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Topic: Prekallikrein

	Prekallikrein (Site not responding. Last check: 2007-10-23)
		Prekallikrein (or Fletcher factor) is a proenzyme that circulates in plasma in a 1:1 complex with high-molecular weight kininogen (HWMK).
		In prekallikrein deficiency, extended incubation of the reagents with the patient plasma prior to addition of calcium chloride will shorten the prolonged APTT (as prekallikrein enhances factor XII activation, factor XII activation can proceed in the presence of a deficiency of prekallikrein as long as there is extended contact with the thromboplastin reagent).
		Prekallikrein deficiency has been reported in a family of Belgian horses, a family of miniature horses and in 2 dogs.
	www.diaglab.vet.cornell.edu /clinpath/modules/coags/prekall.htm (277 words)

	Abstract
		Prekallikrein deficiency (Fletcher defect) is a rare coagulation disorder characterised by a severely prolonged PTT with a silent clinical picture.
		The promoter region, all the 15 exons and the exon-intron boundaries of KLK3 gene were amplified using specific primers described in literature [1] We have investigated the prekallikrein gene in order to clarify the molecular basis of a family with this defect.
		His parents showed slightly decreased levels of prekallikrein and were considered to be heterozygous for the defect.
	www.blackwellpublishing.com /isth2003/abstract.asp?id=9373 (308 words)

	KLKB1 - kallikrein B, plasma (Fletcher factor) 1
		Assay of Fletcher factor (plasma prekallikrein) using an artificial clotting reagent and a modified chromogenic assay.
		Severe prekallikrein (Fletcher factor) deficiency was diagnosed in a 49-year-old woman and in 3 of her siblings.
		Plasma prekallikrein (Fletcher factor) deficiency in a patient with chronic lymphocytic leukemia.
	www.ihop-net.org /UniPub/iHOP/gi/89690.html (1095 words)

	Prekallikrein / Methods / Tech Support / Support / Home - DiaPharma Group, Inc.
		The activation of plasma prekallikrein is mediated by the Hageman factor on negatively charged surfaces and in presence of HMW kininogen.
		This method is related to the use of a prekallikrein activator composed by ellagic acid, phospholipid, Hageman factor and HMW kininogen, which was commercially available from Chromogenix.
		Mechanized assay of plasma prekallikrein by activation with Pseudomonas aeruginosa elastase and amidolysis of chromogenic substrate.
	www.diapharma.com /support/tech_support/methods__1/prekallikrein (941 words)

	Prekallikrein
		Abstract Prekallikrein is a coagulation protein involved in the early stages of intrinsic pathway activation.
		If prekallikrein assays are normal, HMWK assays may be considered.
		Acquired, usually mild-to-moderate decreases in prekallikrein may be found in liver disease or disseminated intravascular coagulation (DIC).
	www.mgh.harvard.edu /pathology/coagbook/CO002600.htm (747 words)

	Plasma prekallikrein activation and kallikrein production assay - usptntsrv1 (Site not responding. Last check: 2007-10-23)
		A method for activating prekallikrein to produce kallikrein in the absence of FXIIa includes mixing prekallikrein with the activator and a composition comprising high molecular weight kininogen and zinc ions.
		The present invèntion relates to a method for the activation of plasma prekallikrein using heat shock protein 90 (hereinafter abbreviated as HSP 90) or a phosphate ion in the absence of an activated blood coagulation factor XII (hereinafter abbreviated as FXIIa).
		Thus, the activated blood coagulation factor XII (FXIIa) acts on the plasma prekallikrein (hereinafter abbreviated as PK) which exists in the same plasma to convert it to a plasma kallikrein which is an enzyme in an activated form.
	www.uspatentserver1.com /691/6913900.html (1020 words)

	[No title]
		The activation of plasma prekallikrein is mediated by the Hageman factor on negatively charged surfaces and in presence of HMW kininogen.
		This method is related to the use of a prekallikrein activator composed by ellagic acid, phospholipid, Hageman factor and HMW kininogen, which was commercially available from Chromogenix.
		Mechanized assay of plasma prekallikrein by activation with Pseudomonas aeruginosa elastase and amidolysis of chromogenic substrate.
	www.chromogenix.com /methods/Plasma_Prekallikrein.htm (900 words)

	Prekallikrein
		The amount of prekallikrein in the patient plasma is determined from a standard curve that plots known amounts of prekallikrein against PTT values.
		Additional Information Prekallikrein is one of the contact factors that participates in the activation of the intrinsic pathway of coagulation when blood is exposed to a negatively charged foreign surface.
		Prekallikrein deficiency is rare and does not cause bleeding, despite prolongation of the PTT.
	www.massgeneral.org /pathology/coagbook/CO002600.htm (747 words)

	Identification of Prekallikrein and High-Molecular-Weight Kininogen as a Complex in Human Plasma -- Mandle et al. 73 ...
		Prekallikrein and high-molecular-weight kininogen were found associated in normal human plasma at a molecular weight of 285,000, as assessed by gel filtration on Sephadex G-200.
		This prekallikrein could be isolated at a molecular weight of 285,000 after plasma deficient in high-molecular-weight kininogen was combined with plasma that is congenitally deficient in prekallikrein.
		I-labeled prekallikrein and high-molecular-weight kininogen to the respective deficient plasma yielded a shift in the molecular weight of prekallikrein, and complex formation could be demonstrated by incubating prekallikrein with high-molecular weight kininogen.
	www.pnas.org /cgi/content/abstract/73/11/4179 (732 words)

	Prekallikrein (Fletcher factor) deficiency -- Sollo and Saleem 15 (4): 279 -- Annals of Clinical and Laboratory Science
		Prekallikrein (Fletcher factor) deficiency -- Sollo and Saleem 15 (4): 279 -- Annals of Clinical and Laboratory Science
		One new case and 29 reported cases of hereditary prekallikrein (Fletcher factor) deficiency are reviewed.
		Prekallikrein levels are less than two percent of normal levels.
	www.annclinlabsci.org /cgi/content/abstract/15/4/279 (191 words)

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