| | eMedicine - Precocious Puberty : Article by Paul B Kaplowitz, MD, PhD (Site not responding. Last check: 2007-11-06) |
 | | For many years, puberty was considered precocious in girls younger than 8 years; however, a recent study and review suggest that age 7 years is a more appropriate age boundary for white girls and age 6 years for fl girls. |
 | | The hypothesized mechanisms that suppress onset of puberty are (1) the HPG axis, which is highly sensitive to feedback inhibition by small amounts of sex steroids and (2) the release of high-amplitude pulses of gonadotropin-releasing hormone (GnRH) by the hypothalamus, which are suppressed by central neural pathways. |
 | | Age: If precocious puberty in females (mostly central) is defined as the early onset of breast development, then the data of Herman-Giddens et al (Image 1) can be used to estimate frequency of CPP at different ages in both white girls and fl girls. |
| www.emedicine.com /ped/topic1882.htm (4625 words) |