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Topic: Plasmin

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	Plasmin - Wikipedia, the free encyclopedia
		Plasmin is an important degrading enzyme (EC 3.4.21.7) of many proteins of blood plasma but specifically of fibrin clots.
		Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation).
		Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.
	en.wikipedia.org /wiki/Plasmin (140 words)

	Potential Mechanisms for the Plasmin-Mediated Release and Activation of Latent Transforming Growth Factor-{beta}1 from ...
		by 0.01 U/ml plasmin from RC matrices by 57–85% at all
		of low-dose plasmin is LTBP1, causing the release of latent
		Plasmin is also shown to cleave small quantities of the large complex in the plasmin-sensitive hinge region, releasing large latent TGF-ß1 complexes (2), and small amounts of active TGF-ß1 from the soluble large complex (3).
	endo.endojournals.org /cgi/content/full/140/12/5806 (6020 words)

	Proteases in Milk (Site not responding. Last check: 2007-10-21)
		Plasmin, plasminogen, and plasminogen activators are associated with the casein micelles and milk fat globule membranes in milk.
		Plasmin activity is also affected by mastitis when the increased number of somatic cells contributes to increased plasminogen activators which in turn activate plasminogen into plasmin.
		Plasmin activity in milk is affected by factors such as stage of lactation, breed of cow, disease condition, and nutritional and lactational effects.
	www.aces.uiuc.edu /~ansystem/dairyrep96/Aslam.html (1154 words)

	Laminin Degradation by Plasmin Regulates Long-Term Potentiation -- Nakagami et al. 20 (5): 2003 -- Journal of ...
		plasmin for 6 hr was sufficient to degrade laminin.
		was degraded by this pretreatment with plasmin in organotypic
		and degraded by plasmin (Chen and Strickland, 1997
	www.jneurosci.org /cgi/content/full/20/5/2003 (5051 words)

	Mammary Involution, Plasminogen/Plasmin System (Site not responding. Last check: 2007-10-21)
		Plasminogen is the precursor of the active plasmin, and this activation reaction requires the enzyme plasminogen activator (PA).
		Plasmin so produced could then initiate proteolysis within the alveoli, which must occur before tissue remodeling can occur.
		Plasminogen/plasmin system should be regarded as an example of how proteases are involved in the involution process; other extracellular matrix proteases have been described more recently in the mammary gland, such as gelatinase and stromelysin, as well as protease inhibitors like TIMP (tissue inhibitor of metalloproteases) and PAI-1 (plasminogen activator inhibitor 1)(Talhouk et al., 1992).
	animsci.agrenv.mcgill.ca /servers/anbreed/involute/plasmin.htm (491 words)

	Ultrastructure of the vitreoretinal interface following plasmin assisted vitrectomy -- Gandorfer et al. 85 (1): 6 -- ...
		Plasmin (1 or 2 U/0.1 ml) was injected into the vitreous cavity of 24 eyes of freshly slaughtered pigs.
		Plasmin induces a cleavage between the vitreous cortex and the ILM without morphological changes to the retina.
		Posterior vitreous detachment induced by injection of plasmin and sulfur hexafluoride in the rabbit vitreous.
	bjo.bmjjournals.com /cgi/content/full/85/1/6 (3158 words)

	Plasmin Promotes an Endothelium-Dependent Adhesion of Neutrophils : Involvement of Platelet Activating Factor and ...
		and plasmin, correlated with the synthesis of PAF by HUVEC and
		Plasmin stimulated the synthesis of PAF by HUVEC and the adhesion of
		After 15-minute treatment with plasmin (0.1 U/mL), HUVEC progressively lose their network of stress fibers with accumulation of F-actin at the periphery of the cells and in correspondence to ruffles; arrows indicate areas of lateral cell margin retraction with formation of intercellular gaps (B).
	circ.ahajournals.org /cgi/content/full/93/12/2152 (5289 words)

	The Plasmin System Is Induced by and Degrades Amyloid-beta Aggregates -- Tucker et al. 20 (11): 3937 -- Journal of ...
		the Kcat of nonaggregated fibrin cleavage by plasmin is 7/sec
		Kastrikina TF, Taran LD, Kudinov SA (1986) Kinetic characteristics of fibrinogen and fibrin hydrolysis by plasmin 1 and 2 and miniplasmin.
		Van Nostrand WE, Porter M (1999) Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity.
	www.jneurosci.org /cgi/content/full/20/11/3937 (4930 words)

	Haematologic Technologies - Human Plasmin
		Plasminogen (whether Glu-1, Lys-77 or Val-442) is converted to the active serine protease plasmin by hydrolysis of the Arg560-Val561 peptide bond yielding an NH -terminal heavy (A) chain and a COOH-terminal light (B) chain linked by 2 disulfide bonds (1-3).
		Plasmin is a serine protease with broad specificity which, in addition to cleavage of fibrin, is capable of activation and/or degradation of compounds of the coagulation, kinin generation and complement systems.
		Although plasmin can be inhibited by a number of plasma protease inhibitors in vitro, regulation of plasmin in vivo is thought to occur mainly through its interaction with α2-antiplasmin, and to a lesser extent, α2-macroglobulin.
	www.haemtech.com /Enzymes/Plasmin.htm (388 words)

	p11 Regulates extracellular plasmin production and invasiveness of HT1080 fibrosarcoma cells -- CHOI et al. 17 (2): 235 ...
		Role of p11 in plasmin formation and degradation on the cell surface.
		A) Plasmin formation and degradation were examined by immunoblot analysis with mouse anti-human plasminogen monoclonal antibody.
		Serine proteinase plasmin is one of the key proteinases that
	www.fasebj.org /cgi/content/full/17/2/235 (6381 words)

	Distinct dose-dependent effects of plasmin and TPA on coagulation and hemorrhage -- Stewart et al. 101 (8): 3002 -- ...
		Antiplasmin activity was fully depleted with plasmin at 6 mg/kg, a dose that decreased fibrinogen and factor VIII to 20% to 30% of initial activity.
		The disparate dose-dependent effects of TPA and plasmin on coagulation and bleeding are shown in Figure 6.
		At a plasmin dose of 8 mg/kg, the nadir fibrinogen concentration dropped below the lower limit of quantification, in association with the appearance of excessive bleeding.
	www.bloodjournal.org /cgi/content/full/101/8/3002 (4207 words)

	Accurate milk enzyme measurement may cut cheese processing cost
		With this information, they were able to create a model of the plasmin system function that can be used in future studies into the enzyme's impact on milk products.
		Plasmin is the substance that gives cheeses that have been aged longer a sharper flavor.
		FT-IR spectra of plasminogen and plasmin in water and solutions containing sodium caseinate, whey protein concentrate, and a mixture of -lactoglobulin and sodium caseinate were obtained using attenuated total reflectance (ATR) FT-IR.
	news.uns.purdue.edu /html4ever/030529.Mauer.plasmin.html (947 words)

	[No title]
		The glycoprotein, plasmin inhibitor, is a serine protease inhibitor of molecular weight 65-70 kD, present in plasma at a concentration of approximately 1 m mol/l (3).
		Since plasmin and plasmin inhibitor forms a 1:1 molar complex the excess of plasmin added to the test should be minimised to avoid the influence of other inhibitors.
		Petersen LC, Clemmensen I. Kinetics of plasmin inhibition in the presence of synthetic tripeptide substrate.
	www.ifcc.org /ejifcc/vol13no2/130201007n.htm (2342 words)

	Plasmin Cleaves Tumor Necrosis Factor {alpha} Exodomain from Sheep Follicular Endothelium: Implication in the Ovulatory ...
		Plasmin Cleaves Tumor Necrosis Factor {alpha} Exodomain from Sheep Follicular Endothelium: Implication in the Ovulatory Process -- Murdoch et al.
		Ovulation in the sheep is predicated on plasmin up-regulation
		Plasmin is a pleiotropic serine protease derived from plasminogen
	www.biolreprod.org /cgi/content/full/60/5/1166 (2499 words)

	Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular ...
		Plasmin substrate, N-(p-tosyl)-Gly–Pro–Lys p-nitroanilide acetate (30 µg), was used for the spectrophotometric measurements.
		Enolase matrix (0.1 ml) was incubated with different amounts of plasmin (10, 20, 30 or 40 µg) for 30 min, then unbound plasmin was washed away.
		Enolase-associated plasmin was monitored by chromogenic assay in the presence of 0, 10, 20, 30 or 40 mmol EACA l
	jmm.sgmjournals.org /cgi/content/full/52/8/615 (4193 words)

	Plasmin-Coated Borrelia burgdorferi Degrades Soluble and Insoluble Components of the Mammalian Extracellular Matrix -- ...
		PLG by the spirochete occurs in the feeding tick.
		Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages.
		Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.
	iai.asm.org /cgi/content/full/67/8/3929 (4464 words)

	Acquisition of Plasmin Activity by Fusobacterium nucleatum subsp. nucleatum and Potential Contribution to Tissue ...
		Plasmin is a trypsin-like serine protease with a large
		Plasmin activity generated on the bacterial cell surface by streptokinase could be inhibited at a level of approximately 80%
		Plasmin activity was measured by incubation of cells with the chromogenic substrate and determination of the absorbance at 405 nm.
	iai.asm.org /cgi/content/full/67/12/6439 (3451 words)

	eMedicine - Alpha2-Plasmin Inhibitor Deficiency : Article by Rajalaxmi McKenna, MD, FACP
		PI is the most important physiologic inhibitor of plasmin, which is the principal protease of the fibrinolytic pathway.
		Plasmin not only degrades fibrin, which is its principal substrate, but it also degrades fibrinogen, factors V and VIII, proteins involved in platelet adhesion (glycoprotein I and vWF), platelet aggregation (glycoprotein IIb/IIIa) and maintenance of platelet aggregates (thrombospondin, fibronectin, histidine-rich glycoprotein), and the attachment of platelets and fibrin to the endothelial surface.
		PI is cross-linked to fibrin, thus conferring resistance to degradation by plasmin, and it interferes with the adsorption of plasminogen to fibrin.
	www.emedicine.com /med/topic109.htm (6612 words)

	Processing of Laminin-5 and Its Functional Consequences: Role of Plasmin and Tissue-type Plasminogen Activator -- ...
		plasmin at concentrations of 0.01, 0.1, and 1 µg/ml for 90 min.
		SCC12 cells were plated onto pp126 ECM, pp126 ECM that had been treated with plasmin (Pm) (1 µg/ml for 90 min), MCF-10A ECM, affinity-purified pp126 laminin-5, affinity-purified pp126 laminin-5 treated with plasmin (Pm) (1 µg/ml for 90 min), or pp126 ECM treated with 10 µg/ml tPA overnight.
		Plasmin is generated by cleavage of the proenzyme
	www.jcb.org /cgi/content/full/141/1/255 (6256 words)

	Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKK{beta}-mediated ... (Site not responding. Last check: 2007-10-21)
		The catalytic center of plasmin was blocked by preincubation with the irreversible inhibitor VPLCK.
		with plasmin (1.43 CTA U/mL) or LPS (1 µg/mL).
		Induction of TF expression on the monocyte membrane by plasmin.
	www.bloodjournal.org /cgi/content/full/97/12/3941 (5222 words)

	Safety and Efficacy of Dispase and Plasmin in Pharmacologic Vitreolysis -- Wang et al. 45 (9): 3286 -- Investigative ...
		Safety and Efficacy of Dispase and Plasmin in Pharmacologic Vitreolysis -- Wang et al.
		Autologous plasmin enzyme in the surgical management of diabetic retinopathy.
		Effect of plasminogen activator, plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.
	www.iovs.org /cgi/content/full/45/9/3286 (2271 words)

	Plasmin and Plasminogen Activator Inhibitor Type 1 Promote Cellular Motility by Regulating the Interaction between the ...
		Plasmin and Plasminogen Activator Inhibitor Type 1 Promote Cellular Motility by Regulating the Interaction between the Urokinase Receptor and Vitronectin
		Plasmin cleavage of vitronectin reduces cellular binding and adhesion and induces cellular detachment.
		Linder, and K.T. Preissner (1996) Limited plasmin proteolysis of vitronectin: characterization of the adhesion protein as morpho-regulatory and angiostatin-binding factor.
	www.jci.org /cgi/content/full/100/1/58 (6660 words)

	The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer -- Cox et al. 54 (2): 169 -- Thorax
		The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer -- Cox et al.
		The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer
		Plasmin is a 90 kDa serine protease capable of activating prometalloproteinases and degrading fibrin, fibronectin, and vitronectin.
	thorax.bmjjournals.com /cgi/content/full/54/2/169 (6326 words)

	Proteolysis in Alzheimer's disease: Can plasmin tip the balance? -- Periz and Fortini 1 (6): 477 -- EMBO Reports (Site not responding. Last check: 2007-10-21)
		Possible models for the role of plasmin in the development of Alzheimer’s disease.
		Tucker, H.M., Kihiko-Ehmann, M., Wright, S., Rydel, R.E. and Estus, S. (2000) The plasmin system is induced by and degrades amyloid-ß aggregates.
		Van Nostrand, W.E. and Porter, M. (1999) Plasmin cleavage of the amyloid ß-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity.
	emboreports.npgjournals.com /cgi/content/full/1/6/477 (1196 words)

	Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D -- McColl et al. 198 (6): 863 -- The Journal of ... (Site not responding. Last check: 2007-10-21)
		Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D -- McColl et al.
		Calbiochem) was incubated with plasmin in PBS for 30 min at
		Plasmin (1 U/ml; 130 nM) was incubated with a range of
	www.jem.org /cgi/content/full/198/6/863 (3570 words)

	Plasminogen Activation/Plasmin in Rheumatoid Arthritis: Matrix Degradation and More -- Judex and Mueller 166 (3): 645 ...
		propose that the plasmin substrate is a complement component.
		cleavage by plasmin to induce the inflammatory phase of CIA.
		Campbell PG, Andress DI: Plasmin degradation of insulin-like growth factor binding protein-5 (IGFBP-5): regulation by IGF-5-(201–218).
	ajp.amjpathol.org /cgi/content/full/166/3/645 (1747 words)

	Potential Mechanisms for the Plasmin-Mediated Release and Activation of Latent Transforming Growth Factor-{beta}1 from ...
		the role of plasmin in the activation of soluble and matrix-bound
		that the effects of high-dose plasmin could be altered to mimic
		and/or plasmin is present in very small amounts in the cartilage
	endo.endojournals.org /cgi/content/abstract/140/12/5806 (522 words)

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