
	Where results make sense

Topic: Polyketide

Related Topics

Macrolide

Tetracycline

Antibiotic

Sulfamethoxazole

Quinolones

Azithromycin

Erythromycin

Vancomycin

Trimethoprim

Ciprofloxacin

Glycopeptide antibiotic

A82

Doxycycline

Colistin

Leisha Hailey

In the News (Fri 25 Jul 08)

Gordon Brown

Derby County

Mike Huckabee

Lute Olson

Pearl Harbor

Sonia Gandhi

Ricky Hatton

Narendra Modi

Jesus Christ

Rudy Giuliani

	Peter Leadlay Research Group, Polyketide Antibiotic Biosynthesis
		Polyketides are natural products which provide a staggering range of clinically effective drugs.
		Subsequently, the polyketide chain is extended by condensation with methylmalonate (from methylmalonyl CoA) pre-loaded on the ACP domain of an extension module.
		The polyketide is then released from the enzyme by a thioesterase domain and post PKS enzymes such as glycosyl- and methyltransferases complete the biosynthesis.
	www.bio.cam.ac.uk /~pflgroup/research.htm (637 words)

	Polyketide
		Polyketides are structurally a very diverse family of natural products with an extremely broad range of biological activities and pharmacological properties.
		Polyketide antibiotics, antifungals, cytostatics, anticholesterolemics, antiparasitics, coccidiostatics, animal growth promotants and natural insecticides are in commercial use.
		The polyketide chain is handed over from the ACP domain of the previous module to the KS domain of the current module, catalyzed by the KS domain.
	www.ibpassociation.org /encyclopedia/Chemistry/Polyketide.php (499 words)

	BioMed Central \| Full text \| ASMPKS: an analysis system for modular polyketide synthases
		Polyketides are synthesized by serialized reactions of a set of enzymes called polyketide synthase(PKS)s, which coordinate the elongation of carbon skeletons by the stepwise condensation of short carbon precursors.
		Polyketides are synthesized by serialized reactions of a set of enzymes called polyketide synthase(PKS)s [6], which coordinate the elongation of carbon skeletons by the stepwise condensation of short carbon precursors [7].
		The PKS composition and the chemical structure of a polyketide in the database are displayed by the PKS navigation component (Figure 2A), which shows the arrangements of the PKSs with their domain composition and draws the intermediate chain for a selected polyketide.
	www.biomedcentral.com /1471-2105/8/327 (3783 words)

	[No title] (Site not responding. Last check: 2007-10-31)
		Polyketides are such a group of secondary metabolites, exhibiting remarkable diversity both in terms of their structure and function
		Polyketide natural products are known to possess a wealth of pharmacologically important activities, including antimicrobial, antifungal, antiparasitic, antitumor and agrochemical properties.
		Polyketides are usually categorised on the basis of their chemical structures.
	linux1.nii.res.in /~pksdb/polyketide.html (1101 words)

	Technology Platform - Polyketides
		Polyketide gene alteration permits our molecular biologists to make precise structural changes in a complex molecule by altering the gene that specifies a targeted building block of that molecule.
		This is important because many polyketides are produced by microorganisms that are difficult to grow, or in which recombinant DNA methods have not been developed.
		Large polyketide libraries are then generated by reassembling the gene with various combinations of the altered fragments.
	www.kosan.com /technology-platform.html (492 words)

	Cyano Biotech GmbH - Publications
		Dieckmann, R. and Schwecke, T. (2002) Modular Polyketide Synthases.
		Dittmann, E., B.A. Neilan, T. Börner (2001) Molecular biology of peptide and polyketide biosynthesis in cyanobacteria.
		Schwecke T, Aparicio JF, Molnar I, König A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, Böhm, GA, Staunton J, and Leadlay PF, (1995) The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
	www.cyano-biotech.com /concept/publications.html (751 words)

	Biosynthesis of Polyketides in Heterologous Hosts -- Pfeifer and Khosla 65 (1): 106 -- Microbiology and Molecular ...
		The KS domain accepts the starter acetate unit or a growing polyketide chain and catalyzes the condensation with a malonyl unit loaded onto the ACP domain by the AT/MT. The level of reduction applied for a particular iteration is denoted near the arrows.
		The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
		Cloning, characterization, and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
	mmbr.asm.org /cgi/content/full/65/1/106 (6376 words)

	Novel Polyketide Synthase from Nectria haematococca -- Graziani et al. 70 (5): 2984 -- Applied and Environmental ...
		The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B biosynthesis.
		A melanin polyketide synthase (PKS) gene from Nodulisporium sp.
		Polyketide synthase genes in insect- and nematode-associated fungi.
	aem.asm.org /cgi/content/full/70/5/2984 (3214 words)

	[No title]
		The elucidation of molecular features that govern fatty acid, polyketide and sugar biosynthesis will help us understand how natural products are made and evolved in nature, and will enable rational design of de novo natural products for novel drug discovery.
		Polyketides, a large family of complicated and structurally diverse natural products (> 7000 compounds identified), are an extremely rich source of bioactive molecules.
		De novo polyketides can be synthesized by genetic engineering of PKS domains via domain rearrangement, as well as by in vivo feeding of synthetic precursors.
	www.chem.uci.edu /people/faculty/sctsai (913 words)

	Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes - Nature ...
		Beck, B.J., Aldrich, C.C., Fecik, R.A., Reynolds, K.A. and Sherman, D.H. Iterative chain elongation by a pikromycin monomodular polyketide synthase.
		Wu, N., Cane, D.E. and Khosla, C. Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases.
		Ashley, G.W. and Carney, J.R. API-mass spectrometry of polyketides.
	www.nature.com /nbt/journal/v23/n9/full/nbt1128.html (4055 words)

	Biotica - Drug Discovery through Synthetic Biology of Polyketides and Polyketide natural products (Site not responding. Last check: 2007-10-31)
		Polyketides are an extensive class of structurally diverse natural products which provide a staggering range of clinically effective drugs.
		Polyketides are produced by the stepwise condensation of simple carboxylic acid precursors, in a fashion similar to fatty acid biosythesis.
		In a further sub-set of 'mixed' structures, elements of polyketide and non-ribosomal peptide origin are combined, such as in rapamycin and epothilone A. Polyketides are synthesized by a wide range of naturally occuring organisms, including bacteria, fungi, marine organisms and plants.
	www.biotica.co.uk /polyketides.htm (239 words)

	Combinatorial polyketide biosynthesis at higher stage : Article : Molecular Systems Biology
		Natural polyketides derived from giant PKS complexes were mostly isolated from microbes in the soil, but were increasingly discovered also in the oceans and have served as lead products for some of the most important pharmaceuticals currently on the market (Staunton and Weissman, 2001).
		Multienzymes determining the order and configuration of a given polyketide are composed of repetitive modules consisting of sets of domains carrying the active sites for the successive activation, modification and elongation of single carbon building blocks.
		The extraordinary high diversity of polyketide products, however, is achieved by an optional use of domains for the modification of ketogroups and by the use of different substrates for chain initiation and extension.
	www.nature.com /msb/journal/v1/n1/full/msb4100033.html (1187 words)

	Biotica - Cancer Drug Discovery through polyketides and polyketide combinatorial biosynthesis (Site not responding. Last check: 2007-10-31)
		Polyketides are a diverse class of natural products that have been a prolific source of commercially significant pharmaceuticals, currently representing worldwide sales in excess of $20 billion pa. The Company applies its technology platform to discover polyketides that are potentially useful therapeutics for the treatment of cancer and other diseases.
		Due to the structural complexity of these polyketides, chemical modifications available to traditional organic synthesis are limited and their production is often challenging.
		This permits the structural modification of polyketides via extension or contraction of the polyketide chain, incorporation of non-natural ‘starter’ and ‘extender’ units providing altered substitution patterns, control of oxidation state and stereochemistry of side-chains, and manipulation of post-PKS processing steps such as glycosylation and methylation.
	www.biotica.co.uk /about.htm (336 words)

	High Resolution Structural Study of a Modular Polyketide Synthase Didomain
		PKS enzymes catalyze the synthesis of polyketides, which include a number of antibiotics, anticancer agents, antiparasitics, and immunosuppressants.
		The distance is too large to be traversed by the long arm of a statically positioned acyl carrier protein, needed to ferry growing polyketides along the synthase backbone.
		Principal investigator Chaitan Khosla of Stanford University was recently elected a fellow to the American Association for the Advancement of Science for his contributions to the field of metabolic chemistry and engineering, particularly to the biosynthesis of polyketide antibiotics.
	www-ssrl.slac.stanford.edu /research/pks_summary.html (315 words)

	Pathology
		During this latent phase, the duration of which is widely variable, the bacteria begin to produce a polyketide toxin which has cytotoxic effects on nearby adipocytes.
		This toxin is the first polyketide ever isolated and purified from a pathogenic bacterium, although polyketides are quite common in other bacterial species, especially soil bacteria.
		Polyketides have variable biological functions, displaying immunosuppression as well as antibiotic, antifungal, and cytostatic activities.
	www.arches.uga.edu /~mesaros/pathology.htm (674 words)

	Faculty Profile for Shiou-Chuan (Sheryl) Tsai
		This carboxylation reaction is one of the most important metabolic regulation checkpoints by committing acyl-CoA to the biosynthesis of fatty acids and polyketides.
		The hexameric architecture of the beta-subunit of ACC, a highly-regulated enzyme complex that commits acyl-CoA to fatty acid and polyketide biosynthesis.
		In nature however, polyeketides are made by polyketide synthase (PKSs), a multi-domain enzyme cluster that catalyzes repeated chain elongations and chain modifications.
	www.faculty.uci.edu /profile.cfm?faculty_id=4944 (905 words)

	Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis -- Kennedy et al. 284 ...
		Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid
		Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase.
		Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes.
	www.sciencemag.org /cgi/content/short/284/5418/1368 (730 words)

	Analysis of Genes Involved in Biosynthesis of Coronafacic Acid, the Polyketide Component of the Phytotoxin Coronatine ...
		Polyketide synthetases (PKS) are generally classified as type I or II enzyme systems and consist of protein complexes that
		Liyanage, H., Palmer, D. Ullrich, M., and Bender, C. Characterization and transcriptional analysis of the gene cluster for coronafacic acid, the polyketide component of the phytotoxin coronatine.
		Penfold, C. Bender, C. and Turner, J. Characterisation of genes involved in biosynthesis of coronafacic acid, the polyketide component of the phytotoxin coronatine.
	jb.asm.org /cgi/content/full/180/13/3330 (5900 words)

	Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations -- Cane et al. 282 (5386): 63 -- Science
		Polyketides and non-ribosomal peptides are two large families of complex natural products that are built from simple carboxylic
		Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.
		Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.
	www.sciencemag.org /cgi/content/abstract/282/5386/63 (1381 words)

	Connection of Propionyl-CoA Metabolism to Polyketide Biosynthesis in Aspergillus nidulans -- Zhang et al. 168 (2): 785 ...
		oxidation on polyketide biosynthesis, wild-type and mutant strains
		RNA was isolated either after 30 hr of growth in GMM or 3 or 7 hr after switching to fatty acid or amino acid supplemented medium.
		, 1995 Polyketide synthesis in vitro on a modular polyketide synthase.
	www.genetics.org /cgi/content/full/168/2/785 (4021 words)

	Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis ...
		Polyketides are well known as the components of a variety of
		A new pathway for polyketide synthesis in microorganisms.
		Piel, J. A polyketide synthase-peptide synthase gene cluster from an uncultured bacterial symbiont of Paederus beetles.
	aac.asm.org /cgi/content/full/48/9/3468 (5557 words)

	Alliance plans to improve polyketide production
		Polyketides are naturally occurring drug-like molecules, formed by microorganisms in the soil, that constitute the biggest source of natural product-based therapeutics.
		The antibiotics erythromycin and tetracycline and anti-tumour agents doxorubicin and epothilone all come from this class, which is second only to the penicillins in terms of their importance as naturally-derived medicines.
		The primary aim is to expand the diversity of polyketides that can be produced and used in drug discovery efforts, although the programme could also lead to new ways to manufactur these drugs using bacterial fermentation.
	www.drugresearcher.com /news/ng.asp?id=58383-alliance-plans-to (418 words)

	A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator -- ...
		Blanco, G., Pereda, A., Méndez, C. and Salas, J. Cloning and disruption of a fragment of Streptomyces halstedii DNA involved in the biosynthesis of a spore pigment.
		Davis, N. and Chater, K. Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics.
		Lombó, F., Blanco, G., Fernández, E., Méndez, C. and Salas, J. Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumour mithramycin.
	mic.sgmjournals.org /cgi/content/full/147/11/3083 (4080 words)

	Searle Scholar Profile : Ben Shen (1997)
		Currently we are studying two types of molecules: polyketides such as thermorubin produced by Thermoactinomyces vulgaris and peptides such as the bleomycins produced by Streptomyces vercitillus.
		Anticancer drug bleomycin, produced by Streptomyces verticillus, is a natural hybrid metabolite of peptide and polyketide biosynthesis and the bleomycin peptide/polyketide backbone is assembled by the bleomycin synthetase that should bear the characteristics of both peptide synthetase and polyketide synthase (PKS).
		Thermorubin, a polyketide antibiotic produced by a thermphilic actinomycete Thermoactinomyces vulgaris, is assembled from one molecule of salicylic acid and eleven molecules of malonyl CoA, presumably catalyzed by the thermorubin PKS.
	www.searlescholars.net /people/1997/shen.html (354 words)

Try your search on: Qwika (all wikis)