| | Biophysical Journal: Reconstituted fusion pore (Site not responding. Last check: ) |
 | | ABSTRACT Fusion pores or porosomes are basket-like structures at the cell plasma membrane, at the base of which, membrane-bound secretory vesicles dock and fuse to release vesicular contents. |
 | | Conformation that the inverted cups are fusion pores, as they appear from within the cell, was revealed from AFM studies demonstrating attached secretory vesicles, and from immunoAFM studies demonstrating the localization of t-SNARE proteins at the base of the fusion pore or porosome cup (Jena et al., 2003). |
 | | Because fusion pores or porosomes are stable structures at the cell PM, we hypothesized that if membrane-bounded secretory vesicles or zymogen granules (ZGs) were to fuse at the base of the fusion pore, it should be possible to isolate ZG-associated fusion pore complexes. |
| www.findarticles.com /p/articles/mi_qa3938/is_200309/ai_n9288702 (1153 words) |