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Topic: Piperazin


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In the News (Sat 26 Dec 09)

  
  PIPERAZIN - LoveToKnow Article on PIPERAZIN
When taken into the body the drug is partly oxidized and partly eliminated unchanged.
Outside the body piperazin has a remarkable power of dissolving uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Lycetol, lysidine and sidonal are bodies having similar action.
www.1911encyclopedia.org /P/PI/PIPERAZIN.htm   (103 words)

  
 PIPERAZINE (DIETHYLENEDIAMINE)
Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position (als called 1,4-hexahydropyrazine).
It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane.
The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants.
www.chemicalland21.com /arokorhi/lifescience/phar/PIPERAZINE.htm   (237 words)

  
 Piperazin adipinat (Piperazin adipinate) [www.sopharma.com]
Piperazin adipinate 0.25 g in one tablet for children and
The administration of the drug induces elimination of the parasites in 90-95 % of the cases, repeated intake can result in almost 100 % elimination.
Piperazin administration requires a preliminary preparation of the patients or a special diet: laxatives are prescribed only in cases susceptible to constipation (in the evening before the intake of the drug).
www.sopharma.net /categories/408/40811pipeazin_adipinat.html   (374 words)

  
 Slobodna Dalmacija
Nova droga, točnog naziva klorofenil piperazin djeluje stimulativno i halucinogeno na središnji živčani sustav, a ima učinak sličan amfetamninu, metamfetaminu te MMDA-u, poznatijem kao ecstasy.
Zbog činjenice da piperazin, inače i antihelminitik, odnosno lijek protiv glista, nije na popisu opojnih droga ili psihotropnih tvari koje se koriste za izradu opojnih droga, odnedavno se po ilegalnim laboratorijima sintetiziraju kemikalije koju su "dopuštene", odnosno ne mogu se kazneno goniti i procesuirati, a imaju učinak nalik ecstasyju.
Klorofenil piperazin je jedna od njih, a na narkotržištu se distribuira kao "droga nalik na MDMA".
arhiv.slobodnadalmacija.hr /20050303/novosti04.asp   (786 words)

  
 Benzothiophene derivatives and corresponding use and composition US Patent 6262056   (Site not responding. Last check: 2007-11-03)
In these compounds the aromatic ring (Ar.sup.2) is not directly attached to the piperazine ring, but through a spacer X (CH.sub.2, CO, etc.), unlike the compounds of the present invention.
As stated above, the object of the present invention are new benzothiophene derivatives of the general formula (1), and the corresponding compositions and the use thereof for obtaining compositions having a pharmacological activity.
A third process for the preparation of the formula (1a) ketones consists of converting, by methods described in the literature, a substituent in a formula (1a) compound into a different substituent, thereby obtaining another different compound responding structurally to the same type of formula (1a).
patents.nimblewisdom.com /patent/6262056-Benzothiophene-derivatives-and-corresponding-use-and-composition   (6335 words)

  
 PERPHENAZINE
Perphenazine is a short-acting piperazine phenothiazine antipsychotic drug which exhibits a more propensity for producing extrapyramidal reactions than the group of phenothiazine antipsychotic drugs, and used orally and intramuscularly.
It may occur less hypertension but less potentiating effect on CNS depressants, anesthetics sedating than the group of phenothiazine antipsychotic drugs.
We are pleased to receive your any questions or remarks.
www.chemicalland21.com /AROKORHI/lifescience/phar/PERPHENAZINE.htm   (320 words)

  
 Publications from the department of Occupational and Environmental Medicine - 1986   (Site not responding. Last check: 2007-11-03)
Hagmar L, Welinder H. Prevalence of specific IgE antibodies against piperazine in employees of a chemical plant.
Hagmar L. Occupational respiratory disease caused by piperazine.
Skarping G, Bellander T, Mathiasson L. Determination of piperazine in working atmosphere and in human urine using derivatization and capillary gas chromatography with nitrogen- end mass-selective detection.
www.ymed.lu.se /papers/publications/publ86.html   (616 words)

  
 Quinolinone derivatives and uses thereof - Patent 6943169
In the case of α-haloalkyl heteroaryl compounds, suitable protection group strategies may be employed to avoid unwanted heteroatom alkylation during this step.
Many substituted piperazines of this sort, including N-methyl piperazine and 3,5-dimethylpiperazine for example, are commercially available or prepared by well known techniques and may be used in the procedure of Scheme A. In other embodiments of the invention, Step 4 may be omitted and Steps 5-7 carried out in place thereof.
A cross coupling amination reaction is then carried out in Step 4 wherein the N-arylalkyl-benzoxazinone compound o is reacted with a nitrogen-containing heterocycle f in the presence of a palladium catalyst to replace the leaving group G with a heterocyclyl group and provide the heterocyclyl-N-arylalkyl-benzoxazinone compound IX.
www.freepatentsonline.com /6943169.html   (9799 words)

  
 World Intellectual Property Organization   (Site not responding. Last check: 2007-11-03)
Another preferred group of compounds of Formulas I and II have the above formulas wherein W3 is substituted pyrolidine.
Another preferred group of compounds of Formulas I and II have the above formulas wherein W3 is piperazine Another preferred group of compounds of Formulas I and II have the above formulas wherein W3 is substututed piperazine.
is piperazine or substituted piperazine, R2 is alkyloxy, and RI is alkyl or cycloalkyl.
www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/38315.010531&ELEMENT_SET=DECL   (3214 words)

  
 5ht7 antagonists and inverse agonists patent invention   (Site not responding. Last check: 2007-11-03)
[0405] The title compound was prepared in an analogous fashion to Example 7, Step 3, utilizing the title compound from Example 9, Step 1 (51 mg, 0.14 mmol) in 0.75 ml toluene, 1-methyl piperazine (91 ul, 0.81 mmol), palladium(II)acetate (6.4 mg, 0.028 mmol), 2,2'-bisdiphenylphosphanyl-[1,- 1']binaphthalenyl (17.4 mg, 0.028 mmol) and sodium-tert-butoxide (108 mg, 1.1 mmol).
[0416] The title compound was prepared in an analogous fashion to Example 7, Step 3, utilizing the title compound from Example 10, Step 1 (112 mg, 0.31 mmol) in 2.0 ml toluene, 1-methyl piperazine (207 ul, 1.86 mmol), palladium(II)acetate (142 mg, 0.62 mmol), 2,2'-bisdiphenylphosphanyl-[1,1- ']binaphthalenyl (386 mg, 0.62 mmol) and sodium-tert-butoxide (238 mg, 2.48 mmol).
[0427] The title compound was prepared in an analogous fashion to Example 7, Step 3, utilizing the title compound from Example 11, Step 1 (234 mg, 0.62 mmol) in 3.0 ml toluene, 1-methyl piperazine (416 ul, 13.7 mmol), palladium(II)acetate (28.5 mg, 0.12 mmol), 2,2'-bisdiphenylphosphanyl-[1,- 1']binaphthalenyl (77 mg, 0.12 mmol) and sodium-tert-butoxide (358 mg, 3.7 mmol).
www.freshpatents.com /5ht7-antagonists-and-inverse-agonists-dt20041118ptan20040229874.php?type=description   (12930 words)

  
 PRIJEDOR. RS. BA -[]- oficijelni sajt grada Prijedora   (Site not responding. Last check: 2007-11-03)
Policija je mislila da je u Pavlovićevom stanu pronašla 19 bijelih tableta ekstazija, ali je toksiološko vještačenje pokazalo da su dotične tablete zapravo sintetička droga medicinskog imena piperazin.
Derivati piperazina koriste se u antidepresivima, a dotična droga do sada nije bila uvedena u popis opojnih droga u Hrvatskoj,
Piperazin djeluje kao halucinogen na centralni nervni sistem, te izaziva gubitak tečnosti, edem mozga, konvulzije, ubrzan rad srca, visok pritisak i temperaturu, a uzimanje piperazina može biti opasno po život
www.prijedor.rs.ba /radiotext/vijestie/radiotext_done.shtml?vjid=1332   (330 words)

  
 Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor ...
Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor Interact with a Common Receptor Microdomain -- Kortagere et al.
Articles by Kortagere, S. Articles by Schetz, J. Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor Interact with a Common Receptor Microdomain
the protonatable amine of the piperidine or piperazine pharmacophore.
molpharm.aspetjournals.org /cgi/content/full/66/6/1491   (5716 words)

  
 651931 1 Boc 4 2 methoxycarbonyl 4 nitrophenyl piperazine
651931 1 Boc 4 2 methoxycarbonyl 4 nitrophenyl piperazine
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www.sigmaaldrich.com /catalog/search/ProductDetail?ProdNo=651931&Brand=ALDRICH   (45 words)

  
 ENZAL CHEMICALS (INDIA) P.LTD - Manufacturer of Piperazine Intermediate, Drug Intermediate, Speciality Chemicals for ...
ENZAL CHEMICALS (INDIA) P.LTD - Manufacturer of Piperazine Intermediate, Drug Intermediate, Speciality Chemicals for Bulk Drugs etc.
Following are the product coming under PIPERAZINES Category.
Click on Product Name or Specification for more details
enzal.com /ProductList.asp?Category=PIPERAZINES   (34 words)

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