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Topic: Piperine

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	Bioperine - Black pepper extract may enhance your nutrient absorption
		Piperine is the active constituent responsible for pepper's ability to increase the bioavailability of nutrients.
		Because it is lipophilic (has an affinity for fatty tissue), piperine may interact with the lipid component of the intestinal cell membrane to facilitate enhanced nutrient permeability.
		Piperine has been found to stimulate the release of catecbolamines that initiate the process of thermogenesis in the GI tract, thereby increasing the energy available for digestion.
	www.discount-vitamins-herbs.net /bioperine.htm (970 words)

	Piperine
		Piperine is an alkaloid found naturally in plants belonging to the Piperaceae family, such as Piper nigrum L, commonly known as fl pepper, and Piper longum L, commonly known as long pepper.
		Piperine is the major pungent substance in these plants and is isolated from the fruit of the fl pepper and long pepper plants.
		Piperine was said to be non-mutagenic, however, in a study examining effects of the substance on the germ cells of Swiss albino mice.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/pip_0322.shtml (1697 words)

	MEDLINE_1966-1995 - Resultado de la búsqueda <página 1>
		Piperine inhibited arylhydrocarbon hydroxylation, ethylmorphine-N-demethylation, 7-ethoxycoumarin-O-deethylation and 3-hydroxy-benzo(a)pyrene glucuronidation in rat postmitochondrial supernatant in vitro in a dose-dependent manner.
		Piperine inhibition of these reactions in postmitochondrial supernatant from 3-methylcholanthrene- and phenobarbital-treated rats was similar to the controls.
		Piperine caused noncompetitive inhibition of hepatic microsomal AHH from the untreated and 3-methylcholanthrene-treated rats with a Ki of 30 microM which was close to the apparent Km of AHH observed in the controls.
	www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1966-1995&exprSearch=3917507&indexSearch=UI&lang=e (303 words)

	Directory of open access journals
		Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper.
		The antitumor activity of piplartine was related to inhibition of the tumor proliferation rate, as observed by reduction of Ki67 staining, a nuclear antigen associated with G1, S, G2, and M cell cycle phases, in tumors from treated animals.
		Piperine was more toxic to the liver, leading to ballooning degeneration of hepatocytes, accompanied by microvesicular steatosis in some areas, than piplartine which, in turn, was more toxic to the kidney, leading to discrete hydropic changes of the proximal tubular and glomerular epithelium and tubular hemorrhage in treated animals.
	www.doaj.org /doaj?func=abstract&id=167604&recNo=14&toc=1 (327 words)

	CiteULike: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. (Site not responding. Last check: 2007-10-29)
		Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
		In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers.
		Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%.
	www.citeulike.org /user/anihawkinson/article/1034797 (431 words)

	[No title]
		Piperine depleted substance P and somatostatin whereas capsaicin depleted substance P and cholecystokinin in the dorsal horn in rats Micevych 1983
		Piperine may be inducing alterations in membrane dynamics & permeation characteristics, with induction in synthesis of proteins associated with cytoskeletal function, resulting in an increase in small intestine absorptive surface, thus assisting efficient permeation through the epithelial barrier.
		Piperine and capsaicin had chronotropic and inotropic effects in rat heart, deplete calcitonin gene-related peptide and is not affected by antagonists to norepinephrine, acetylcholine, histamine and serotonin Miyauchi 1989
	www.herbmed.org /viewherb.asp?varHerb_ID=111 (5153 words)

	Bioperine
		In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers.
		Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h); the increase in bioavailability was 2000%.
		It is postulated that the bioenhancing mechanism of piperine to increase plasma levels of supplemental coenzyme Q10 is nonspecific and possibly based on its description in the literature as a thermonutrient.
	www.slimirex.com /bioperine (1406 words)

	Quest Health Library (Site not responding. Last check: 2007-10-29)
		Piperine is a pungent alkaloid present in Piper nigrum Linn and Piper longum
		The dose of piperine considered to be bioenhancing for absorption of nutrients
		Piperine was shown to be an effective antioxidant in this recent study.
	www.nutricentre.com /questhealthlibrary/herbs/piperine.aspx (621 words)

	Piperine multiplies the strength of many supplements and drugs
		Piperine users whose drug or supplement regimens employ numerous or unusual substances should be on the lookout for undesired side effects resulting from piperine’s alteration of the bioavailability of these other substances.
		Piperine dosing should therefore be coordinated with the dosing of the substances whose bioavailability one wants to enhance, since too long an interval between the piperine dose and the dose of another substance may result in the piperine effects having disappeared during the interim.
		Piperine is one of those delightful surprises that occasionally come to light in spite of there being no reason to expect them to exist at all.
	www.delano.com /Articles/piperine-multiplies.html (2210 words)

	Black Pepper, Herb Monograph - Flora Health Herb Encyclopedia
		Piperine, one of the main alkaloids of fl pepper, has been shown to possess bioavailability-enhancing activity with a broad range of different drugs.
		Research suggests that piperine may induce changes within the digestive tract that increases the absorptive surface of the small intestine and improves drug permeation through the epithelial barrier.
		Research shows that piperine given to albino mice with daily oral doses of 2.50 mg/kg for 15 days lowered the serum levels of both the thyroid hormones, thyroxin and triiodothyronine as well as glucose concentrations with a concomitant decrease in hepatic 5'D enzyme and glucose-6-phospatase activity.
	www.florahealth.com /Flora/home/canada/HealthInformation/Encyclopedias/BlackPepper.asp (687 words)

	Herbal Extracts Manufacturers,Herbal Extracts Exporters,India (Site not responding. Last check: 2007-10-29)
		Piperine decreased the rate and amplitude of respiration and showed nonspecific blockade of acetylcholine, histamine and 5-hydroxytryptamine induced spasm on isolated guinea pig and rabbit intestine.
		Acute toxicity studies with piperine, piperlongumine and piperlonguminine were carried out in mice, rat and dog with oral and intraperitoneal route.
		In mice, oral LD(50) was 56.2+8.0, 110.1+7.8 and 115.3+9.5 mg/kg with piperine, piper- lonigumine and piperlonguminine respectively.
	www.eco-planet.com /herbalextracts/pepperlongum.htm (371 words)

	SI - readmsg.aspx msgid=23391702
		This suggests that piperine could modulate the membrane dynamics due to its apolar nature by interacting with surrounding lipids and hydrophobic portions in the protein vicinity, which may decrease the tendency of membrane lipids to act as stearic constrains to enzyme proteins and thus modify enzyme conformation.
		Ultra structural studies with piperine showed an increase in microvilli length with a prominent increase in free ribosomes and ribosomes on the endoplasmic reticulum in enterocytes, suggesting that synthesis or turnover of cytoskeletal components or membrane proteins may be involved in the observed effect.
		In conclusion, it is suggested that piperine may be inducing alterations in membrane dynamics and permeation characteristics, along with induction in the synthesis of proteins associated with cytoskeletal function, resulting in an increase in the small intestine absorptive surface, thus assisting efficient permeation through the epithelial barrier.
	www.siliconinvestor.com /readmsg.aspx?msgid=23391702 (404 words)

	AJA
		Piperine is known to possess pharmacological properties, such as antipyretic, analgesic and anti-inflammatory activities [1], and has been used in Ayurvedic medicine (a traditional Indian system of medicine) for the treatment of various diseases for thousands of years.
		Piperine was shown to impair fertilization in vitro by inhibiting calcium influx to sperm which is necessary for sperm capacitation and acrosome reaction [5].
		Piperine is known to possess protective antioxidant properties and a dose of 100 mg/kg of piperine has been shown to augment the antioxidant defense system against benzo[a]pyrene-induced carcinogenesis in lungs [8].
	www.asiaandro.com /1008-682X/7/363.htm (2597 words)

	Piperine Information
		Mostly, piperine in fl pepper is used as a culinary spice.
		So, there may be a link between piperine and weight loss, and people in some countries use it exactly for this reason, but studies are needed to confirm whether it is effective for this purpose.
		Besides piperine and serotonin, piperine has also been shown to: help the body absorb and utilize vitamins, minerals and nutrients, such as beta-carotene (plant form of vitamin a), curcumin, selenium, pyridoxine (vitamin B6), and others.
	www.nutritional-supplement-info.com /piperine.html (430 words)

	Piperine : by Ray Sahelian, M.D.
		Piperine : by Ray Sahelian, M.D. Piperine by Ray Sahelian, M.D. Dried, ground pepper is one of the most common spices in European cuisine and its descendants, having been known and prized since antiquity for both its flavor and its use as a medicine.
		Piperine from fl (Piper nigrum Linn) and long (P. longum Linn) peppers increased the AUC of phenytoin, propranolol and theophylline in healthy volunteers and plasma concentrations of rifamipicin (rifampin) in patients with pulmonary tuberculosis.
		Piperine was found to be cytotoxic towards DLA and EAC cells at a concentration of 250 microg/ml.
	www.raysahelian.com /piperine.html (525 words)

	Nutritional Supplement Bible - Piperine
		Additionally, the piperine found in fl pepper extract was found in a 1994 study to reduce cigarette craving by inhaling the vapor.
		Studies have proven that piperine does increase thermogenic activity as it increases the body's metabolic rate, which does help weight loss, but to canonize it as a weight loss aid is exaggeration at this point and requires more studies to validate that premise.
		I've been taking this multivitamin multimineral supplement with piperine for over a year and are very pleased with the results to our health.
	www.nutritional-supplement-bible.com /piperine.html (744 words)

	Homogeneous, free-flowing liquid black pepper oleoresin composition - Patent 4409257
		The piperine component is, of course, the component which is responsible for the "bite" of the pepper and, conventionally, fl pepper oleoresin is an extract of pepper produced by extracting the piperine, volatile oils and fixed oils from dried pepper pods by the use of a solvent, such as alcohol, acetone or ethylene dichloride.
		Since the piperine component is dissolved, it is completely dispersible in the food or beverage in which it is ultimately incorporated.
		The piperine content is commonly measured by a spectrophotometric procedure, as disclosed for instance in Food Chemical Code, 3rd Ed., 1981, p.
	www.freepatentsonline.com /4409257.html (2240 words)

	It:Piperine - ChemWiki (Site not responding. Last check: 2007-10-29)
		Piperine is a substance found naturally in plants belonging to the Piperaceae family, such as Piper nigrum L, commonly known as fl pepper.
		The chemical makeup of piperine was later isolated during laboratory synthesis in 1882 and 1894.
		Piperine is naturally a more yellowish powder, while after synthesis it has a stronger green tint to it.
	www.ch.ic.ac.uk /wiki/index.php?title=It:Piperine&redirect=no (873 words)

	MEDLINE_1996-2006 - Resultado de la búsqueda <página 1>
		Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice.
		The effect of piperine on the inhibition of lung metastasis induced by B16F-10 melanoma cells was studied in C57BL/6 mice.
		The elevated levels of serum sialic acid and serum gamma glutamyl transpeptidase activity in the untreated control animals was significantly reduced in the animals treated with piperine.
	www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1996-2006&exprSearch=12553376&indexSearch=UI&lang=e (247 words)

	Quest Health Library .com - Health Conditions, Vitamins, Minerals, Supplements, Herbs and more.
		This study was designed to evaluate the effectiveness of piperine on the bioavailability of drugs such as vasicine (brain stimulant) and sparteine (used to induce labour by stimulating the contraction of the womb).
		In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation was evaluated on the bioavailability of curcumin alone, serum levels were either undetectable or very low.
		Concomitant administration of piperine 20 mg produces much higher concentrations from 0.25 to 1 h post drug the increase in bioavailability was 2000%.
	www.questhealthlibrary.com /herbs/piperine (780 words)

	:: BIOPERINE :: - Peer Reviewed Articles (Site not responding. Last check: 2007-10-29)
		The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
		Vladimir Badmaev, M.D., Ph.D., Muhammed Majeed, Ph.D. and Edward P. Norkus Ph.D. The effectiveness of an extract from the fruit of fl pepper, consisting of a minimum of 98% pure alkaloid piperine was evaluated for its ability to improve serum response of beta-carotene during oral supplementation using a double-blind, crossover study design.
		Supplementation with beta-carotene plus piperine for 14 days produced a 60% greater increase in area under the serum beta- carotene curve (AUC) than was observed during supplementation with beta-carotene plus placebo.
	www.bioperine.com /reviewed_articles.htm (712 words)

	Piperine - LoveToKnow 1911
		PIPERINE, C17H,9N03, an alkaloid found in the fruits of Piper nigrum and P.
		The synthesis of piperine follows from the interaction of piperyl chloride (formed from piperic acid and phosphorus pentachloride) and piperidine (L. Rugheimer, Ber., 1882, 15, p.
		This page was last modified 03:03, 30 Aug 2006.
	www.1911encyclopedia.org /Piperine (322 words)

	Piperine Report
		Piperine, is a patent-pending form of "Bioperine" which has been proved in medical trials and research to enhance the body’s natural thermogenic activities.
		Piperine increases the body's thermogenic activity, which is directly related to the process of generating energy in the cells.
		Piperine increases the much needed thermal energy mass (biophysics) on a molecular cellular basis by increasing the energy supply that is now pouring or flooding across the once defective intestinal lining and barrier, of a sick or aged patient; on to the liver with direct operations related to Thermogenesis.
	www.cochranfoundation.com /reports/piperin.htm (1486 words)

	:: Sabinsa Corporation ::
		Bioperine is a pure piperine extract obtained from fl pepper fruits that are cultivated in the damp, nutrient rich soil regions of southern India.
		The extract of piperine, in the patent pending form of Bioperine, has been clinically tested in the United States and shown to significantly enhance the bioavailability of various supplemented nutrients through increased absorption.
		If piperine were to remain captive in the form of raw fl pepper, its bioavailability enhancing properties would be liberated much too late to have any effect on nutrient absorption.
	www.sabinsa.com /bioperin_bro.htm (798 words)

	Indian Spices and Chinese Market
		Incubation of Piperine or safrole with dithionite or NADPH-reduced microsomes from untreated rats resulted in a modified type II difference spectrum with absorption maximum at 427nm and a trought at 408nm.
		With oral administration of Piperine to rats at 170mg/kg level, the metabolites in urine showed piperonylic acid, piperonyl alcohol, pipernol and vanillia in free form in 0-96 hours, while metabolites in bile showed only piperic acid in 0-96 hours.
		On administration of Piperine to male albino rats, 97% was absorbed irrespective of mode of dosing.
	www.indianspices.com /html/s1308mup.htm (920 words)

	Fyi: Bioperine Concerns - Mind and Muscle Forums
		Piperine is "a potent inhibitor of UDP-GDH [UDP-glucose dehydrogenase (UDP-GDH)]” and of "glucuronidation potentials of rat and guinea pig liver and intestine" [1].
		Oral administration of piperine in rats strongly inhibited the hepatic AHH [arylhydrocarbon hydroxylase] and UDP-glucuronyltransferase activities." [2] "Piperine caused a concentration-related decrease in UDP-glucuronic acid content and the rate of glucuronidation in the [intestinal] cells.
		Piperine is a pure, pungent alkaloid constituent of fl and long peppers (piper nigrum and piper longum), which is a most common spice used throughout the world.
	www.mindandmuscle.net /forum/index.php?showtopic=23700 (3645 words)

	Pattaraporn Khongboon (Site not responding. Last check: 2007-10-29)
		The effects of piperine at the doses of 10, 100 and 250 mg/kg BW on hepatic drug metabolizing enzyme activities were also studied.
		While, the inhibitory effect of piperine 10 mglkg BW feeding for 2, 4, and 8 weeks on fecal bacterial ß-glucuronidase activity was not observed.
		These finding indicate that piperine pretreatment at the doses of 10, 100 and 250 mg/kg BW could decrease the total number of ACF and the possible mechanism of its inhibitory effect on DMH-induced ACF formation may come from the direct effect of piperine on the fecal bacterial ß-glucuronidase.
	www.cri.or.th /~estm/abstract/sctx-4136705.htm (405 words)

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