| |
| | Prenatal Testing |
 | | Many years' experience has shown conventional karyotyping of cultured amniocytes to be a reliable, cost effective and highly accurate means of prenatal diagnosis of a wide range of chromosome abnormalities, its only disadvantage being the period during which cells need to be cultured prior to analysis. |
 | | Several commercial kits are now available, but presently all have the disadvantage that inherent technical limitations, combined with the need to contain their price within acceptable limits, restrict their scope to the accurate detection of non-mosaic forms of the common aneuploidies, trisomies 13, 18 and 21 and numerical sex chromosome abnormalities. |
 | | Although rapid testing for common aneuploidies clearly offers advantages to some groups of patients, its widespread applicability and its desirability as a screening technique for use for all current prenatal diagnostic referrals, remains under review. |
| www.bshg.org.uk /documents/official_docs/prenat1.htm (674 words) |
|