Podophyllum resin is a potent spindle poison that blocks mitosis metaphase in a manner similar to colchicine.
Podophyllum is caustic but its action differs from those of most caustics in that its effect is neither direct nor immediate: rather, the disruption of cells and erosion of tissue occur slowly subsequent to arrest of cell division and impairment of other cellular processes.
Podophyllum is mutagenic in Lalmonella typhimurium strain of bacteria.
Podophyllum peltatum L. Click on a thumbnail to view an image, or see all the Podophyllum thumbnails at the PLANTS Gallery
Podophyllum peltatum L. occures in the following states: Alabama, Arkansas, Connecticut, District of Columbia, Delaware, Florida, Georgia, Iowa, Illinois, Indiana, Kansas, Kentucky, Louisiana, Massachusetts, Maryland, Maine, Michigan, Minnesota, Missouri, Mississippi, North Carolina, Nebraska, New Hampshire, New Jersey, New York, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Virginia, Vermont, Wisconsin, West Virginia
Podophyllum peltatum L. This plant is listed by the U.S. federal government or a state.
Effects of Podophyllum compositum and Podophyllum peltatum L. derived podophyllotoxin on human polymorphonuclear ...(Site not responding. Last check: )
Podophyllum peltatum L. derived compounds exhibited an enhanced oxidative response to a subsequent challenge with bacterial formyl-peptides.
Podophyllum derived compound was observed on neutrophils stimulated with 50 ng/ml phorbol ester.
Podophyllum 4x occurred at nominal doses of podophyllotoxin which were much lower (0.025 µg/ml) than the doses of pure podophyllotoxin that caused the same effect (about 1 µg/ml).
The genus Podophyllum is a rich source of podophyllotoxin, an aryltetralin lignan that has important biological activities (Leander and Rosen 1988) and is the precursor of semisynthetic chemotherapeutic drugs such as etoposide, teniposide, and etopophos (Stähelin and Wartburg 1991; Imbert 1998).
Podophyllum peltatum is found throughout the wooded landscape of the eastern half of North America (Meijer 1974).
Podophyllum peltatum is known to have a high degree of self-incompatibility and while it is possible that the slightly different genotypes might be the result of pollination events it is very unlikely.
Podophyllum should not be applied to friable, bleeding, or recently biopsied warts, because systemic absorption of the medication may be increased.
Podophyllum should not be used on moles or birthmarks, since acute inflammation or ulceration may occur.
A 25% Podophyllum Resin Topical Solution USP may be prepared extemporaneously by mixing 25 grams of the alcohol-soluble extractive of podophyllum resin in alcohol and 10 grams of the alcohol-soluble extractive of benzoin in alcohol, and diluting with alcohol to make 100 mL.
Also, keep podophyllum away from the eyes and other mucous membranes, such as the inside of the nose, mouth, or vagina.
Therefore, apply petrolatum around the affected area before you apply podophyllum, and/or apply talcum powder to the treated area immediately after you apply podophyllum.
After podophyllum is applied, allow it to remain on the affected area for 1 to 6 hours as directed by your doctor.
Podophyllum resin is a powdered mixture of resins extracted from the roots of Podophyllum pelltatum.
Podophyllum resin should not be applied to large areas of skin, nor should it be used in the treatment of cervical, urethral, anorectal or oral warts.
Preparations of podophyllum resin should be used only under close medical supervision because potentially serious local and systemic toxic effects can result from prolonged or excessive applications.
Podophyllum is used to treat warts of the anal and genital areas.
Podophyllum paint is usually applied by a doctor or nurse once a week and washed off within six hours.
Podophyllum occasionally causes skin irritation such as itching, pain, rashes, swelling, ulceration or scabbing.
www.patient.co.uk /showdoc/30003726 (455 words)
MedlinePlus Drug Information: Podophyllum (Topical)(Site not responding. Last check: )
However, it is not known whether topical podophyllum passes into breast milk.
Children—Although there is no specific information comparing use of topical podophyllum in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
Although there is no specific information comparing use of topical podophyllum in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
Anti-inflammatory effects of Podophyllum hexandrum (RP-1) against lipopolysaccharides induced inflammation in mice.
Anti-inflammatory potential of aqueous extract of Podophyllum hexandrum, a plant well documented in Ayurvedic literature for various therapeutic purposes, was investigated.
Premkumar, I. and Goel, H.C., Iron chelation and related properties of Podophyllum hexandrum, a possible role in radioprotection.
The plants long, thin rhizome is the most poisonous part, but also the most useful (since the 1820's the plant has been recognized as being of medicinal value in the official U.S.A Pharmacopoeia) because it contains high concentrations of the compounds podophyllotoxin and alpha and beta peltatin, all of which have anti-cancer properties.
Now in closing it is apparent that Podophyllum is a medicine of most extensive service; it's greatest power lies in its action upon the liver and bowels.
Podophyllum is a powerful medicine exercising an influence on every part of the system, stimulating the glands to healthy action.
Viable Herbal Solutions is a company that researches, develops, tests, manufactures and distributes unique formulations of proprietary herbal-based products by combining high quality herbs, and concentrated herbal extracts, from all over the world.
Syngonium podophyllum (PIER species info)(Site not responding. Last check: )
podophyllum: "Stems glaucous (at least in northern Central America), smooth, lacking any emergences; leaf segments usually somewhat unequal, not of relatively uniform size and shape; petioles subterete or with only an obtuse medial rib; staminate flowers truncate at the apex with an indication of the line of fusion; Mexico to Panama" (Croat, 1981).
Additional online information about Syngonium podophyllum is available from the Hawaiian Ecosystems at Risk project (HEAR).
Taxonomic information about Syngonium podophyllum may be available from the Germplasm Resources Information Network (GRIN).
The following is a list of health concerns for which Podophyllum is listed as a homeopathic remedy.
Refer to the individual concerns for more information.
Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.