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Topic: Podophyllotoxin

In the News (Tue 29 Dec 09)

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Marvin Harrison

Peter Chernin

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Mickey Rourke

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Hugh Jackman

	Bioprospecting for Podophyllotoxin
		Podophyllotoxin is a natural lignan that is currently being used as a precursor to semi-synthetic anti-cancer drugs etoposide, teniposide, and etopophos.
		In addition, podophyllotoxin is also the precursor to a new derivative CPH 82 that is being tested for rheumatoid arthritis in Europe and other derivatives for the treatment of psoriasis and malaria (Leander and Rosen 1988; Lerndal and Svensson 2000).
		Podophyllotoxin preparations are also on the market for dermatological use to treat genital warts (Beutner 1996) and recently, immune-stimulatory activities of podophyllotoxin have been reported (Pugh et al.
	www.hort.purdue.edu /newcrop/ncnu02/v5-545.html (1667 words)

	Patent 5300500
		The present invention relates to novel 4.beta.-amino podophyllotoxin analog compounds useful in the treatment of tumors, to methods of synthesis of the compounds, and to methods of treating tumors with pharmaceutical preparations containing the compounds.
		Also disclosed are methods of synthesizing the 4.beta.-amino podophyllotoxin analogs corresponding to structures (a) and (b), and methods of their use in treating tumors, as well as pharmaceutical compositions containing the compounds for use in tumor treatment.
		In the treatment method of the invention, a podophyllotoxin analog of the type described above is suspended in a pharmaceutically acceptable carrier and administered in a pharmaceutically effective amount to reduce tumor growth in a mammalian subject.
	www.freepatentsonline.com /5300500.html (6053 words)

	The American Mayapple and its Potential for Podophyllotoxin Production
		Since the total synthesis of podophyllotoxin is an expensive process, availability of the compound from natural renewable resources is an important issue for pharmaceutical companies that manufacture these drugs.
		These accessions were proven to be stable podophyllotoxin chemotypes and confirmed as chemotypes by cultivating them in different growing conditions for three consecutive years and harvesting their blades for lignan extraction (Moraes et al.
		Future demand of podophyllotoxin derivatives may be affected by additional approvals within the anticancer drug market and also by the new therapeutic targets currently being investigated.
	www.hort.purdue.edu /newcrop/ncnu02/v5-527.html (3075 words)

	Radioprotective Effect of Podophyllotoxin in Saccharomyces cerevisiae - Begell House Inc. (Site not responding. Last check: 2007-10-08)
		Podophyllotoxin is one of the major constituents of the whole extract of Podophyllum.
		Podophyllotoxin was not mutagenic or recombinogenic at radioprotective doses (2.5 μg/mL).
		This study indicates that podophyllotoxin is radioprotective in yeast, and its radioprotective effects in higher eukaryotes would be worth investigating.
	dx.doi.org /10.1615/JEnvPathToxOncol.v23.i2.60 (222 words)

	Patent 5057616
		Podophyllotoxin is recovered from podophyllum resin with improved efficiency by adsorbing impurities out of a solution using a solid adsorbent, preferably alumina.
		This improvement finds application in an overall process for purifying podophyllotoxin from podophyllum resin in which the podophyllotoxin is first crystallized from the podophyllum resin, the crystals so formed are dissolved and subjected to the solid adsorbent treatment, crystals are then recovered and optionally recrystallized and dried to give the desired product.
		We have found that weight ratios of adsorbent to crude podophyllotoxin in the range of from about 0.5 to 1 to about 5 to 1 are useful with ratios of from about 1 to 1 to about 3 to 1 being preferred.
	www.freepatentsonline.com /5057616.html (3941 words)

	DermoTopics \| 2 (2001) \| Podophyllotoxin-Creme
		Sie ist in dieser Ausgabe von DermoTopics enthalten: "GD-Stellungnahme: Podophyllin oder Podophyllotoxin zur Behandlung von Genitalwarzen" und auch auf der GD-Homepage (www.gd-online.de) hinterlegt.
		Podophyllotoxin, das aktive Wirkprinzip des Podophyllins, wird in Bezug auf sein Toxizitätspotential wesentlich günstiger beurteilt.
		Podophyllotoxin ist weder mutagen, noch kanzerogen und wirkt nicht zytotoxisch.
	www.dermotopics.de /german/ausgabe_2_01_d/podophyllotoxin_2_01_d.htm (440 words)

	PODOPHYLLOTOXIN CONTENT IN LEAVES OF EASTERN RED CEDAR (JUNIPERUS VIRGINIANA)
		Podophyllotoxin is used to manufacture drugs for treatment of cancer, rheumatoid arthritis, genital warts, psoriasis, and multiple sclerosis.
		The objective of the survey was to examine variations in podophyllotoxin content due to sampling date and plant type.
		Samples of 100 g of fresh leaf tissue were collected from juvenile, immature, mature male, and mature female plants and then dried, ground, extracted in chloroform, and analyzed with HPLC to measure podophyllotoxin content.
	www.actahort.org /books/629/629_11.htm (314 words)

	Variation in podophylloresin and podophyllotoxin contents in different populations of Podophyllum hexandrum (Site not responding. Last check: 2007-10-08)
		Podophyllotoxin 1, 2, 4, 8, 10 and 20 ppm from Sigma Chemicals, USA, was used as standard.
		Resin and podophyllotoxin contents in the rhizomes of different populations are shown in Figure 1.
		While the maximum resin contents were found in population 17.P3 and lowest in population 23.P9, toxin contents were highest in population 9.K2 and lowest in population 5.G2 to 7.G5.
	www.iisc.ernet.in /~currsci/oct25/articles24.htm (792 words)

	Antitumor properties of podophyllotoxin and related compounds. (Site not responding. Last check: 2007-10-08)
		Antitumor properties of podophyllotoxin and related compounds.The lignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide.
		The mechanism by which podophyllotoxin blocks cell division is related to its inhibition of microtubule assembly in the mitotic apparatus.
		Other podophyllotoxin derivatives has also been reported which retained or even improved the cytotoxic activity, but these were weak inhibitors of topoisomerase II in vitro; the data revealed that such analogs exhibit a different, as yet unknown, mechanism of action.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/8616884.html (406 words)

	Podophyllotoxin - Patient UK
		Podophyllotoxin is used to treat warts of the anal and genital areas.
		Podophyllotoxin is usually applied twice a day for three days.
		If you are applying podophyllotoxin yourself, try to apply it to the individual warts, avoiding the surrounding skin.
	www.patient.co.uk /showdoc/30003727 (434 words)

	Enhanced Production of Podophyllotoxin by Fed-batch Cultivation of Podophyllum hexandrum (Site not responding. Last check: 2007-10-08)
		The fed-batch cultivation was able to enhance the biomass and podophyllotoxin accumulation to 48 g/L (DCW basis) and 43.2 mg/L, respectively, in 60 d.
		The volumetric productivity of podophyllotoxin in fed-batch cultivation was found to be 0.72 mg/(L. d) as opposed to 0.53 mg/(L. d) in batch cultivation under optimized culture conditions.
		La productivité volumétrique de podophyllotoxine dans la culture à alimentation discontinue s’avère de 0,72 mg/(L.j) comparativement à 0,53 mg/(L.j) dans la culture discontinue dans des conditions de culture optimales.
	pubs.nrc-cnrc.gc.ca /cjche/ch811011-5.html (367 words)

	Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their ...
		Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants -- Liu et al.
		Articles by Liu, S. Articles by Cheng, Y. Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants
		Substitution of podophyllotoxin with a group in the beta configuration at
	molpharm.aspetjournals.org /cgi/content/abstract/36/1/78 (250 words)

	[In vitro comparison of podophyllotoxin analogues; etoposide, teniposide and NK 611 using human lung cancer cell lines]. (Site not responding. Last check: 2007-10-08)
		[In vitro comparison of podophyllotoxin analogues; etoposide, teniposide and NK 611 using human lung cancer cell lines].
		In terms of the fifty percent tumor growth inhibitory concentration (IC 50) determined by MTT assay, teniposide was most potent among the drugs.
		These results indicate that NK 611 may play a role in a salvage chemotherapy for patients with resistant SCLC.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/7886934.html (115 words)

	Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds -- Sakurai et al. ...
		Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds -- Sakurai et al.
		Articles by Sakurai, H. Articles by Lee, K. Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds
		Podophyllotoxin (PD) and its derivative etoposide (VP-16), a clinically
	molpharm.aspetjournals.org /cgi/content/abstract/40/6/965 (313 words)

	Podophyllotoxin EU, Without Prescription, Lowest Price Euro. Europe, Buy Podophyllotoxin Online From Mexico Pharmacy.
		Description: Podophyllotoxin (Podofilox) is used to remove certain types of warts on the outside skin of the genital areas (penis or vulva).
		Neither the gel nor the solution is used to treat warts that occur inside the rectum, vagina, or urine passageways inside the penis (male) or the vulva (female).
		Podophyllotoxin (Podofilox) works by destroying the skin of the wart.
	www.prescription-europe.com /Podophyllotoxin.htm (375 words)

	Randomised controlled trial and economic evaluation of podophyllotoxin solution, podophyllotoxin cream, and podophyllin ...
		Podophyllotoxin 0.3% cream appeared to be associated with a
		Podophyllotoxin 0.5% v podophyllin 20% to treat penile warts.
		An open, comparative study of the efficacy of 0.5% podophyllotoxin lotion and 25% podophyllin solution in the treatment of condyloma acuminata in males and females.
	sti.bmjjournals.com /cgi/content/full/79/4/270 (3626 words)

	Podophyllotoxin Information and Resources Online at The Drug Database - Find Useful Articles and Websites on ...
		Podophyllotoxin (podofilox) and its derivatives, etoposide and teniposide, are all cytostatic (antimitotic) glucosides.
		Results: In the principal analysis both podophyllotoxin solution (OR 2.93, 95% CI 1.56 to 5.50) and podophyllotoxin cream (OR 1.97, 95% CI 1.04...
		studies have found that pure podophyllotoxin formulations are associated with less adverse...
	www.thedrugdatabase.com /directory/P/Podophyllotoxin (283 words)

	Podophyllotoxin: A Precursor to Anti-Cancer Drugs (Site not responding. Last check: 2007-10-08)
		Podophyllotoxin: A Precursor to Anti-Cancer Drugs Mayapple Anti-Cancer Treatment
		Podophyllotoxin is in a class of compounds called aryl tetralin lignans.
		This could be undertaken in the native plant which produces the drug, or in an a
	www.galactosemia.com /discussion/messages/12781.html (632 words)

	Condyline (Site not responding. Last check: 2007-10-08)
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	Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon ...
		Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubules -- Hammonds et al.
		Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubules
		Podophyllotoxin acted against an early viral process, as an antiviral
	jmm.sgmjournals.org /cgi/content/abstract/45/3/167 (332 words)

	Podophyllotoxin as a probe for the colchicine binding site of tubulin -- Cortese et al. 252 (4): 1134 -- Journal of ... (Site not responding. Last check: 2007-10-08)
		Podophyllotoxin as a probe for the colchicine binding site of tubulin -- Cortese et al.
		podophyllotoxin domains, hence this lability can be ascribed to the
		podophyllotoxin and colchicine each have at least two points of attachment
	www.jbc.org /cgi/content/abstract/252/4/1134 (296 words)

	Usages of Podophyllotoxin?Pharmacology of Podophyllotoxin and...
		Usages of Podophyllotoxin?Pharmacology of Podophyllotoxin and Related Compounds Podophyllotoxin in high concentration from MDidea Group.Basic Data: [Chemical Name]:Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one,5,8,8a,9-tetrahydro-9-hydroxy-5- (3,4,5-trimethoxyphenyl)- [Synoms]:Condylox;NSC 24818;Podofilox;Podophyllinic acid lactone; Podophyllotoxine(NSC-24818)Germany: Podophyllotoxin; podofyllotoksin[Botanical Source]:Diephylleia Sinensis Li, Common Dysosma Rhizome; Rhizoma Dysosmae Versipellis [Formula]: C22H22O8 Basic Function:Precursor to Anti-Cancer Drugs,Treatment against flat acetowhite penile human papillomavirus.
		Podophyllotoxin (podofilox) and its derivatives, etoposide and teniposide, a re all cytostatic (antimitotic) glucosides.
		Podofilox is an extract of the mayapple which generally acts as a cell poiso n which cells undergoing mitosis (division) are particularly vulnerable to.
	www.ccba.bc.ca /discuss1/_disc1/00000f62.htm (503 words)

	Podophyllotoxin online - buy Podophyllotoxin - order Podophyllotoxin without prescription
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	www.yourhealthypharmacy.com /o/n_drug/Podophyllotoxin.shtml (192 words)

	Podophyllotoxin:treatment against flat acetowhite penile human papillomavirus (Site not responding. Last check: 2007-10-08)
		There were five relevant papers for imiquimod [2-6] and two for podophyllotoxin
		and for podophyllotoxin in particular there were a number of high quality studies
		Podophyllotoxin 2 37/50 74 (62 to 86) 4/40 10 (1 to 19) 7.0 (2.7 to 18) 1.6 (1.3
	www.galactosemia.com /discussion/messages/12779.html (1700 words)

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	www.american-pharmacys.com /order-online-free-prescription/drugs/Podophyllotoxin.html (314 words)

	Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule ... (Site not responding. Last check: 2007-10-08)
		Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues -- Gupta 43 (2): 505 -- Cancer Research
		Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues
		studies for the various podophyllotoxin analogues examined are discussed.
	cancerres.aacrjournals.org /cgi/content/abstract/43/2/505 (292 words)

	DermoTopics \| 2 (2001) \| GD-Stellungnahme: Podophyllin oder Podophyllotoxin
		Neben dem als aktives Prinzip aufgefassten Lignan Podophyllotoxin besteht Podophyllin aus einer Reihe weiterer Substanzen.
		Derzeit stehen in Deutschland zwei Podophyllotoxin-haltige Fertigarzneimittel zur Verfügung: Condylox® Lösung mit fünf Milligramm Podophyllotoxin auf einen Milliliter Grundlage aus Ethanol, Milchsäure, Natriumlactat sowie Wartec® Creme 0,15 Prozent mit 7,5 Milligramm Podophyllotoxin auf fünf Gramm Grundlage.
		(9) von Krogh E: Podophyllotoxin in Serum: adsorption subsequent to three-day repeated application of a 0,5 percent ethanolic preparation on condylomata acuminata.
	www.dermotopics.de /german/ausgabe_2_01_d/podophyllin_2_01_d.htm (1198 words)

	Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule ...
		Articles by Paulson, J. Articles by McClure, W. The Journal of Cell Biology, Vol 67, Issue 2 461-467, Copyright © 1975 by The Rockefeller University Press
		Inhibition of transport by podophyllotoxin: an interaction with microtubule protein
		isomers colchicine and podophyllotoxin, are poor inhibitors of axoplasmic
	www.jcb.org /cgi/content/abstract/67/2/461 (142 words)

	Condyline
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	USDAinterface
		Canel, C., Dayan, F.E., Moraes, R.M., and Burandt, C.L. Enhanced yield of podophyllotoxin from natural products through in situ conversion methods.
		Canel, C.; Dayan F. E.; Ganzera, M.; Khan, I.A.; Rimando, A.; Burandt, C.L.; Moraes, R. High yield of podophyllotoxin from leaves of Podophyllum peltatum by situ conversion of podophyllotoxin-4-O-B-D-glucopyranoside.
		Dayan, F.E., Kuhajek, J., Canel, C., Watson, S.B., and Moraes, R.M. Podophyllum and peltatum possesses a beta-glucosidase with high substrate specificity for the aryltetralin lignan podophyllotoxin, Biochimica et Biophysica Acta, 1646: 157-163.
	www.umiss.edu /depts/usda/usdapub.html (3703 words)

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