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Topic: Polygenic


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  Alcoholism: Encyclopedia of Genetic Disorders
Alcoholism is thought to be a polygenic disorder; that is, more than one gene appears to be involved in its transmission.
Because alcoholism is a polygenic disorder, and because genes often change their levels of activity in response to the effects of alcohol, microarrays allow researchers to track the activity levels of a large number of genes simultaneously.
As of 2001, it is thought that changes in gene function may be a factor in the human brain's long-term adaptations to heavy drinking.
health.enotes.com /genetic-disorders-encyclopedia/alcoholism   (4493 words)

  
 Alzheimer's disease - Definition, Description, Causes and symptoms, Demographics, Diagnosis, Treatments, Prognosis, ...   (Site not responding. Last check: 2007-11-01)
The brains of people with Down syndrome age prematurely, so that those who develop early-onset AD are often only in their late 40s or early 50s when the symptoms of the disease first appear.
Genetic research indicates that late-onset Alzheimer's disease is a polygenic disorder; that is, its development is influenced by more than one gene.
It has been known since 1993 that a specific form of a gene for apolipoprotein E (apoE4) on human chromosome 19 is a genetic risk factor for late-onset AD.
www.minddisorders.com /A-Br/Alzheimer-s-disease.html   (5406 words)

  
 Research onTourette syndrome, ADHD, genetics of behavior and related disorders.   (Site not responding. Last check: 2007-11-01)
P#49 : Comings, D.E., Wu, H., Chiu, C., Ring, R.H., Dietz, G., and Muhleman, D. Polygenic inheritance of Tourette syndrome, stuttering, ADHD, conduct and oppositional defiant disorder: The Additive and Subtractive Effect of the three dopaminergic genes - DRD2, DÂ¥?H and DAT1.
P#60 : Comings, D.E. Why Different Rules are Required for Polygenic Inheritance: Lessons from Studies of the DRD2 Gene.
Comings, D.E. Child Dev 2002 Jul-Aug;73(4):1046-51 Parent-daughter transmission of the androgen receptor gene as an explanation of the effect of father absence on age of menarche.
www.hopepress.com /html/research.html   (2353 words)

  
 Genetic Disease Information
Inheritance Patterns of Monogenic Disorders - From the Genetic Interest Group in the U.K. Genetics - From the Medical Encyclopedia at MEDLINEplus.
(2) Multifactorial (also called complex or polygenic) - This type is caused by a combination of environmental factors and mutations in multiple genes.
For example, different genes that influence breast cancer susceptibility have been found on chromosomes 6, 11, 13, 14, 15, 17, and 22.
www.ornl.gov /hgmis/medicine/assist.html   (2023 words)

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