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Topic: Plasma cell


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  Plasma cell - Wikipedia, the free encyclopedia
Plasma cells (also called plasma B cells or plasmocytes) are cells of the immune system that secrete large amounts of antibodies.
They differentiate from B cells upon stimulation by an antigen and are the principal effector cells involved in humoral immunity.
Plasma cells are large lymphocytes with a large cytoplasm-to-nucleus ratio and a characteristic appearance on light microscopy.
en.wikipedia.org /wiki/Plasma_cell   (332 words)

  
 Cell Membranes   (Site not responding. Last check: 2007-10-09)
The plasma membrane serves as the interface between the machinery in the interior of the cell and the extracellular fluid (ECF) that bathes all cells.
Phospholipids are amphiphilic with the hydrocarbon tail of the molecule being hydrophobic; its polar head hydrophilic.
Furthermore, those that project into the aqueous surroundings of the cell are usually glycoproteins, with many hydrophilic sugar residues attached to the part of the polypeptide exposed at the surface of the cell.
users.rcn.com /jkimball.ma.ultranet/BiologyPages/C/CellMembranes.html   (446 words)

  
 [No title]   (Site not responding. Last check: 2007-10-09)
Plasma Cell Myeloma (Multiple vs. Solitary) (median survival—3 years) Multiple Myeloma is characterized by multiple neoplastic tumorous masses of plasma cells located in the bone marrow and scattered throughout the skeletal system.
This is considered to be a disease of hematopoietic stem cells that differentiates predominantly along the B cell-plasma cell pathway.
The proliferation and differentiation of the neoplastic plasma cells is dependent on IL-6.
www.muhealth.org /~md2003/draftnotes/11-15plasma.doc   (1489 words)

  
 Glossary
Protein produced by a plasma cell that is generated in reaction to a foreign protein (antigen), thus producing an immunity against that protein; also known as an immunoglobulin.
Protein produced by a plasma cell that is generated in reaction to a foreign protein (antigen), thus producing an immunity against that protein; also known as an antibody.
Medication that stimulates the growth of cells found in the oral cavity and skin and reduces the duration and severity of oral mucositis (inflammation of the lining of the digestive tract) after intensive chemotherapy and radiotherapy for hematologic cancers.
www.multiplemyeloma.org /about_myeloma/2.10.02.html   (5841 words)

  
 THE MERCK MANUAL, Sec. 11, Ch. 140, Plasma Cell Dyscrasias   (Site not responding. Last check: 2007-10-09)
Plasma cell dyscrasias: A group of clinically and biochemically diverse disorders of unknown etiology characterized by the disproportionate proliferation of one clone of B cells and the presence of a structurally and electrophoretically homogeneous (monoclonal) immunoglobulin or polypeptide subunit in serum or urine.
Plasma cell dyscrasias vary from asymptomatic, apparently stable conditions (in which only the protein is present) to clinically symptomatic and progressive neoplasms (eg, multiple myeloma).
Plasma cell dyscrasias are classified in Table 140-1.
www.merck.com /pubs/mmanual/section11/chapter140/140a.htm   (346 words)

  
 Plasma Cell Neoplasm - July 2001: 707420   (Site not responding. Last check: 2007-10-09)
In 29 stem cells harvests and 19 BM samples obtained 3 months after autologous transplantation, we have investigated the presence of residual myelomatous PC; they were detected in 44% of the stem cell collections and in 61% of the BM samples obtained after transplant.
Plasma cell leukemia is also a rare form of plasma cell dyscrasia (2% to 4% of all myelomas).
In particular, a semiquantitative score of the extension and intensity of bone marrow uptake was derived and correlated with both the clinical status of the disease and plasma cell bone marrow infiltration.
www.acor.org /cnet/707420.html   (12552 words)

  
 Plasma Cell Neoplasia   (Site not responding. Last check: 2007-10-09)
As fully mature B-lymphocytes, plasma cells have acquired the complex skill of producing immunoglobulin molecules, better known as antibodies.
The clue to this mystery is that malignant plasma cells have probably matured from a malignant, less terminally differentiated precursor that is their proliferating and circulating source.
These plasma cells may be morphologically identical to their benign, mature counterparts or they may have various immature or blastic features such as large nuclei, prominent nucleoli or fine chromatin (see marrow aspirate smears).
pleiad.umdnj.edu /hemepath/pc/pc.html   (1062 words)

  
 Hematology Plasma cell   (Site not responding. Last check: 2007-10-09)
A plasma cell is a mature B lymphocyte that is specialized for antibody (immunoglobulin) production.
Plasma cells are rarely found in the peripheral blood.
Plasma cells are seen in multiple myeloma, plasma cell leukemia, Waldenström's macroglobulinemia, and MGUS (monoclonal gammopathy of uncertain significance.
www.wadsworth.org /chemheme/heme/microscope/plasmacell.htm   (161 words)

  
 Introduction: Plasma Cell Disorders: Merck Manual Home Edition
Plasma cell disorders (plasma cell dyscrasias) are uncommon.
Plasma cells develop from B lymphocytes, a type of white blood cell, and normally produce antibodies (immunoglobulins), which help the body fight infection.
In plasma cell disorders, one clone of plasma cells multiplies uncontrollably; as a result, this clone produces vast amounts of a single antibody (monoclonal antibody) known as the M-protein.
www.merck.com /mrkshared/mmanual_home2/sec14/ch175/ch175a.jsp   (304 words)

  
 Multiple myeloma and other plasma cell neoplasms
Plasma cell neoplasms are diseases in which certain cells in the blood (called plasma cells) become cancer.
Plasma cell neoplasms are grouped together depending on the type of plasma cell cancer that is found.
Plasma cell tumors are found only outside the bone and the bone marrow in the soft tissues, usually the tonsils or tissues around the nose.
cancerweb.ncl.ac.uk /cancernet/210392.html   (2126 words)

  
 Archives of Pathology & Laboratory Medicine: Plasma cell granuloma of the thyroid: A case report and review of the ...   (Site not responding. Last check: 2007-10-09)
We report a case of plasma cell granuloma of the thyroid in a 46-year-old woman with a 20-year history of euthyroid goiter and a positive family history of goiter in 3 close relatives.
Plasma cell granuloma (PCG) of the thyroid is an uncommon lesion; a search of the English literature identified only 6 previously reported cases.
Inflammatory myofibroblastic tumor encompasses a heterogeneous group of benign tumors characterized by various degrees of myofibroblastic proliferation and chronic inflammation.1 Plasma cell granuloma of the thyroid, on the other hand, is characterized by diffuse infiltration of the thyroid parenchyma by a benign plasmacytic infiltrate without myofibroblastic infiltration.
www.findarticles.com /p/articles/mi_qa3725/is_200205/ai_n9067136   (453 words)

  
 Plasma Cell Pododermatitis
Plasma Cell Pododermatitis is a foot pad disease of the cat which is fairly classical in its appearance yet its significance is poorly understood as many affected cats do not require therapy.
The fact that this cell of the active immune system is involved in this condition implies some sort of immune stimulation in the genesis of the disease.
Understanding of Plasma Cell Pododermatitis has not progressed far enough to begin to suggest what sort of stimulation this might be.
www.marvistavet.com /html/body_plasma_cell_pododermatitis.html   (389 words)

  
 Ear, Nose & Throat Journal: Plasma cell granuloma of the thyroid with Hashimoto's thyroiditis: report of a rare ...   (Site not responding. Last check: 2007-10-09)
As only eight cases have been previously reported in the literature, plasma cell granuloma of the thyroid gland is a rare entity.
Plasma cell granuloma is a non-neoplastic proliferation of polyclonal plasma cells within a fibrous stroma.
Plasma cell granuloma usually occurs in the lungs, but cases of extrapulmonary manifestations have been documented in multiple organs.
www.findarticles.com /p/articles/mi_m0BUM/is_1_82/ai_97754547   (520 words)

  
 B Cells and T Cells   (Site not responding. Last check: 2007-10-09)
Repeated mitosis leads to the development of a clone of cells bearing the same antigen receptor; that is, a clone of cells of the identical specificity.
T cells is to monitor all the cells of the body, ready to destroy any that express foreign antigen fragments in their class I molecules.
T cells bind an epitope consisting of an antigen fragment lying in the groove of a class II histocompatibility molecule.
users.rcn.com /jkimball.ma.ultranet/BiologyPages/B/B_and_Tcells.html   (1889 words)

  
 Plasma Cell Neoplasm - June 2001: 706420   (Site not responding. Last check: 2007-10-09)
AB - Originating from a post-switch memory B cell or plasma cell compartment in peripheral lymphoid tissues, malignant myeloma cells accumulate in the bone marrow of patients with multiple myeloma.
In addition, we show that HA-mediated survival and proliferation of myeloma cells is associated with a down-regulation in the expression of p27(kip1) cyclin-dependent kinase inhibitor and a hyperphosphorylation of the retinoblastoma protein (pRb).
In plasma cell tumors such as multiple myeloma the repression of MHC-II is associated with the loss of CIITA.
www.acor.org /cnet/706420.html   (6628 words)

  
 Plasma Membrane1   (Site not responding. Last check: 2007-10-09)
Image of Plasma Membrane - A large cartoon image of a cell membrane, followed by an in depth discussion on each component making up the membrane, the chemical compounds present, and the mechanisms which the plasma membrane carries out.
The plasma membrane forms a small pocket or infolding around the material to be internalized.
A vesicle forms after the cell pinches off the infolded membrane, and the enclosed materials are then sorted to the interior of the cell.
darwin.nmsu.edu /~molbio/cell/PM.html   (1098 words)

  
 AllRefer Health - Multiple Myeloma (Malignant Plasmacytoma, Plasma Cell Dyscrasia, Plasma Cell Myeloma, Plasmacytoma of ...
Multiple myeloma is a cancer of the plasma cells in bone marrow.
Multiple myeloma is characterized by the excessive growth and malfunction of plasma cells in the bone marrow.
This causes anemia, susceptibility to infection, and increased tendencies toward bleeding.
health.allrefer.com /health/multiple-myeloma-info.html   (375 words)

  
 indiacancer.org - Plasma Cell Neoplasma   (Site not responding. Last check: 2007-10-09)
Plasma cells found only outside the bone and the marrow in the soft tissues, usually the tonsils or the tissues around the nose.
Plasma cells that produce a certain type of M-protein are circulating in the blood.
The stem cells are now treated with drugs to kill any cancer ingredient in them and are then cryogenically frozen until they can be transplanted to the patient.
www.indiacancer.org /coca/p/pcn.html   (1985 words)

  
 Multiple Myeloma
Plasma cells are the cells responsible for forming antibodies against bacteria and foreign proteins.
For reasons that are unclear, these cells lose their ability to respond to controlling signals from a hierarchy of immune cells.
Plasma cells then divide and form abnormal proteins, which results in damage to the bone, the bone marrow, and/or other organs of the body.
www.clevelandclinic.org /myeloma   (771 words)

  
 [No title]   (Site not responding. Last check: 2007-10-09)
Plasma Cell Dyscrasias Definition This spectrum of disorders refers to the neoplastic proliferation of a single clone of plasma cells (terminally differentiated B cells) with a resultant increase in serum levels of a single type of homogenous immunoglobulin or its fragments.
Robbins further states that 20% of these patients will develop in 10-15 years to one of the plasma cell dyscrasias (Myeloma, Macroglobulinemia or Amyloidosis) The levels of monoclonal proteins in these patients are generally followed for 30 years to monitor for increasing levels and progression to one of the plasma cell dyscrasias.
Heavy Chain Disease This disorder is characterized by neoplastic medullary and extramedullary infiltrates of plasma cells (usually IgG, A or M) and precursors that synthesize only heavy chains.
www.muhealth.org /~md2003/updatenotes/dyscrasia.doc   (1787 words)

  
 Plasma Cell Stomatitis   (Site not responding. Last check: 2007-10-09)
A biopsy is needed to confirm the diagnosis but this is the characteristic appearance of “plasma cell stomatitis.” It is an extremely painful condition.
A biopsy of the mouth is needed to confirm that the problem is actually Plasma Cell Stomatitis and not something of similar appearance but requiring different treatment.
Plasma Cell Stomatitis is a painful, chronic condition.
www.marvistavet.com /html/body_plasma_cell_stomatitis.html   (857 words)

  
 Lymphomas: B cell and plasma cell neoplasms
Monoclonal proliferations are presumed to be neoplastic; polyclonal populations are not
B cells express surface immunoglobulin, consisting of heavy chain and kappa or gamma light chains; immunoglobulin is associated with CD79a/CD79b complex to form a B cell antigen receptor complex
B cell lymphomas: clonal light chain rearrangement is usually specific for the presence of a B cell neoplasm
www.pathologyoutlines.com /lymphoma.html   (2565 words)

  
 Plasma cell definition - Allergies: allergy symptoms, treatment, and medications by MedicineNet.com
Plasma cell: A type of white blood cell that produces and secretes antibodies.
A plasma cell is a fully differentiated lymphocyte in the B-cell (not the T-cell) lineage.
Plasma cell malignancies include multiple myeloma, Waldenstrom macroglobulinemia, and plasma cell leukemia.
www.medterms.com /script/main/art.asp?articlekey=4935   (199 words)

  
 Cytoskeleton-Plasma Membrane-Cell Wall Continuum in Plants. Emerging Links Revisited -- Baluska et al. 133 (2): 482 -- ...
Adhesive pectins (in orange color) in the cell wall (CW) are known to line the outer face of the plasma membrane (PM) and to accomplish endocytosis-driven recycling (orange circles).
Mellersh DG, Heath MC (2001) Plasma membrane-cell wall adhesion is required for expression of plant defense responses during fungal penetration.
Oparka KJ, Crawford JW (1994) Behavior of plasma membrane, cortical endoplasmic reticulum and plasmodesmata during plasmolysis of onion epidermal cells.
www.plantphysiol.org /cgi/content/full/133/2/482   (5264 words)

  
 Plasma Membrane-Cell Wall Contacts -- Kohorn 124 (1): 31 -- PLANT PHYSIOLOGY
In the simplest sense, cell walls are a carbohydrate and protein structures that surround and separate cells.
-Glc polymers in the absence of a plasma membrane rosette.
Willats WG, Knox JP (1996) A role for arabinogalactan-proteins in plant cell expansion: evidence from studies on the interaction of beta-glucosyl Yariv reagent with seedlings of Arabidopsis thaliana.
www.plantphysiol.org /cgi/content/full/124/1/31   (5715 words)

  
 How Antibodies are Produced
Both macrophages and lymphocytes can be found near an infection, and the interaction between these cells is important in eliminating infection.
The stimulated B cell undergoes repeated cell divisions, enlargement and differentiation to form a clone of antibody secreting plasma cells.
through specific antigen recognition of the invader, clonal expansion and B cell differentiation you acquire an effective number of plasma cells all secreting the same needed antibody.
www.cellsalive.com /antibody.htm   (232 words)

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