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	Pimozide - Wikipedia, the free encyclopedia
		Pimozide is used in its oral preparation in schizophrenia and chronic psychosis (on-label indications in Europe only), Gilles de la Tourette syndrome and resistant tics (Europe, USA and Canada).
		Plasma levels of pimozide can vary widely between patients, and in insufficient response therapeutic drug monitoring may be required to ascertain that the patient is developing adequate plasma levels before withdrawing the drug and attempting other antipsychotics.
		In particular, pimozide is known for causing the unpleasant extrapyramidal side-effect akathisia (commonly referred to as "restless pacing") in a large percentage of those who take it.
	en.wikipedia.org /wiki/Pimozide (976 words)

	MedlinePlus Drug Information: Pimozide
		Pimozide is used to control tics (unusual movements or sounds that the patient may be able to hold back for a short time but cannot really control) caused by Tourette's disorder.
		Pimozide should only be used to treat severe tics that stop the patient from learning, working, or performing normal activities.
		Pimozide is also used sometimes to treat schizophrenia, and certain behavior, personality, movement, and psychiatric disorders in adults.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a686018.html (975 words)

	Pimozide: Use in Dermatology
		Pimozide is widely used in psychiatry for chronic psychoses, schizophrenia, the syndrome of Gilles de la Tourette and to a certain extent, also in dermatology.
		Pimozide is excreted in breast milk at the same or higher concentration of that in the plasma.
		Pimozide, a selective blocker of dopamine receptors, remains the drug of choice for treatment of delusions of parasitosis, though large, controlled studies are lacking.
	dermatology.cdlib.org /92/reviews/pimozide/vanvloten.html (1287 words)

	Pimozide Drug Information
		Pimozide (PIM-oh-zide) is used to treat the symptoms of Tourette's syndrome.
		Pimozide works in the central nervous system to help control the vocal outbursts and uncontrolled, repeated movements of the body (tics) that interfere with normal life.
		Taking pimozide together with medicines that are used during surgery or dental or emergency treatment may increase the CNS depressant effects.
	www.drugs.com /cons/Pimozide.html (1893 words)

	Orap Tablets Drug Information Orap Tablets
		Also, pimozide, at a dose about 15 times that given humans, caused an increase in the number of benign tumors of the pituitary gland in female mice, it is not possible to say how important this is. Similar tumors were not seen in rats given pimozide, nor at lower doses in mice, which is reassuring.
		In mice, pimozide causes a dose-related increase in pituitary and mammary tumors.
		Pimozide did not have mutagenic activity in the Ames test with four bacterial test strains, in the mouse dominant lethal test or in the micronucleus test is rats.
	www.drugs.com /PDR/Orap_Tablets.html (4332 words)

	Orap, Pimozide Pharmacology - HealthyPlace.com
		Pimozide is not indicated in the management of patients with mania or acute schizophrenia.
		Therefore, it should not be administered to nursing mothers or to women of child-bearing potential, particularly during the first trimester of pregnancy, unless, in the opinion of the physician, the expected benefits of the drug to the patient outweigh the potential risk to the fetus or child.
		Clinical trials with pimozide (orap) indicate that it is not effective in, and therefore should not be used in the management of, manifestations of chronic schizophrenia in which the main symptoms include agitation, excitement and anxiety.
	www.healthyplace.com /medications/orap.asp (1214 words)

	Antipsychotic Medications Anti-psychotic Drugs pimozide, Orap
		Pimozide is a diphenylbutylpiperidine derivative with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients.
		Pimozide has relatively little sedative action and can be used as a once daily medication.Pimozide is not indicated in the management of patients with mania or acute schizophrenia.
		Because pimozide prolongs the QT interval of the ECG it is contraindicated in patients with congenital long QT syndrome, patients with a history of cardiac arrhythmias, or patients taking other drugs which prolong the QT interval of the ECG.
	www.support4hope.com /medications/antipsychotic/pimozide_orap.htm (1099 words)

	Identification and Characterization of Human Cytochrome P450 Isoforms Interacting with Pimozide -- Desta et al. 285 ...
		Pimozide (10 µM) was incubated with at least two inhibitor concentrations in HLMs, and the combined inhibitory effect of ketoconazole (1 µM) and furafylline (10 µM) was tested.
		Because omeprazole inhibited the N-dealkylation of pimozide in
		Soudijn W and Wijngaarden I (1969) The metabolism and excretion of the neuroleptic pimozide by the Wistar rat.
	jpet.aspetjournals.org /cgi/content/full/285/2/428 (5990 words)

	Pimozide (ORAP) Contraindicated with... (Site not responding. Last check: 2007-10-21)
		The labeling for pimozide (Orap), approved for the treatment of TouretteÀ$Às disorder, has been updated to contraindicate use of pimozide in patients receiving macrolide antibiotics such as clarithromycin, erythromycin, azithromycin, and dirithromycin.
		Pimozide prolongs the QT interval of the electrocardiogram, an effect that is believed to predispose patients to fatal cardiac arrhythmias.
		A plausible explanation for the cases of sudden death with concomitant clarithromycin and pimozide is a metabolic interaction that leads to increased pimozide plasma concentrations and thus an increased risk of cardiac arrhythmia.
	www.fda.gov /medbull/oct96/pimozide.html (216 words)

	Pimozide for schizophrenia or related psychoses (Cochrane Review) (Site not responding. Last check: 2007-10-21)
		Background: Pimozide was first formulated in the late 1960s and continues to be marketed for the care of those with schizophrenia or related psychoses such as delusional disorder.
		Pimozide has similar efficacy to that of typical antipsychotic drugs for the outcomes of change in global functioning, mental state, relapse and leaving the study early.
		Pimozide was more likely to cause parkinsonian tremor (RR 1.6 CI 1.1-2.3, NNH 6 CI 3-44) and lead to a requirement for antiparkinsonian medication more frequently (RR 1.8, CI 1.2-2.6, NNH 3 CI 2-5) than other drugs.
	www.cochrane.org /cochrane/revabstr/ab001949.htm (563 words)

	T-type calcium channels in the regulation of afferent and efferent arterioles in rats -- Feng et al. 286 (2): 331 -- ...
		Pimozide caused significant afferent (n = 5) and efferent arteriolar (n = 5) vasodilation at concentrations of 1, 10, and 100 µmol/l.
		Pimozide (P; 5 µmol/l, n = 7) or mibefradil (M; 1 µmol/l, n = 5) alone and pimozide (5 µmol/l) or mibefradil (1 µmol/l) plus diltiazem (D; 10 µmol/l) significantly increased afferent arteriolar diameters, but no additive effect of diltiazem on afferent arteriolar diameter was observed.
		Effects of pimozide on autoregulation of afferent arteriolar diameter in response to increases in perfusion pressure.
	ajprenal.physiology.org /cgi/content/full/286/2/F331 (5356 words)

	The Ca2+ Channel Antagonists Mibefradil and Pimozide Inhibit Cell Growth via Different Cytotoxic Mechanisms -- ...
		Inhibition of cell growth may be attributed, at least in part, to arrest of cells in a specific phase of the cell cycle.
		Induction of apoptosis and necrosis by pimozide and mibefradil in Y79 cells.
		Strobl JS, Melkoumian Z, Peterson VA and Hylton H (1998) The cell death response to gamma-radiation in MCF-7 cells is enhanced by a neuroleptic drug, pimozide.
	molpharm.aspetjournals.org /cgi/content/full/62/2/210 (6499 words)

	Pimozide (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-21)
		Studies in rats and rabbits given more than the highest recommended human dose of pimozide have shown fewer pregnancies, slowed development of the fetus, and toxic effects in the mother and fetus.
		It is not known whether pimozide passes into breast milk.
		Children are especially sensitive to the effects of pimozide.
	www.mayoclinic.com /health/drug-information/DR202466 (1880 words)

	pimozide (oral) - [Medication] (Site not responding. Last check: 2007-10-21)
		Pimozide is used to suppress the motor and phonic tics associated with Tourette's disorder.
		Pimozide is in the FDA pregnancy category C. This means that it is not known whether pimozide will be harmful to an unborn baby.
		Pimozide may also increase the side effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (medicines that treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and any other drug that makes you feel sleepy or relaxed.
	www.bcbswny.com /kbase/multum/d00898a1.htm (1547 words)

	Pimozide - Drugs & Vitamins - Drug Library - DrugDigest
		Pimozide can also treat conditions that may cause you to hear or see things that others do not.
		Pimozide has the potential to interact with many medications.
		It may be several weeks before you see the full effects of pimozide.
	www.drugdigest.org /DD/DVH/MissedDose/0,3918,545\|Pimozide,00.html (722 words)

	Orap Side Effects, and Drug Interactions - Pimozide - RxList Monographs (Site not responding. Last check: 2007-10-21)
		Because ORAP prolongs the QT interval of the electrocardiogram, an additive effect on QT interval would be anticipated if administered with other drugs, such as phenothiazines, tricyclic antidepressants or antiarrhythmic agents, which prolong the QT interval.
		Accordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects.
		Patients should avoid grapefruit juice because it may inhibit the metabolism of pimozide by CYP 3A4.
	www.rxlist.com /cgi/generic3/orap_ad.htm (908 words)

	Pimozide - Talk Medical
		Do not take Pimozide without first talking to your doctor if you are pregnant or could become pregnant during treatment.
		Continue to take Pimozide and talk to your doctor if you experience ·dizziness or drowsiness; ·insomnia; ·nausea or vomiting; ·diarrhea or constipation; ·dry mouth; or ·blurred vision or sensitivity of the eyes to light.
		Pimozide may increase the risk of having a seizure.
	www.talkmedical.com /medications/4888/Pimozide (1005 words)

	pimozide news articles (Site not responding. Last check: 2007-10-21)
		LEXIVA is contraindicated with ergot derivatives, cisapride, pimozide, midazolam and triazolam.
		Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or...
		The drugs examined were cisapride and domperidone (GI drugs), chlorpromazine, haloperidol and pimozide (anti-psychotics) and erythromycin and clarithomycin...
	www.mongabay.com /drugs/drugs/pimozide.html (838 words)

	Pimozide - Patient UK
		Pimozide used to treat mental illness with symptoms such as hearing, seeing or sensing things that are not there, mistaken beliefs and problems dealing with other people.
		You may have to take pimozide for several weeks before you feel the full effect.
		Pimozide can cause some people's skin to become more sensitive to sunlight than it usually is. Try to avoid the sun and sunbeds until you know how your skin reacts or use a suncream higher than factor 15.
	www.patient.co.uk /showdoc/30002350 (700 words)

	Identification and Characterization of Human Cytochrome P450 Isoforms Interacting with Pimozide -- Desta et al. 285 ...
		Pimozide is a potent neuroleptic that has been used extensively in Europe for the treatment of schizophrenia and other psychiatric
		The effects of preincubation (PI) of pimozide for 5 or 15 min were tested for CYP3A and CYP2D6 isoforms.
		Kerbusch T, Desta Z, Soukhova NV, Thacker D and Flockhart DA (1997) Sensitive assay for pimozide in human plasma using high-performance liquid chromatography with fluorescence detection: application to pharmacokinetic studies.
	www.jpet.org /cgi/content/full/285/2/428 (5990 words)

	Facial Neuralgia Resources: Pimozide
		Pimozide is actually a neuroleptic (anti-psychotic drug) that has been used for treatment of chronic schizophrenia.
		Pimozide can have a variety of serious side effects, like most neuroleptics.
		The most dislikable side effect is that the muscles of the body may begin twitching involuntarily or become unusually rigid.
	facial-neuralgia.org /treatments/drugs/pimozide.html (94 words)

	Progesterone-Mediated Calcium Influx and Acrosome Reaction of Human Spermatozoa: Pharmacological Investigation of ...
		with calmidazolium or pimozide, by phase-contrast and fluorescence
		Uncapacitated or capacitated human sperm suspensions were treated with DMSO (0.1%) at 100 sec to represent the solvent control for pimozide and calmidazolium treatments.
		The pimozide and calmidazolium solvent control (0.1% DMSO) values for uncapacitated and capacitated spermatozoa were 55 ± 8 nM and 76 ± 16 nM, respectively (mean ± SEM).
	www.biolreprod.org /cgi/content/full/60/1/102 (4861 words)

	Clinical Trial: Phase II Pilot Controlled Study of Short Vs Longer Term Pimozide (Orap) Therapy in Tourette Syndrome
		OBJECTIVES: I. Determine whether the time period between randomization and endpoint is longer in the short term pimozide therapy or longer term therapy in patients with Tourette syndrome.
		Determine whether tic severity, medication side effects, academic performance and psychosocial functioning are better in the short term pimozide therapy or longer term pimozide therapy.
		Patients receive pimozide (open label) orally until a stable level of tic control is achieved and remains unchanged for at least 1 month.
	www.clinicaltrials.gov /ct/show/NCT00004652 (277 words)

	Effects of Long-Term Testosterone, Gonadotropin-Releasing Hormone Agonist, and Pimozide Treatments on Gonadotropin II ...
		dopamine antagonist, pimozide (Sigma) [41], was suspended in
		Although the inhibitory effects of pimozide on GtH II release may suggest a stimulatory role of dopamine on GtH II secretion, this finding is not supported by other studies.
		Kinetic study of the distribution of pimozide and metabolites in brain, liver, and blood of the Wistar rat.
	www.biolreprod.org /cgi/content/full/59/5/1153 (7762 words)

	Important Safety Information on Concomitant Use of PAXIL or PAXIL CR and pimozide (Orap) - GlaxoSmithKline Inc. (Site not responding. Last check: 2007-10-21)
		Elevation of pimozide blood concentration may result in QT interval prolongation and severe arrhythmias including Torsade de Pointes.
		and pimozide is contraindicated as paroxetine has been shown to increase plasma pimozide levels.
		Due to the narrow therapeutic index of pimozide and its known ability to prolong the QT interval, and produce severe cardiac arrhythmias including Torsades de Pointes, concomitant use of pimozide and PAXIL
	hc-sc.gc.ca /dhp-mps/medeff/advisories-avis/prof/paxil_2_hpc-cps_e.html (567 words)

	Healthopedia.com Drugs Information - Pimozide : Before Using (Orap)
		In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
		Diet—It is very important that you do not take pimozide with grapefruit juice.
		Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
	www.healthopedia.com /drugs/detailed/pimozide/before-using.html (730 words)

	MedlinePlus Medical Encyclopedia: Gilles de la Tourette syndrome
		In this case, they are not treated, since the medications have side effects that would be worse than the symptoms.
		Antipsychotic medications such as haloperidol (Haldol) and pimozide have historically been used to treat Tourette syndrome.
		Although these medications may be effective in diminishing or eliminating tics, their use is restricted by significant side effects.
	www.nlm.nih.gov /medlineplus/ency/article/000733.htm (814 words)

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