphotyrosine specific antibody while cGMP phosphodiesterase activity was stimulated by the presence of protein kinase and ATP.
		Caffeine was shown, however, to inhibit phosphodiesterase activity in purified cell extracts which suggested that caffeine had a pleiotropic effect.
	escholarship.bc.edu /dissertations/AAI9818617 (365 words)

	IMAP Phosphodiesterase Assay Kit (Site not responding. Last check: )
		The HEFP Phosphodiesterase Assay measures the activity of PDEs that use cAMP or cGMP as a substrate.
		Phosphodiesterase samples are mixed with either fluorescein-cAMP or fluorescein-cGMP Substrate, depending on the enzyme used.
		The IMAP Phosphodiesterase Assay is capable of monitoring both cAMP- and cGMP-dependent phosphodiesterase activity.
	www.moleculardevices.com /pages/reagents/imap_phosphodiesterase.html (443 words)

	Inhibition of phosphodiesterase in olfactory mucosa - Patent 5525329
		applying a phosphodiesterase inhibitor having inhibitory activity toward phosphodiesterase present in olfactory neurons to nasal epithelium in an amount sufficient to diminish the activity of said phosphodiesterase and enhance the sense of smell.
		comparing the activity of the phosphodiesterase in the presence of the test compound to activity of the phosphodiesterase in the absence of the test compound, a smell enhancer being a test compound which diminishes the activity of the phosphodiesterase.
		It is a discovery of the present inventors that a calcium/calmodulin activated phosphodiesterase (CAM-PDE) is the predominant phosphodiesterase (PDE) in olfactory mucosa.
	www.freepatentsonline.com /5525329.html (5194 words)

	Phosphodiesterase
		The cyclic nucleotides cAMP and cGMP are second messengers that carry signals from the cell surface to proteins within the cell, and are found widely in eukaryotes.
		They are rapidly broken down in cells (to terminate the signal) by enzymes called phosphodiesterases.
		We know that phosphodiesterases are important in tubules because the response to cyclic nucleotides is enhanced by phosphodiesterase inhibitors, such as IBMX or (in the case of cGMP) Zaprinast.
	www.mblab.gla.ac.uk /tubules/map/pde.html (101 words)

	Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A -- Soderling et al. 96 (12): ...
		Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
		R. WALMRATH, and H. Coaerosolization of Phosphodiesterase Inhibitors Markedly Enhances the Pulmonary Vasodilatory Response to Inhaled Iloprost in Experimental Pulmonary Hypertension.
		Expression of Phosphodiesterase 4D (PDE4D) Is Regulated by Both the Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinase Signaling Pathways.
	www.pnas.org /cgi/content/short/96/12/7071 (1658 words)

	Molecular Cloning and Expression of Human Myocardial cGMP-Inhibited cAMP Phosphodiesterase -- Meacci et al. 89 (9): ...
		Molecular Cloning and Expression of Human Myocardial cGMP-Inhibited cAMP Phosphodiesterase -- Meacci et al.
		Isoforms of Cyclic Nucleotide Phosphodiesterase PDE3A in Cardiac Myocytes
		Induction of Phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in Human Peripheral Blood T-lymphocytes by 8-Bromo-cAMP and Gs-coupled Receptor Agonists.
	www.pnas.org /cgi/content/short/89/9/3721 (1081 words)

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