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Topic: Polycystic kidney disease


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  Polycystic kidney disease - Wikipedia, the free encyclopedia
PKD is characterized by the presence of multiple cysts (polycystic) in both kidneys.
ADPKD is, however, a systemic disease with cysts in other organs such as the liver, seminal vesicles, pancreas, and arachnoid mater and non-cystic abnormalities such as intracranial aneurysms and dolichoectasias, dilatation of the aortic root and dissection of the thoracic aorta, mitral valve prolapse, and abdominal wall hernias.
In 85% of patients, ADPKD is caused by mutations in the gene PKD1 (chromosomal locus 16p13.3-p13.1); in 15% of patients mutations in PKD2 (chromosomal locus 4q21-q23) are causative.
en.wikipedia.org /wiki/Polycystic_kidney_disease   (1072 words)

  
 MedlinePlus Medical Encyclopedia: Polycystic kidney disease
Polycystic kidney disease is an inherited kidney disorder that enlarges the kidneys and interferes with their function because of multiple cysts on the kidneys.
Polycystic kidney disease (PKD) is an inherited disorder (with autosomal dominant inheritance -- if one parent carries the gene, the children have a 50% chance of developing the disorder) where multiple clusters of cysts form on the kidneys.
PKD is associated with brain aneurysms,diverticula of the colon, and with cysts in the liver, pancreas, and testes.
www.nlm.nih.gov /medlineplus/ency/article/000502.htm   (863 words)

  
 Polycystic Kidney Disease   (Site not responding. Last check: 2007-09-02)
Polycystic kidney disease (PKD), sometimes called autosomal dominant polycystic kidney disease, is a life- threatening genetic disorder that eventually produces end- stage renal (kidney) disease in the majority of cases.
Patients progressing to end- stage renal disease, must have either hemodialysis (a removal of the toxic substances in the blood by a machine that acts as an artificial kidney) or a kidney transplant to survive.
Polycystic kidney disease causes fluid- filled cysts to form in the kidneys, disrupting the ability of the kidneys to remove harmful toxins from the body.
www.coolware.com /health/medical_reporter/kidney2.html   (1125 words)

  
 Polycystic kidney disease - Genetics Home Reference
Mutations in the PKD1, PKD2, and PKHD1 genes cause polycystic kidney disease.
Mutations in the PKHD1 gene cause autosomal recessive polycystic kidney disease.
Although polycystic kidney disease is usually a genetic disorder, a small percentage of cases are not caused by gene mutations.
ghr.nlm.nih.gov /condition=polycystickidneydisease   (1148 words)

  
 TMR - Polycystic Kidney Disease
Polycystic kidney disease (PKD), sometimes called autosomal dominant polycystic kidney disease, is a life-threatening genetic disorder that eventually produces end-stage renal (kidney) disease in the majority of cases.
Patients progressing to end-stage renal disease, must have either hemodialysis (a removal of the toxic substances in the blood by a machine that acts as an artificial kidney) or a kidney transplant to survive.
Polycystic kidney disease causes fluid-filled cysts to form in the kidneys, disrupting the ability of the kidneys to remove harmful toxins from the body.
medicalreporter.health.org /tmr0795/polycyst0795.html   (1088 words)

  
 Polycystic kidney disease
Polycystic kidney disease is a disease in which a large number of fluid filled cysts form within the kidneys.
Polycystic kidney disease is now recognised as a particular problem in Persians and Exotic Shorthairs because it is an inherited disease which has become very common in these breeds.
Polycystic kidney disease (PKD) is an inherited condition that causes multiple cysts (pockets of fluid) to form in the kidneys.
www.fabcats.org /pkd.html   (980 words)

  
 Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys.
Autosomal recessive polycystic kidney disease is caused by a particular genetic flaw that is different from the genetic flaw that causes autosomal dominant polycystic kidney disease.
Ultrasound examination of kidneys of relatives can be helpful; for example, a parent or grandparent with autosomal dominant polycystic kidney disease cysts could help confirm diagnosis of autosomal dominant polycystic kidney disease in a fetus or child.
aaaaq.com /kidney_urologic/polycystic_kidney_disease   (2712 words)

  
 Polycystic Kidney Disease- Health Encyclopedia and Reference
Polycystic kidney disease (PKD) is an inherited disease that causes cysts to form in the kidneys.
These renal (of the kidney) cysts are filled with fluid and formed by individual nephrons, the subunits of the kidney.
The patient is unaware of the disease unless some complication; hypertension, blood in the urine, pain caused by bleeding into the kidney, a stone or infection, calls attention to the kidney, usually long before kidney failure has developed.
www.drkoop.com /encyclopedia/43/69.html   (671 words)

  
 eMedicine - Polycystic Kidney Disease : Article by Henrique M Lederman, MD, PhD   (Site not responding. Last check: 2007-09-02)
Children with polycystic kidneys and liver involvement were assigned to perinatal, neonatal, infantile, or juvenile groups on the basis of their age at presentation and, in some cases, on the knowledge that a sibling had the condition.
Once PKD is diagnosed, the frequency of outpatient follow-up with the nephrologist depends on the degree of renal dysfunction and on complicating features such as a failure to thrive, nutritional and feeding difficulties, hypertension, electrolyte disturbances, urinary infections, and hepatic fibrosis (ie, portal hypertension).
Boal DK, Teele RL: Sonography of infantile polycystic kidney disease.
www.emedicine.com /ped/topic1846.htm   (5880 words)

  
 Health Information - Yale Medical Group
Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts filled with fluid in the kidneys.
PKD can also cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain.
Autosomal recessive PKD is a rare, inherited form of polycystic kidney disease thought to be caused by a particular genetic flaw that is different from the genetic flaw that causes autosomal dominant PKD.
ymghealthinfo.org /content.asp?page=P01490   (790 words)

  
 Polycystic Kidney Disease - Digestion and digestive-related information on MedicineNet.com
Polycystic kidney disease (PKD) is a disorder that is characterized by the growth of numerous cysts in the kidneys.
PKD cysts can replace much of the mass of the kidneys, thereby reducing kidney function and leading to kidney failure.
The kidneys are two organs, each about the size of a fist, that are located in the upper part of the abdomen, towards the back.
www.medicinenet.com /polycystic_kidney_disease/article.htm   (508 words)

  
 Polycystic Kidney Disease - nephrologychannel
Acquired cystic kidney disease (ACK) affects patients with chronic renal failure and causes hematuria, erythrocytosis (increase in red blood cells), and is associated with the development of cancer.
Polycystic kidney disease (PKD) is the most frequently inherited disease; it affects approximately 600,000 people in the United States and over 12,000,000 worldwide.
PKD autosomal dominant types 1 and 2 are linked to a protein abnormality on chromosomes 16 and 4, respectively, and run in families.
www.nephrologychannel.com /polycystic   (403 words)

  
 Polycystic Kidney Disease
Polycystic kidney disease, or PCKD, is an inherited kidney disorder in which multiple cysts grow in the kidneys, destroying normal kidney tissue.
Because it is an inherited defect, children of a parent with PKD have a 50 percent chance of inheriting the disease.
He or she may perform a kidney biopsy, in which a small sample of kidney tissue is removed for examination under a microscope.
www.hmc.psu.edu /healthinfo/jkl/kidneydisease.htm   (869 words)

  
 Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a well documented abnormality in domestic cats.
PKD is not a new disease and has been reported in the literature for over 30 years.
Early onset, bilateral presentation (both kidneys), and multiple cysts are all traits of the heritable form of the disease.
www.vgl.ucdavis.edu /service/cat/PKD.html   (714 words)

  
 Polycystic Kidney Disease (PKD) -- familydoctor.org   (Site not responding. Last check: 2007-09-02)
Polycystic kidney disease (PKD) is an inherited disease that affects the kidneys.
PKD is generally worse in men, fls and patients with sickle cell disease.
PKD can be diagnosed in unborn babies using a test called amniocentesis (analysis of the amniotic fluid that surrounds the baby) or a test called chorionic villus sampling (examination of a small piece of the placenta).
familydoctor.org /142.xml   (606 words)

  
 Cat Fanciers' Association: Polycystic Kidney Disease
Polycystic kidney disease is an inherited kidney disease that has been found in Persian cats.
Polycystic disease is a disease that shows up later in life (late onset) with enlarged kidneys and kidney dysfunction occurring between three and 10 years of age (on average at seven years of age).
As PKD is the result of an autosomal dominant gene, it is relatively easy to track and eliminate.
www.cfainc.org /health/pkd.html   (937 words)

  
 Polycystic Kidney Disease   (Site not responding. Last check: 2007-09-02)
In some rare cases, the cause of autosomal dominant PKD occurs spontaneously in the child soon after conception—in these cases the parents are not the source of this disease.
For this reason, autosomal dominant PKD is often called "adult polycystic kidney disease." Yet, in some cases, cysts may form earlier, even in the first years of life.
Autosomal recessive PKD is caused by a particular genetic flaw that is different from the genetic flaw that causes autosomal dominant PKD.
kidney.niddk.nih.gov /kudiseases/pubs/polycystic   (2508 words)

  
 Polycystic Kidney Disease
Polycystic kidney disease in Persian cats culminates in chronic renal failure after a variable clinical course.
Polycystic disease of the kidney and liver in an adult Persian cat.
Polycystic kidneys and peritoneopericardial diaphragmatic hernia in the cat: A case report.
www.netcat.org /pkd.html   (991 words)

  
 the Feline PKD Home Page; Information about "Autosomal Dominant Polycystic Kidney Disease" in cats
Polycystic Kidney Disease is an inherited kidney disease that has been found in Persian/Exotic cats.
PKD is most easily diagnosed by ultrasound, which can identify the disease very early in its course.
Polycystic Kidney Disease is a slowly progressive disease.
www.felinepkd.com   (832 words)

  
 Polycystic Kidney Disease
In some rare cases, the cause of autosomal dominant PKD occurs spontaneously in the child soon after conception--in these cases the parents are not the source of this disease.
The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases, one of the National Institutes of Health, under the U.S. Public Health Service.
The clearinghouse, authorized by Congress in 1987, provides information about diseases of the kidneys and urologic system to people with such afflictions and their families, health care professionals, and the public.
www.medhelp.org /gov/www42.htm   (2242 words)

  
 UpToDate Patient information: Polycystic kidney disease
The primary manifestations of renal infection in PKD are fever and flank pain.
In those with PKD1 disease, the probability of a positive ultrasonogram is estimated to be 8 percent in patients younger than age 10 and increases to almost 100 percent by the age of 30.
Not all patients with kidney disease are alike, and it is important that your situation is evaluated by someone who knows you as a whole person.
patients.uptodate.com /topic.asp?file=kidn_dis/6183   (2960 words)

  
 Polycystic kidney disease (PKD, or PCKD)
Infantile polycystic kidney disease is rare, causes liver damage as well as kidney trouble, and unfortunately often leads to affected children dying when they are young.
Almost all patients with PKD have high blood pressure – this is a problem with many kidney diseases.
The diagnosis may be hard to make, because PKD patients may often have blood in their urine on testing, and they have other reasons for pain in the region of the kidneys.
renux.dmed.ed.ac.uk /EdREN/EdRenINFObits/PCKDLong.html   (1173 words)

  
 eMedicine - Polycystic Kidney Disease : Article by Roser Torra, MD, PhD
Because the disease is caused mainly by truncating mutations in the PKD1 and PKD2 genes, inadequate levels of polycystin (haplo insufficiency) may cause ADPKD.
Polycystic liver disease belongs to a family of liver diseases characterized by an overgrowth of biliary epithelium and supportive connective tissue.
Ensure that patients are aware that this disease is hereditary and that their children have a 50% chance of acquiring the disease.
www.emedicine.com /med/topic1862.htm   (4144 words)

  
 Polycystic Kidney Disease   (Site not responding. Last check: 2007-09-02)
Kidneys are one of the most common organs transplanted and PKD is a leading cause of kidney failure requiring kidney transplants.
Sometimes the kidneys can grow from their normal size (about the size of an apple or fist) to the size of a football and can weigh up to 38 pounds.
One of the problems with this disease is that it is a heritable condition and every sibling or child has a fifty percent chance of also suffering from PKD.
www.usoe.k12.ut.us /curr/science/core/bio/genetics/polycystic_kidney.htm   (443 words)

  
 Healthopedia.com - Polycystic Kidney Disease (Polycystic Disease of the Kidneys)
Polycystic kidney disease (PKD) is an inherited condition that results in abnormally formed kidneys.
The earlier symptoms begin, the more severe the disease usually is. All three forms are inherited from either one or both parents, depending on the type of PKD.
Polycystic kidney disease results in malformed kidneys, which are filled with small sacs, or cysts, instead of normal kidney tissue.
www.healthopedia.com /polycystic-kidney-disease   (415 words)

  
 Polycystic Kidney Disease
The common inherited disorder is characterized by cysts in the kidneys and other organs, high blood pressure, and aneurysms (bulges in blood vessels, which may burst) in the brain.
Carefully controlling blood pressure and using ACE-inhibitors or ARBs significantly delays or prevents kidney disease and failure from diabetes and other causes by reducing protein in the urine and preventing damage to the small blood vessels in the kidneys.
Earlier trials of these treatments in PKD were not definitive, possibly because a small number of patients were involved.
www.medicalnewstoday.com /medicalnews.php?newsid=36645   (698 words)

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