Plasma protein binding

Plasma protein binding - Factbites
Where results make sense
About us | Why use us? | Reviews | PR | Contact us

Topic: Plasma protein binding

Note: these results are not from the primary (high quality) database.

In the News (Fri 1 Jan 10)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	NONNECKE ET AL., March 2001
		Plasma retinol and retinol-binding protein concentrations were correlated positively, corroborating the role of vitamin A nutriture in the regulation of retinol-binding protein secretion from the liver.
		In the present study, retinol-binding protein concentrations in plasma from preruminant calves supplemented with 0, 1700 (i.e., current NRC requirement), 34,000, or 68,000 IU of vitamin A daily from birth to 27 d of age (n = 6/treatment) were quantified.
		Within individuals, retinol-binding protein concentrations in plasma are regulated and remain constant except in extremes of vitamin A nutriture or in disease.
	www.adsa.org /jds/abs/2001/d0130641.htm

	Novel Human Corticosteroid-Binding Globulin Variant with Low Cortisol-Binding Affinity -- Emptoz-Bonneton et al. 85 (1): 361 -- Journal of Clinical Endocrinology & Metabolism
		Forest MG, Bertrand J. 1972 Studies of the protein binding of dihydrotestosterone (17-hydroxy-5-androstane-3-one) in human plasma (in different physiological conditions and effect of medroxyprogesterone).
		Because serum dilution is known to perturb the plasma protein
		The binding capacity of CBG and its affinity for cortisol
	jcem.endojournals.org /cgi/content/full/85/1/361

	Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate -- Cosmi et al. 95 (1): 118 -- Circulation
		Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate -- Cosmi et al.
		Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate
		As further evidence that plasma proteins do not influence the
	circ.ahajournals.org /cgi/content/abstract/95/1/118 (498 words)

	last meeting.html
		The retinol-binding protein found in tissue has a molecular weight of 14,000 and carries retinol as a non-covalently-bound ligand; the retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of 21,000-22,000.
		The RBP belongs to a superfamily of protein structure.
		Retinol is a lipid alcohol in which the hydrophilic hydroxyl tail is attached to its otherwise all hydrophobic hydrocarbon chain.
	www.uwec.edu /hartsesc/webpages/xi/trbp.html (498 words)

	Regulation of Hepatic Vitamin A Storage in a Rat Model of Controlled Vitamin A Status during Aging -- Dawson et al. 130 (5): 1280 -- Journal of Nutrition
		The molar ratio of plasma retinol to RBP is known to be correlated
		Ross A. Retinol esterification by mammary gland microsomes from the lactating rat.
		RBP or ß-actin mRNA was quantified by densitometry (NIH
	www.nutrition.org /cgi/content/full/130/5/1280 (498 words)

	Human protein: Q5T865 - Single stranded DNA binding protein 3. EMBL Bioinformatic Harvester
		acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
		Human protein: Q5T865 - Single stranded DNA binding protein 3.
		ref:NP_036578.1 - single-stranded DNA binding protein 2; single-stranded-DNA-binding protein 2; hypothetical protein; single-stranded DNA-binding protein 2 [Homo sapiens]
	harvester.embl.de /harvester/Q5T8/Q5T865.htm (603 words)

	Ontogeny of corticosteroid-binding globulin biosynthesis in the rat.
		Plasma levels of maternal and fetal CBG fluctuate during gestation, and this may be due to changes in the biosynthesis and/or clearance of the protein.
		We have, therefore, studied the ontogeny of CBG biosynthesis in the rat by using a solution hybridization assay to measure hepatic CBG mRNA levels.
	www.arclab.org /medlineupdates/abstract_1989877.html (603 words)

	Espin Contains an Additional Actin-binding Site in Its N Terminus and Is a Major Actin-bundling Protein of the Sertoli Cell-Spermatid Ectoplasmic Specialization Junctional Plaque -- Chen et al. 10 (12): 4327 -- Molecular Biology of the Cell
		Petruszak, J.A.M., Nehme, C.L., and Bartles, J.R. Endoproteolytic cleavage in the extracellular domain of the integral plasma membrane protein CE9 precedes its redistribution from the posterior to the anterior tail of the rat spermatozoon during epididymal maturation.
		Actin binding by recombinant espin(339-720), a fragment from the N terminus of espin that is missing the C-terminal actin-bundling module, and the mapping of its actin-binding site by deletion mutagenesis.
		Oko, R., Hermo, L., and Hecht, N.B. Distribution of actin isoforms within cells of the seminiferous epithelium of the rat testis: evidence for a muscle form of actin in spermatids.
	www.molbiolcell.org /cgi/content/full/10/12/4327 (603 words)

	TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
		Because some effects of TNF-alpha are mediated, at least in part, by the brain [plasma corticosterone (CORT) elevation] and some are mediated by peripheral organs [reduction of serum protein and corticosteroid binding globulin (CBG)], we also investigated whether the effects of vagotomy are specific to those defense processes mediated by the brain.
		TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.Immune activation leads to production of mediators such as cytokines, which act to induce both brain-mediated and peripheral defense processes.
		TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/1292088.html (603 words)

	Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain -- Grishkovskaya et al. 19 (4): 504 -- The EMBO Journal
		Renoir, J.M., Mercier-Bodard, C. and Baulieu, E.E. Hormonal and immunological aspects of the phylogeny of sex steroid binding plasma protein.
		Binding of thyroid hormones, retinol-binding protein and fluorescent probes to prealbumin and effects of thyroxine on prealbumin subunit self association.
		Joseph, D.R. and Baker, M.E. Sex hormone-binding globulin androgen-binding protein and vitamin K-dependent protein S are homologous to laminin A, merosin and Drosophila crumbs protein.
	embojournal.npgjournals.com /cgi/content/full/19/4/504 (603 words)

	Plasma Total and Glycosylated Corticosteroid-Binding Globulin Levels Are Associated with Insulin Secretion -- Fernández-Real et al. 84 (9): 3192 -- Journal of Clinical Endocrinology & Metabolism
		1990 Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins.
		The binding capacity of serum CBG was measured
		Rosner W. 1990 The functions of corticosteroid binding globulin and sex hormone-binding globulin: recent advances.
	jcem.endojournals.org /cgi/content/full/84/9/3192 (603 words)

	Horst Ibelgaufts'COPE: Cytokines Online Pathfinder Encyclopaedia
		References: Edgar PF Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins.
		The sequence of the N-terminus of the 35 kDa subunit shows 88 percent sequence identity with the N-terminal region of Ficolin-beta (see: Ficolin), a binding protein for transforming growth factor-beta-1 (see: TGF-beta) purified from porcine uterus.
		The protein has a molecular mass of approximately 200 kDa and consists of 35 kDa and 75 kDa subunits.
	www.copewithcytokines.de /cope.cgi?4780 (603 words)

	Steroid-Protein Interactions. XV. ISOLATION AND CHARACTERIZATION OF CORTICOSTEROID-BINDING GLOBULIN FROM HUMAN PLASMA -- Muldoon and Westphal 242 (23): 5636 -- Journal of Biological Chemistry
		of the protein was calculated as 51,700 from sedimentation and
	www.jbc.org /cgi/content/abstract/242/23/5636 (603 words)

	4. The Plasma Membrane
		Working model of the protein-protein interactions in focal adhesions of fibroblasts determined by in vitro binding experiments and immunolocalization.
		Proteins that mediate linkage of the cytoskeleton to the plasma membrane have a common domain of approximately 300 amino acids.
		The glycerophospholipids, the major components of the plasma membrane, are esters of glycerol, where one glycerol is conjugated to two fatty acids and one phosphate.
	www.albany.edu /~abio304/text/4part1.html (603 words)

	Lecture 6. Global Folding - Supersecondary Structure and Protein Morphology
		An example are the calcium-binding proteins calmodulin and troponin C. Here the stabilizing factor may be the binding of 2 calcium ions near the carboxy terminal of the helix.
		-keratin, but also desmin in muscle; vimentin in connective tissue; neurofilament proteins in nerve cells; fibrinogen in plasma; and lamins.
		This stabilizing effect is utilized even in helices that are embedded in globular proteins: A survey of the frequency of specific amino acids at the 2 ends of helices shows that acidic ones preferentially occur at the N terminal, basic ones preferentially at the C terminal.
	www.sunysb.edu /biochem/courses/lectures/5bmo520.html (2105 words)

	Publications
		Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1.
		Exchange factors, effectors, GAPs and motor proteins: common thermodynamic and kinetic principles for different functions.
		Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.
	www.mpi-dortmund.mpg.de /publications/searchform.php3 (2105 words)

	Protein cellular locations
		plasma membrane YFL005w SEC4 GTP-binding protein of the ras superfamily golgi-plasma membrane transport vesicles
		ER YGL226c-a OST5 subunit of N-oligosaccharyltransferase, zeta subunit golgi membrane YGL225w GOG5 GDP-mannose transporter into the lumen of the Golgi tubulin cytoskeleton YGL216w KIP3 kinesin-related protein required for nuclear migration nucleus
		weak similarity to hypothetical protein YLR324w cytoplasm YBR169c SSE2 heat shock protein of the HSP70 family nucleus YBR170c NPL4 nuclear protein localization factor and ER translocation component ER membrane YBR171w SEC66 ER protein-translocation complex subunit actin cytoskeleton YBR172c SMY2 kinesin-related protein nuclear envelope YBR173c UMP1 proteasome maturation factor ER membrane
	www.cs.man.ac.uk /img/gims/Location.html (2539 words)

	Membrane Lecture Notes
		The binding of a membrane protein/glycoprotein to some other cellular or extracellular substance, molecule, ion, etc. can/will result in a 3-dimensional conformational change in that membrane protein.
		Or the topological equivalent of the outer leaflet of the plasma* membrane, i.e., the luminal facing leaflet of an organelle membrane.
		At high temperatures cholesterol tends to reduce membrane fluidity, probably by interacting with the hydrocarbon tails of the phospholipid and glycolipid molecules.
	www.d.umn.edu /~sdowning/Membranes/lecturenotes.html (2539 words)

	keywlist.txt
		AC KW-0303 DE Protein component of gap junctions which are specialized regions of DE the plasma membrane formed by a cluster of channels allowing small DE molecules to diffuse from the cytosol of one cell to that of an DE adjacent cell.
		AC KW-0197 DE Protein binding cyclosporin or protein whose function is inhibited by DE cyclosporin, e.g.
		The resistance is often due either to mutations that DE prevent antibiotic binding to the protein or to amplification of the DE gene encoding the protein.
	us.expasy.org /txt/keywlist.txt (2539 words)

	WU Libraries Bio. Dept. 2002 Publications
		Three novel MYB proteins with one DNA binding repeat mediate sugar and hormone regulation of α-amylase gene expression.
		Proteomics of Synechocystis sp strain PCC 6803 - Identification of plasma membrane proteins.
		Rice TATA binding protein interacts functionally with transcription factor IIB and the RF2a bZIP transcriptional activator in an enhanced plant in vitro transcription system.
	www.library.wustl.edu /units/biology/reprints/2002.html (2253 words)

	Protein cellular locations
		plasma membrane YFL005w SEC4 GTP-binding protein of the ras superfamily golgi-plasma membrane transport vesicles
		nucleus YDL017w CDC7 protein kinase nucleolus YDL014w NOP1 fibrillarin unspecified membrane YDL012c
		nucleus YCL055w KAR4 regulatory protein required for pheromone induction of karyogamy genes nucleus YCL054w SPB1 required for ribosome synthesis, putative methylase ER membrane YCL052c PBN1 required for post-translational processing of the protease B precursor Prb1p ER lumen YCL043c PDI1 protein disulfide-isomerase precursor cytoplasm YCL040w GLK1 aldohexose specific glucokinase actin cytoskeleton
	www.cs.man.ac.uk /img/gims/Location.html (2253 words)

	Millipore - Technical Library - MultiScreen Filter Assembly with Ultracel-PPB Membrane: Drug plasma protein binding (PPB) assays: reproducibility and correlation
		Due to the importance of plasma protein binding data in characterizing a drug’s behavior and proper dosing, there is an increasing need to make this measurement as early as possible in the discovery process.
		The Plasma Protein Binding assay (see Figure 1) measures the protein binding of a drug or compound in serum or plasma.
		The extent of plasma protein binding (PPB) is critical to predicting a drug’s pharmacokinetic/ dynamic profile.
	www.millipore.com /publications.nsf/docs/AN1732en00 (2253 words)

	Haematologic Technologies - Human Protein S
		In the presence of protein S, a moderate increase (3-10 fold) in the rate of factor Va and factor VIIIa inactivation by APC is observed in plasma and on the surface of unstimulated platelets.
		It has been suggested that g-carboxyglutamic acid (gla) dependent binding of protein S to negatively charged phospholipids may function to concentrate C4BP at cell surfaces following injury.
		Protein S is a single chain vitamin K-dependent protein which is thought to function in both the coagulation and complement cascades (1,2).
	www.haemtech.com /Cofactors/Protein_S.htm (2253 words)

	15. Regulation by Synthesis and Degradation of Macromolecules
		In the absence of ubiquitination the fate of the integral protein is to be recycled to the plasma membrane.
		Co-chaperones mediate the binding of denatured proteins to the chaperones.
		Membrane proteins of the ER are ubiquitinated and degraded by the proteasome pathway.
	www.albany.edu /~abio304/text/15part2.html (2253 words)

	PSU Chemistry Blake R. Peterson
		This research is based on our discovery that protein binding motifs linked to N-alkyl derivatives of 3beta-cholesterylamine can be directly loaded into plasma membranes of living mammalian cells to promote the endocytosis of impermeable protein ligands.
		The cellular uptake of ligands mediated by these synthetic receptors appears to mimic endocytic cellular penetration mechanisms employed by certain protein toxins and viruses.
		Estrogen and androgen receptors are major protein targets of cancer chemotherapy.
	www.chem.psu.edu /profs/Peterson.html (842 words)

	Pawson Lab Research on Domains
		Such phospholipid-binding domains serve both to concentrate signaling proteins at specific subregions of the plasma membrane, and to regulate the enzymatic activities of their host proteins, either directly or by co-recruitment of another regulatory protein.
		An ever-increasing body of data suggests that proteins involved in the regulation of cellular events such as signal transduction, the cell cycle, protein trafficking, targeted proteolysis, cytoskeletal organization and gene expression are constructed in a modular fashion from a combination of interaction and catalytic domains.
		Interaction domains are often used repeatedly in numerous different proteins to mediate a particular type of molecular recognition, and indeed the human genome is predicted to encode at least 120 SH2 domains.
	www.mshri.on.ca /pawson/domains.html (943 words)

	The Transmembrane Domain of Syntaxin 1A Is Critical for Cytoplasmic Domain Protein-Protein Interactions -- Lewis et al. 276 (18): 15458 -- Journal of Biological Chemistry
		Syntaxin 1A was initially identified as a 35 kDa protein in the plasma membrane of amacrine cells (1), as a subunit of
		fusion proteins and used as affinity matrices for the binding
		Protein was visualized using an anti-C2B domain antibody that partially cross-reacts with C2A; both native synaptotagmin as well as the immobilized fusion protein are detected.
	www.jbc.org /cgi/content/full/276/18/15458 (6052 words)

	Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network -- Brajenovic et al. 279 (13): 12804 -- Journal of Biological Chemistry
		Co-expression of Mo25 and PAPK redistributes both proteins to the nucleus, although a small fraction of the complex is recruited to the plasma membrane (j–l).
		the binding of the adenomatous polyposis coli protein to microtubules
		B, summary of co-immunoprecipitation results: 0, proteins not found to be associated; 1, interaction seen only with one of the two proteins immunoprecipitated; 2, proteins were found associated regardless of which protein was subjected to immunoprecipitation.
	www.jbc.org /cgi/content/full/279/13/12804 (4772 words)

	Resource for the Visualization of Biological Complexity (RVBC); Wadsworth Center, NYS Department of Health
		Frozen-hydrated triads should be a readily amenable to the application of high-precision immuno-EM to identify protein components that are resolved in the tomograms.
		Interactions between the dihydropyridine receptor and the cytoplasmic region of the RyR are thought to mediate communication between the plasma membranes/transverse tubules and the transmembrane, ion-conducting region of the RyR in the SR.
		RyRs are known to interact directly in with several proteins in skeletal muscle to form a signal-transducing complex known as the triad junction.
	www.wadsworth.org /rvbc/ryano.htm (4772 words)

	Institut f�r Grenzfl�chenverfahrenstechnik Universität Stuttgart
		1999, Tilton, New Hampshire, U.S.A. Tovar, G., Schmucker, J., Bernhagen, J., Brunner, H. Protein Binding Supports for Direct Use in MALDI-TOF-MS: Surface Functionalization of Microfiltration Membranes and Microbeads.
		Schmucker, J., Traulsen, D., Müller, M., Oehr, C., Brunner, H., Tovar, G. Covalent surface functionalization of polymeric and ceramic membranes: Molecular recognition based on the biotin streptavidin affinity system.
		Tovar, G., Schmucker, J., Eyb, H., Müller, M., Brunner, H. Covalent surface functionalization of polymeric and ceramic membranes: Molecular recognition based on the biotin streptavidin affinity system.
	www.uni-stuttgart.de /igvt/forschung/publikationen.html (4772 words)

Try your search on: Qwika (all wikis)

Topic: Plasma protein binding

Ads by Google

Related Topics

In the News (Fri 1 Jan 10)