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Topic: Pluripotential hematopoietic stem cell

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	NationMaster - Encyclopedia: Dendritic cell
		Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets).
		However, the exact genesis and development of the different types and subsets of dendritic cells and their interrelationship is only marginally understood at the moment, as dendritic cells are so rare and difficult to isolate that only in recent years they have become subject of focused research.
		Category: Mononuclear phagocytes Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets).
	www.nationmaster.com /encyclopedia/Dendritic-cell (3061 words)

	Stem Cell Research: From Start To Infinite Possibility \| References
		The promise of hematopoietic stem cell transplantation for autoimmune diseases.
		Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord.
		Stem cell and progenitor cell transplantation in multiple sclerosis: the discrepancy between neurobiological attraction and clinical feasibility.
	www.newdrugs.com /stem-cell-references.htm (1966 words)

	Lateral Plate Mesoderm
		The cells forming the atrial and ventricular musculature, the cushion cells of the valves, the Purkinje conducting fibers, and the endothelial lining of the heart are all generated from these two clusters (Mikawa 1999).
		In early blood cell formation (in the mesoderm surrounding the mammalian yolk sac), the endothelial cells of the blood islands appear to be heterogeneous HIMs, inducing the stem cells to form different blood and lymphocyte lineages (Lu et al.
		The hematopoietic stem cells that last the lifetime of the organism are derived from the mesodermal area surrounding the aorta.
	www.ncbi.nlm.nih.gov /books/bv.fcgi?indexed=google&rid=dbio.section.3693 (6598 words)

	Modelling X-chromosome inactivation in human blood cells
		Stem cells are vital to the development of an organism.
		Thus stem cells have two functions — first they divide to form daughter stem cells so that there is a pool of pluripotential stem cells kept throughout life; second, they develop into "specialized cells" of the respective system.
		Stem cells not only supply the progenitor cells to these systems at the respective stages of development, but also supply them with replacement cells further in life when there is a depletion of a certain kind of cell pool.
	www.zoology.ubc.ca /~otto/Research/xci.html (1714 words)

	Red Gold . Blood Journey . Phase 1 \| PBS
		Blood cells are produced in the bone marrow, a jellylike substance inside the bones that is composed of, among other things, fat, blood, and special cells that turn into the various kinds of blood cells.
		All blood cells come from the same kind of stem cell, which has the potential to turn into any kind of blood cell.
		As the blood cells develop from the stem cells in the marrow, they seep into the blood that passes through the bones and on into the bloodstream.
	www.pbs.org /wnet/redgold/journey/phase1_a2.html (0 words)

	Ross S Basch M.D.
		All of the cells of the blood are derived from a common ancestor.
		They are uniquely specialized cells, whose role is to provide progenitors for the various hematopoietic lineages in a demand-responsive manner, while protecting the stem cell pool from depletion.
		Cells resembling stem cells can be isolated from different sources such as bone marrow, mobilized peripheral blood, cord blood and fetal liver.
	www.med.nyu.edu /research/baschr01.html (457 words)

	PCBE: Transcripts (November 16, 2006): Session Session 1: Stem Cell Research Update
		Now, these cells that give rise to the three germ layers, ectoderm, mesoderm, endoderm, and the germ cell lineage, these are the pluripotential cells that are in the focus of science and also public discussions, and both together, the pluripotential cells and the germ cells, comprise the mammalian germline.
		You have cells that make themselves again at more different stage of cells, but there are different levels of stem cells, and you can take the first cells, the mother of all stem cells, the oocyte, that after being fertilized forms a zygote, which is totipotent.
		The pioneer of transplantation of germline stem cells is Ralph Brinster.
	www.bioethics.gov /transcripts/nov06/session1.html (8627 words)

	Spartanburg SC \| GoUpstate.com \| Spartanburg Herald-Journal
		Hematopoietic stem cells (HSC) are stem cells and the early precursor cells which give rise to all the blood cell types that include both the myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets and some dendritic cells) and lymphoid lineages (T-cells, B-cells, NK-cells, some dendritic cells).
		Cells can be obtained directly by removal from the hip using a needle and syringe, or from the blood following pre-treatment with cytokines, such as G-CSF (granulocyte colony stimulating factors), that induce cells to be released from the bone marrow compartment.
		Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal.
	www.goupstate.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=pluripotential_hematopoietic_stem_cell (0 words)

	Out of Eden: Stem Cells and Their Niches
		For example, when hematopoietic stem cells are transplanted from one mouse to another the final engraftment phenotype is determined simply by the ratio of host to donor stem cells, which suggests that there is no need to deplete the host stem compartment to make space for the newly added stem cells (13).
		In addition, removing a stem cell or progenitor from the, community of neighbors that are telling it what to do may lead to the up-regulation, reexpression, or de novo activation of surface receptors for a wide range of signaling factors, some of which are present in the new niche.
		Although the self-renewal of mouse ES cells in culture is promoted by leukemiainhibiting factor or related cytokines (29), self-renewal of human pluripotential stem cells is not (1), which illustrates just one of the reasons why it is important to compare the properties of human and mouse ES cells.
	www.genethik.de /stem_cells/stem_cells7.htm (3263 words)

	Haematopoietic stem cell - Haematopoieticstemcell
		PHSC are the precurser cells which give rise to all the blood cell types of both the myeloid and lymphoid lineages.
		As stem cells, they are defined by their ability to form multiple cells types and their ability to self-renew.
		Cells can be obtained directly by removal from the hip using a needle and syringe, or from the blood following pre-treatment with cytokines that induce cells to be released from the bone marrow compartment.
	www.kopete.org /Haematopoietic-stem-cell.html (439 words)

	Pluripotential hemopoietic stem cell . Enpsychlopedia
		Hematopoietic stem cells (HSC) are stem cells found in the bone marrow.
		Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal.
		Cells can be obtained directly by removal from the hip using a needle and syringe, or from the blood following pre-treatment with cytokines, such as G-CSF (granulocyte colony stimulating factors), that induce cells to be released from the bone marrow compartment.
	www.enpsychlopedia.org /psypsych/Pluripotential_hemopoietic_stem_cell (738 words)

	U.S. Patent: 5786323 - Use of stem cell factor and soluble interleukin-6 receptor to induce the development of ...
		Stem cell factor in combination with gp130 signaling supports proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells.
		Zsebo et al., "Stem Cell Factor is Encoded at the S/Locus of the Mouse and is the Ligand for the c-kit Tyrosine Kinase Receptor", Cell, 63:213-224 (1990).
		The present invention relates to the use of stem cell factor in association with interleukin-6 and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells.
	www.everypatent.com /comp/pat5786323.html (4439 words)

	Horst Ibelgaufts'COPE: Cytokines & Cells Online Pathfinder Encyclopaedia
		The compartment of hematopoietic stem cells appears to be heterogeneous since the various types of stem cells may differ in their immunogenic and reconstitutive capacity (Korbling and Anderlini, 2001).
		Hematopoietic stem cells are quite rare and constitute approximately 4-400/105 normal bone marrow cells**, depending upon the assay used.
		The molecular nature of the mechanisms underlying stem cell renewal and of mechanisms preventing exhaustion of stem cell pools throughout the entire life span of an organism are still under intensive study but are as yet largely unknown.
	www.copewithcytokines.de /cope.cgi?key=Hematopoietic%20stem%20cells (1929 words)

	Pluripotential hemopoietic stem cell (Site not responding. Last check: )
		Pluripotential hemopoietic stem cells or pluripotential hematopoietic stem cells (PHSCs) are stem cells found in the bone marrow.
		Bone marrow cells are extracted from an animal, which is then subjected to Radiation.
		Once this is accomplished, the previously collected cells are then injected into the blood stream and eventually make their way into the Spleen (which has a similar environment as bone marrow for hemopoiesis).
	www.ufaqs.com /wiki/en/pl/Pluripotential%20hemopoietic%20stem%20cell.htm (549 words)

	CRDG
		The pluripotent stem cell holds enormous therapeutic potentials and the research theme of Stem Cells and Regenerative Medicine is therefore a priority area of development for the Centre.
		Stem cells form the basic building progenitors for all types of cells, which constitute the many different tissues in the body.
		The pluripotential hematopoietic stem cells are stem cells found in the bone marrow.
	www.hku.hk /crdg/themes/stem_cell.htm (687 words)

	ATSDR - CSEM - Benzene Toxicity: Physiologic Effects
		Pluripotential stem cells and lymphocytic cells are the probable targets of benzene toxicity.
		Paroxysmal nocturnal hemoglobinuria, a disorder in which the breakdown of the red blood cells is accelerated and results in bleeding into the urine during sleep when the condition is active, has been associated with benzene exposure.
		Cytogenetic abnormalities of bone marrow cells and circulating lymphocytes have been observed in workers exposed to benzene-abnormalities not unlike those observed after exposure to ionizing radiation.
	www.atsdr.cdc.gov /HEC/CSEM/benzene/physiologic_effects.html (797 words)

	Advances in Stem Cell Research
		Such information, which we currently have only for the hematopoietic, or blood-producing, stem cells of the bone marrow, may suggest therapies to increase the number of residual stem cells in a damaged tissue.
		To learn how to reprogram stem cells efficiently we need to study a whole range of experimental systems in which previously silent genes are reactivated and active ones switched off.
		A second approach is to use pluripotential stem cells lines derived from embryos at the blastocyst stage, reached soon after fertilization of the egg and before implantation into the uterus.
	www.hhmi.org /bulletin/stemcells/3.html (0 words)

	Banking Blood Cell Cord Stem Storage
		Pluripotential hemopoietic stem cell - Pluripotential hemopoietic stem cells or pluripotential hematopoietic stem cells (PHSCs) are stem cells found in the bone marrow.
		An example of a multipotent stem cell is a hematopoietic cells â” a blood stem cells that can develop into several types of blood cells, but cannot develop into brain cells or other types of cells.
		The authors debate such contentious issues as the appropriateness of transplants in older patients, how many stem cells are sufficient for engraftment, banking blood cell cord stem storage and the pros banking blood cell cord stem storage and cons of umbilical cord blood transplantation.
	www.wholelifeexpos.com /bankingbloodcellcordstemstorage.html (514 words)

	definition of stem cell
		Stem cells are classified into several types : 1) totipotential : these are the first cells of the embryo (up to 8 cells).
		They have the capacity to produce all the cells, tissues and organs that make up the human body ; 2) pluripotential : these are embryonic cells from the first 16 to 32 cells.
		Their power to differentiate is less than that of embryonic stem cells.
	www.cite-sciences.fr /lexique/definition1.php?definition=2&idmot=30&iddef=84&idmedia=&page=&rech_lettre=&num_page=9&recho=&radiob=&resultat=&habillage=standard&lang=an&id_expo=2&id_habillage=15 (141 words)

	Hematopoietic stem cell
		There are a lot of differences between the human and mice hematopoietic cell markers for the commonly accepted type of hematopoietic stem cells.
		Traditional purification method used to yield a reasonable purity level of mouse hematopoietic stem cells generally requires a large(~10-12) battery of markers, most of which were surrogate markers with little functional significance and thus partial overlap with the stem cell populations and sometimes other closely related cells which are not stem cells.
		SLAM (Signaling lymphocyte activation molecule) family is a group of >10 molecules whose genes are mostly located tandemly in a single locus on chromosome 1 (mouse), all belonging to a subset of immunoglobulin gene superfamily, and originally thought to be involved in T-cell stimulation.
	www.danceage.com /biography/sdmc_Pluripotential_hemopoietic_stem_cell (1354 words)

	ImmInst.org [Powered by Invision Power Board]
		Cultured human embryonic stem cells, for instance, must be grown on top of a layer of mouse fibroblasts in order for their pluripotential state to be maintained.
		Since cells in multicellular do not devide by their maximal rate limited by their healtyness one could suspect that cells that are not fully healthy still could devide at the maximal division rate for this kind of multicellular cells.
		For example, a clone of hematopoietic stem cell can be damaged in such a way that it divides just a little faster then all the other hematopoietic stem cells and thus slowly takes over the bone-marrow.
	www.imminst.org /forum/index.php?s=&act=Print&client=printer&f=44&t=11824 (686 words)

	Horst Ibelgaufts'COPE: Cytokines & Cells Online Pathfinder Encyclopaedia
		Cells that give rise to colonies smaller than 1 mm in these assays are usually referred to as low proliferative potential colony-forming cells (abbr.
		HPP-CFC, unlike LTC-IC (long-term culture-initiating cells), are not considered to be a measure of true pluripotential hematopoietic stem cells but, rather, of their slightly more differentiated progeny (primitive hematopoietic progenitor cells, abbr.
		Journal of Clinical Investigation 70: 242-253 (1982); Han M et al In vitro expansion of murine hematopoietic progenitor cells in liquid cultures for bone marrow transplantation: effects of stem cell factor.
	www.copewithcytokines.de /cope.cgi?key=HPP%2dCFC (1034 words)

	Untitled Document (Site not responding. Last check: )
		This progenitor cell originates from the pluripotential stem cell.
		Members of the MPS include histiocytes in connective tissues, fixed and free macrophages in the lymph nodes, spleen, and bone marrow, kupffer cells of the liver, alveolar macrophages, osteoclasts, Langerhans cells in the epidermis, intraglomerular mesangial macrophages in the kidneys, microglial cells in the nervous system and serosal macrophages in the pleural and peritoneal cavities.
		They are derived from hematopoietic stem cells in the bone marrow, and they enter the circulation and randomly migrate into various tissues and body cavities and become macrophages.
	www.vet.purdue.edu /bms/nour/bms520/content/blood/monocyte3.htm (247 words)

	University of London - Leukotriene B-4 is a chemoattractant for mast cell pr...
		University of London - Leukotriene B-4 is a chemoattractant for mast cell pr...
		Leukotriene B-4 is a chemoattractant for mast cell progenitors.
		Pluripotential hematopoietic stem cells in the bone marrow give rise to committed mast cell progenitors that transit via the blood to tissues throughout the body, where they mature.
	www.newsrx.com /newsletters/Medicine-and-Law-Weekly/2005-09-02/082920053331522MLW.html (195 words)

	Host stem cells can selectively reconstitute missing lymphoid lineages in irradiation bone marrow chimeras -- Rivera et ...
		from pluripotential stem cells to mature lymphocytes are not
		From stem cells to lymphocytes: biology and transplantation.
		Identification of a lineage of multipotent hematopoietic progenitors.
	bloodjournal.hematologylibrary.org /cgi/content/full/101/11/4347 (5284 words)

	In vitro Generation of Hematopoietic Stem Cells from an Embryonic Stem Cell Line -- Palacios et al. 92 (16): 7530 -- ... (Site not responding. Last check: )
		Hematopoietic stem cells (HSC) are unique in that they give rise both to new stem cells (self-renewal) and to all blood cell types.
		Embryonic stem (ES) cells were induced to differentiate by coculture with the stromal cell line RP010 and the combination of interleukin (IL) 3, IL-6, and F (cell-free supernatants from cultures of the FLS4.1 fetal liver stromal cell line).
		Cell cytometry analysis of the mononuclear cells produced in the cultures was consistent with the presence of PgP-1
	www.pnas.org /cgi/content/short/92/16/7530 (905 words)

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