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PGM1/YKL127W Summary Phosphoglucomutase (EC:5.4.2.2) catalyzes the interconversion of glucose-6-phosphate and glucose-1-phosphate and is important for carbohydrate metabolism in a variety of organisms, ranging from bacteria to humans (3, 4, 1, 5). Phosphoglucomutase is also required for the synthesis of N-linked glycoproteins, extracellular glycans, and UDP-glucose (3, 4, 5, 6). Phosphoglucomutase also indirectly effects calcium uptake and homeostasis because glucose-1-phosphate and glucose-6-phosphate effect cation uptake (7, 8, 4). db.yeastgenome.org /cgi-bin/locus.pl?locus=YKL127W   (513 words)

The Herbert Newby McCoy Award 1991 Winner It is involved with the metabolism of glucose, where it functions to interconvert glucose 1-phosphate and glucose 6-phosphate so that regulation of those enzymes involved with the subsequent degradation of glucose 6-phosphate or the storage of glucose 1-phosphate can be used to control the relative importance of immediately-usable versus stored energy. Thus, the enzyme is able to convert a molecule of glucose 1-phosphate to glucose 6-phosphate even in the presence of other sugar phosphates at a ratio of 1:50,000, without disturbing the surrounding population, and it accomplishes with 0.001 sec what would require hundreds of years in the absence of a catalyst. Ray’s initial studies with phosphoglucomutase defined the reaction pathway of the enzyme and were the first to define the order of substrate-metal ion binding in a metal-ion activated enzymic reaction. www.purdue.edu /Research/ORA/mccoy1991.shtml   (1093 words)

Journal of Insect Science: Vol. 8 | Article 18 The objective of the present study was to examine the polymorphism of nonspecific esterases and phosphoglucomutase and on that basis to analyze the allelic frequency and degree of genetic heterogeneity with different breeds of mulberry silkworm introduced into Bulgaria from different ecological-geographic areas. Phosphoglucomutase is expressed in the fat body, the silk glands, the gut and the testes and ovaries. Esterase and phosphoglucomutase are very suitable markers for analysis of the inter-breed and intra-breed polymorphism for the mulberry silkworm, and for determining the level of genetic variability. www.insectscience.org /8.18   (2311 words)

Beryllium Journal Articles Related Chelation and Ferritin Be2+ can be transferred reversibly between phosphoglucomutase and ferritin depending upon the relative concentrations of the 2 proteins. Incubation of ferritin containing Be2+ with 4-10 fold molar excess of phosphoglucomutase (with respect to Be2+) removed 90% of the Be2+ from ferritin. The rates of inactivation of phosphoglucomutase by Be2+ donated by apoferritin or ferritin were identical. shell.dim.com /~mhj/Beryllium_chelation-1965-1999.htm   (2688 words)

Marchase, Richard B. These data will be used to construct mutant phosphoglucomutase molecules so that the interaction and specificity of phosphoglucomutase with intracellular organelles and proteins can be determined and manipulated. Our expectation is that the overexpression of mutant phosphoglucomutase will result in a cellular phenotype in which cytoplasmic calcium levels are inappropriately regulated. Fu, L., Bounelis, P., Dey, N., Browne, B.L., Marchase, R.B., and Bedwell, D.M. The Post-Translational Modification of Phosphoglucomutase is Regulated by Galactose Induction and Glucose Repression in Saccharomyces cerevisiae. main.uab.edu /show.asp?durki=5399   (447 words)

Phosphoglucomutase: evidence for a new locus expressed in human milk -- Cantu and Ibarra 216 (4546): 639 -- Science Phosphoglucomutase: evidence for a new locus expressed in human milk -- Cantu and Ibarra 216 (4546): 639 -- Science Phosphoglucomutase: evidence for a new locus expressed in human milk Electrophoretic study of phosphoglucomutase (PGM) in human milk revealed different patterns that can be explained by the existence of a locus distinct from the common PGM1, PGM2, and PGM3. www.sciencemag.org /cgi/content/short/216/4546/639   (220 words)

Phosphoglucomutase 1, Homo sapiens - UniGene Hs.1869 Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; Pgm2p Tissues and development stages from this gene's sequences survey gene expression. Homo sapiens cDNA, FLJ92549, highly similar to Homo sapiens phosphoglucomutase 1 (PGM1), mRNA www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=1869   (190 words)

Improvement of Galactose Uptake in Saccharomyces cerevisiae through Overexpression of Phosphoglucomutase: Example of ... in a reaction catalyzed by phosphoglucomutase (23, 38). Phosphoglucomutase is an in vivo lithium target in yeast. Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible. aem.asm.org /cgi/content/full/71/11/6465   (4700 words)

Functional diversity of the phosphoglucomutase superfamily: structural implications -- Levin et al. 12 (9): 737 -- ... The regions important for the phosphoglucomutase activity are shown in bold. Andersen,A.P., Wyroba,E., Reichman,M., Zhao,H. and Satir,B.H. (1994) The activity of parafusin is distinct from that of phosphoglucomutase in the unicellular eukaryote Paramecium. Zhao,H. and Satir,B.H. (1998) Parafusin is a membrane and vesicle associated protein that cycles at exocytosis. peds.oxfordjournals.org /cgi/content/full/12/9/737   (4359 words)

Molecular and Biochemical Characterization of Cytosolic Phosphoglucomutase in Maize . Expression during Development and ... Molecular and Biochemical Characterization of Cytosolic Phosphoglucomutase in Maize. Phosphoglucomutase (PGM) catalyzes the interconversion of glucose (Glc)-1- and Glc-6-phosphate in the synthesis and consumption Molecular and biochemical characterization of cytosolic phosphoglucomutase in wheat endosperm (Triticum aestivum L. cv. www.plantphysiol.org /cgi/content/abstract/117/3/997   (509 words)

Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces ... Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces cerevisiae -- Csutora et al. Phosphoglucomutase is a key enzyme of glucose metabolism that The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiae. ajpcell.physiology.org /cgi/content/full/289/1/C58   (6059 words)

iHerb: HerbalGram The Journal of the American Botanical Council Retinal protection may be aided by anthocyanidinic retinal phosphoglucomutase and glucose-6-phosphatase inhibition (Cluzel et al., 1969). Caselli, L. Studio clinico ed elettroretinografico sull'attivita degli antocianosidi [Clinical and electroretinographic study on activity of anthocyanosides]. [Phosphoglucomutase and glucose-6-phosphatase activities of the retina and anthocyanoside extracts from Vaccinium myrtillus (study in vitro and in vivo)] [In French]. www.herbalgram.org /iherb/expandedcommissione/he005.asp   (2080 words)

Phosphoglucomutase - References Ray, W., and Post, C.: The Oxyvanadium Constellation in Transition-State-Analogue Complexes of Phosphoglucomutase and Ribonuclease. Ray, W., and Puvathingal, J.: Characterization of a Vanadate-Based-Transition-State-Analogue Complex of Phosphoglucomutase by Kinetic and Equilibrium Binding Studies. Ray, W., Jr., and Roscelli, G.: The Addition and Release of Magnesium in the Phosphoglucomutase Reaction. www.worthington-biochem.com /PGM/references.html   (389 words)

Homologous Genes for Enolase, Phosphogluconate Dehydrogenase, Phosphoglucomutase, and Adenylate Kinase are Syntenic on ... Homologous Genes for Enolase, Phosphogluconate Dehydrogenase, Phosphoglucomutase, and Adenylate Kinase are Syntenic on Mouse Chromosome 4 and Human Chromosome 1p -- Lalley et al. Homologous Genes for Enolase, Phosphogluconate Dehydrogenase, Phosphoglucomutase, and Adenylate Kinase are Syntenic on Mouse Chromosome 4 and Human Chromosome 1p It is possible to generate interspecific somatic cell hybrids that preferentially segregate mouse chromosomes, thus making possible mapping of mouse genes. www.pnas.org /cgi/content/abstract/75/5/2382   (445 words)

Evolutionary trace analysis of the {alpha}-D-phosphohexomutase superfamily -- Shackelford et al. 13 (8): 2130 -- ... Davies, E.J., Tetlow, I.J., Bowsher, C.G., and Emes, M.J. Molecular and biochemical characterization of cytosolic phosphoglucomutase in wheat endosperm (Triticum aestivum L. cv. Ray Jr., W.J., Burgner 2nd, J.W., and Post, C.B. Characterization of vanadate-based transition-state-analogue complexes of phosphoglucomutase by spectral and NMR techniques. Whitehouse, D.B., Tomkins, J., Lovegrove, J.U., Hopkinson, D.A., and McMillan, W.O. A phylogenetic approach to the identification of phosphoglucomutase genes. www.proteinscience.org /cgi/content/full/13/8/2130   (4347 words)

Abstracts: Identification of the pgmG gene, encoding a bifunctional protein with phosphoglucomutase and ... Abstracts: Identification of the pgmG gene, encoding a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, in the Gellan gum-producing strain Sphingomonas paucimobilis ATCC 31461 Identification of the pgmG gene, encoding a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, in the Gellan gum-producing strain Sphingomonas paucimobilis ATCC 31461 Identification of the pgmG gene, which encodes a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, has been successful. www.faqs.org /abstracts/Biological-sciences/Identification-of-the-pgmG-gene-encoding-a-bifunctional-protein-with-phosphoglucomutase-and-phosphom.html   (480 words)

References - phosphoglucomutase - HORT640 - Metabolic Plant Physiology - Department of Horticulture and Landscape ... Davies EJ, Tetlow IJ, Bowsher CG, Emes MJ 2003 Molecular and biochemical characterization of cytosolic phosphoglucomutase in wheat endosperm (Triticum aestivum L. cv. Lytovchenko A, Sweetlove L, Pauly M, Fernie AR 2002 The influence of cytosolic phosphoglucomutase on photosynthetic carbohydrate metabolism. Penger A, Pelzer-Reith B, Schnarrenberger C 1994 cDNA sequence for the plastidic phosphoglucomutase from Spinacia oleracea (L.). www.hort.purdue.edu /rhodcv/hort640c/referen/pgm.htm   (1272 words)

EC 5.4.2.2 Purification and properties of phosphoglucomutase from Escherichia coli. Najjar, V.A. Phosphoglucomutase, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. Ray, W.J. and Roscelli, G.A. A kinetic study of the phosphoglucomutase pathway. www.chem.qmul.ac.uk /iubmb/enzyme/EC5/4/2/2.html   (154 words)

Phosphoglucomutase Polymorphism : an Unusual Type in Negroes Phosphoglucomutase Polymorphism : an Unusual Type in Negroes The G. Hooper Foundation and the Haematology Unit, Department of Medicine, University of California Medical Center, San Francisco, California. PHOSPHOGLUCOMUTASE is present in human erythrocytes in different forms. www.nature.com /nature/journal/v210/n5041/abs/2101183a0.html   (106 words)

UniProtKB/Swiss-Prot entry P00949 [PGM1_RABIT] Phosphoglucomutase-1 Lee Y.S. Marks A.R. Gureckas N. Lacro R. Nadal-Ginard B. Kim D.H. "Purification, characterization, and molecular cloning of a 60-kDa phosphoprotein in rabbit skeletal sarcoplasmic reticulum which is an isoform of phosphoglucomutase."; Molecular function: phosphoglucomutase activity (inferred from sequence or structural similarity from AgBase). View cluster of proteins with at least 50% / 90% / 100% identity. www.expasy.ch /uniprot/P00949   (408 words)

Calzyme - Manufacturers of Enzymes , Proteins , Coenzymes , Substrates and Related Biochemicals Glucose-1-phosphate can be used as a substrate in the assay of the activities of phosphoglucomutase and UDP-glucose pyrophosphorylase and also in the preparation of other sugar phosphates. Glucose-1-P is converted to Glucose-6-P with phosphoglucomutase (EC 2.7.5.1). Initiate the reaction by adding 0.10 ml of phosphoglucomutase solution to the cuvette. calzyme.com /commerce/catalog/spcategory.jsp?category_id=1004   (241 words)

Phosphoglucomutase Is an in Vivo Lithium Target in Yeast -- Masuda et al. 276 (41): 37794 -- Journal of Biological ... Phosphoglucomutase Is an in Vivo Lithium Target in Yeast -- Masuda et al. Lithium stress causes an increase of the phosphoglucomutase activity Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces cerevisiae www.jbc.org /cgi/content/abstract/276/41/37794   (621 words)

Role for Phosphoglucomutase in Vibrio fischeri-Euprymna scolopes Symbiosis -- DeLoney et al. 184 (18): 5121 -- The ... Role for Phosphoglucomutase in Vibrio fischeri-Euprymna scolopes Symbiosis -- DeLoney et al. Phosphoglucomutase activity was determined by the method of Molecular cloning and characterization of the pgm gene encoding phosphoglucomutase of Escherichia coli. jb.asm.org /cgi/content/full/184/18/5121   (5452 words)

Identification of a Phosphoglucomutase 1 (PGM 1) Variant in a Case of Murder/Suicide Identification of a Phosphoglucomutase 1 (PGM 1) Variant in a Case of Murder/Suicide A murder/suicide case is reported in which a phosphoglucomutase (PGM) 1*W9 variant was detected in a woman, her child, and from blood collected at the scene. Author Franco MA, Goetz RJ Title Identification of a Phosphoglucomutase 1 (PGM 1) Variant in a Case of Murder/Suicide Symposium, Committee on www.astm.org /DIGITAL_LIBRARY/JOURNALS/FORENSIC/PAGES/1376.htm   (110 words)

Tuber-specific Cytosolic Expression of a Bacterial Phosphoglucomutase in Potato (Solanum tuberosum L.) Dramatically ... Tuber-specific Cytosolic Expression of a Bacterial Phosphoglucomutase in Potato (Solanum tuberosum L.) Dramatically Alters Carbon Partitioning -- Lytovchenko et al. Tuber-specific Cytosolic Expression of a Bacterial Phosphoglucomutase in Potato (Solanum tuberosum L.) Dramatically Alters Carbon Partitioning of an Escherichia coli phosphoglucomutase in the cytosol. pcp.oxfordjournals.org /cgi/content/short/46/4/588   (367 words)

The CDG Family Network Web Page The work of Wada et al (reported in 1992) showing that in these patients part of serum transferrin was completely devoid of glycans, strongly suggested that the defect was in an early glycosylation step. This led to a new breakthrough by his discovery of a deficient activity of phosphomannomutase, an enzyme not previously reported in man. Indeed, until then it was thought that the transformation of mannose 6-phosphate into mannose 1-phosphate, and that of glucose 6-phosphate into glucose 1-phosphate was carried out by one and the same enzyme, phosphoglucomutase. The year before (1994) our group, in collaboration with H. Schachter from Toronto and G. Spik from Lille, reported the basic defect (N-acetylglucosaminyltransferase II deficiency) of a CDG with a completely different serum transferrin IEF pattern (that we have call the type 2 pattern). www.cdgs.com /_about.html   (3689 words)

NREL: Technology Transfer - Isolated Gene Encoding an Enzyme with UDP-Glucose Pyrophosphorylase and Phosphoglucomutase ... Isolated Gene Encoding an Enzyme with UDP-Glucose Pyrophosphorylase and Phosphoglucomutase Activities from Cyclotella Cryptica The present invention relates to a cloned gene which encodes an enzyme, the purified enzyme, and the applications and products resulting from the use of the gene and enzyme. The gene, isolated from Cyclotella cryptica, encodes a multifunctional enzyme that has both UDP-glucose pyrophosphorylase and phosphoglucomutase activities. www.nrel.gov /technologytransfer/ip/data.php/patent/5928932   (138 words)

Reactome: phosphoglucomutase 1 complex (name copied from entity in Homo sapiens) [cytosol] Reactome: phosphoglucomutase 1 complex (name copied from entity in Homo sapiens) [cytosol] We would greatly appreciate your comments, suggestions and bug reports. phosphoglucomutase 1 complex (name copied from entity in Homo sapiens) [cytosol] www.reactome.org /cgi-bin/eventbrowser?DB=gk_current&ID=289632   (43 words)

UniProtKB/Swiss-Prot entry P36871 [PGM1_HUMAN] Phosphoglucomutase-1 Takahashi N. Neels J.V. "Intragenic recombination at the human phosphoglucomutase 1 locus: predictions fulfilled."; March R.E. Putt W. Hollyoake M. Ives J.H. Lovegrove J.U. Hopkinson D.A. Edwards Y.H. Whitehouse D.B. "The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination."; Molecular function: phosphoglucomutase activity (inferred from direct assay from UniProtKB). www.expasy.org /uniprot/P36871   (570 words)

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