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Topic: Progeria

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	genome.gov \| Learning About Progeria
		Progeria is an extremely rare genetic disease of childhood characterized by dramatic, premature aging.
		In the past, doctors had to base a diagnosis of progeria solely on physical symptoms, such as skin changes and a failure to gain weight, that were not fully apparent until a child's first or second year of life.
		This genetic test for Hutchinson-Gilford progeria syndrome also serves to reassure parents of affected children that their disorder stems from a sporadic genetic mutation and that therefore it is unlikely that any future offspring would have the condition.
	www.genome.gov /11007255 (905 words)

	Progeria - Health Centers News Story - WFTV Orlando
		Progeria is a disease that produces rapid aging, beginning in childhood.
		Progeria is a rare condition that is remarkable because its symptoms strongly resemble normal human aging, but occur in young children.
		Progeria results in rapid aging of a child, beginning with growth failure in the first year of life.
	www.wftv.com /encyclopedia/6862348/detail.html (717 words)

	Progeria
		Ninety percent of children with progeria have a mutation on the gene that encodes the protein lamin A. Progeria usually occurs sporadically, and is not seen in siblings of affected children, although -- in very rare circumstances -- more than one child in a family can have progeria.
		Progeria results in rapid aging of a child, beginning with growth failure in the first year of life.
		Progeria children (male and female) are thin and balding, with wizened narrow faces and old-appearing skin.
	www.healthtalk.com /multiplesclerosis/encyclopedia/?p=1/001657.htm (423 words)

	Progeria syndrome: Encyclopedia of Genetic Disorders
		Progeria syndrome is an extremely rare genetic disorder of unknown origin that manifests as premature aging in children.
		Progeria affects many parts of the body including the skin, bones, and arteries.
		Progeria syndrome is also known as Hutchinson-Gilford progeria syndrome, HGPS or Gilford syndrome.
	health.enotes.com /genetic-disorders-encyclopedia/progeria-syndrome (141 words)

	Kids.Net.Au - Encyclopedia > Progeria (Site not responding. Last check: )
		Progeria is an extremely rare genetic condition which causes physical changes that resemble greatly accelerated aging in sufferers.
		It is an autosomal recessive[?] condition and effects around 1 in 8 million newborns.
		The condition was later named Hutchinson-Gilford Progeria syndrome, the name was derived from the Greek for "prematurely old".
	www.kids.net.au /encyclopedia-wiki/pr/Progeria (170 words)

	Progeria: Too Young To Be Old--AllYourTV.com
		Children with Progeria are, in spirit, just the same as any other child, but physically, they look like very old men and women and live an average lifespan of only 13 years.
		Progeria is a condition characterized by an appearance of accelerated aging among children.
		Progeria is believed to be caused by a sporadic new mutation, which happens at the time of conception.
	www.allyourtv.com /moviesspecials/p/moviesspecialsprogeria.html (323 words)

	Progeria : American Pregnancy Association
		Progeria is a genetic condition that occurs in 1 of every 4 to 8 million newborns.
		Progeria or HGPS is a rare, fatal genetic condition characterized by an appearance of accelerated aging in children.
		Unfortunately, progeria often leads to death caused by atherosclerosis (heart disease) at an average age of thirteen years (with a range of about 8 – 21 years).
	www.americanpregnancy.org /birthdefects/progeria.htm (647 words)

	Progeria - Memory Alpha, the Star Trek Wiki
		Progeria is a genetic disease which very rarely occurred among Human children until it was eradicated in the 22nd century.
		Progeria caused children to age much more rapidly than normal, usually leading to an early death.
		In 2374, progeria was the only disease the Doctor could think of when Chakotay was suffering from progeria-like symptoms, though it would have been the first case in two centuries and the first ever diagnosed with an adult.
	memory-alpha.org /en/wiki/Progeria (134 words)

	AllRefer Health - Progeria (Hutchinson-Gilford Syndrome)
		Progeria is a disease that produces rapid aging starting in childhood.
		Progeria is a rare condition but has come into public awareness because its symptoms strongly resemble normal human aging as well as the appearance of several affected children in movies on national television.
		Progeria results in rapid aging of children, beginning with growth failure during the first year of life that results in disproportionately small bodies given the size of their heads.
	health.allrefer.com /health/progeria-info.html (387 words)

	Camera Works: Health (washingtonpost.com)
		Progeria is a very rare genetic disorder that induces an extreme acceleration of the aging process.
		Werner's syndrome, one of several diseases in which progeria is manifested, appears in adults usually ages 30 to 40 although initial symptoms occur sometime around puberty.
		Hutchinson-Gilford Progeria Syndrome (HGPS), also known as the "classic" form of progeria, is perhaps the most brutal as it exhibits signs within the first two years of life.
	washingtonpost.com /wp-srv/photo/galleries/progeria/index.htm (399 words)

	Richland College, Biol. 2402 - Genetics of Progeria
		Progeria has been determined to be genetic, that is, the disease is passed along during cell division in the formation of a fetus.
		The disease is not necessarily hereditary because parents of children with progeria are not affected, nor do they carry a gene for it.
		It is unlikely to have more than one child in a given family affected with progeria because of the rarity of the disease.
	www.rlc.dcccd.edu /MATHSCI/reynolds/progeria/genetics/progeriagenetics.htm (455 words)

	Progeria
		Progeria is considered to be the result of a dominant mutation because the gene in question has one normal copy and one abnormal copy, as opposed to a recessive mutation in which both copies are abnormal.
		Progeria affects between 1 in 8 million (approx.) children, with a total reported incidence of just over 100 in the century since it's been identified.
		Most children with Progeria live no longer than their early teenage years, though one or two have lived to be as old as 20 or 21.
	www.manbir-online.com /diseases/progeria.htm (416 words)

	Hutchinson-Gilford progeria syndrome - Genetics Home Reference
		Hutchinson-Gilford progeria syndrome is a genetic condition characterized by the dramatic, rapid appearance of aging beginning in childhood.
		Mutations in the LMNA gene cause Hutchinson-Gilford progeria syndrome.
		Hutchinson-Gilford progeria syndrome is considered an autosomal dominant condition, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
	ghr.nlm.nih.gov /condition=hutchinsongilfordprogeriasyndrome (570 words)

	Progeria Disease
		Hutchinson-Gilford progeria syndrome (HGPS), named after Jonathan Hutchinson, who first described the disease in 1886 and Hastings Gilford (1904), who was the first to refer to the disease as progeria Most children with progeria die from heart disease before age 15.
		Progeria is a rare genetic disease causing accelerated aging and cardiovascular disease in Explore UC NewsWire for the latest word in scientific research, health care, the economy, the arts and society from around the UC system.
		When Hayley was diagnosed with Progeria in 1999 we had never heard of it and Progeria is a rare genetic disease that causes accelerated aging in children.
	www.amtprague.com /progeria-disease.htm (342 words)

	Hutchinson Gilford Progeria Syndrome - Hutchinson Gilford Progeria Syndrome
		According to recent evidence, Progeria may be a de novo dominant trait.
		It develops during cell division in a newly conceived child or in the gametes of one of the parents.
		A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person.
	www.medicalgeo.com /Med-Diseases-Ho---Hy/Hutchinson-Gilford-Progeria-Syndrome.html (447 words)

	CIGNA - Progeria, Hutchinson Gilford
		Progeria is caused by a mutation of the gene LMNA, or lamin A. The lamin A protein is the scaffolding that holds the nucleus of a cell together.
		Newborns with Hutchinson-Gilford progeria syndrome may have certain suspicious findings may be present at birth, such as unusually taut, shiny, hardened (i.e., "scleroderma-like") skin over the buttocks, upper legs, and lower abdomen; bluish discoloration of the skin and mucous membranes within the midportion of the face (midfacial cyanosis); and/or a "sculptured" nose.
		The researchers determined that the most common cause of progeria is a single-letter “misspelling” in a gene on chromosome 1 that codes for lamin A, a protein that is a key component of the membrane surrounding the cell’s nucleus.
	www.cigna.com /healthinfo/nord130.html (3354 words)

	genome.gov \| 2003 Release: Gene for Premature Aging Disorder
		Derived from the Greek word for old age, "geras," progeria is estimated to affect one in 8 million newborns worldwide.
		This partnership eventually led to funding for progeria research and the formation of the PRF Genetics Consortium, a group of 20 scientists whose common goal is to find the genetic cause of progeria and to develop ways of treating the disease.
		However, when Dr. Eriksson conducted laboratory tests on cells from progeria patients, she found that the minute change in the LMNA gene's DNA sequence dramatically changed the way in which the sequence was spliced by the cell's protein-making machinery.
	www.genome.gov /11006962 (1567 words)

	Richland College, Biol. 2402 - Introduction to Progeria
		Progeria is a rare genetic disease resulting in accelerated aging.
		It is known as the progeria of childhood and is usually diagnosed in the first or second year of life.
		Werner syndrome is commonly referred to as "progeria of the adult." It was first described in 1904 by general practitioner Otto Werner.
	www.rlc.dcccd.edu /MATHSCI/reynolds/progeria/intro/progeria1.htm (472 words)

	Malady of the Month Archives - Progeria
		This means that these children develop the symptoms of other diseases, which normally occur only in people in their seventies or eighties, at the early age of ten or twelve years.
		The head is disproportionally large and bald and the facial appearance is one of hollow cheeks with a tight skin, scanty eyebrows and eyelashes, a pointed nose and, frequently, either crowded or missing teeth.
		A severe growth retardation develops and progression of the aging process is equally as relentless; premature atherosclerosis causes many children with progeria to have their first stroke or heart attack at a very early age, mostly between their twelfth and fifteenth year of life.
	www.asylumeclectica.com /asylum/malady/archives/progeria.htm (581 words)

	Healthy Mothers, Healthy Babies: Q&A with Burton Edelstein, DDS, MPH
		Progeria is known as a “premature aging”; syndrome, which affects children in a lot of different ways, but their cardiovascular system is the major system affected.
		Progeria affects one in four, to one in eight million children, but in a way it affects all of us because these children die of the typical heart disease that affects aging individuals.
		However, since Progeria is not passed down through generations (it is a sporadic autosomal dominant defect), it is very unlikely that the sibling of a child with Progeria will carry the Progeria defect.
	www.hmhb.org /lgordon.html (1351 words)

	NORD - National Organization for Rare Disorders, Inc.
		Progeria, or Hutchinson-Gilford progeria syndrome, is a rare, fatal, genetic condition of childhood with striking features resembling premature aging.
		Children with progeria die of heart disease (atherosclerosis) at an average age of 13 years, with a range of about eight to 21 years.
		Progeria is caused by a mutation of the gene LMNA, or lamin A. The lamin A protein is the scaffolding that holds the nucleus of a cell together.
	www.rarediseases.org /search/rdbdetail_abstract.html?disname=Progeria%2C%20Hutchinson%20Gilford (572 words)

	Progeria Medical Information
		Progeria is a disease that produces rapid aging, beginning in childhood.
		Progeria is a rare condition that is remarkable because its symptoms strongly resemble normal human aging, but occur in young children.
		Ninety percent of children with progeria have a mutation on the gene that encodes the protein lamin A. Progeria usually occurs without cause.
	www.drugs.com /enc/progeria.html (411 words)

	Progeria - MayoClinic.com
		Progeria is a progressive genetic disorder that causes children to age rapidly, beginning in their first two years of life.
		The average life expectancy for a child with progeria is 13, but some with the disease die younger and some live longer — up to the age of 30.
		For at least 90 percent of children with progeria, the cause of death is a complication of the progressive stiffening of the arteries that lead to the heart and brain.
	www.mayoclinic.com /health/progeria/DS00936 (251 words)

	Progeria Progress: Studies Show How Mutant Protein Hurts Hearts
		In children with progeria, a mutant protein accumulates in blood vessel cells, hampering their ability to grow and multiply or killing them outright.
		Both shed important new light on the progression of progeria, a rare and fatal genetic condition that causes accelerated aging in children.
		A Brown Medical School graduate, Gordon created the Progeria Research Foundation in 1999, one year after her son, Sam, was diagnosed with the condition.
	www.medicalnewstoday.com /medicalnews.php?newsid=38055 (871 words)

	Progeria
		Ninety percent of children with progeria have a mutation on the gene that encodes the protein lamin A. Progeria usually occurs sporadically, and is not seen in siblings of affected children, although -- in very rare circumstances -- more than one child in a family can have progeria.
		Progeria results in rapid aging of a child, beginning with growth failure in the first year of life.
		Progeria children (male and female) are thin and balding, with wizened narrow faces and old-appearing skin.
	www.healthcentral.com /ency/408/001657.html (427 words)

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