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Topic: Phosphofructokinase

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	PFK1 - Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic ...
		The periodic motions of the reactants are mainly caused by the antagonistic allosteric effects of the adenine nucleotides on the activities of the phosphofructokinase and fructose 1,6-bisphosphatase.
		Activities of the glycolytic marker enzymes hexokinase, phosphofructokinase and pyruvate kinase were increased 1.7 to 3-fold in liver and/or adipose tissue by selenate treatment as compared to mice on selenium deficiency and mice with selenite administration.
		PFK1 is a homologue of PFKP (phosphofructokinase, platelet) from Homo sapiens.
	www.ihop-net.org /UniPub/iHOP/gi/33447.html (2672 words)

	Mouse (C57BL/KsJ) liver phosphofructokinase. Allosteric kinetics and age-related changes in the genetically diabetic ... (Site not responding. Last check: 2007-09-17)
		Comparative kinetic studies with liver phosphofructokinase isolated from both the normal (C57BL/KsJ) and the genetically diabetic (C57BL/KsJ-db) mice of 9 to 10 and 15 to 16 weeks of age showed that the enzyme from the livers of diabetic mice exhibited decreased activity at subsaturating concentrations of fructose 6-phosphate.
		Thus, there appears to be a correlation between the change in properties of liver phosphofructokinase and the expression of hyperglycemia and obesity in the genetically diabetic mice.
		The decreased activity of liver phosphofructokinase in the older diabetic animals may well be one of the causes of the increased blood glucose levels.
	www.arclab.org /medlineupdates/abstract_6450202.html (275 words)

	FRISC > Faculty Profiles > Kosaku Uyeda, Ph.D.
		The activity of the pentose phosphate pathway, glycolytic route and the regulation of phosphofructokinase in the kidney of lean and genetically obese (ob/ob) mice; comparison with effects of diabetes.
		Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii.
		Phosphofructokinase from Dirofilaria immitis: effect of fructose 2,6-bisphosphate and AMP on the non-phosphorylated and phosphorylated forms of the enzyme.
	invention.swmed.edu /frisc/faculty/uyeda/profile.shtml (3544 words)

	Rate-limiting step of glycolysis
		The phosphorylation of fructose 6-phosphate is highly exergonic and irreversible, and phosphofructokinase, the enzyme that catalyzes it, is the key enzyme in glycolysis.
		Phosphofructokinase is the key enzyme in the control of glycolysis (p.
		The misconception at the heart of this question is at the heart of the failure of genetic engineering during the quarter century since it became technically feasible to produce useful effects on industrially important metabolic fluxes.
	bip.cnrs-mrs.fr /bip10/rls.htm (791 words)

	Glycolysis - Wikipedia, the free encyclopedia
		Phosphofructokinase is an important control point in the glycolytic pathway since it is immediately downstream of the entry points for hexose sugars.
		Citrate is an example of a metabolite that regulates phosphofructokinase by enhancing the inhibitory effect of ATP.
		Low pH also inhibits phosphofructokinase activity and prevents the excessive rise of lactic acid during anaerobic conditions that could otherwise cause a drop in blood pH (acidosis), (a potentially life threatening condition).
	en.wikipedia.org /wiki/Glycolysis (3139 words)

	Developmental changes in heart and muscle phosphofructokinase isozymes. (Site not responding. Last check: 2007-09-17)
		Phosphofructokinase isozymes of fetal, neonatal, and adult rat heart and skeletal muscle were characterized by DEAE-cellulose chromatography, agarose gel electrophoresis, and immunodiffusion with specific antisera.
		The results of these studies indicate that in skeletal muscle and heart the levels of the major liver phosphofructokinase isozyme (PFK-L2) and the muscle phosphofructokinase isozyme (PFK-M) are dependent on the developmental status of the rat.
		Further, in fetal heart another phosphofructokinase isozyme (33% of total phosphofructokinase activity) was found by DEAE-cellulose chromatography which is different from PFK-M and PFK-L2.
	www.arclab.org /medlineupdates/abstract_6455419.html (303 words)

	InterPro: IPR000023 Phosphofructokinase
		One enzyme that utilises this reaction is phosphofructokinase (PFK), which catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway [ 2, 3 ].
		Moore S.A. Ronimus R.S. Roberson R.S. Morgan H.W. The structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi.
		Riley-Lovingshimer M.R. Ronning D.R. Sacchettini J.C. Reinhart G.D. Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000023 (3288 words)

	IngentaConnect Emetine Inhibits Glycolysis in Isolated, Perfused Rat Hearts (Site not responding. Last check: 2007-09-17)
		M emetine on the activities of phosphofructokinase and hexokinase were measured in homogenates from perfused hearts.
		M emetine or control perfusion on the utilization of fructose-6-phosphate by phosphofructokinase in centrifugation supernatants of homogenates and in reconstituted 27,000g pellets was measured.
		Phosphofructokinase and, consequently, glycolytic flux appear to be subcellular targets for emetine in the heart.
	www.ingentaconnect.com /content/hum/ct/2003/00000003/00000004/art00002 (241 words)

	Twofold Reduction of Phosphofructokinase Activity in Lactococcus lactis Results in Strong Decreases in Growth Rate and ...
		lactis the genes pfk, pyk, and ldh, encoding the glycolytic enzymes phosphofructokinase, pyruvate kinase, and lactate
		of phosphofructokinase was the primary cause of slower growth
		Another consequence of reduced phosphofructokinase activity could be an accumulation of upstream metabolites, i.e., glucose-6-phosphate.
	jb.asm.org /cgi/content/full/183/11/3458 (6301 words)

	Glycolysis--The Details
		Binding of ATP to phosphofructokinase lowers its affinity for the substrate, fructose 6-phosphate.
		Therefore, phosphofructokinase is regulated by the energy charge of the cell.
		Liver fructose 2,6-bisposphate acts on phosphofructokinase by increasing its affinity for fructose 6-phosphate and decreasing the ability of ATP to inhibit the enzyme.
	www.db.uth.tmc.edu /faculty/alevine/1521_2000/glydetail.htm (1447 words)

	The dimorphic yeast Yarrowia lipolytica possesses an atypical phosphofructokinase: characterization of the enzyme and ...
		The dimorphic yeast Yarrowia lipolytica possesses an atypical phosphofructokinase: characterization of the enzyme and its encoding gene -- Flores et al.
		The dimorphic yeast Yarrowia lipolytica possesses an atypical phosphofructokinase: characterization of the enzyme and its encoding gene
		Lorberg, A., Kirchrath, L., Ernst, J. and Heinisch, J. Genetic and biochemical characterization of phosphofructokinase from the opportunistic pathogenic yeast Candida albicans.
	mic.sgmjournals.org /cgi/content/full/151/5/1465 (4763 words)

	Glycolysis--Fructose 2,6-bisphosphate
		The glycolytic enzyme phosphofructokinase is phosphofructokinase-1 (PFK-1) although it is usually referred to as phosphofructokinase or PFK.
		Fructose 2,6-bisphosphate also overcomes the inhibition of phosphofructokinase which normally occurs in the presence of increased ATP concentrations.
		the activity of phosphofructokinase I. Therefore, the higher the concentration of fructose 6-phosphate, the faster it is converted to fructose 1,6-bisphosphate by the phosphofructokinase I enzyme.
	www.dentistry.leeds.ac.uk /biochem/uttb/F26BP.HTM (815 words)

	References - phosphofructokinase - HORT640 - Metabolic Plant Physiology - Department of Horticulture and Landscape ...
		Davies SE, Brindle KM 1992 Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae.
		Glass-Marmor L, Beitner R 1999 Taxol (paclitaxel) induces a detachment of phosphofructokinase from cytoskeleton of melanoma cells and decreases the levels of glucose 1,6-bisphosphate, fructose 1,6-bisphosphate and ATP.
		Turner WL, Plaxton WC 2003 Purification and characterization of pyrophosphate- and ATP-dependent phosphofructokinases from banana fruit.
	www.hort.purdue.edu /rhodcv/hort640c/referen/pfk.htm (2337 words)

	ESSFTA: PFK - Phosphofructokinase Deficiency in the English Springer Spaniel (Site not responding. Last check: 2007-09-17)
		Phosphofructokinase (PFK) deficiency is an inherited disease that affects both the field trial and show lines of English Springer Spaniels.
		Based on the information this test provides the continued spread of this disease, the costs for diagnosis and management, and animal suffering can all be prevented.
		Frequency of Phosphofructokinase (PFK) Deficiency in English Springer Spaniels: A Longitudinal and Randomized Study
	www.essfta.org /Health_Research/pfk.htm (427 words)

	UBEP 2000 Seventh Annual Undergraduate Research Symposium (Site not responding. Last check: 2007-09-17)
		As a phosphofructokinase antibody is currently unavailable, tubulin antibody was used to perfect the technique, and to ensure that single embryos would yield a sufficient amount of protein to be detected by the antibody.
		By measuring the enzyme activity in heterozygote adult flies, Currie and Sullivan (JBC 269 24679, 1994) reported that the gene for Pfk was complementation group B in the X-1 region of Chromosome 2 in Drosophila.
		Since phosphofructokinase mutants are not lethal until fairly late in development, these third instar larva are ideal to use in deletion mapping.
	lifesciences.asu.edu /ubep2000/abstracts/abst62 (1213 words)

	6.3.3 Hormonal control of phosphofructokinase and fructose-1,6-bisphosphatase
		The hormones bind to their respective receptors on the cell surface, which then promote formation (glucagon and epinephrin) or degradation (insulin) of cAMP.
		Phosphofructokinase 2 has two opposite activities: In the dephosphorylated state, it acts as a kinase and therefore increases the level of fructose-2,6-bisphosphate.
		It should be noted that ATP and AMP adjust the activity of phosphofructokinase and fructose-1,6-bisphosphatase according to the intracellular situation, whereas the hormones, via cAMP and fructose-2,6-bisphosphate, control the same enzymes on behalf of the metabolism of the body as a whole.
	watcut.uwaterloo.ca /webnotes/Metabolism/page-6.3.3.html (290 words)

	eMedicine - Glycogen Storage Disease, Type VII : Article by Wayne E Anderson
		Phosphofructokinase deficiency leads to muscle pain and exercise-induced fatigue and weakness.
		Phosphofructokinase is found in muscle tissue and red blood cells.
		Findings on electromyography testing in patients with phosphofructokinase deficiency may be normal.
	www.emedicine.com /med/topic913.htm (1766 words)

	A model of Phosphofructokinase and glycolytic oscillations in the pancreatic [beta]-cell Biophysical Journal - Find ...
		We also propose that the rapid equilibrium between different oligomeric forms of phosphofructokinase may reduce the oscillation period sensitivity to phosphofructokinase activity.
		Methodologically, we show that a satisfying description of phosphofructokinase kinetics can be achieved using the irreversible Hill equation with allosteric modifiers.
		The third enzyme of the glycolysis, phosphofructokinase (PFK), has for a long time been known to cause oscillations in the glycolysis in yeast and muscle (Goldbeter and Caplan, 1976; Hess, 1997).
	www.findarticles.com /p/articles/mi_qa3938/is_200307/ai_n9283239 (933 words)

	HealthGene - Canine Phosphofructokinase Deficiency
		Canine Phosphofructokinase Deficiency is an inherited disorder that causes premature breakdown (hemolysis) of red blood cells, and a reduced tolerance for exercise.
		Canine Phosphofructokinase Deficiency shows an autosomal recessive mode of inheritance; therefore two copies of the defective gene, one inherited from each parent, have to be present for a dog to be affected by the disease.
		Carriers (dogs with one copy of the mutant gene and one copy of the normal gene) have about one half normal enzyme activity in red blood cells and muscle tissue, and are clinically unaffected, but can pass the defective gene onto their offspring.
	www.healthgene.com /vet/C106.asp (389 words)

	Phosphofructokinase deficiency - Patient UK
		Phosphofructokinase deficiency - Patient UK PatientPlus articles are written for doctors and so the language can be technical.
		However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people.
		Phosphofructokinase breaks down glycogen and deficiency causes ineffective glycolysis during exercise, resulting in pain, weakness, and cramps in the muscle.
	www.patient.co.uk /showdoc/40001772 (759 words)

	Animal Health Trust \| DNA Test for Phosphofructokinase in English Springer Spaniels
		The genetic defect underlying phosphofructokinase deficiency in English Springer Spaniels has been identified by research groups at the University of Pennsylvania.
		It is a tiny change (point mutation) in the M-type phosphofructokinase gene.
		The DNA test involves determining the sequence (ie the structure) of the gene in the critical region by amplifying the part of the gene containing the mutation using the polymerase chain reaction.
	www.aht.org.uk /sci_diag_disc_genetic_phos.html (178 words)

	Expression of caveolin-1 in lymphocytes induces caveolae formation and recruitment of phosphofructokinase to the plasma ...
		Expression of caveolin-1 in lymphocytes induces caveolae formation and recruitment of phosphofructokinase to the plasma membrane -- Vallejo and Hardin, 10.1096/fj.04-2380fje -- The FASEB Journal
		Compartmentation of carbohydrate metabolism has been shown in a wide range of tissues including reports of one compartment of glycolysis associated with the plasma membrane of cells.
		We have previously found that phosphofructokinase (PFK) appeared to colocalize with the fairly ubiquitous plasma membrane protein caveolin-1 (CAV-1), consistent with a role for CAV-1 as an anchor for glycolysis to the plasma membrane.
	www.fasebj.org /cgi/content/abstract/04-2380fjev1 (369 words)

	Phosphofructokinase - Wikipedia, the free encyclopedia
		PFK (Poulet Frit Kentucky) is also the name for KFC in French-speaking Quebec, Canada.
		Phosphofructokinase (PFK) is the most important regulatory enzyme (EC 2.7.1.11) of glycolysis.
		It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors.
	en.wikipedia.org /wiki/Phosphofructokinase (319 words)

	Quantification fo allosteric influence of Escherichia coli phosphofructokinase by frequency domain fluroescence ...
		ABSTRACT The allosteric properties of the wild-type Escherichia coli phosphofructokinase were compared to the E187A mutant by using frequency-domain techniques.
		Coupling interactions giving rise to positive entropy components are manifested by increasing flexibility of the ternary complexes rather than the binary complexes.
		The primary strategy of Escherichia coli phosphofructokinase (PFK) regulation is for a single inhibitor phosphoenolpyruvate (PEP) or activator MgADP to bind to an alternative (allosteric) site and influence the affinity of substrates toward the enzyme.
	www.findarticles.com /p/articles/mi_qa3938/is_200307/ai_n9283086 (943 words)

	Phosphofructokinase (Site not responding. Last check: 2007-09-17)
		A tetramer is a protein comprised of four subunits (tetra = four), so a homotetramer is a protein made of four of the same subunits (homo=same).
		Shown here in light blue is the Fructose-1,6-bisphosphate (FBP), and shown in bright red is the adenosine 5' diphosphate (ADP), both of which are the products of the enzymatic activity of Phosphofructokinase.
		Rypniewski, W. and Evans, P. (1989) Crystal structure of Unliganded Phosphofructokinase from Escherichia coli.
	www.wiley.com /college/boyer/0470003790/structure/pfk/pfk_text.htm (315 words)

	Tarui Disease
		Symptoms of this hereditary metabolic disorder are caused by a lack of the enzyme phosphofructokinase in muscle and a partial deficiency of the enzyme in red blood cells.
		The condition is caused by a deficiency of the enzyme phosphofructokinase.
		All samples obtained during family studies of a certain metabolic muscle disease such as Phosphofructokinase Deficiency or Acid Maltase Deficiency will be tested only for the disease genes in question.
	hw.healthdialog.com /kbase/nord/nord397.htm (1156 words)

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