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Topic: PremRNA

In the News (Fri 25 Dec 09)

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	JEFFREY PATTON, Ph.D. (Site not responding. Last check: 2007-10-20)
		All of the current projects in Dr. Patton's laboratory are concerned with the splicing of premessenger RNA (premRNA).
		The metabolism of cofactors that are necessary for premRNA splicing is one of the current interests of Dr. Patton's laboratory.
		In addition, the gene expression by the alternative premRNA splicing of HPV transcript is another focus of the laboratory.
	www.med.sc.edu /pathology/FACULTY/PATTON.HTM (395 words)

	In vivo splicing of the premRNAs from early region 3 of adenovirus-2: association of precursors, intermediates and ...
		In vivo splicing of the premRNAs from early region 3 of adenovirus-2: association of precursors, intermediates and products with hnRNP -- Gallinaro et al.
		In vivo splicing of the premRNAs from early region 3 of adenovirus-2: association of precursors, intermediates and products with hnRNP
		To elucidate the function of hnRNP in the splicing of premRNA, we studied
	nar.oxfordjournals.org /cgi/content/abstract/14/10/4171 (249 words)

	JBPC Journalclub » Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis. (Site not responding. Last check: 2007-10-20)
		Eukaryotes have evolved elaborate splicing mechanisms to remove introns that would otherwise destroy the protein-coding capacity of genes.
		Nuclear premRNA splicing requires sequence motifs in the intron and is mediated by a ribonucleoprotein complex, the spliceosome.
		Here we demonstrate the presence of a splicing apparatus in the protist Trichomonas vaginalis and show that RNA motifs found in yeast and metazoan introns are required for splicing.
	jbpc.mbl.edu /journalclub/index.php?p=46 (228 words)

	Monaco 2004
		As the dystrophin gene itself will not be altered, the effect of the antisense treatment will not be permanent, so it will have to be repeated at intervals still to be determined.
		For this new method, the U7-snRNAs were genetically modified so that they no longer bound to the histone premRNA but only to the splice sites in the region of exon 23 of the pre-mRNA of the mouse dystrophin.
		To achieve this, a gene coding for the modified U7-snRNA together with a creatine kinase enhancer was packed into plasmids as vectors and then transferred into isolated myoblasts of the mouse.
	www.smdf.se /monaco_2004.htm (12410 words)

	Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis -- Vanácová et al. 102 (12): ...
		introns from premRNAs is present in trichomonads, and that the
		from the premRNA precisely at the predicted positions (Fig.
		The use of analogous splicing pathways by group II introns and nuclear premRNA has been taken to support a common
	www.pnas.org /cgi/content/full/102/12/4430 (4175 words)

	BIOL414/614 at UMBC - editosome
		Anchor binding domain: A 33kDa editosome protein that has RNA recognition and glycine-rich motifs and a 44kDa protein essential for editing form the main core of this domain, these proteins help in the stability of the complex.The anchor duplex is bound by this domain of the model.
		Upstream stablization domain: This doamin helps in the stable interaction between the upstream region of premRNA and 3'region/Utail of gRNA.
		Catalysis domain: After the orintation of premRNA to be edited and gRNA that specify the editing to editosome, catalysis domain which conatins the editing enzymes catalyses the insertion or the deletion as directed by gRNAs.
	www.umbc.edu /bioclass/biol414/wiki/index.php?page=editosome (156 words)

	Postprandial Induction of Chaperone Gene Expression Is Rapid in Mice -- Dhahbi et al. 132 (1): 31 -- Journal of ... (Site not responding. Last check: 2007-10-20)
		Effects of feeding on hepatic GRP78 mRNA and premRNA abundance in mice.
		Hepatic RNA was hybridized either to probe 1, which produced a 257-base protected fragment (labeled GRP78 premRNA in lanes 7–12), or to probe 2, which produced a 200-nucleotide protected fragment (labeled GRP78 premRNA in lanes 13–18).
		Quantification of the abundance of the protected fragments representing the GRP78 mRNA (B) and premRNA (C).
	www.nutrition.org /cgi/content/full/132/1/31 (5408 words)

	Targeting of U2AF65 to Sites of Active Splicing in the Nucleus -- Gama-Carvalho et al. 137 (5): 975 -- The Journal of ...
		Although much is known about the biochemical details of splicing in vitro, the organization of RNA processing in the cell
		Splicing of Balbiani ring 1 gene premRNA occurs simultaneously with transcription.
		Two members of a conserved family of nuclear phosphoproteins are involved in premRNA splicing.
	www.jcb.org /cgi/content/full/137/5/975 (7040 words)

	Splicing 2003 will highlight the potential impact of alternative RNA splicing on drug discovery
		Alternative RNA splicing is a tightly regulated process that controls overall protein functionality and diversity.
		Notably, research will be presented regarding the Drosophila Down Syndrome cell adhesion molecule gene (Dscam), where a single premRNA can generate more than 38,000 different transcripts, highlighting the complexity of the regulatory system that governs the alternative RNA splicing process.
		Dr Bruno Tocqué, CEO of ExonHit Therapeutics, commented: “I am very pleased that we have been able to assemble this distinguished group of scientists to present at Splicing 2003.
	www.exonhit.com /html/news/2003_07_10.htm (1005 words)

	Tiscali - Search
		Molecular neurogenetics research dedicated to neurological genetic diseases such as polyglutamine neurodegeneration (Huntington and Spinocerebellar ataxia 2) and stroke / macroangiopathy / aneurysm.
		We study premRNA splicing in the yeast Saccharomyces cerevisiae, in particular the protein-protein and protein-RNA interactions within the spliceosome.
		Annual prize for outstanding research in molecular biology applied to biomedicine in Italy.
	directory.tiscali.it /Science/Biology/Biochemistry/Laboratories/Researchers (1265 words)

	Mirago : Science: Biology: Biochemistry and Molecular Biology: Institutions: Laboratories: Researchers
		Auburger, Georg - Molecular neurogenetics research dedicated to neurological genetic diseases such as polyglutamine neurodegeneration (Huntington and Spinocerebellar ataxia 2) and stroke / macroangiopathy / aneurysm.
		Beggs, Jean - Research focused on premRNA splicing in the yeast Saccharomyces cerevisiae, in particular the protein-protein and protein-RNA interactions within the spliceosome at the University of Edinburgh, UK.
		Biotec Award Winners - Annual prize for outstanding research in molecular biology applied to biomedicine in Italy.
	www.miragorobot.com /scripts/dir.aspx?cat=Top/Science/Biology/Biochemistry_and_Molecular_Biology/Institutions/Laboratories/Researchers (1656 words)

	Monochloramine induces reorganization of nuclear speckles and phosphorylation of SRp30 in human colonic epithelial ...
		Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo.
		RNA polymerase II targets premRNA splicing factors to transcription sites in vivo.
		Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells.
	ajpcell.physiology.org /cgi/content/full/285/5/C1294 (5814 words)

	Evidence for a Posttranscriptional Role of a TFIIICalpha -like Protein in Chironomus tentans -- Sabri et al. 13 (5): ...
		Protein-coding RNAs are synthesized as precursors (premRNAs), packed into ribonucleoprotein (premRNP) complexes, and processed
		vivo the export of premRNAs that are defective in splicing and/or
		was initially identified as a premRNA splicing factor (Patton
	www.molbiolcell.org /cgi/content/full/13/5/1765 (7447 words)

	T Cell Receptor (TCR) Mini-Gene mRNA Expression Regulated by Nonsense Codons: A Nuclear-associated Translation-like ...
		premRNA splicing or mature mRNA stability in the nuclear fraction
		We also demonstrated that this is a selective effect
		on fully spliced mRNA; premRNA levels were not measurably affected
	www.jem.org /cgi/content/full/185/6/985 (5463 words)

	Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast -- Yashiroda and ...
		After 3 h incubation at 37 °C, significant accumulation of premRNA of both genes was observed
		Figure 7 Hub1 is involved in premRNA splicing.
		there are few genes that require premRNA splicing in S.
	www.genestocellsonline.org /cgi/content/full/9/12/1189 (4019 words)

	Reduced Serum Insulin-Like Growth Factor (IGF) I Is Associated with Reduced Liver IGF-I mRNA and Liver Growth Hormone ... (Site not responding. Last check: 2007-10-20)
		decreased processing of IGF-I premRNA (10), and decreased stability
		processing of IGF-I premRNA (10) and decreased stability of
		of both classes of IGF-I premRNA is decreased) and/or a decrease
	www.nutrition.org /cgi/content/full/133/8/2555 (4435 words)

	Rapid Evolution of the Sex-Determining Gene, transformer: Structural Diversity and Rate Heterogeneity Among Sibling ...
		This switch is regulated by SXL binding to a polypyrimidine
		target doublesex (dsx) premRNA repeat elements (Inoue et al.
		Then dsx premRNA is alternatively spliced in females
	mbe.oxfordjournals.org /cgi/content/full/20/3/441 (5333 words)

	Higher order chromatin organisation and function: a three-dimensional in situ analysis of structure, transcription and ... (Site not responding. Last check: 2007-10-20)
		Higher order chromatin organisation and function: a three-dimensional in situ analysis of structure, transcription and replication
		In collaboration with R. van Driels group, an extensive analysis of intranuclear distribution of premRNA transcription sites and of newly synthesized RNA has been carried out following microinjection of Br-UTP into the cytoplasm of cultured cells.
		The use of gridded coverslips as cell supports allowed us to follow individual cells during a given period of labeling time.
	www.sbf.admin.ch /htm/services/publikationen/international/frp/eu-abstracts/html/fp/fp4/bm95.0823.html (414 words)

	More about Dr Melki by Lasik Eye Care... (Site not responding. Last check: 2007-10-20)
		Boston Eye Group Dr.Melki performs the first implantable contact lens (Verisye) in Boston.
		in SMN1 and 2 premRNA splicing SMN1 gene therapy using virus vectors Dr. Judith Melki Therapeutic research strategies in SMA mouse models Dr. Terence Flotte Recombinant AAV...
		March 22, 2000 The second animal model for SMA is announced by Dr. Judith Melkis lab in France.
	www.eyecare-a2z.com /eye-care/dr_melki.html (766 words)

	Regulation of flowering time in Arabidopsis by K homology domain proteins -- Mockler et al. 101 (34): 12759 -- ...
		The FCA/FY complex interacts with the FCA premRNA
		in the processing of the AGAMOUS premRNA and floral organ development
		We report here a study of the flowering-time gene FLK
	www.pnas.org /cgi/content/full/101/34/12759 (4382 words)

	Biogenesis of small nuclear RNPs -- Kiss 117 (25): 5949 -- Journal of Cell Science
		spliceosomal snRNPs function in removal of premRNA introns and
		to the site of transcription and splicing of the host premRNA
		Before accumulating in the nucleolus, intronic box C/D snoRNAs
	jcs.biologists.org /cgi/content/full/117/25/5949 (1800 words)

	::aktion benni & co e.V.: Verein zur Förderung der Muskeldystrophie Duchenne Forschung:: (Site not responding. Last check: 2007-10-20)
		of the non-coding intron sequences from the premRNA.
		This technique will influence the conversion of premRNA
		modified so that they no longer bound to the histone premRNA
	www.abc-online.org /index.php?id=392&backPID=392&tt_news=45 (10026 words)

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