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Topic: Podocyte

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	RedNova News - Science - Podocyte biology and the emerging understanding of podocyte diseases (Site not responding. Last check: 2007-10-13)
		Podocytes are injured in many forms of human and experimental glomerular disease, including minimal-change disease (MCD), focal segmental glomerulosclerosis (FSGS), collapsing glomerulopathy, diabetic nephropathy, membranous glomerulopathy, crescentic glomerulonephritis, and lupus nephritis [1, 3, 17].
		The podocyte surface is divided into two parts by the slit diaphragm: the luminal side, facing the urinary space, and the abluminal side which corresponds to the sole of the foot processes and is located against the GBM.
		In particular, the WT1 expression is lost in podocytes of both collapsed glomeruli and normal-appearing glomeruli in collapsing glomerulopathy, indicating that the podocyte phenotype is dysregulated [62].
	www.rednova.com /news/display?id=34359 (5636 words)

	The Number of Podocyte Slit Diaphragms Is Decreased in Minimal Change Nephrotic Syndrome -- PATRAKKA et al. 52 (3): 349 ... (Site not responding. Last check: 2007-10-13)
		in 125 (median 69%) of the podocyte pores (Fig.
		(C) The effacement of the podocyte foot processes is evident in the capillary wall of a patient with MN, leading to a decrease in the frequency of slit pores.
		The proportion of the podocyte slit pores where the slit diaphragms are present in control (TIN) and nephrotic kidney samples.
	www.pedresearch.org /cgi/content/full/52/3/349 (3549 words)

	Podocyte Biology and Response to Injury -- Mundel and Shankland 13 (12): 3005 -- Journal of the American Society of ...
		The actin cytoskeleton is the common downstream pathway and receives input form three podocyte domains: the apical domains, the lateral SD-containing domain, and the basal domain of the FP sole plate, which links the podocyte to the GBM.
		(33) with fusion of podocyte FP and obliteration of filtration
		diseases characterized by the absence of podocyte proliferation
	jasn.asnjournals.org /cgi/content/full/13/12/3005 (7061 words)

	Identification and characterization of a glomerular-specific promoter from the human nephrin gene -- Wong et al. 279 ...
		Podocytes are highly specialized cells that make up a major portion of the glomerular filtration barrier in the kidney.
		Podocytes are an integral component of the glomerular filter and play a pivotal role in the progression of many renal diseases.
		Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria.
	ajprenal.physiology.org /cgi/content/full/279/6/F1027 (3317 words)

	Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of {alpha}3(IV) Collagen Production by ... (Site not responding. Last check: 2007-10-13)
		podocyte, which produces VEGF in a constitutive manner (9).
		Immunofluorescent staining of cultured mouse podocytes demonstrated VEGFR-1 protein, visible as a red fluorescence signal (A), that was largely abrogated by the addition of VEGFR-1–blocking peptide to the anti–VEGFR-1 primary antibody (Ab) (B).
		overactivity in diabetic glomerulopathy is to stimulate podocyte
	diabetes.diabetesjournals.org /cgi/content/full/53/11/2939 (4920 words)

	Expression of Functional CCR and CXCR Chemokine Receptors in Podocytes -- Huber et al. 168 (12): 6244 -- The Journal of ...
		Note that podocyte bands with the expected sizes are present in the CCR4, 8, 9, and 10 lane and in the CXCR1, CXCR3, CXCR4, and CXCR5 lane, whereas in human glomerula (lower panels), bands of CCR1–10 and CXCR1–5 are positive.
		In podocytes grown in FCS, mRNA of the CXCR subtypes 1, 3, 4,
		The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy.
	www.jimmunol.org /cgi/content/full/168/12/6244 (5933 words)

	Podocyte Flattening and Disorder of Glomerular Basement Membrane Are Associated with Splitting of Dystroglycan-Matrix ...
		Podocyte Flattening and Disorder of Glomerular Basement Membrane Are Associated with Splitting of Dystroglycan-Matrix Interaction -- Kojima et al.
		Podocyte Flattening and Disorder of Glomerular Basement Membrane Are Associated with Splitting of Dystroglycan-Matrix Interaction
		Podocyte flattening by protamine sulfate perfusion after perfusion of isolated kidneys with 500 µg protamine sulfate/ml HBSS.
	jasn.asnjournals.org /cgi/content/full/15/8/2079 (5697 words)

	Insight into Podocyte Differentiation from the Study of Human Genetic Disease: Nail-Patella Syndrome and ... (Site not responding. Last check: 2007-10-13)
		Majumdar A, Drummond IA 1999 Podocyte differentiation in the absence of endothelial cells as revealed in the zebrafish avascular mutant, cloche.
		Kriz W, Lemley KV 1999 The role of the podocyte in glomerulosclerosis.
		Lachapelle M, Bendayan M 1991 Contractile proteins in podocytes: immunocytochemical localization of actin and alpha-actinin in normal and nephrotic rat kidneys.
	www.pedresearch.org /cgi/content/full/51/5/551 (4136 words)

	Human Immunodeficiency Virus-1 Tat Induces Hyperproliferation and Dysregulation of Renal Glomerular Epithelial Cells -- ...
		Podocyte growth was evaluated by the XTT assay (by viable cell counting, 100% increase = increase from 4
		induced by [61-86] peptide or basal proliferation of podocytes.
		A: F-actin distribution in fixed and permeabilized podocytes after incubation for 2 hours at 37°C. F-actin distribution in podocytes stimulated with 10 ng/ml of Tat for 2 hours at 37°C. Five experiments were performed with similar results.
	ajp.amjpathol.org /cgi/content/full/161/1/53 (5554 words)

	Roles of the podocyte in glomerular function -- Pavenstädt 278 (2): 173 -- AJP - Renal Physiology
		Effect of ramipril, nifedipine, and moxonidine on glomerular morphology and podocyte structure in experimental chronic renal failure.
		The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal glomerulosclerosis and HIV-associated nephropathy.
		Epitope-specific antibodies to the 43-kD glomerular membrane protein podoplanin cause proteinuria and rapid flattening of podocytes.
	ajprenal.physiology.org /cgi/content/full/278/2/F173 (3816 words)

	Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria -- White et al. 51 (10): 3083 -- Diabetes
		Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria -- White et al.
		Increases in glomerular volume that are a result of increases in M with no accompanying increase in C will not change the number of podocytes per unit surface area.
		Podocyte damage and loss may be important factors in the development
	diabetes.diabetesjournals.org /cgi/content/full/51/10/3083 (4106 words)

	Recurrent focal glomerulosclerosis in the era of genetics of podocyte proteins: theory and therapy -- Ghiggeri et al. ...
		Recurrent focal glomerulosclerosis in the era of genetics of podocyte proteins: theory and therapy
		Podocyte proteins as a clue for explaining proteinuria in inherited FSGS
		Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome.
	ndt.oupjournals.org /cgi/content/full/19/5/1036 (2792 words)

	Podocyte Loss and Progressive Glomerular Injury in Type II Diabetes -- Pagtalunan et al. 99 (2): 342 -- Journal of ...
		The average number of podocytes per glomerulus was determined using the method of Weibel (22).
		the podocyte resembles the peripheral neuron in its inability
		P-Cadherin is decreased in diabetic glomeruli and in glucose-stimulated podocytes in vivo and in vitro studies
	www.jci.org /cgi/content/full/99/2/342 (5264 words)

	Early Glomerular Filtration Defect and Severe Renal Disease in Podocin-Deficient Mice -- Roselli et al. 24 (2): 550 -- ...
		WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis.
		CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.
		Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation.
	mcb.asm.org /cgi/content/full/24/2/550 (5839 words)

	Roles of the podocyte in glomerular function -- Pavenstädt 278 (2): 173 -- AJP - Renal Physiology
		Roles of the podocyte in glomerular function -- Pavenstädt 278 (2): 173 -- AJP - Renal Physiology
		The podocyte is the most differentiated cell type in the glomerulum, which forms a crucial component of the glomerular filtration
		properties of the podocyte and the mechanisms of its cellular
	ajprenal.physiology.org /cgi/content/abstract/278/2/F173 (463 words)

	Early Glomerular Filtration Defect and Severe Renal Disease in Podocin-Deficient Mice -- Roselli et al. 24 (2): 550 -- ...
		Podocytes are specialized epithelial cells covering the basement
		underlying the role of podocytes in glomerular filtration are
		Ghiggeri, G. M., Carraro, M., Vincenti, F. Recurrent focal glomerulosclerosis in the era of genetics of podocyte proteins: theory and therapy.
	mcb.asm.org /cgi/content/abstract/24/2/550 (435 words)

	Enhanced podocalyxin expression alters the structure of podocyte basal surface -- Economou et al. 117 (15): 3281 -- ...
		Enhanced podocalyxin expression alters the structure of podocyte basal surface -- Economou et al.
		Enhanced podocalyxin expression alters the structure of podocyte basal surface
		the extent of adhesion and spreading of podocytes to both collagen
	jcs.biologists.org /cgi/content/abstract/117/15/3281 (281 words)

	Clinical Study: 05-DK-0015, Retinoids for Podocyte Disease (Site not responding. Last check: 2007-10-13)
		In animal models of kidney disease, retinoids restore podocyte phenotype toward normal and reduce proteinuria.
		The objective of this phase II trial is to evaluate safety and develop preliminary evidence of efficacy of retinoid treatment in patients with podocyte disease.
		Histologic endpoints will include change in linear extent podocyte foot process effacement, extent of podocyte proliferation, and expression of podocyte genes at the RNA and protein levels.
	clinicalstudies.info.nih.gov /cgi/detail.cgi?A_05-DK-0015.html (1153 words)

	Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis -- ...
		Yang, Y., Gubler, M.C. and Beaufils, H. (2002) Dysregulation of podocyte phenotype in idiopathic collapsing glomerulopathy and HIV-associated nephropathy.
		Barisoni, L., Kriz, W., Mundel, P. and D'Agati, V. (1999) The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy.
		Shimojo, H. (1998) Adaptation and distortion of podocytes in rat remnant kidney.
	hmg.oupjournals.org /cgi/content/full/12/18/2379 (8003 words)

	Cell Biology of the Glomerular Podocyte -- Pavenstädt et al. 83 (1): 253 -- Physiological Reviews
		Cell Biology of the Glomerular Podocyte -- Pavenstädt et al.
		Glomerular podocytes are highly specialized cells with a complex cytoarchitecture.
		of podocytes during the maintenance and failure of the glomerular
	physrev.physiology.org /cgi/content/abstract/83/1/253 (1292 words)

	Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis -- ...
		Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis -- Patek et al.
		Murine Denys–Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis
		A WT1 Co-regulator Controls Podocyte Phenotype by Shuttling between Adhesion Structures and Nucleus
	hmg.oupjournals.org /cgi/content/abstract/12/18/2379 (584 words)

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