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Topic: Placebo

Related Topics

Placebo effect

Randomized controlled trial

Clinical trial

Cohort study

Oral contraceptive pill

Experiment

Hawthorne effect

Testing statistical hypotheses

Contraceptive pill

Pharmacodynamics

FDA

Pharmacokinetics

Statistical assumptions

Informed consent

Statistical inference

In the News (Mon 23 Nov 09)

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	PlaceboWorld
		Placebo have parted company with drummer of 11 years, Steve Hewitt, due to personal and musical differences.
		Placebo have just returned from the USA where they were part of the high profile ‘Projekt Revolution Tour’ alongside Linkin Park and My Chemical Romance.
		Brian Molko and Stefan Olsdal will begin work on Placebo’s 6th studio album next Spring and are in no rush to find an immediate replacement for Steve.
	www.placeboworld.co.uk (312 words)

	The Mysterious Placebo (Skeptical Inquirer January 1997)
		Spontaneous remission and the placebo effect, which are known as nonspecific effects, are significant phenomena that have great impact on consumers and health-care professionals.
		Beecher's seminal paper "The Powerful Placebo" (Beecher 1955) is among the most frequently cited and was undoubtedly responsible for the double-blind study design having been adopted as the universal standard.
		In addition, placebos "need not always be beneficial and may be frankly toxic: dermatitis medicamentosa and angioneurotic edema (allergic-type reactions) have resulted from placebo therapy.
	www.csicop.org /si/9701/placebo.html (1117 words)

	placebo. The Columbia Encyclopedia, Sixth Edition. 2001-05
		Placebo medications are sometimes prescribed when a drug is not really needed or when one would not be appropriate because they make patients feel well taken care of.
		A traditional placebo’s lack of side effects, however, often identifies it, so an older drug is sometimes used in drug tests instead of or in addition to a placebo.
		The “placebo effect” is an apparent improvement in health due not to any treatment but only to the patient’s belief that he or she will improve (as by taking a dummy pill that is thought to be a cure).
	www.bartleby.com /65/pl/placebo.html (262 words)

	placebo effect
		A placebo (Latin for "I shall please") is a medication or treatment believed by the administrator of the treatment to be inert or innocuous.
		Whether the placebo effect is mainly psychological, misunderstood spontaneous healing, due to showing care and attention, or due to some combination of all three may not be known with complete confidence.
		Their meta-study of 114 studies involving placebos found "little evidence in general that placebos had powerful clinical effects...[and]...compared with no treatment, placebo had no significant effect on binary outcomes, regardless of whether these outcomes were subjective or objective.
	www.skepdic.com /placebo.html (2424 words)

	placebo effect
		A placebo (Latin for "I shall please") is a medication or treatment believed by the administrator of the treatment to be inert or innocuous.
		Whether the placebo effect is mainly psychological, misunderstood spontaneous healing, due to showing care and attention, or due to some combination of all three may not be known with complete confidence.
		Their meta-study of 114 studies involving placebos found "little evidence in general that placebos had powerful clinical effects...[and]...compared with no treatment, placebo had no significant effect on binary outcomes, regardless of whether these outcomes were subjective or objective.
	skepdic.com /placebo.html (2424 words)

	Placebo Effect
		The "placebo effect is an improvement in health due not to any treatment but only to the patient's belief that he or she will improve (as by taking a dummy pill that is thought to be a cure).
		The placebo effect is the measurable or observable effect on a person or group that has been given a placebo treatment.
		A placebo is an inert substance, or "fake" surgery or therapy, used as a control in an experiment or given to a patient for its possible or probable beneficial effect.
	www.angelfire.com /hi/TheSeer/placebo.html (1621 words)

	PLACEBO: STARRING YOU
		The deadline for submitting videos has passed, and Placebo will only be using videos that were submitted before 11:59 pm on April 13th.
		Placebo and Capitol Records were very excited by all of the passion and effort that went into each and every fan video.
		Come back and visit the Placebo Group to connect with other fans and comment on their videos.
	about.motionbox.com /placebo/mb_placebo.html (339 words)

	Placebo Effects Prove the Value of Suggestion
		A placebo, as used in research, is an inactive substance or procedure used as a control in an experiment.
		A placebo effect occurs when the placebo, which cannot on its own merit have any affect, does in fact have the same or similar affect as the experimental substance or procedure.
		The placebo effect has been reported in just about every research situation in which placebos were used, and in many circumstances where the use of placebos was not intended but the effect was the same anyway.
	www.bcx.net /hypnosis/placebo.htm (1638 words)

	Placebo effect - Better Health Channel.
		The placebo effect is triggered by the person's belief in the treatment and their expectation of feeling better, rather than the specific form the placebo takes.
		A remission during a course of placebos may be coincidence, and not due to the placebos at all.
		Critics of placebos maintain that deception is wrong, regardless of whether the deceived patient experiences an end to their symptoms.
	www.betterhealth.vic.gov.au /bhcv2/bhcarticles.nsf/pages/Placebo_effect?OpenDocument (1124 words)

	Spontaneous Remission and the Placebo Effect
		In medicine the effect of suggestion is referred to as the "placebo effect." The Latin word placebo means "I shall please." A placebo effect is a beneficial response to a substance, device, or procedure that cannot be accounted for on the basis of pharmacologic or other direct physical action.
		This design cannot distinguish an effect of placebo from the natural course of the disease, regression to the mean (the tendency for random increases or decreases to be followed by observations closer to the average), or the effects of other factors.
		Placebos appeared to produce modest benefit in studies of pain and in other studies where the outcome being measured was similarly subjective.
	www.quackwatch.org /04ConsumerEducation/placebo.html (1811 words)

	Placebo Effect: The Power of the Sugar Pill
		In these trials a placebo is obligatorily administered to a control group of patients, and later the results of this group are compared with those obtained in the group that receives the active medicine, whose action one intends to demonstrate.
		We could then define placebo effect as the therapeutically positive (or negative) result of expectations implanted in the nervous system of the patients, through conditioning, consequent to the prior use of medicines, contacts with doctors, and information obtained by means of reading and remarks of other people.
		To conclude, we remind that some authors consider that the placebo effect has a dark side, because the cures due to it favor the perpetuation of the use of ineffective and irrational medicinal therapeutic procedures, as those used in the so-called "alternative medicine".
	www.cerebromente.org.br /n09/mente/placebo1_i.htm (2166 words)

	Placebo + Six By Seven @ Brixton Academy, London : gig review
		Placebo did have the advantage of a significantly larger performing space - when the fl tab was hauled down we were agog at the sheer size of The Academy's stage.
		There was never any real doubt that the new Placebo album would dominate proceedings and thus it proved, with a string of heavy guitar songs unwound to put Six By Seven to shame.
		That song will stand as Placebo's finest moment for some time, for while the new material is inoffensive it is also rather forgettable compared to what went before.
	www.musicomh.com /gigs/placebo.htm (816 words)

	PlaceboWorld: News
		Placebo's cover of Kate Bush's classic song 'Running Up That Hill' was featured at the end of the brand new episdoe that aired on the Fox Channel at 7pm in the USA December 13th.
		Placebo's cover of the Kate Bush classic 'Running Up That Hill', has been picked to feature in the first episode of the new season of The OC, which will be broadcast tonight in the USA.
		Placebo very much regret having to cancel a show and are aware how disappointing this is for the fans who’ve bought tickets and have been waiting a long time to see the band.
	www.placeboworld.co.uk /news/index.html (2918 words)

	frontline: the alternative fix: snake oil: the placebo effect \| PBS
		Allopathic doctors have tended to see the placebo as something that is useless in their practice, and believe, in fact, that is unethical to give because it's a kind of deception.
		Placebo responses are pure healing responses from within that are elicited by belief.
		It's a large placebo dose, if you will...There's a psychiatrist, Walter Brown, who studies depression and was fascinated by the placebo.
	www.pbs.org /wgbh/pages/frontline/shows/altmed/snake/placebo.html (1009 words)

	Medicinal Mimicry: Science News Online, Feb. 3, 2001 (Site not responding. Last check: )
		Scientists at the conference reported findings suggesting that response to a placebo may rest on both the meaning that a person associates with a particular treatment and his or her previous experience with medication.
		The placebo response is both a conscious response to the meaning of therapy and a conditioned response to treatment from a health professional, some researchers contend.
		To see whether a placebo could elicit a conditioned response from the mice, Ader followed the sweet drink in the third group with injections of cyclophosphamide or saline in a random pattern such that each mouse got two doses of the active drug in a month.
	www.sciencenews.org /articles/20010203/bob9.asp (2507 words)

	Therapeutic Placebo Effect by P Kinser
		We most often hear of placebos in clinical tests of new medications or treatments, where one group in the study is given the actual medication and the other receives a placebo which feels, tastes, appears exactly like the drug.
		The placebo group's reactions to the placebo serve as a base-line against which the effects of the drug can be studied.
		However, studies of the exact physiological mechanism of the placebo effect are rare and difficult, especially when in most cases the use of a placebo is to test the effect of another drug.
	serendip.brynmawr.edu /bb/neuro/neuro99/web1/Kinser.html (1871 words)

	Wired News: Why Sugar Pills Cure Some Ills
		The brain is a "crucial player," said Leitner during a workshop on placebos at a February meeting of the American Association for the Advancement of Science.
		Several patients who took placebos felt better, and the scans showed their brains reacted like those of subjects in the antidepressant group, but not those who went through "talk" therapy.
		In other words, placebos seemed to work on the parts of the brain that are also affected by actual drugs.
	www.wired.com /news/medtech/0,1286,62296,00.html (703 words)

	MDD July/August 1999: The Mysterious Placebo Effect
		Researchers still may be inclined to view placebo effects as a nuisance or as a background noise that complicates clinical trial design.
		This is particularly true in crossover trials, she said, when participants are informed that they will receive placebo at some point in the trial, as opposed to being told simply that they may receive a placebo at some point in the study.
		One alternative is a “putative placebo trial”, in which the new drug is compared with a standard thrombolytic; in that case, the difference between the two is compared with that 2% or 2.5%.
	pubs.acs.org /hotartcl/mdd/99/aug/mysterious.html (2508 words)

	BBC NEWS \| Health \| Acupuncture 'more than a placebo'
		Sceptics have said that any benefits gained from acupuncture are merely down to a person's expectation that the treatment will work.
		Their findings, based on a series of experiments and brain scan results, are published in the journal NeuroImage.
		This was a pathway known to be associated with acupuncture treatment and thought to be involved in pain modulation.
	news.bbc.co.uk /1/hi/health/4493011.stm (485 words)

	NIH Guide: THE PLACEBO EFFECT IN CLINICAL PRACTICE
		Placebo effects can be defined as the positive physiological or psychological changes associated with the use of inert medications, sham procedures, or therapeutic symbols within a healthcare encounter.
		Placebo effects may also be viewed as a subset of a larger group of mind-brain-body effects such as the psycho- physiological effects of religious beliefs and devotional practices, meditation, faith-based healing, hypnosis, and the effects of cultural and social economic systems on the prevalence and severity of specific diseases.
		Participants in the “Science of the Placebo” meeting discussed a number of methodological and ethical issues that needed to be addressed related to the use of placebo controls in clinical trials.
	grants.nih.gov /grants/guide/rfa-files/RFA-AT-02-001.html (3862 words)

	FDA Approves Sale Of Prescription Placebo \| The Onion - America's Finest News Source
		In its most common form, placebo is a white, crystalline substance of a sandy consistency, obtained from the evaporated juice of the Saccharum officinarum plant.
		According to Bergen, initial research has shown placebo to be effective in the treatment of bipolar disorder, depression, dysthymia, panic disorder, post traumatic stress disorder, seasonal affective disorder, and stress.
		As industry analysts predict the drug's sales will top $25 billion in the first year, the approval of placebo is expected to unleash one of the pharmaceutical industry's biggest marketing battles to date.
	www.theonion.com /content/node/39082 (793 words)

	Official Ticketmaster site. Placebo tickets, dates
		The album was a surprise hit in the U.K., where such singles as "Nancy Boy" and "Bruise Pristine" became hits, as the group became the toast of the British music weeklies and supported their debut with opening for such outfits as a the reunited Sex Pistols, U2, and Weezer.
		The relationship between Placebo and Bowie continued to blossom, as Bowie made a special appearance on-stage with the band during a tour stop in New York, in addition to both parties uniting for a re-recording of the title track from Without You I'm Nothing (issued as a single in 1999).
		Placebo's singles collection, Once More With Feeling: Singles 1996-2004 was released before the year's end.
	www.ticketmaster.com /artist/779705?brand=none (1016 words)

	UMHS Press Release: Thinking the pain away?
		As the researchers alerted participants that the placebo was coming, and injected the placebo dose, the amount of additional concentrated salt water needed to maintain participants' pain over time increased — indicating a reduction in pain sensitivity that the subjects were not aware of.
		Nine of the participants were classified as “high placebo responders” because they had more than a 20 percent difference between pain and placebo scans in their average pain ratings per volume of salt water infused — in other words, the placebo effect was strong.
		The power of placebos to ease pain symptoms has been well-documented in many groups of subjects and illnesses, but the researchers started with healthy young males to rule out the impact of chronic pain, mood disorders and hormone variations, which can also affect the endorphin system.
	www.med.umich.edu /opm/newspage/2005/placebo.htm (1384 words)

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