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Topic: Poliovirus

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	Poliomyelitis - Wikipedia, the free encyclopedia
		The poliovirus is a small RNA (ribonucleic acid) virus that has three different strains and is extremely infectious.
		After the person is exposed to the poliovirus, the virus is expelled through faeces for several weeks and it is during this time that a polio outbreak can occur in a community.
		Once the poliovirus invades the intestines, it is absorbed by the capillaries in the walls of the intestine and is then carried by the bloodstream throughout the body.
	en.wikipedia.org /wiki/Polio (2412 words)

	Synthetic Life
		The synthetic poliovirus cDNA was transcribed by RNA polymerase into viral RNA, which translated and replicated in a cell-free extract, resulting in the de novo synthesis of infectious poliovirus.
		Poliovirus, an enterovirus of the Picornaviridae, is a small, nonenveloped, icosahedral virus consisting of five different macromolecules: 60 copies each of capsid polypeptides VP1, -2, -3, and -4 and one copy of the positive-sense, single-stranded RNA genome (~7.5 kilobases in length) (Fig.
		The presence or absence of genetic markers in the inoculated virus and the virus isolated from the spinal cords of paralyzed mice was confirmed by amplification of the viral RNA by RT-PCR and restriction enzyme analysis.
	www.evilbible.com /Synthetic_Life.htm (2376 words)

	Poliovirus (Site not responding. Last check: 2007-10-18)
		Poliovirus is the etiologic agent of poliomyelitis, a human disease of the central nervous system.
		Infection by poliovirus is initiated by attachment to specific cell surface molecules or receptors.
		The background of the image is the actual micrograph that was used to calculate the reconstruction of the complex and the faint dark spots are images of the individual virions.
	bilbo.bio.purdue.edu /~baker/projects/picorna/polio/polio.html (126 words)

	Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice -- Boot et ...
		Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice
		Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection.
		Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut.
	jvi.asm.org /cgi/content/full/77/11/6541 (2189 words)

	Ipol Indications, Dosage, Storage, Stability - Poliovirus Vaccine - RxList Monographs
		Immunity induced by inactivated poliovirus vaccine and excretion of virus.
		Vaccination with inactivated poliovirus vaccine and oral poliovirus vaccine in Denmark.
		Response to hemophilic patients to poliovirus vaccination: Correlation with HIV serology and with immunological parameters.
	www.rxlist.com /cgi/generic/polio_ids.htm (2115 words)

	Polio -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-18)
		It may proceed to the (The fluid (red in vertebrates) that is pumped by the heart) blood stream and into the (The portion of the vertebrate nervous system consisting of the brain and spinal cord) central nervous system causing (One of the contractile organs of the body) muscle weakness and often paralysis.
		The three strains of poliovirus result in non-paralytic polio, paralytic polio, and (additional info and facts about bulbar polio) bulbar polio.
		The poliovirus attacks the spinal column and the (A neuron conducting impulses outwards from the brain or spinal cord) motor neurons -- which control physical movement.
	www.absoluteastronomy.com /encyclopedia/p/po/polio.htm (1955 words)

	POLIOVIRUS VACCINE LIVE ORAL TRIVALENT
		To accomplish this with live poliovirus vaccine, it is necessary for the virus to multiply in the intestinal tract.
		The immune response to Poliovirus Vaccine Live Oral Trivalent is similar to that induced by natural infection with poliovirus and includes the development of secretory antibody within the intestinal tract.
		Poliovirus Vaccine Live Oral Trivalent can be administered simultaneously with DPT, MMR or Haemophilus influenzae type b (Hib) conjugate vaccines without increased side effects; the immune response to each antigen is adequate and comparable to that found in patients receiving these vaccines according to the routine schedule.
	www.whale.to /m/polio.html (1344 words)

	Pathogenesis of poliovirus infection in PVRTg mice: poliovirus replicates in peritoneal macrophages -- Buisman et al. ...
		Pathogenesis of poliovirus infection in PVRTg mice: poliovirus replicates in peritoneal macrophages
		The pathogenesis of poliovirus infection, responsible for the
		of poliovirus in PVRTg mice, and in the induction of the mucosal
	vir.sgmjournals.org /cgi/content/full/84/10/2819 (4497 words)

	Polio.Com: Orimune®
		The poliovirus vaccine should be used with caution in patients with a history of neomycin hypersensitivity or streptomycin hypersensitivity because these agents may be used in the preparation of OPV.
		Poliovirus antibodies may be excreted into breast milk, and breast-feeding is not recommended for 2-3 hours before or after inoculation in neonates immunized at birth.
		Poliovirus may be shed in the feces (and possibly from the pharynx) of vaccinees for 6-8 weeks after OPV administration.
	www.stemrich.com /hci/polio/orimune.htm (1223 words)

	Eckard Wimmer (Site not responding. Last check: 2007-10-18)
		Poliovirus is the prototype of a very large family of human pathogens, the Picornaviridae.
		Although HCV and poliovirus are very different viruses in many aspects of their molecular biology, surprisingly, many of their basic mechanisms of replication are related.
		Chemical and molecular studies have shown that poliovirus is a remarkably simple biological entity: an aggregate consisting of only five different species of macromolecules (four proteins and one single-stranded RNA) that form an icosahedral particle of altogether 241 macromolecules.
	www.uhmc.sunysb.edu /microbiology/Wimmer.html (881 words)

	Will The Poliovirus Eradication Program Rid the World of Childhood Paralysis? (Site not responding. Last check: 2007-10-18)
		The mystery deepens when we examine World Health Organization (WHO) statistics on AFP and poliovirus infection in the Dominican Republic for the last several years.Although the number of cases of AFP in the Dominican Republic from 1996 to 1999 range from 4 to 24, not a single case of poliovirus was detected.
		Like poliovirus researchers before them, it is clear that Dulbecco and Vogt were propagating disease-associated substances in their tissue cultures, and that they later transferred these substances to monkeys in whom acute flaccid paralysis developed.
		One hundred of those were classified as poliovirus-related, leaving 209 cases"two-thirds of the total"probably due to a cause other than poliovirus (with the caveat that epidemiological statistics are not perfectly accurate in every country of the world).
	www.chronicillnet.org /articles/paralyticpolio.html (6753 words)

	WHO \| Poliomyelitis
		This followed the certification of the eradication of smallpox in 1980, progress during the 1980s towards elimination of the poliovirus in the Americas, and Rotary International’s commitment to raise funds to protect all children from the disease.
		As long as a single child remains infected with poliovirus, children in all countries are at risk of contracting the disease.
		Stopping wild poliovirus transmission: The highest priority is reaching all children during SIAs in the remaining seven endemic countries.
	www.who.int /mediacentre/factsheets/fs114/en (1820 words)

	MedlinePlus Drug Information: Poliovirus Vaccine (Systemic) (Site not responding. Last check: 2007-10-18)
		Poliovirus (poe-lee-oh VYE-russ) vaccine is an active immunizing agent used to prevent poliomyelitis (polio).
		There are two types of polio vaccine that are given by injection, poliovirus vaccine inactivated (IPV) and poliovirus vaccine inactivated enhanced potency (eIPV).
		The type of vaccine that is given by mouth is called poliovirus vaccine live oral (OPV).
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202470.html (1638 words)

	Poliovirus tropism and attenuation are determined after internal ribosome entry -- Kauder and Racaniello 113 (12): 1743 ...
		for the increased susceptibility to poliovirus infection is
		mouse that is susceptible to poliovirus infection by the oral
		Determinants in the 5' noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype.
	www.jci.org /cgi/content/full/113/12/1743 (6810 words)

	Oral Poliovirus Vaccine
		In 1961, type 1 and 2 monovalent oral poliovirus vaccine (MOPV) was licensed, and in 1962, type 3 MOPV was licensed.
		In 1963, trivalent oral poliovirus vaccine (OPV) was licensed and largely replaced IPV use.
		Only primates are susceptible to all three serotypes of poliovirus, so the safety of oral poliovirus vaccine (OPV) and its consistency have been tested in the monkey neurovirulence test (MNVT).
	www.brown.edu /Courses/Bio_160/Projects2000/Polio/PoliovirusOPV.htm (834 words)

	Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal ...
		Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection -- Crotty et al.
		Time-course of poliovirus titre (p.f.u./mg) in cPVR mice (
		Phenotype of Sabin poliovirus vaccine strains in cPVR mice
	vir.sgmjournals.org /cgi/content/full/83/7/1707 (6384 words)

	[No title] (Site not responding. Last check: 2007-10-18)
		For the first time, scientists have used the genetic map of the poliovirus to construct a man-made version of the crippling virus -- in a move they say illustrates the potential for humans to manufacture viruses for use as bio-weapons.
		Many researchers have believed poliovirus could be "recreated" using the published data on the virus' genome, but no one had done the work.
		The poliovirus project required nearly three years of work at a highly sophisticated research laboratory using the most advanced DNA synthesis technology available at State University of New York of Stony Brook.
	www.mercola.com /2002/jul/27/fake_poliovirus.htm (1181 words)

	Importation of Wild Poliovirus into Qinghai Province - China, 1999
		The isolates were later differentiated as wild poliovirus type 1 at the National Poliovirus Laboratory in Beijing.
		The Qinghai poliovirus strain is closely related (98%) to poliovirus isolates from central and northern India during 1998-1999, but unrelated to polioviruses that circulated in China until 1994.
		Preliminary data from this investigation suggest that the polio case in Qinghai was caused by importation of wild poliovirus with limited circulation.
	www.cdc.gov /mmwr/preview/mmwrhtml/mm4906a1.htm (932 words)

	Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with ...
		Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen -- Mandl et al.
		of poliovirus, or the attenuated vaccine strain, to elicit MHC
		Poliovirus recombinant stocks were produced as described previously (10).
	www.pnas.org /cgi/content/full/95/14/8216 (5886 words)

	La Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site ...
		1 poliovirus (Mahoney strain) at a MOI of 5.
		Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro.
		Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.
	mcb.asm.org /cgi/content/full/24/15/6861 (5935 words)

	[No title] (Site not responding. Last check: 2007-10-18)
		The sequence of l060 3'-terminal nucleotides of poliovirus RNA as determined by a modification of the dideoxynucleotide method.
		Harber, J.J., Bradley, J., Anderson, C.W., and Wimmer, E., The Catalysis of the Poliovirus VPO Maturation Cleavage is Not Mediated by Serine 10 of VP2.
		Antigenic Hybrids of Poliovirus: Trivalent Polioviruses, and Characterization of a Poliovirus/Rhinovirus Hybrid.
	www.uhmc.sunysb.edu /microbiology/Wimmerref.html (7505 words)

	Poliovirus proves IRES-istible in vivo -- Semler 113 (12): 1678 -- Journal of Clinical Investigation
		of poliovirus was identified in the stem-loop V region of the
		Ren, R., and Racaniello, V.R. Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice.
		Tissue-specific replicating capacity of a chimeric poliovirus that carries the internal ribosome entry site of hepatitis C virus in a new mouse model transgenic for the human poliovirus receptor.
	www.jci.org /cgi/content/full/113/12/1678 (2356 words)

	Mucosal Immunization of Cynomolgus Macaques with Two Serotypes of Live Poliovirus Vectors Expressing Simian ...
		Poliovirus is an attractive live virus vector for several reasons.
		Analyzing the mucosal immune response generated by the live poliovirus vector was a primary goal of this study.
		Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen.
	jvi.asm.org /cgi/content/full/73/11/9485 (8111 words)

	\|\| DukeMedNews \|\| Researchers Use Crippled Poliovirus to Attack Brain Cancer
		In the study, the modified poliovirus rapidly killed cancer cells derived from primary brain tumors as well as cells derived from breast and colon cancer metastases -- all within a matter of four to six hours.
		In fact, polio is known to be one of the quickest killers of infected host cells, producing approximately a thousand additional infectious viral units per infected cell, he said.
		But giving the modified poliovirus to humans -- even to terminal brain cancer patients -- requires rigorous testing to understand the mechanism behind its virulence in cancer cells and its impotence in normal brain cells.
	www.dukemednews.org /news/article.php?id=7273 (1128 words)

	Surveillance for Poliovirus Vaccine Adverse Events, 1991 to 1998: Impact of a Sequential Vaccination Schedule of ...
		Surveillance for Poliovirus Vaccine Adverse Events, 1991 to 1998: Impact of a Sequential Vaccination Schedule of Inactivated Poliovirus Vaccine Followed by Oral Poliovirus Vaccine -- Wattigney et al.
		Plotkin SA Current issues in evaluating the efficacy of oral poliovirus vaccine and inactivated poliovirus vaccine immunization.
		Von Magnus H, Peterson I Vaccination with inactivated poliovirus vaccine and oral poliovirus vaccine in Denmark.
	pediatrics.aappublications.org /cgi/content/full/107/5/e83 (4055 words)

	Picornaviruses
		In both cases the receptor molecule is a long molecule, sticking out from of the surface of the cell and binding to a "canyon" on the virus particle.
		For poliovirus, this is a vigorous process, with nearly all translation of cellular genes blocked.
		Replication of the virus in the CNS occurs in the 'grey matter', particularly motor neurones in the anterior horns of the spinal cord and brain stem.
	www-micro.msb.le.ac.uk /3035/Picornaviruses.html (3176 words)

	poliovirus vaccine - OneLook Dictionary Search
		We found 4 dictionaries with English definitions that include the word poliovirus vaccine:
		Tip: Click on the first link on a line below to go directly to a page where "poliovirus vaccine" is defined.
		Phrases that include poliovirus vaccine: oral poliovirus vaccine, inactivated poliovirus vaccine, live oral poliovirus vaccine, poliovirus vaccine inactivated, poliovirus vaccine live oral, more...
	www.onelook.com /?w=poliovirus+vaccine&ls=all (112 words)

	POLIOVIRUS VACCINE - INJECTION (Ipol, Poliovax) side effects, medical uses, and drug interactions.
		POLIOVIRUS VACCINE - INJECTION (Ipol, Poliovax) side effects, medical uses, and drug interactions.
		MedicineNet Home > Medications A-Z List > poliovirus vaccine-injection
		Please consult your healthcare provider before beginning any course of supplementation or treatment.
	www.medicinenet.com /poliovirus_vaccine-injection/article.htm (430 words)

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