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| | BioMed Central | Full text | The DNA polymerase activity of Pol epsilon holoenzyme is required for rapid and efficient ... |
 | | Three structurally and functionally distinct DNA polymerases, known as DNA polymerases α, δ, and ε (Pol α,-δ, and -ε, respectively), are required for chromosomal DNA replication in yeasts [1-3]. |
 | | Because this portion of the enzyme includes all known DNA polymerase and exonuclease motifs, these results suggest that the DNA polymerase activity of Pol ε is dispensable for chromosomal DNA replication in yeast [15,16,27]. |
 | | However, because the amino-terminal portion of Pol ε, that is required for its DNA polymerase- and exonuclease activities, is dispensable for yeast DNA replication, repair, and viability [15,16,27], the role of Pol ε during DNA replication has remained obscure. |
| www.biomedcentral.com /1471-2091/7/21 (5878 words) |
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