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Topic: Progenitor cell

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	Cell infusions boost heart function, revive damaged heart muscle
		“The infusion of progenitor cells was associated with a reduction in the size of muscle damage, a significant improvement in pumping function, and less enlargement of the heart within four months after a heart attack,” said co-author Andreas M. Zeiher, M.D., chairman of the department of internal medicine at the University of Frankfurt in Germany.
		The small study corroborates previous research that indicates stem and progenitor cells can reduce heart attack damage, and thus, the heart enlargement and failure that often follows. The findings indicate that progenitor cell therapy enhances regeneration of the left ventricle after heart attack.
		Neither the improvements in heart functioning nor the decrease in dead muscle correlated with the number of cells infused into a patient. Instead, the team’s analysis indicated that the key to the improvements was the ability of cells to migrate from the artery into the heart muscle.
	www.americanheart.org /presenter.jhtml?identifier=3015985 (621 words)

	NDI Terminology - cell (Site not responding. Last check: 2007-10-21)
		A cell is the fundamental, structural, and functional unit of living organisms.
		reticular cells - The cells forming the reticular fibers of connective tissue; those forming the framework of lymph nodes, bone marrow, and spleen are part of the reticuloendothelial system and under appropriate stimulation may differentiate into macrophages.
		A blood cell progenitor, or mother cell, having the capacity for both replication and differentiation, and giving rise to various morphologically recognizable precursors of different blood cell lines, such as the proerythrocyte and myeloblast, which cannot self-replicate and must differentiate into more mature daughter cells.
	www.ndif.org /Terms/cell.html (158 words)

	Search for the preadipocyte progenitor cell -- Hausman and Hausman 116 (12): 3103 -- Journal of Clinical Investigation
		(or preadipocyte) and the preadipocyte precursor cell (or progenitor
		These observations were substantiated by examination of the preadipocyte progenitor cells and endothelial cells by electron microscopy and studies of the major extracellular components (25, 26).
		Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow.
	www.jci.org /cgi/content/full/116/12/3103 (1701 words)

	World Intellectual Property Organization (Site not responding. Last check: 2007-10-21)
		The progenitor cells of the invention, as modulated by a compound of the invention, are useful for transplantation (i.
		A stem cell is a developmentally pluripotent or multipotent cell.
		cells that are undifferentiated stem cells that are isolated from a postpartum perfused placenta.
	www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=03/87333.031023&ELEMENT_SET=DECL (9416 words)

	Progenitor Cell Therapy's History — Progenitor Cell Therapy (Site not responding. Last check: 2007-10-21)
		On March 1, 1999 PCT acquired the hematopoietic progenitor cell and tissue processing laboratory from Hackensack University Medical Center (HUMC), located in Hackensack, New Jersey.
		Subsequent to its acquisition by PCT, the laboratory was upgraded to a custom-built, 2,500 square foot, state-of-the-art manufacturing facility in a new building within the HUMC hospital complex.
		The laboratory is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT), and its operations are based upon quality systems, as described in Title 21 CFR compliance with cGMP and cGTP guidelines promulgated by the FDA.
	www.progenitorcelltherapy.com /history_milestones (201 words)

	3DM PuraMatrix Publications
		Furthermore, the self-assembling peptide nanofiber microenvironments recruit progenitor cells that express endothelial markers, as determined by staining with isolectin and for the endothelial-specific protein platelet— endothelial cell adhesion molecule-1.
		Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold.
		Viable cell densities of dynamically compressed cultures differed from free-swelling controls by less than 20%, demonstrating that changes in PG synthesis were due to an increase in the average biosynthesis per viable cell.
	www.puramatrix.com /pubs/index.htm (4386 words)

	Progenitor Cell Transplantation
		Intracoronary progenitor cell application did not incur any measurable ischemic myocardial damage, but one patient experienced distal embolization before cell therapy.
		During hospital follow-up, one patient in each cell group developed myocardial infarction; one of these patients died of cardiogenic shock.
		Intracoronary infusion of progenitor cells (either BMC or CPC) is safe and feasible in patients after acute myocardial infarction successfully revascularized by stent implantation.
	www.cardiologyonline.com /journal_articles/Progenitor_Cell.htm (299 words)

	RFA-DK-02-027: NIDDK PROGENITOR CELL GENOME ANATOMY PROJECTS
		This grant award mechanism will support characterization of appropriate stem cell lines that are broadly relevant to study of the target organ at multiple stages of target organ development and differentiation, determination of gene expression patterns in those cell lines, and development of appropriate functional genomics tools to characterize the genes expressed.
		Given the importance of developing new in vivo models for studying and assaying stem cell function, the need for improved isolation and recovery of stem cells, and the need for methods to maintain ex vivo cell populations that retain their pluripotency, it is essential to characterize genomic features of stem cells and their committed daughters.
		In the gut, epithelial renewal in the stomach, small intestine, and colon is sustained by populations of multipotent stem cells that reside in distinct anatomic units.
	grants.nih.gov /grants/guide/rfa-files/RFA-DK-02-027.html (7055 words)

	This Is MS -- Unbiased Multiple Sclerosis Research, News, and Community - Stem Cell Research: Scientists Create ...
		But what progenitor cells lack in potential, they make up for with commitment: They have already "decided" exactly what type of cell to become in the body, an advantage when treating a disease where one specific cell type is at risk.
		The progenitor cells are immortalized at a stage when they only give rise to the type of neuron we want, thus becoming an ongoing source of these neurons," says Goldman, who is professor of Neurology and chief of the department’s Division of Cell and Gene Therapy.
		The result was a line of immortal progenitor cells giving rise only to human spinal neurons, including both motor neurons and interneurons, two of the most clinically important cell types of the spinal cord.
	www.thisisms.com /modules.php?name=News&file=article&sid=59 (1279 words)

	Holistic Health Encyclopedia - S (Site not responding. Last check: 2007-10-21)
		As a cell accumulates keratinohyalin granules, it is thought that rupture of lysosomal membranes release lysosomal enzymes that eventually cause cell death.
		The deeper cells of the stratum corneum retain their desmosomal junctions, but as they are pushed to the surface by newly forming cells of the stratum germinativum (SG), the dead cells gradually break apart and are lost, a process called desquamation.
		The cells that divide in the statum germinativum soon begin to accumulate many desmosomes on their outer surface which provide the characteristic “prickles” of the stratum spinosum (SS), which is often called the prickle-cell layer.
	www.myholistic.com /glossary/S.php3 (8360 words)

	Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: ...
		Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect -- Papadaki et al.
		Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect
		Establishment of nurse-like stromal cells from bone marrow of patients with rheumatoid arthritis: indication of characteristic bone marrow microenvironment in patients with rheumatoid arthritis.
	www.bloodjournal.org /cgi/content/full/99/5/1610 (5585 words)

	p27Kip1 and p57Kip2 Regulate Proliferation in Distinct Retinal Progenitor Cell Populations -- Dyer and Cepko 21 (12): ...
		B, Cyclin D1 protein was broadly expressed in progenitor cells occupying the outer neuroblastic layer (onbl) at E14.5 in the mouse retina.
		Dyer MA, Cepko CL (2000a) p57 regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina.
		Young RW (1985) Cell differentiation in the retina of the mouse.
	www.jneurosci.org /cgi/content/full/21/12/4259 (7504 words)

	Dynal® CD34 Progenitor Cell Selection System (Site not responding. Last check: 2007-10-21)
		cells (haematopoietic progenitor cells) with an intact antigen profile.
		Human stem cells can be positively isolated directly from bone marrow, cord blood or mobilised peripheral blood samples.
		The isolated CD34 cells are antibody- and bead-free and can be cultured for 4-5 days with GM-CSF and TNFa (optional) and a further 9 days with GM-CSF, IL-4 and TNFa.
	www.dynalbiotech.com /kunder/dynal/dynalpub401.nsf/print/1E6F57529F521809C1256C540048502C?OpenDocument (180 words)

	Service Testimonials — Progenitor Cell Therapy (Site not responding. Last check: 2007-10-21)
		The processes were staggered by about 15 minutes so I was able to observe all the operators loading [ingredient], adding cell suspensions, re-suspending pellets, use of scales and centrifuges, and their aseptic techniques.
		Both the harvest and the formulation at [concentration of cells/ml] in [cryopreservative], vialling, and controlled rate freeze process were also completed in reasonable time.
		He said; ттІThe event will focus on тcellular bio-processingт т“ looking at the technology required to get stem cell products to market, an area where CELS is developing plans to significantly enhance the regionтs capability.
	www.progenitorcelltherapy.com /service_testimonials (1007 words)

	B-153 Stem Cell and Progenitor Cell Therapy: Current Uses and Future Possibilities (Site not responding. Last check: 2007-10-21)
		The advances that have occurred in cell therapy, at least on the research front, are so all-encompassing that many were not even dreamed of at the time the previous report was written.
		For the purposes of this report, a progenitor cell has the capacity to create progeny that are more differentiated than itself and retains the capacity to replenish the pool of progenitors.
		By that definition, both embryonic stem cells and adult stem cells are also progenitor cells, as well as the more immediate precursors to terminally differentiated cells.
	www.bccresearch.com /biotech/B153.html (1942 words)

	Peripheral Blood Progenitor Cell Transplantation
		Peripheral blood progenitor cells (PBPC) are used with increasing frequency to reconstitute hematopoiesis following myeloablative therapy in cancer patients.
		In the mid 1980s, trials of PBPC transplants began in patients with acute leukemia or lymphoma in whom autologous bone marrow harvest was not feasible because of hypocellularity or tumor involvement.
		The risk of tumor cell contamination is presumed lower with PBPC than with bone marrow transplantation, but this has yet to be proved.
	www.centerspan.org /pubs/news/sp94b.htm (711 words)

	Arch Ophthalmol -- Abstract: Retinal Progenitor Cell Xenografts to the Pig Retina: Morphologic Integration and ...
		Arch Ophthalmol -- Abstract: Retinal Progenitor Cell Xenografts to the Pig Retina: Morphologic Integration and Cytochemical Differentiation, October 2005, Warfvinge et al.
		After 5 weeks, fewer GFP+ cells were found.
		Progenitor Cells from the Porcine Neural Retina Express Photoreceptor Markers After Transplantation to the Subretinal Space of Allorecipients
	archopht.ama-assn.org /cgi/content/abstract/123/10/1385 (316 words)

	Stem Cell Mobilization -- Cottler-Fox et al. 2003 (1): 419 -- Hematology
		Physiological migration of hematopoietic stem and progenitor cells.
		Mobilized peripheral blood stem/progenitor cells are primed by several inflammatory molecules for their chemotactic responses to sdf-1: a molecular explanation as to why mobilized peripheral blood cells engraft faster than bone marrow cells after transplantation.
		Impact of preleukapheresis cell counts on collection results and correlation of progenitor cell dose with engraftment after high-dose chemotherapy in patients with germ-cell cancer.
	www.asheducationbook.org /cgi/content/full/2003/1/419 (9841 words)

	G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration -- Mizuno ...
		G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration -- Mizuno et al.
		Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan; and
		progenitor cells divide in an asymmetric manner and migrate
	www.pnas.org /cgi/content/abstract/102/35/12365?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&titleabstract=migration&andorexacttitleabs=and&andorexactfulltext=and&searchid=1125504152394_4674&stored_search=&FIRSTINDEX=0&sortspec=relevance&fdate=8/1/2005&journalcode=pnas (336 words)

	Umbilical Cord Blood Progenitor Cell Transplantation (Site not responding. Last check: 2007-10-21)
		Cord blood banking is a process of salvaging the cord and placental blood and cryogenically freezing it immediately after the birthing process.
		This commonly discarded by-product of birth was identified in the mid-1980's as a rich source of stem/progenitor cells.
		The first human transplant with stem cells recovered from cord blood was performed in 1988.
	www.bcbsmo.com /medical_policies/surgery/umbilical_cord.htm (438 words)

	STEM CELL & PROGENITOR CELL THERAPY: CURRENT USES AND FUTURE POSSIBILITIES - Market Size, Market Share and Demand ...
		This includes, for example, the replacement of the blood and immune systems with blood stem cells, the use of neural stem cells to treat neurodegenerative systems, the use of mesenchymal stem cells to repair bones and joints, liver stem cells for liver failure, and the potential use of therapeutic cloning to repair other tissues.
		This report is necessary and timely because of the rapid advances that have been made in the field - cell therapies in the pipeline have the potential to replace many of the pharmaceuticals currently marketed to treat chronic diseases, like Parkinson's disease and diabetes.
		Companies involved in stem cell therapies are profiled and markets are estimated for these therapies through 2005.
	bcc.ecnext.com /coms2/summary_0279-84342_ITM (1257 words)

	PUBLICATIONS - Jeffrey J. Chalmers (Site not responding. Last check: 2007-10-21)
		Pulse-injection studies of blood progenitor cells in a quadrupole magnetic flow sorter.
		Progenitor cell isolation with a high-capacity quadrupole magnetic flow sorter,
		Cell damage of microcarrier and suspended cell culture as a function of extensional forces and local energy dissipation
	www.che.eng.ohio-state.edu /~chalmers/publist.htm (1382 words)

	Progenitor Cell Therapy (Site not responding. Last check: 2007-10-21)
		, LLC (PCT) is the leading laboratory platform company serving the developing cell therapy industry.
		We offer a full range of cell therapy process design, development, regulatory, advisory, consulting and manufacturing support services to companies developing cellular therapeutics to treat a wide variety of diseases.
		We are equipped to handle projects at all stages of product development.
	www.progenitorcelltherapy.com (72 words)

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