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Topic: Polypeptide

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In the News (Thu 20 Jun 19)

  Peptide - Wikipedia, the free encyclopedia
A polypeptide is a single linear chain of amino acids.
A protein is one or more polypeptides more than about 50 amino acids long.
An oligopeptide or (simply) a peptide is a polypeptide less than 30-50 amino acids long.
en.wikipedia.org /wiki/Polypeptide   (627 words)

 Patent 6,538,123
Preferably, a portion of the C polypeptide of HCV responsible for thr regulatory activity may be a portion of the C polypeptide ranging from the amino acid at position 1 to the amino acid in one of positions 48 to 191.
A portion of the E1 polypeptide of HCV responsible for the interaction of the C polypeptide with the E1 protein may be in particular the C-terminal domain of the E1 polypeptide, preferably the domain at positions 330 to 380 or at positions 370 to 380.
A polypeptide, a mixture or a molecule of DNA useful for the purposes of the present invention may be formulated in or with liposomes, preferably neutral or anionic liposomes, microspheres ISCOMs or virus-like particles (VLPs), in order to promote the screening of the protein or of the polypeptide or to increase the immune response.
www.pharmcast.com /Patents/Yr2003/Mar2003/032503/6538123_Hepatitis932593.htm   (3522 words)

 Washington Research Foundation: Foundation: Yeast Licensing Program
The, process of Claim 1, wherein the amino acid sequence of said polypeptide is selected to correspond to the amino acid sequence of a polypeptide selected from the group consisting of the normal and hybrid human interferons, human proinsulin, the A and B chains of human insulin, human growth hormone, somatostatin, and thymosin alpha 1.
The DNA expression vector of Claim 13, wherein the polypeptide comprises the amino acid sequence of a polypeptide having the activity of a polypeptide selected from the group consisting of normal and hybrid human interferons, human proinsulin, the A and B chains of human insulin, human growth hormone, somatostatin, and thymosin alpha 1.
The yeast strain of Claim 34, wherein said polypeptide comprises the amino acid sequence of a polypeptide having the activity of a polypeptide selected from the group consisting of normal and hybrid human interferons, human proinsulin, the A and B chains of human insulin, human growth hormone, somatostatin, and thymosin alpha 1.
www.wrfseattle.org /foundation/5854018patentclaims.asp   (1132 words)

 Patent 6,485,972
Polypeptides or other compounds are said to be "substantially pure" when they are within preparations that are at least 60% by weight (dry weight) the compound of interest.
The oocyte is contacted with w Wnt polypeptide either in vivo prior to retrieval or in vitro prior to the IVF procedure.
Wnt polypeptides are also used to increase the number of mature oocytes by culturing a sample containing immature oocytes in a culture medium which includes a Wnt polypeptide.
www.pharmcast.com /Patents/Yr2002/November2002/112602/6485972_WNT112602.htm   (828 words)

 World Intellectual Property Organization   (Site not responding. Last check: 2007-11-05)
: 2 ; and a polypeptide comprising residues 20 to 523 of
a polypeptide comprising residues 1 to 22 of
The term"secretory signal sequence"denotes a DNA sequence that encodes a polypeptide (a"secretory peptide") that, as a component of a larger polypeptide, directs the larger polypeptide through a secretory pathway of a cell in which it is synthesized.
www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/38505.010531&ELEMENT_SET=DECL   (7304 words)

 United States Patent Application: 0040091967
A method of producing a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2, comprising the steps of: culturing a host cell comprising an expression vector which encodes the polypeptide under conditions whereby the polypeptide is expressed; and isolating the polypeptide.
A test compound which increases histone acetyltransferase activity of the polypeptide relative to histone acetyltransferase activity in the absence of the test compound is thereby identified as a potential agent for increasing extracellular matrix degradation.
A purified histone acetyltransferase polypeptide is separated from other compounds that normally associate with the histone acetyltransferase polypeptide in the cell, such as certain proteins, carbohydrates, or lipids, using methods well-known in the art.
appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20040091967".PGNR.&OS=DN/20040091967&RS=DN/20040091967   (17274 words)

 At3g49470 - nascent polypeptide-associated complex (NAC) domain-containing protein   (Site not responding. Last check: 2007-11-05)
At3g49470 is a homologue of Naca (nascent polypeptide-associated complex alpha polypeptide) from Mus musculus.
At3g49470 is a homologue of NACA (nascent-polypeptide-associated complex alpha polypeptide) from Homo sapiens.
At3g49470 is a homologue of Nacalpha (Nascent polypeptide associated complex protein alpha subunit) from Drosophila melanogaster.
www.ihop-net.org /UniPub/iHOP/gg/9456.html   (168 words)

 World Intellectual Property Organization   (Site not responding. Last check: 2007-11-05)
a) a polypeptide comprising a contiguous sequence of fourteen amino acids of SEQ ID 2; and b) polypeptide comprising a contiguous sequence of 14 amino acids of SEQ ID Within an embodiment, the polypeptide molecule is between 78 and 305 amino acids in length.
For example, a DNA segment encoding a specified polypeptide is a portion of a longer DNA molecule, such as a plasmid or plasmid fragment, that, when read from the 5'to the 3'direction, encodes the sequence of amino acids of the specified polypeptide.
Regardless of the particular nucleotide sequence of a variant MAPP gene, the gene encodes a polypeptide that is characterized by its cell-cell interaction activity, or by the ability to bind specifically to an anti-MAPP antibody.
www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/09293.010208&ELEMENT_SET=DECL   (7723 words)

 Polypeptide Hormones -- Ryan and Pearce 125 (1): 65 -- PLANT PHYSIOLOGY
Polypeptide signaling is an emerging field in plant biology, particularly in areas of defense, fertilization, growth, and
A novel class of polypeptide hormones that regulate cell division was purified and characterized by Y. Matsubayashi and Y.
The polypeptide hormones that have now been identified in plants are presented in Table I.
www.plantphysiol.org /cgi/content/full/125/1/65   (2486 words)

The primary structure of a segment of a polypeptide chain or of a protein is the amino-acid sequence of the polypeptide chain(s), without regard to spatial arrangement (apart from configuration at the alpha-carbon atom).
The alpha-helix and beta-structure conformations for polypeptide chains are generally the most thermodynamically stable of the regular secondary structures.
However, unlike alpha-helices which are composed of residues from a continuous polypeptide segment (i.e., hydrogen bonds between CO of residue I and NH of residue I+3), beta-sheets are formed from strands that are very often from distant portions of the polypeptide sequence.
www.friedli.com /herbs/phytochem/proteins.html   (11287 words)

 Polypeptide Conformations 4-6
In polypeptide chemistry the term "conformation" should be used, in conformity with current usage, to describe different spatial arrangements of atoms produced by rotation about covalent bonds; a change in conformation does not involve the breaking of chemical bonds (except hydrogen bonds) or changes in chirality (see Cahn et al.
On the other hand in polypeptide chemistry the term "configuration" is currently used to describe spatial arrangements of atoms whose interconversion requires the formal breaking and making of covalent bonds (note: this usage takes no account of the breaking or making of hydrogen bonds).
The secondary structure of a segment of polypeptide chain is the local spatial arrangement of its main-chain atoms without regard to the conformation of its side chains or to its relationship with other segments.
www.chem.qmw.ac.uk /iupac/misc/ppep4.html   (1382 words)

 RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root growth and development -- Pearce et al. 98 (22): 12843 -- ...
The synthetic tomato polypeptide was synthesized by using 9-fluorenylmethyl chloroformate solid-phase chemistry with a peptide
The polypeptide was dissolved in 50 mM ammonium bicarbonate
The RALF polypeptide sequence is at the C terminus of the preproprotein and is underlined.
www.pnas.org /cgi/content/full/98/22/12843   (3280 words)

 Polypeptide Hormones -- Ryan et al. 14 (Supplement 1): 251 -- THE PLANT CELL   (Site not responding. Last check: 2007-11-05)
A model for the receptor complex and its interaction with the polypeptide CLV3, which regulates the balance of cell proliferation and organ formation in the shoot and flower meristems of Arabidopsis.
The complex results in the activation of the receptor kinase and the phosphorylation of ARCI, which may lead to the activation of aquaporins to limit the access of water to the incompatible pollen.
In soybean, a 12–amino acid polypeptide and a 24–amino acid polypeptide are translated from overlapping ORFs.
www.plantcell.org /cgi/content/full/14/suppl_1/S251   (7115 words)

 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1
The acceptor substrate specificity of a pure polypeptide N-acetylgalactosaminyltransferase has been examined with synthetic polypeptides with sequences identical, or similar to those found in porcine mucin or human erythropoietin.
UDP-GalNac: polypeptide N-acetylgalactosaminyltransferase from swine trachea epithelium was purified to homogeneity by procedures which included affinity chromatography on Sepharose 4B columns containing bound deglycosylated Cowper's gland mucin.
GALNT1 is a homologue of gly-3 (Polypeptide N-acetylgalactosaminyltransferase 3) from Caenorhabditis elegans.
www.ihop-net.org /UniPub/iHOP/gg/88523.html   (814 words)

 Cotranslational Protein Folding -- Fedorov and Baldwin 272 (52): 32715 -- Journal of Biological Chemistry
wider) as the length of the polypeptide increases, and as the
An upper limit of the rate of cotranslational folding is imposed by the rate of polypeptide synthesis.
polypeptides in the presence of chaperones and folding catalysts.
www.jbc.org /cgi/content/full/272/52/32715   (4561 words)

 Drug Development Technology - PolyPeptide Laboratories - Peptides for the Pharmaceutical Industry   (Site not responding. Last check: 2007-11-05)
PolyPeptide Laboratories is a group of manufacturing companies serving the pharmaceutical and biotech industry with peptides and expert regulatory support.
Because the facilities in Torrance and in Scandinavia all have large-scale cGMP manufacturing and regulatory affairs capabilities, the PolyPeptide Laboratories Group is ideally suited to supporting regulatory submissions for cGMP peptides in both Europe and the United States.
PolyPeptide Laboratories also offers small-scale custom synthesis services to support basic research, in particular for pharmacological investigations, which require exceptionally pure substances.
www.drugdevelopment-technology.com /contractors/synthesis/poly   (630 words)

 Title of Invention: Antifungal polypeptide and proc ess for its production
Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
The polypeptide according to the invention is synthesized from Aspergillus giganteus with aerobic cultivation.
For enzymatic cleavage, the polypeptide is incubated at 37.degree.
www.nal.usda.gov /bic/Biotech_Patents/1995patents/05421839.html   (3650 words)

 A nascent polypeptide domain that can regulate translation elongation -- Fang et al. 101 (12): 4059 -- Proceedings of ...
The amount of radiolabel in band F at 30 min in each experiment was normalized to 100%, and the radiolabel in each band at each time point was calculated as a fraction of this value.
White, radiolabel in intermediate N; gray, radiolabel in intermediate I; fl, radiolabel in full-length polypeptide F. The total (not normalized) radiolabel in bands N, I, and F at 3 min was 88% of the amount at 30 min.
Edeine was added at 2 min, and polypeptide products were analyzed as described in Fig.
www.pnas.org /cgi/content/full/101/12/4059   (3626 words)

 BBC Education - AS Guru - Biology - Biological Molecules - Proteins - Amino Acid Polymers - Peptides
A polypeptide is formed when a large number of amino acids are joined together.
The bond formed as a result between the two amino acids is called a peptide bond.
Polypeptides fold up in a complicated and controlled way to produce proteins.
www.bbc.co.uk /education/asguru/biology/02biologicalmolecules/01proteins/12polymers/06polymers_b/index.shtml   (123 words)

 Calculation of pI for a polypeptide   (Site not responding. Last check: 2007-11-05)
Here are some practice problems for calculating the pI of a polypeptide.
To find the uncharged molecule, first figure out what the charge on the polypeptide is after the loss of each proton.
As base is added the first proton is removed from the terminal carboxyl group and the charge on the polypeptide is now +1.
wwwchem.csustan.edu /chem4400/pppI.htm   (296 words)

 Gastric inhibitory polypeptide links overnutrition to obesity -- Ballinger 52 (3): 319 -- Gut
Further purification of a polypeptide demonstrating enterogastrone activity.
Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat.
Oben J, Morgan L, Fletcher J, et al Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1 (7–36) amide, on fatty acid synthesis in explants of rat adipose tissue.
gut.bmjjournals.com /cgi/content/full/52/3/319   (1116 words)

 The Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide and Islet Function -- Filipsson et al. 50 (9): 1959 ...   (Site not responding. Last check: 2007-11-05)
Uddman R, Luts A, Arimura A, Sundler F: Pituitary adenylate cyclase-activating polypeptide (PACAP), a new vasoactive intestinal peptide (VIP)-like peptide in the respiratory tract.
Hannibal J, Fahrenkrug J: Pituitary adenylate cyclase-activating polypeptide in intrinsic and extrinsic nerves of the rat pancreas.
Straub SG, Sharp GW: A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide.
diabetes.diabetesjournals.org /cgi/content/full/50/9/1959   (7176 words)

 Polypeptide definition - Medical Dictionary definitions of popular medical terms
Polypeptide definition - Medical Dictionary definitions of popular medical terms
Polypeptide: A peptide consisting of 2 or more amino acids.
Amino acids make up polypeptides which, in turn, make up proteins.
www.medterms.com /script/main/art.asp?articlekey=7766   (169 words)

 polypeptide   (Site not responding. Last check: 2007-11-05)
3, subfamily A, polypeptide 5 Synonyms: CYP3A5 Gene Ontology...
Short introduction to amino acid chemistry that provides some information about naturally occurred amino acids, their three dimensional structure and Stereochemistry.
VAST permits, for a particular 3D structure currently stored, to provides a means of retrieving related structures which are also currently stored there.
www.chemindustry.net /chemnames/P/polypeptide.html   (179 words)

 Polypeptide of protein P140 and DNAS encoding it (US5804411)
Polypeptide of protein p140 and DNAs encoding it
An isolated DNA molecule encoding a polypeptide of protein p140 having the amino acid sequence shown in SEQ ID No. 1.
US5804411 issued 1998-09-08 Polypeptide of protein P140 and DNAS encoding it
www.delphion.com /details?pn=US05804411__&language=en   (299 words)

 GALNT2 - Polypeptide N-acetylgalactosaminyltransferase 2   (Site not responding. Last check: 2007-11-05)
The GalNAc-T4 isoenzyme was found in the apical cell layers, whereas GalNAc-T2 was found in the supranuclear region of the basal cell layers of both cornea and conjunctiva.
GALNT2 is a homologue of gly-4 (Polypeptide N-acetylgalactosaminyltransferase 4) from Caenorhabditis elegans.
GALNT2 is a homologue of pgant2 (Polypeptide N-acetylgalactosaminyltransferase 2) from Drosophila melanogaster.
www.pdg.cnb.uam.es /UniPub/iHOP/gg/88524.html   (364 words)

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