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Topic: Premature aging

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  Senescence - Wikipedia, the free encyclopedia
Aging is generally characterized by the declining ability to respond to stress, increasing homeostatic imbalance and increased risk of disease.
Since few were alive at older ages and their contribution to the next generation was therefore small relative to the large cohorts of younger age groups, the force of selection against such late-acting deleterious mutations was correspondingly small.
Despite the lack of a connection between circular DNA and aging in higher organisms, extra copies of Sir2 are capable of extending the lifespan of both worms and flies.
en.wikipedia.org /wiki/Premature_aging   (3317 words)

 Diagnose-Me: Condition: Premature/Signs of Aging
Premature aging of the brain, circulation, heart, joints, skin, digestive tract, and immune system can begin at any time of life.
Sometimes premature aging occurs without any symptoms until, suddenly, there is a catastrophic event such as a heart attack, cancer, or a stroke.
If premature aging can be halted and normal function reestablished, then people not only will live longer but also will have a higher quality of life with the elimination of pain.
www.diagnose-me.com /cond/C234585.html   (2418 words)

 Progeria - Wikipedia, the free encyclopedia
Unlike most other "accelerated aging diseases" (such as Werner's syndrome, Cockayne's syndrome or xeroderma pigmentosum), progeria is not caused by defective DNA repair.
This results in the premature aging symptoms of progeria, although the mechanism connecting the mishappen nucleus to the symptoms is not known.
This reference is somewhat counterintuitive, as progeria causes rapid aging and death, while Methuselah was known for living to a very great age.
en.wikipedia.org /wiki/Progeria   (1224 words)

 Causes of Aging Skin   (Site not responding. Last check: 2007-10-31)
Aging caused by the genes we inherit is called intrinsic (internal) aging.
The other type of aging is known as extrinsic (external) aging and is caused by environmental factors, such as exposure to the sun’s rays.
Freckles, age spots, spider veins on the face, rough and leathery skin, fine wrinkles that disappear when stretched, loose skin, a blotchy complexion, actinic keratoses (thick wart-like, rough, reddish patches of skin), and skin cancer can all be traced to sun exposure.
www.skincarephysicians.com /agingskinnet/BasicFacts.html   (1469 words)

 Aging and mitochondria. cancer,heart disease,multiple sclerosis,stress
Mitochondrial impairment has been linked to the degenerative diseases of normal aging and because these same impairments are also being found in younger aged people they are thought to be the cause of “premature aging” and therefore why younger people are developing these diseases of the aged.
That is because while they are contributors to aging and pre-mature aging in their own right, they are also the known prime contributors to impaired mitochondrial and cellular function.
While we are certain many more aspects of the body’s interacting metabolic systems will be implicated as causative of premature aging and the aged, this article looks at the known factors about mitochondrial functioning that we have control over NOW in our quest for homeostasis, health and relief from needless pain.
www.heattreat.ca /aging.php   (3636 words)

Using genetically engineered mice, Arceci's team knocked out part of the "core engine" of the PASG gene, decreasing methylation throughout the genome and allowing the wrong genes, particularly those associated with premature aging, to be active all the time.
The result was that mice with this mutated PASG protein showed signs of premature aging and profound growth problems, including low birth-weight, graying and loss of hair, skeletal abnormalities, reduced fat and early death.
Not to be confused with a cell death process called apoptosis, which cuts the DNA into a million pieces, this aging process, called replicative senescence, lets the cell live for a limited period of time with a reduced number of cell divisions before it ages and dies.
www.hopkinsmedicine.org /Press_releases/2004/04_27_04.html   (404 words)

 National Sleep Foundation
As people age they tend to have a harder time falling asleep and more trouble staying asleep than when they were younger.
In addition to changes in sleep architecture that occur as we age, other factors affecting sleep are the circadian rhythms that coordinate the timing of our bodily functions, including sleep.
As we age, there is an increased incidence of medical problems, which are often chronic.
www.sleepfoundation.org /sleeptionary/index.php?id=7   (1322 words)

 The Analyst - Internet Health Report: Condition: Premature/Signs of Aging
Without the diseases of premature aging, a normal life expectancy is estimated to be 120 years.
Results showed that children born to mothers under the age of 25 have nearly double the chance of living to be 100 than those born to older mothers.
Aging is regarded as a slow cooking process also, where these same glycotoxins form in various tissues of the body.
www.digitalnaturopath.com /cond/C234321.html   (3141 words)

 Premature aging - WrongDiagnosis.com
Causes of Premature aging (Disease Database) Premature aging (9 conditions)
The cause of Premature aging may be more easily identified if other symptoms exist.
The following medical conditions are some of the possible causes of Premature aging as a symptom.
www.wrongdiagnosis.com /sym/premature_aging.htm   (526 words)

 BioMed Central | Full text | Aging syndrome genes and premature coronary artery disease
Aging syndrome genes and premature coronary artery disease
The high prevalence of CAD in older age groups suggests that some forms of atherosclerosis are an integral part of the aging process, and inherited premature aging (or progeroid) syndromes are associated with extensive vascular disease[5].
A second aging disorder, Hutchison-Gilford Progeria Syndrome (HGPS), is the result of recurrent de novo mutations of a single nucleotide in exon 11 of the LMNA gene have been shown to cause the progeroid disorder)[8,9].
www.biomedcentral.com /1471-2350/6/38   (3891 words)

 Aging mechanisms -- Takahashi et al. 97 (23): 12407 -- Proceedings of the National Academy of Sciences
A family lineage exhibiting progeria (premature aging) indicates that senescence is, at least to some extent, controlled genetically.
The klotho phenotype (premature aging) is caused by a disruption of the single gene, klotho.
This pairing is accomplished is accomplished by colocalization of all of the telomeres at SPB, and dynamic movement of chromosomes led by SPB (11).
www.pnas.org /cgi/content/full/97/23/12407   (1590 words)

 Avoiding Premature Aging   (Site not responding. Last check: 2007-10-31)
Aging can be described as the progressive deterioration of virtually every bodily function over time.
To protect from this to happen it is important to remove waste that can throw the biological chemistry off balance by supporting the body's eliminatory organs and to supply the cells with nutrients that neutralize the oxygen radicals.
Premature cell death or poor cellular function is the major cause of rapid aging.
www.afpafitness.com /articles/PrematureAge.htm   (1263 words)

 Eternal Health Anti Aging program by World Anti aging expert Dr Michael Elstein
The accumulation of lead, aluminium and mercury is considered to be the major culprit of premature brain aging.
Lapses of memory and reduced visual capability are considered to be the early signs of premature brain aging.
You will discover whether you are aging prematurely and you will be provided with customized guidelines as to how you can prevent the aging process.
www.eternalhealth.org /anti_aging/anti_aging_medicine.htm   (580 words)

 Hyaluronic Acid: Can it Prevent Premature Aging?
Since the ABC special on hyaluronic acid called it the "Fountain of Youth", it is interesting that one of the defining characteristics of premature aging syndromes, such as Progeria, is hyaluronic acid abnormalities.
In a study of rats, hyaluronic acid turnover and metabolism were affected by age, dietary composition, and caloric intake.
Many of the features of premature aging syndromes and connective tissue disorders are also known to be caused by nutritional deficiencies, and not surprisingly these are often the same nutritional factors that influence the manufacture of hyaluronic acid.
www.ctds.info /hyaluronic_acid.html   (1704 words)

 * The secret of Aging.
The secret is: Aging is not caused by the passing of years, but rather from an overload of information that the body has decided to store on a cellular level.
And the fact that after waking up from the deep lethargic sleep people age instantly has only one explanation: it's not the amount of time that you have slept, it's the amount of information you have accumulated during those sleeping years.
Gouliaev, MD, licensed in Russia, aging is always accompanied by the accumulation of unnecessary information (stress, empty useless conversations) encoded in the body's cells.
www.yourhealth911.com /articles/other/anti_aging.html   (1512 words)

 premature aging phenotypes in mice   (Site not responding. Last check: 2007-10-31)
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death.
PASG mutant mice provide a useful model for the study of aging as well as the mechanisms regulating epigenetic patterning during development and postnatal life.
www.cryonet.org /cgi-bin/dsp.cgi?msg=24310   (217 words)

 Untitled Document
Adults with Down syndrome show undeniable signs of premature aging within their brains, and these features are detectable with routine MRI’s.
Premature aging in adults with Down syndrome involves only physical changes, and living skills will not be affected.
Research is continuing to see how much of the decline in function can be attributed to the normal, albeit premature, aging in individuals with Down syndrome and how much is caused by Alzheimer’s disease and other forms of dementia.
www.rnceus.com /adown/aging.htm   (454 words)

 Resources in Social Gerontology
Aging is not a singular process: we age biologically, psychologically, and sociologically, and the "aging experience" is determined by the unique interactions between these various clocks.
The challenge is to push the field from being a multidisciplinary endeavor to being a interdisciplinary endeavor, to ultimately understanding the complex interactions between biological, psychological, sociological, and cultural processes.
The aging experience is, for instance, shaped by individuals' birth cohorts and the slices of social history intersecting their biographies; by their genetic make-up and personality types; and by their positions within the stratification orders of social class, gender, race and ethnicity.
www.trinity.edu /~mkearl/geron.html   (752 words)

 PA-05-136: Testing Stem Cell Therapy in Mouse Models of Premature Aging
However, testing the role of stem cells in normal, physiological aging is hampered by many technical difficulties, including their extremely slow rate of turnover, and the lack of viability of mice genetically altered to lack such a basic cell compartment as stem cells.
The role of stem cells in healthy aging can be explored by activating or invigorating the resident pools of stem cells, or alternatively, by supplementing aging organisms with fresh, young and vigorous stem cells, and by measuring whether or not this procedure extends lifespan or inhibits (or even reverses) age-dependent loss of tissue function.
For these purposes, a model of accelerated aging is defined as a mouse model where a shortened lifespan is accompanied by the accelerated appearance of a plethora of age-related diseases.
grants.nih.gov /grants/guide/pa-files/PA-05-136.html   (5399 words)

 New Mouse Model Aids Research on Aging Syndrome - National Cancer Institute
In the mice, accelerated aging was most apparent in the skin, which thinned dramatically and lost hair.
Similarly, the mice had either incomplete development of the skeleton or a premature loss of bone mass, also characteristic of children with progeria.
The mutant form of the gene associated with progeria symptoms causes disruption in the structure of the cell nucleus.
www.cancer.gov /newscenter/pressreleases/progeria   (505 words)

 Premature Aging And DNA Repair, The World Health Network - Anti-Aging and Longevity
In humans, failure of transcription-coupled repair is the cause of Cockayne Syndrome, an extreme form of accelerated aging that is inevitably fatal early in life.
Cooper and her colleagues illuminated, for the first time, the roles played by two important proteins in recognizing blockages in transcription and in initiating an efficient method of repair; their results suggested a previously unsuspected mechanism for the repair process.
In contrast, Cockayne Syndrome is marked not by skin cancer but by severe physical and mental retardation -- victims have an unusually small brain and fail to grow and develop normally after birth; pronounced wasting usually begins in the first year of life.
www.worldhealth.net /p/premature-aging-and-dna-repair-2005-11-30.html   (1971 words)

 Stress Linked To Premature Aging
Chronic stress appears to hasten the shrivelling of the tips of the bundles of genes inside cells, which shortens their lifespan and speeds the body's deterioration, according to a small but first-of-its-kind study involving mothers caring for chronically ill children.
"This is the first time that psychological stress has been linked to a cellular indicator of aging in healthy people." The findings could lead to new ways to detect the early physical effects of stress and monitor whether attempts to alleviate its effects are working, she said.
While cautioning that the findings needed to be confirmed by additional research, other scientists said the results represent an unprecedented step in deciphering the intricacies of the mind-body connection.
www.rense.com /general60/stress.htm   (233 words)

 Premature aging   (Site not responding. Last check: 2007-10-31)
Premature aging news vertical portal can now be syndicated quickly and easily using our new Really Simple Syndication feeds.
UV radiation from the sun causes premature aging of the skin and......
For any further understanding that could lead to the prevention, treatment, and/or cure of the disorders, we recommend that affected individuals seek the advice or counsel of his or her own personal physician(s).
premature-aging.diseasemap.com   (298 words)

 Clare Caldwell Massage Therapist - Stop the Clock Prevent Premature Aging
Aging is a fact of life that is unavoidable and unpredictable.
Premature aging is the result of careless living and is preventable.
This is where premature aging is most visible.
www.massagetherapynj.com /aging.htm   (260 words)

 Artherosclerosis & Premature Aging   (Site not responding. Last check: 2007-10-31)
Though we don't necessarily turn brown with actual rust, we do get age spots, gray hair, wrinkles, aches and pains and are subject to various disease processes.
Free radical attack is one of the main causes of atherosclerosis and premature aging.
Heavy Metal Overload in the walls of coronary arteries seems to decrease levels of nitric oxide, a compound known as "Endothelial Relaxing Factor,"- without this substance normal blood flow is impeded therefore increasing the risk of vascular blockages.
www.relfe.com /IDetoxamin/artherosclerosis_aging.htm   (873 words)

 Genomic Instability And Premature Aging, The World Health Network - Anti-Aging and Longevity
Premature aging syndromes often result from mutations in nuclear proteins involved in genomic integrity.
For example Hutchinson-Gilford progerial syndrome (HGPS), a severe form of early-onset premature aging, is caused by truncation in the protein lamin A. Lamin A is a nuclear protein important for chromatin attachment, DNA replication and nuclear organization.
The results indicate that mutations in prelamin A and lamin A perturb DNA damage response and repair, resulting in genomic instability which might contribute to certain types of premature aging.
www.worldhealth.net /p/genomic-instability-and-premature-aging-2005-07-06.html   (516 words)

 genome.gov | 2003 Release: Gene for Premature Aging Disorder
Derived from the Greek word for old age, "geras," progeria is estimated to affect one in 8 million newborns worldwide.
The children appear to have an aging rate that is 5 to 10 times what is normal." Dr. Brown is widely regarded as the world's leading clinical expert on progeria.
Death occurs on average at age 13, usually from heart attack or stroke.
www.genome.gov /11006962   (1567 words)

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