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Topic: Piroxicam

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	MedlinePlus Drug Information: Piroxicam
		NSAIDs such as piroxicam may cause ulcers, bleeding, or holes in the stomach or intestine.
		Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints).
		Piroxicam is also sometimes used to treat gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints) and ankylosing spondylitis (arthritis that mainly affects the spine).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a684045.html (1221 words)

	Piroxicam
		Piroxicam is used in acute gout attacks and in cases of dysmenorrhoea.
		In adults Piroxicam is administered orally in daily dose of 20 mg, given as a single daily dose or divided in two doses of 10 mg each.
		Piroxicam has a high affinity to the plasma proteins and due to this fact the concurrent administration with coumarin anticoagulants, sulfonamides, nelidix acid, oral antidiabetic agents, triiodothyronine, cyclophosphamide, and digoxin can lead to an increase in their plasma levels.
	www.sopharma.com /piroxicam.phtml (545 words)

	Piroxicam - Wikipedia, the free encyclopedia
		Piroxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component.
		It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.
		Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor.
	en.wikipedia.org /wiki/Piroxicam (145 words)

	Piroxicam in postoperative pain (Site not responding. Last check: 2007-10-24)
		Piroxicam 20 mg is not associated with increased adverse effects in single dose administration.
		Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) which is used mainly in the treatment of rheumatic disorders.
		Inclusion criteria were randomised, double-blind, placebo controlled trials of piroxicam in postoperative pain; adult patients; baseline pain of moderate to severe intensity; oral and/or intramuscular administration; pain outcome at least four hours.
	www.jr2.ox.ac.uk /bandolier/booth/painpag/Acutrev/Analgesics/AP026.html (376 words)

	GNC - HealthNotes - Piroxicam
		Piroxicam is used to treat rheumatoid arthritis and osteoarthritis.
		Until more is known, people taking piroxicam for long periods should have their blood checked regularly for high potassium levels and may need to avoid high potassium intake with the guidance of a health practitioner.
		Piroxicam may prevent inflammation by blocking the activity of enzymes that depend on folic acid.
	www.gnc.com /health_notes/healthnotes.aspx?ContentID=1463008 (565 words)

	PetPlace.com - Article: Piroxicam (Feldene®)
		Piroxicam has been used in combination with other drugs to treat transitional cell carcinoma, a bladder cancer in dogs.
		Piroxicam should not be used in animals with known hypersensitivity or
		Piroxicam should be avoided in animals with a history of bleeding, inflammation or perforation of the stomach or intestinal mucosa (lining).
	petplace.netscape.com /netscape/nsArtShow.asp?artID=1535 (438 words)

	Piroxicam (Site not responding. Last check: 2007-10-24)
		This is a graph of the molar extinction coefficient of Piroxicam dissolved in hexane.
		This is the fluorescence emission spectrum of Piroxicam dissolved in hexane.
		The quantum yield is 0.035 [M. Yoon, H. Choi, H. Kwon, and K. Park, "Solvent dependence of absorption and fluorescence spectra of piroxicam.
	omlc.ogi.edu /spectra/PhotochemCAD/html/piroxicam.html (221 words)

	Piroxicam topical - Patient UK
		Piroxicam is used to relieve pain and inflammation in the muscles, tendons and joints, it is also used for pain caused by rheumatism.
		Piroxicam works by reducing the effect of irritant chemicals which are produced by the body as a response to inflammation.
		Piroxicam may cause your skin to become more sensitive to sunlight than it is usually.
	www.patient.co.uk /showdoc/30003698 (697 words)

	[No title] (Site not responding. Last check: 2007-10-24)
		The handling of piroxicam is complicated due to its possible tautomeric switches and polymorphism.
		Moreover, since the dissolution profile is strictly dependent on the intramolecular structure assumed by piroxicam in the inclusion compound, the manufacturing process should be able to achieve the complete conversion of piroxicam in the zwitter-ionic form.
		A 1: 2.5 piroxicam: P-cyclodextrin inclusion compound obtained by the process of claims 1 to 5, characterized by the Raman spectrum of Figure 1.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=03/105906.031224&ELEMENT_SET=DECL (2850 words)

	Tenoxicam, piroxicam, diclofenac and indomethacin for osteoarthritis (Site not responding. Last check: 2007-10-24)
		A study to determine the efficacy of safety and tenoxicam versus piroxicam, diclofenac and indomethacin in patients with osteoarthritis: a meta-analysis.
		When tenoxicam was compared with piroxicam, the relative benefit was 1.1 (1 to 1.2) and the number-needed-to-treat was 12 (7 to 54) for successful treatment, suggesting no benefit of tenoxicam over piroxicam.
		When tenoxicam was compared with piroxicam, the relative benefit was 1.1 (1 to 1.1) and the number-needed-to-treat was 20 (11 to 243) for successful treatment, suggesting no difference between tenoxicam and piroxicam.
	www.jr2.ox.ac.uk /bandolier/booth/painpag/Chronrev/OARA/CP010.html (717 words)

	piroxicam - Arthritis and arthritic conditions, medications, and treatment on MedicineNet.com
		PRESCRIBED FOR: Piroxicam is used for the treatment of inflammation and pain that results from rheumatoid arthritis and osteoarthritis.
		Piroxicam is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding.
		Piroxicam is best discontinued at least five days in advance of the procedure.
	www.medicinenet.com /piroxicam/article.htm (579 words)

	Single dose piroxicam for acute postoperative pain (Site not responding. Last check: 2007-10-24)
		Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties, and is used mainly for treating rheumatic disorders.
		For single doses of piroxicam 20 mg and 40 mg the respective numbers-needed-to-treat for at least 50% pain relief were 2.7 (2.1 to 3.8) [95% confidence interval] and 1.9 (1.2 to 4.3) [95% confidence interval] compared with placebo over 4-6 hours in moderate to severe postoperative pain.
		Piroxicam appears to be of similar efficacy to other non-steroidal anti-inflammatory drugs (NSAIDs) and intramuscular morphine 10 mg when used as a single oral dose in the treatment of moderate to severe postoperative pain.
	www.cochrane.org /reviews/english/ab002762.html (523 words)

	Feldene Capsules Drug Information Feldene Capsules
		Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid and most organic solvents.
		Ninety-nine percent of plasma piroxicam is bound to plasma proteins.
		Experiments in dogs have demonstrated that the use of multiple-dose treatments with activated charcoal could reduce the half-life of piroxicam by more than 50% and systemic bioavailability by as much as 37% when activated charcoal is given as late as 6 hours after ingestion of piroxicam.
	www.drugs.com /PDR/Feldene_Capsules.html (3716 words)

	Health Library - (Site not responding. Last check: 2007-10-24)
		Piroxicam is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis.
		Piroxicam should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart.
		If you are taking piroxicam as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.
	yalenewhavenhealth.org /library/healthguide/en-us/drugguide/topic.asp?hwid=d00343a1 (1297 words)

	Piroxicam - Patient UK
		Piroxicam is used to relieve pain and inflammation in rheumatic disease including juvenile arthritis, sprains, strains, backache and gout.
		Piroxicam works by preventing the production of irritant chemicals that cause pain and inflammation in the body.
		Piroxicam is available in capsule, tablet, dispersible tablet, melt-in-the-mouth tablet, suppository, gel and injection form.
	www.patient.co.uk /showdoc/30002275 (848 words)

	Piroxicam
		Piroxicam might have completely faded into obsolescence were it not for possible anti-tumor effects found especially useful in the treatment of bladder cancers.
		Questions persist as to how piroxicam is able to suppress such tumors and currently it is believed that this effect relates to immune system related effects rather than direct action against the tumor cells.
		Piroxicam should not be used in combination with other COX-1 inhibiting drugs such as steroids or other NSAIDs.
	www.marvistavet.com /html/body_piroxicam.html (444 words)

	Piroxicam - Drugs & Vitamins - Drug Library - DrugDigest
		PIROXICAM (Feldene®) is a nonsteroidal anti-inflammatory drug (NSAID).
		It is especially important not to use piroxicam during the last 3 months of pregnancy unless specifically directed to do so by your health care provider.
		Piroxicam may cause problems in the unborn child or complications during delivery.
	www.drugdigest.org /DD/DVH/Uses/0,3915,550\|Piroxicam,00.html (873 words)

	[No title]
		Jpn J Cancer Res 1997 Jun;88(6):543-552 The effects of the non-steroidal anti-inflammatory drug (NSAID) piroxicam and the carotenoids lycopene and beta-carotene, alone or in combination, on the development of rat superficial urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were studied.
		Male Fischer 344 rats, 6 weeks old, were given 0.05% BBN in the drinking water for 8 weeks followed by administration of piroxicam (0.0075% in the diet), lycopene (0.0025% in the drinking water) and/or beta-carotene (0.0025% in the drinking water) for 12 weeks, then killed for histological analysis of urinary bladder lesions.
		Piroxicam alone, piroxicam+lycopene, and piroxicam +lycopene+ beta-carotene all significantly decreased the incidences and numbers of transitional cell carcinomas (TCCs), but the combination of piroxicam with carotenoids did not result in a clear improvement in the preventive potential of piroxicam.
	www.lycopene.org /documents/doc/3455Blad1989-2002.doc (1692 words)

	Public Citizen \| Publications - Testimony of Sidney M. Wolfe, MD, Before the FDA Arthritis Advisory Committee on the ...
		The petition we filed in December, 1994, to entirely ban piroxicam was largely based on a series of eight published case-control epidemiological studies comparing piroxicam to other NSAIDs, all of which were published after our 1986 petition, including five published in 1993 or 1994.
		Between the first marketing of piroxicam in 1982 and July, 1994, according to data obtained from FDA, there were 299 deaths reported in people using piroxicam, including 144 people whose deaths were related to serious gastrointestinal (GI) complications such as ulcers, perforations or bleeding.
		Piroxicam should not be used just because of its once-a-day convenience for patients, all of whom could use low doses of other NSAIDs or other safer alternatives to piroxicam.
	www.citizen.org /publications/release.cfm?ID=5568 (936 words)

	Transmucosal Permeation of Topically Applied Diclofenac and Piroxicam
		Diclofenac and piroxicam are sparingly soluble in water, hence their release is favored from aqueous solutions and hydrophilic bases such as gels, which are poor solvents for these drugs.
		The pKa-value of diclofenac is 4, whereas that of piroxicam is 6.3 (dioxane:water 2:1).27 At the pH values of the PBS buffer system used in this study, ie, 7.4, approximately 99.9% of the diclofenac and approximately 92.6% of the piroxicam are present in their dissociated forms.
		The net effect of these complex interactions between the constituents of the mucosa, piroxicam, and the components of the donor vehicle that might enhance drug permeability or retain it in the formulation are difficult to predict.
	www.jrnlappliedresearch.com /articles/Vol3Iss3/VanDerBikl.htm (3087 words)

	Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers: [Un gel de ...
		Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers: [Un gel de piroxicam, compare a une creme EMLA, est associe a moins de douleur apres une canulation veineuse chez des volontaires] -- Dutta et al.
		Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers
		Occurrence of erythema and edema with EMLA or with piroxicam
	www.cja-jca.org /cgi/content/full/50/8/775 (1342 words)

	PIROXICAM
		PIROXICAM may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
		Caution is advised when using PIROXICAM in the elderly because they may be more sensitive to the effects of the drug.
		PIROXICAM should be used only when clearly needed during pregnancy.
	piroxicam.health-effects.net (696 words)

	Inhibition of acid secretion by the nonsteroidal anti-inflammatory drugs diclofenac and piroxicam in isolated gastric ...
		piroxicam or diclofenac in the assay mixture caused a dose-dependent
		Binding of voltaren and piroxicam with the membranes of erythrocyte ghosts and liposomes.
		Effects of the nonsteroidal anti-inflammatory drug piroxicam on energy metabolism in the perfused rat liver.
	ajpgi.physiology.org /cgi/content/full/286/5/G711 (6208 words)

	Chemopreventive Efficacy of Combined Piroxicam and Difluoromethylornithine Treatment of Apc Mutant Min Mouse Adenomas, ... (Site not responding. Last check: 2007-10-24)
		Mice were treated with piroxicam mixed in the diet at dosages of 0, 25, 50, or 100 ppm beginning soon after weaning at age 30 days; treatment was continued until death at age 90 days when blood plasma was collected for assay of platelet thromboxane B
		Mice were treated with piroxicam mixed in the diet and/or DFMO mixed in the drinking water at the dosages indicated beginning soon after weaning at age 30 days; treatment was continued until death at age 90 days.
		Piroxicam Is an Ineffective Inhibitor of N-Nitrosomethylbenzylamine-induced Tumorigenesis in the Rat Esophagus
	cancerres.aacrjournals.org /cgi/content/full/60/7/1864 (5931 words)

	Piroxicam Pain Pharmatia Pharmacy: drugs & medicines
		If you drink more than three alcoholic beverages a day, piroxicam may increase the risk of dangerous stomach bleeding.
		* Piroxicam is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by arthritis.
		Piroxicam may increase the sensitivity of the skin to sunlight.
	pharmatia.net /pain/piroxicam.php (1615 words)

	BestBETs: Intramuscular piroxicam is better than Intramuscul... (Site not responding. Last check: 2007-10-24)
		You wonder if an alternative NSAID, piroxicam, given by the IM route would be as effective as the diclofenac you are reluctant to give.
		[exp piroxicam OR piroxicam.mp OR feldene.mp] AND [exp diclofenac OR diclofenac.mp OR voltarol.mp] AND [exp kidney calculi OR exp Ureteral calculi OR renal colic.mp]
		Al-Waili NS and Saloom KY. Intramuscular piroxicam versus intramuscular diclofenac sodium in the treatment of acute renal colic: double-blind study.
	www.bestbets.org /cgi-bin/bets.pl?record=00249 (331 words)

	Piroxicam - VeterinaryPartner.com - a VIN company!
		There are a plethora of products including over the counter for routine aches and pains (aspirin, ibuprofen, ketoprofen, etc.) and stronger prescription products (celecoxib, rofecoxib, etc.) Piroxicam is one of the prescription products for human use.
		Currently, COX-2 selective NSAIDs are available and medications such as piroxicam have become less popular. Piroxicam might have completely faded into obsolescence were it not for possible anti-tumor effects found especially useful in the treatment of bladder cancers.
		Piroxicam is also used in some cases of feline lower urinary tract disease that have been refractory to other therapies. Cats seem to be especially sensitive to NSAID side effects, so this would be considered a last resort treatment for cats.
	www.veterinarypartner.com /Content.plx?P=A&A=1560&S=1&SourceID=52 (518 words)

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