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Topic: Pindolol

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	Data Sheet
		Pindolol may reduce the oxygen requirement of the heart at any level of effort by blocking catecholamine-induced increases in the heart rate, systolic blood pressure and the velocity and extent of myocardial contraction.
		Pindolol is partially metabolised in the by the liver with approximately 40% of an oral dose being excreted unchanged in the urine.
		The principal metabolites of pindolol consist of the conjugated glucuronide and phenolic derivatives of pindolol conjugated with sulphuric or glucuronic acid.
	www.medsafe.govt.nz /profs/datasheet/a/apopindololtab.htm (1425 words)

	Visken Side Effects, and Drug Interactions - Pindolol - RxList Monographs
		Data for pindolol and the positive controls were pooled from several trials because no striking differences were seen in the individual studies, with 1 exception.
		Patients receiving pindolol plus a catecholamine-depleting agent should, therefore, be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension.
		Pindolol has been shown to increase serum thioridazine levels when both drugs are co-administered.
	www.rxlist.com /cgi/generic3/pindolol_ad.htm (415 words)

	Visken - Visken Side Effects - Visken Information - Canada Pharmacy - Canada Drugs
		Pindolol is patially metabolized with approximately 40% of an oral dose being excreted unchanged in the urine.
		The principle metabolites of pindolol consist of the conjugated glucuronide, and phenolic derivatives of pindolol conjugated with sulfuric or glucuronic acid.
		Pindolol should be administered with caution to patients subject to spontaneous hypoglycemia, or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents.
	www.rxcarecanada.com /Visken.asp?prodid=1838 (2292 words)

	WhatMeds.com - Pindolol
		Pindolol, also known by the brand name Visken, is a beta-blocker usually used to treat high blood pressure (hypertension).
		Pindolol’s psychiatric use is as a supplement to Selective Serotonin Reuptake Inhibitors (SSRIs) and Monoamine Oxidase (MAO) Inhibitors to increase their effectiveness in treating depression.
		For Pregnant or Nursing Mothers: Pindolol has caused harm to the fetus in animal studies, and is not recommended during pregnancy.
	www.whatmeds.com /meds/pindolol.html (235 words)

	pindolol Consumer Drug Information
		Pindolol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control.
		Pindolol is in a group of drugs called beta-blockers.
		Pindolol is used to treat hypertension (high blood pressure).
	www.drugs.com /MTM/pindolol.html (1344 words)

	Pindolol
		Pindolol, a type of medication known as a beta blocker, is used in the treatment of high blood pressure.
		If pindolol is taken with certain other drugs, the effects of either could be increased, decreased, or altered.
		Pindolol appears in breast milk and could affect a nursing infant.
	www.healthsquare.com /newrx/pin1611.htm (926 words)

	Risks of pindolol use to augment SSRI treatment of depression
		Pindolol, a known beta blocker, also blocks 5-HT1A receptors, thereby increasing the available amount of serotonin in the synaptic cleft (by preventing autoreceptor inhibitory regulation) (Hjorth and Auerbach, 1994).
		Pindolol was discontinued at the end of the second day.
		Therefore, augmentation with pindolol altered the function of the serotonergic system in a complicated way and it is unlikely that simple increases or decreases of the serotonergic neurotransmitter system adequately explain these phenomena.
	www.priory.com /pindolol.htm (893 words)

	Data Sheet
		PINDOLOL has a plasma-protein binding of 40%, a volume of distribution of 2-3 L/kg and a total clearance of 500 mL/min.
		The elimination half-life of PINDOLOL is 3-4 hours; 30-40% is excreted unchanged in the urine, while 60-70% is excreted via the kidney and liver as inactive metabolites.
		PINDOLOL passes in small quantities into breast milk, but it is unlikely to affect the infant when therapeutic doses are used.
	www.medsafe.govt.nz /profs/datasheet/p/Pindoltab.htm (1388 words)

	RemedyFind: patient ratings of Visken etc. (Pindolol) for Social Phobia (Social Anxiety Disorder)
		Visken (Pindolol) is a beta blocker medication used to reduce blood pressure (hypertension).
		Responder rates in the clinical global impression were 97.2% for the pindolol group and 60.6% for the placebo group.
		Pindolol, an antagonist at somatodendritic pre-synaptic 5HT1A receptors has been investigated as a potential accelerator or potentialisator of antidepressant response.
	www.remedyfind.com /treatments/65/72 (524 words)

	Pindolol
		• Pindolol is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
		Do not take pindolol without first talking to your doctor if you are breast-feeding a baby.
		Pindolol may cause drowsiness, dizziness, and blood pressure changes.
	www.geocities.com /sarahmcraig/pindolol.html (874 words)

	Review: combining pindolol with an SSRI improves early outcomes in people with depression -- Isaac 7 (4): 107 -- ... (Site not responding. Last check: 2007-11-03)
		Effectiveness of pindolol plus serotonin uptake inhibitors in depression: a meta-analysis of early and late outcomes from randomised controlled trials.
		Paroxetine and pindolol: a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency.
		Effect of pindolol in hastening response to Fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial.
	ebmh.bmjjournals.com /cgi/content/full/7/4/107 (649 words)

	Pindolol
		Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity.
		Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
		Pindolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure.
	www.mongabay.com /health/medications/Pindolol.html (540 words)

	pindolol (Site not responding. Last check: 2007-11-03)
		In addition, pindolol has partial agonist activity, with significantly greater agonist than antagonist effects at beta-2 receptors.
		Pindolol may increase plasma triglycerides and decrease HDL-cholesterol, which theoretically could contribute to atherogenesis.
		Because pindolol lowers blood pressure by decreasing vascular resistance and appear to depress cardiac output or heart rate less than other beta-blockers, it may be particularly beneficial for patients with cardiac failure, bradyarrhythmias, or peripheral vascular disease.
	lysine.pharm.utah.edu /netpharm/netpharm_00/druglist/pindolol.htm (298 words)

	MedlinePlus Drug Information: Pindolol
		If pindolol is stopped suddenly, it may cause chest pain or heart attack in some people.
		Pindolol helps control your condition but will not cure it.
		Pindolol is also used sometimes to prevent angina (chest pain) and heart attacks.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a684032.html (709 words)

	Fluoxetine/Pindolol Combo More Effective In Depression
		The authors hypothesised that the addition of a drug such as pindolol would increase the efficacy of fluoxetine and decrease the time to clinical improvement.
		To check this, the degree of depression in patients was assessed twice a week for the first three weeks of the trial and once a week thereafter until the end of the trial (42 days).
		The authors also felt that study of whether pindolol increases the effectiveness of other antidepressant drugs would be worthwhile as knowledge about the neurobiological mechanisms involved would help in the design of more effective treatments.
	www.docguide.com /dg.nsf/PrintPrint/C4D9DFF1224C1903852564A7005C1D5E (391 words)

	Medbroadcast Drug Info
		For treatment of high blood pressure, pindolol may be used alone or in combination with other medications that reduce high blood pressure, particularly thiazide diuretics (water pills).
		For treatment of high blood pressure, the dose of pindolol is usually started at 5 mg twice daily and increased gradually until the best dose is found.
		Pindolol may make it more difficult to treat their allergic reaction with epinephrine.
	www.medbroadcast.com /drug_info_details_pf.asp?brand_name_id=144 (1128 words)

	Visken - Drugs & Vitamins - Drug Library - DrugDigest
		Pindolol controls, but does not cure, high blood pressure (hypertension).
		Ask your prescriber or health care professional what your heart rate and blood pressure should be, and when you should contact him or her.
		It can be 2 weeks or longer before the full effect of pindolol in lowering blood pressure is seen.
	www.drugdigest.org /DD/DVH/Uses/0,3915,546\|Visken,00.html (645 words)

	Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is ... (Site not responding. Last check: 2007-11-03)
		Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low -- Rabiner et al.
		for pindolol occupancy of the 5-HT approximately 10 mg/kg i.p.
		Bordet R, Thomas P, Dupuis B: Effect of pindolol on onset of action of paroxetine in the treatment of major depression: intermediate analysis of a double-blind, placebo-controlled trial.
	ajp.psychiatryonline.org /cgi/content/full/158/12/2080 (1702 words)

	NYU School of Medicine - Department of Psychiatry
		HAM-D Responses of Pindolol and Trimipramine, Fluvoxamine, or Buspirone
		The combination of pindolol and the SSRI produced a marked antidepressant effect.
		The selective activation of postsynaptic 5-HT1A receptors by buspirone in the presence of the presynaptic 5-HT1A antagonist pindolol appears to induce a rapid and robust antidepressant response.
	www.med.nyu.edu /psych/aug/sld035.html (141 words)

	PINDOLOL: buy pindolol, discount pindolol, side effects pindolol - Swiftrx (Site not responding. Last check: 2007-11-03)
		Pindolol belongs to a class of medications called beta-blockers.
		Pindolol may also be used to treat a certain type of chest pain (angina).
		Before taking pindolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., acebutolol); or if you have any other allergies.
	www.meds4u.com /quick_search.jsp?criteria=PINDOLOL (1340 words)

	Medbroadcast Drug Info
		Pindolol belongs to a class of medications called beta-blockers and helps to lower blood pressure by decreasing the demands on the heart.
		The eventual dose of pindolol - hydrochlorothiazide is determined by treating with each of the ingredients separately (i.e., pindolol and hydrochlorothiazide) and finding the best daily dose for each.
		The usual adult dose ranges from one pindolol 10 mg - hydrochlorothiazide 25 mg tablet daily to two pindolol 10 mg - hydrochlorothiazide 50 mg tablets daily, taken in the morning.
	www.medbroadcast.com /drug_info_details_pf.asp?brand_name_id=200 (1341 words)

	Visken Online, Description, Chemistry, Ingredients - Pindolol - RxList Monographs
		Pindolol, a synthetic beta-adrenergic receptor blocking agent with intrinsic sympathomimetic activity is 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol.
		Pindolol is a white to off-white, crystalline powder having a faint odor which is practically insoluble in water; slightly soluble in methanol, and very slightly soluble in chloroform.
		Each tablet for oral administration contains pindolol and the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, pregelatinized starch, and sodium lauryl sulfate.
	www.rxlist.com /cgi/generic3/pindolol.htm (110 words)

	Pindolol.
		Pindolol slows the rate and force of contraction of the heart by blocking certain nerve impulses, thus reducing blood pressure.
		Shortness of breath, wheezing; irregular or slow heartbeat (50 beats per minute or less); pain or feelings of tightness or pressure in the chest; swelling of the ankles, feet, and lower legs; mental depression.
		Dizziness or lightheadedness, especially when rising suddenly to a standing position; decreased sexual ability; unusual fatigue, weakness, or drowsiness; insomnia.
	www.herbs2000.com /medica/pindolol.htm (574 words)

	Effect of Pindolol on Onset of Action of Paroxetine in the Treatment of Major Depression: Intermediate Analysis of a ... (Site not responding. Last check: 2007-11-03)
		Effect of Pindolol on Onset of Action of Paroxetine in the Treatment of Major Depression: Intermediate Analysis of a Double-Blind, Placebo-Controlled Trial -- Bordet et al.
		Artigas F, Perez V, Alvarez E: Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors (letter).
		Tome MB, Isaac MT, Harte R, Holland C: Paroxetine and pindolol: a randomised trial of serotoninergic autoreceptor blockade in the reduction of antidepressant latency.
	ajp.psychiatryonline.org /cgi/content/full/155/10/1346 (3864 words)

	Pindolol, side effects, drug interactions, overdose, dosage
		If Pindolol is not taken regularly, your condition may worsen.
		If you suffer from asthma, chronic bronchitis, emphysema, seasonal allergies or other bronchial conditions, coronary artery disease, or kidney or liver disease, Pindolol should be used with caution.
		If Pindolol is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Pindolol is finished.
	www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/pin1611.shtml (686 words)

	Better, Stronger, Faster: Accelerating Antidepressant Response in Elderly Patients (Site not responding. Last check: 2007-11-03)
		This is a theoretically attractive strategy, according to Dr. Nelson, because pindolol blocks the presynaptic 5-HT receptor.
		For example, one double-blind trial of 80 patients randomized to paroxetine and either pindolol or placebo found that the placebo group required seven additional days to reach the same level of response as the pindolol patients.
		Although the difference "started to level off" by the end of the study, the earlier response with pindolol is still clinically significant, Dr. Nelson said.
	www.neuropsychiatryreviews.com /jun00/npr_jun00_antidepress.html (1643 words)

	Pindolol - Patient UK
		Pindolol is used to treat high blood pressure.
		It works by blocking the transmission of messages to the beta receptors in the heart which slows down the activity of the heart decreasing blood pressure.
		If you suspect that you or someone else has taken an overdose of pindolol contact your doctor or go to the accident and emergency department of your local hospital at once.
	www.patient.co.uk /showdoc/30002622 (635 words)

	Acute vasodilator action of pindolol in humans -- Chang et al. 7 (1): 146 -- Hypertension (Site not responding. Last check: 2007-11-03)
		Acute vasodilator action of pindolol in humans -- Chang et al.
		For a single dose of pindolol the maximal effect on FBF was seen
		influence of pindolol was found on the vasoconstriction induced by the
	hyper.ahajournals.org /cgi/content/abstract/7/1/146 (233 words)

	Pindolol : Comprehensive and up-to-date drug information
		I'm hoping that other folks having edema (water retention/swelling of the ankles/feet) are going in to their MDs to have this checked out.
		I have been on a beta-blocker (pindolol) for 6 months.
		Please consult a licensed health care provider regarding your medical condition.The products mentioned are trademarks of their respective owners and are not owned by meds-help.com.
	www.meds-help.com /pindolol (275 words)

	Medical Dictionary: Pindolol - WrongDiagnosis.com
		Pindolol: an oral beta blocker (trade name Visken) used in treating hypertension
		Because many drug names share similar spellings or sound almost identical when spoken, it is possible to mistake the name of a particular medication.
		The following list attempts to classify Pindolol into categories where each line is subset of the next.
	www.wrongdiagnosis.com /medical/pindolol.htm (271 words)

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