
	Where results make sense

Topic: Polycythaemia

In the News (Sun 12 Oct 08)

Angelina Jolie

Brett Myers

Manmohan Singh

Charlie Manuel

Japanese Grand Prix

Nobel Peace Prize

Halo 3

Swedish Academy

Ricky Ponting

Dalai Lama

	polycythaemia vera - General Practice Notebook
		In polycythaemia rubra vera, as with all myeloproliferative disorders, there are excess granulocytic, and megakaryocytic elements, all derived from a single multipotent stem cell.
		However, in polycythaemia vera the erythroid precursors dominate, and hence there is an absolute increase in red cell mass and blood volume.
		In polycythaemia rubra vera the erythroid offspring are unusual in being sensitive eg to insulin-like growth factor ± interlukin-3 - they are also do not require erythropoietin to avoid apoptosis (programmed cell death).
	www.gpnotebook.co.uk /simplepage.cfm?ID=-281739257 (858 words)

	Medical Dictionary: Polycythaemia - WrongDiagnosis.com
		Polycythaemia: An increase in the total red cell mass of the blood.
		Polycythaemia: Polycythaemia is listed as a type of (or associated with) the following medical conditions in our database: Blood conditions
		Polycythaemia (symptom): An abnormal increase in the number of blood cells in the blood.
	www.wrongdiagnosis.com /medical/polycythaemia.htm (219 words)

	POLYCYTHAEMIA
		Polycythaemia happens when there are too many red blood cells in the circulating blood.
		In these cases, known as polycythaemia rubra vera, it is thought that there is an abnormality of the tissues, such as bone marrow, that make red blood cells.
		Polycythaemia produces a wide variety of symptoms which may arise in almost any part of the body.
	www.mydr.com.au /default.asp?article=519 (564 words)

	About thrombosis: thrombophilia: acquired thrombophilia: myeloproliferative disorders
		Myeloproliferative disorders (MPD) include blood disorders such as polycythaemia vera, idiopathic myelofibrosis, chronic myelogenous leukaemia and essential or primary thrombocythaemia (ET).
		Polycythaemia vera is due to a sustained elevation in the blood's red cell count.
		Treatment of ET aims to reduce the risk of thrombosis by giving aspirin and other antiplatelet drugs, such as clopidogrel, and by reducing the platelet count with certain cytotoxic drugs, such as hydroxyurea.
	www.thrombosis-charity.org.uk /aboutthrom_thrombophilia_acquired_md.htm (294 words)

	BloodMed - General Section (Site not responding. Last check: 2007-11-01)
		Some of the important causes of polycythaemia, classified according to mechanism, are shown in Table 4.4.
		Polycythaemia vera, also referred to as polycythaemia rubra vera or primary proliferative polycythaemia, is a myeloproliferative disorder characterized by overproduction of red cells.
		If it is a true polycythaemia and the patient is not hypoxic, do an ultrasound examination of the abdomen to assess the kidneys and spleen, measure serum erythropoietin concentration and do a trephine biopsy of the bone marrow.
	www.bloodmed.com /home/ebook.asp?book=0865427178&id=4 (8529 words)

	Unexplained Digital Gangrene In A Preterm With Neonatal Hyperviscocity Syndrome
		The only abnormalities observed at the age of 1 hour were mild polycythaemia (haematocrit 66%), profound hypoglycaemia (0.2 mmol/ L) and metabolic acidosis (bicarbonate 16 mmol/ L).
		Polycythaemia and hyperviscosity are common neonatal problems though their symptomatology are non-pathognomonic.
		Kanitkar and Gupta have advocated screening high risk babies, such as small for date, asphyxiated and infants of diabetics for polycythaemia at between 6 - 12 hours of age for early diagnosis and management to prevent complications.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijpn/vol6n1/gangrene.xml (925 words)

	Ms D, 65 years old unmarried lady presented with a cold... (Site not responding. Last check: 2007-11-01)
		Polycythaemia rubra vera (PRV) is the most common of myeloproliferative disorders with an incidence of 0.35 - 2.6/million population (reports varying from.02 in Japan to 22 in Rochester, Minnesota, USA).
		A tentative diagnosis of polycythaemia rubra vera is suggested in presence of high haematocrit, thrombocytosis, leukocytosis, splenomegaly, and a normal oxygen saturation.
		Polycythaemia Rubra Vera Group documented 146 episodes in 1,000 patients, CVAs at 35 were the commonest followed by CAD in 12, DVT in 22, and peripheral ischaemia in 9.
	www.indegene.com /Int/ClinRound/indIntCase19.html (1802 words)

	Polycythaemia (erythrocytosis) and polycythaemia vera
		Polycythaemia means 'many cells in the blood' and logically speaking the term should be applied to the condition in which there is an increase in all of the blood cell components, ie red cells, white cells and platelets.
		In polycythaemia the blood's 'thickness' or viscosity is increased due to the marked increase in number of red cells, and this is the problem that causes the main complications of the disease.
		Specific therapy of polycythaemia itself rather crudely involves removal of blood (venesection), which is performed at varying intervals until a satisfactory level of haematocrit (blood thickness) is obtained.
	www.netdoctor.co.uk /diseases/facts/polycythaemia.htm (3724 words)

	What is polycythaemia? - Miscellaneous - DoctorNDTV
		Polycythaemia is an increase in red blood cell mass which may be due to an actual increase in red
		polycythaemia is classified as either primary or secondary.
		In contrast, secondary polycythaemia can be caused by an external source, such as smokers polycythaemia, or disorders like renal cancer.
	www.doctorndtv.com /faq/detailfaq.asp?id=4311 (428 words)

	Statement Of Principles Concerning Polycythaemia Vera - reasonable hypothesis
		This is a consolidation of Instrument 78 of 1999, Instrument 11 of 2001 and Instrument 30 of 2005 and is not a legal document.
		(b) For the purposes of this Statement of Principles, "polycythaemia vera", also known as polycythaemia rubra vera, means a chronic myeloproliferative disorder, characterised by abnormal proliferation of haematopoietic bone marrow elements, resulting in an absolute increase in red cell mass, an excess of platelets and white blood cells, and splenomegaly, attracting ICD-10-AM code D45.
		"death from polycythaemia vera" in relation to a person includes death from a terminal event or condition that was contributed to by the person’s polycythaemia vera;
	www.dva.gov.au /pensions/statemnt/d001rh.htm (351 words)

	Haema/Αίμα (Site not responding. Last check: 2007-11-01)
		To our knowledge, this is the first case of polycythaemia during leukaemia treatment.
		Chromosomal abnormalities are considered as an etiologic factor of polycythaemia vera.
		Polycythaemia vera during therapy for leukaemia is rare.
	www.mednet.gr /eae/haema/h63-14.htm (155 words)

	Department of Neonatal Medicine - Polycythaemia (Site not responding. Last check: 2007-11-01)
		Polycythaemia is generally defined as a central haematocrit of 65% or more.
		Polycythaemia (venous haematocrit >65%) occurred in approximately 4% of newborn infants
		Effects of polycythaemia and haemodilution on circulation in neonates.
	www.cs.nsw.gov.au /rpa/neonatal/html/newprot/polycythaemia.htm (1300 words)

	FreiDok - Gene expression profiling of patients with Polycythaemia Rubra Vera using cDNA microarrays
		Genexpressionsanalyse von Patienten mit Polycythaemia Rubra Vera mittels cDNA Microarrays
		Granulocyte RNAs from 40 polycythaemia vera (PV) and 12 secondary erythrocytosis (SE) patients were analysed.
		Polycythaemia Rubra Vera, microarrays, myeloproliferative disorders, gene expression, transgenic mice
	www.freidok.uni-freiburg.de /volltexte/1550 (792 words)

	Neonatal Handbook : Polycythaemia
		Polycythaemia is defined as a venous haematocrit greater than 65% and occurs in 0.4 - 4% of newborn infants.
		This may result in increased blood viscosity and therefore reduced blood flow, impaired tissue oxygenation and a tendency to microthrombus formation exacerbated by hypoxia, acidosis and/or poor perfusion.
		The diagnosis of polycythaemia is made on central or peripheral venous blood with a haematocrit over 65%.
	www.rwh.org.au /nets/handbook/index.cfm?doc_id=636&print=yes (359 words)

	Single Test May Spot Blood Cancers
		Researchers looked for the gene in 140 people with one of the three major types of myeloproliferative disorders, including polycythaemia vera,polycythaemia vera, essential thrombocythaemia,essential thrombocythaemia, and idiopathic myelofibrosis.
		A single mutation was found in the JAK2 gene in 97% of the 73 people with polycythaemia vera, 57% of the 51 with essential thrombocythaemia, and 50% of the 16 with idiopathic myelofibrosis.
		By having a single genetic mutation to look for, researchers say it may be possible in the near future to develop blood tests to screen for the mutation and help diagnose myeloproliferative disorders.
	www.webmd.com /content/article/102/106618?src=rss_cancer (404 words)

	handbag.com : surgerydoor (Site not responding. Last check: 2007-11-01)
		RELATIVE POLYCYTHAEMIA Blood is a mixture of cells and a fluid called plasma.
		In relative polycythaemia there is a shortage of plasma, so that the red cells make up more than half the blood.
		As explained, secondary polycythaemia is the result of a disorder elsewhere in the body.
	www.surgerydoor.co.uk /handbagtest/medcon/detail2.asp?level2=Polycythaemia (951 words)

	Polycythaemia Rubra Vera - Patient UK
		Primary polycythaemia is usually PRV but a genetic condition has been described in which there is excessive responsiveness to erythropoetin.
		Secondary polycythaemia is due to hypoxia causing erythropoetin release as in Eisenmenger syndrome, COPD or smoking.
		Ferritin is often low in primary polycythaemia because of increased demand for iron.
	www.patient.co.uk /showdoc/40002355 (1633 words)

	Myeloproliferative disorder, 4-657
		It explains neatly the change from polycythaemia to the fibroblastic changes of myelofibrosis and the sporadic development of leukaemias in some patients with polycythaemia.
		Polycythaemia is simply an excess of the normal red cell production.
		Primary Polycythaemia (rubra vera) is of gradual onset, usually in 6th or 7th decades.
	myweb.lsbu.ac.uk /~dirt/museum/p4-657.html (315 words)

	ABC of clinical haematology: Polycythaemia, primary (essential) thrombocythaemia and myelofibrosis -- Messinezy and ...
		be in favour of a primary marrow disorder such as primary polycythaemia.
		In apparent polycythaemia red cell mass is not increased, and
		Primary polycythaemia should be suspected if the packed cell volume is raised (or the rise is masked by coexisting iron deficiency)
	bmj.bmjjournals.com /cgi/content/full/314/7080/587 (1414 words)

	polycythaemia (too many red blood cells) - HealthBoards Bulletin Board
		I was diagnosed with polycythaemia in November, I was devastated, after reading literature on the internet.
		She told me to stop smoking, and discharged me. I am now worried that in years to come I could develop real polycythaemia and not know.
		My main symptom was facial flushing, this is why I went to the doctor's in the first place.
	www.healthboards.com /ubb/Forum28/HTML/000026.html (804 words)

	Low dose aspirin safely reduced thrombosis in polycythaemia vera -- 328 (7444): 0 -- BMJ
		of thrombotic complications in patients with polycythaemia vera?
		Synopsis Polycythaemia vera is associated with increased blood
		polycythaemia, no contraindication to aspirin, and no other
	bmj.bmjjournals.com /cgi/content/full/328/7444/0-f (304 words)

	Management of polycythaemia in adults with cyanotic congenital heart disease -- THORNE 79 (4): 315 -- Heart
		Adults with polycythaemia secondary to cyanotic congenital heart disease may be at greater risk from injudicious venesection
		The polycythaemia of chronic hypoxaemia may be more precisely termed erythrocytosis as, in contrast to polycythaemia rubra
		This secondary polycythaemia, or erythrocytosis, is a physiological
	heart.bmjjournals.com /cgi/content/full/79/4/315 (1344 words)

	Armin Schumacher, M.D. (Site not responding. Last check: 2007-11-01)
		The radiation-induced microdeletion causes dynamic dysregulation of Fpn1 expression during pre- and postimplantation development, disrupting the function of the sole cellular iron exporter identified in vertebrates to date.
		Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice.
		Disruption of ferroportin1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice.
	imgen.bcm.tmc.edu /molgen/facultyaz/schumacher.html (590 words)

	Polycythaemia rubra vera
		I’m 43 and was diagnosed with polycythaemia a couple of years ago.
		I'm very sorry to hear that you have this distressing condition, and I am assuming that you have the condition whose full name is polycythaemia rubra vera, or PV.
		This is a progressive disorder of the bone marrow that makes it produce excess numbers of red blood cells and thickens the blood.
	www.netdoctor.co.uk /ate/heartandblood/201176.html (469 words)

	A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera : Nature
		On the basis of the model of chronic myeloid leukaemia, it is expected that a constitutive tyrosine kinase activity could be at the origin of these diseases.
		Polycythaemia vera is an acquired myeloproliferative disorder, characterized by the presence of polycythaemia diversely associated with thrombocytosis, leukocytosis and splenomegaly
		Polycythaemia vera progenitors are hypersensitive to erythropoietin and other cytokines
	www.nature.com /nature/journal/v434/n7037/abs/nature03546.html (364 words)

	News - Low-Dose Aspirin Appears Safe and Effective for Prevention of Thombosis in Some Patients With Polycythemia Vera
		Low-dose aspirin is protective against thrombotic complications in patients with polycythaemia vera who have no contraindication to the drug, according to findings from a multicentre, double blind European trial.
		To assess the safety and efficacy of aspirin for prevention of thrombotic complications in patients with polycythaemia vera, the researchers randomly assigned patients who had neither clear indication for nor contraindication against aspirin therapy to receive 100 mg daily of aspirin or placebo.
		The relative risk of major bleeding complications of 1.62 for the aspirin therapy group is consistent, the authors note, with estimates from other primary prevention trials involving subjects who did not have polycythaemia vera.
	www.docguide.com /news/content.nsf/news/F41D3C5C2FD3F51885256E150070A0EE?OpenDocument&c=Thrombosis&count=10 (551 words)

	Statements of Principles — Polycythaemia vera — balance of probability
		This is a consolidation of Instrument 79 of 1999 and Instrument 12 of 2001 and is not a legal document.
		(b) For the purposes of this Statement of Principles, "polycythaemia vera", also known as polycythaemia rubra vera, means a chronic myeloproliferative disorder, characterised by abnormal proliferation of haematopoietic bone marrow elements, resulting in an absolute increase in red cell mass, an excess of platelets and white blood cells, and splenomegaly, attracting ICD-10-AM code D45.
		The factor that must exist before it can be said that, on the balance of probabilities, in relation to the circumstances of a person's relevant service causing or materially contributing to or aggravating polycythaemia vera or death from polycythaemia vera is inability to obtain appropriate clinical management for polycythaemia vera.
	www.dva.gov.au /pensions/statemnt/D001bp.htm (363 words)

	Medical Dictionary: Polycythaemia rubra vera - WrongDiagnosis.com
		Polycythaemia rubra vera: A chronic myeloproliferative disorder characterized by an increased red blood cell production.
		Excessive proliferation of the myeloid lineage is observed as well.
		Terms that may be interchangeable with Polycythaemia rubra vera:
	www.wrongdiagnosis.com /medical/polycythaemia_rubra_vera.htm (225 words)

	haemotology oncology
		Polycythaemia may be relative, primary (polycythaemia rubra vera) or secondary
		To differentiate between polycythaemia rubra vera (PRV) and secondary polycythaemia red cell mass studies are needed.
		Polycythaemia rubra vera is a myeloproliferative disorder caused by clonal proliferation of a marrow stem cell leading to an increase in red cell volume, often accompanied by overproduction of neutrophils and platelets..
	www.aippg.net /forum/viewtopic.php?p=88140 (4896 words)

	Partial plasma exchange transfusion in polycythaemic neonates -- Rothenberg 86 (1): 60 -- Archives of Disease in ...
		The research papers all use hyperviscosity rather than polycythaemia
		Polycythaemia is a risk factor for later neurological abnormality.
		Malon AF, de V Heese H. The management of polycythaemia in the newborninfant.
	adc.bmjjournals.com /cgi/content/full/86/1/60 (601 words)

Try your search on: Qwika (all wikis)