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Topic: Progressive supranuclear palsy

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	MedlinePlus: Progressive Supranuclear Palsy
		The primary NIH organization for research on Progressive Supranuclear Palsy is the National Institute of Neurological Disorders and Stroke
		Progressive supranuclear palsy (PSP) is a rare brain disease.
		However, PSP is dangerous because it increases your risk of pneumonia and choking from swallowing problems and injuries from falling.
	www.nlm.nih.gov /medlineplus/progressivesupranuclearpalsy.html (275 words)

	Progressive supranuclear palsy -- Rehman 76 (896): 333 -- Postgraduate Medical Journal
		Progressive supranuclear palsy is a recessive disorder in linkage disequilibrium with the tau and not the alpha-synuclein gene.
		Dopaminergic and cholinergic lesions in progressive supranuclear palsy.
		Atrophy of the corpus callosum, cognitive impairment, and cortical hypometabolism in progressive supranuclear palsy.
	www.postgradmedj.com /cgi/content/full/76/896/333 (2543 words)

	AllRefer Health - Progressive Supranuclear Palsy (Dementia-Nuchal Dystonia, Palsy - Progressive Supranuclear, ...
		Progressive supranuclear palsy is a disorder caused by damage to certain nerve cells in the brain, characterized by progressive lack of coordination, stiffness of the neck and trunk, difficulties with eye movement, slow movements, cognitive dysfunction, and difficulty walking that can result in falls.
		Progressive supranuclear palsy is a disorder characterized by symptoms similar to Parkinson's disease (including unsteady gait, stiff movements, and mild dementia).
		Progressive supranuclear palsy involves damage to multiple cells of the brain, with loss of the myelin sheath (the covering of the nerve cell that speeds nerve impulse conduction) in some nerves and destruction of the entire nerve in other areas.
	health.allrefer.com /health/progressive-supranuclear-palsy-info.html (441 words)

	Progressive supranuclear palsy Encyclopedia of Medicine - Find Articles
		Progressive supranuclear palsy (PSP; also known as Steele-Richardson-Olszewski syndrome) is a rare disease that gradually destroys nerve cells in the parts of the brain that control eye movements, breathing, and muscle coordination.
		Progressive supranuclear palsy is a disease of middle age.
		PSP affects the brainstem, the basal ganglia, and the cerebellum.
	findarticles.com /p/articles/mi_g2601/is_0011/ai_2601001117?lstpn=article_results&lstpc=search&lstpr=external&lstprs=other&lstwid=1&lstwn=search_results&lstwp=body_middle (1020 words)

	Progressive Supranuclear Palsy (PSP)
		PSP is characterized by symptoms similar to Parkinson's disease such as unsteady gait, unexplained falling, stiff movements, and mild dementia plus other symptoms not normally a part of Parkinson's disease icluding problems with the voluntary movement of the eyes.
		PSP is caused by (or perhaps causes) damage to nerve cells in a portion of the brain called the "midbrain" These cells are involved in eye-movements and balance.
		PSP does not normally cause the uncontrolled shaking (tremor) in muscles at rest that is associated with Parkinson's disease.
	www.neurosy.org /disease/psp/pspinfo.shtml (4105 words)

	Progressive Supranuclear Palsy (PSP)/ Litvan Neurological Research Foundation (Site not responding. Last check: 2007-11-06)
		Progressive supranuclear palsy (PSP) is a neurodegenerative disorder; in fact it is the most common of the atypical parkinsonian disorders.
		PSP is considered to be a "tauopathy"; this is because of specific characteristics found in the brain of those with PSP.
		Usually PSP patients are first diagnosed in their mid 60s; the most common symptom is an instability, or tendency to fall.
	www.lnrf.com /education/PSP.html (428 words)

	Progressive Supranuclear Palsy
		Progressive supranuclear palsy (PSP) is a degenerative neurological disorder of uncertain etiology characterized by gait ataxia, slowing or inability to generate voluntary saccadic eye movements, and axial rigidity.
		PSP is estimated to affect about 4-6.4/100,000 persons, or about 5-6 percent of persons thought to have Parkinsonism.
		Progresive supranuclear palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene.
	www.dizziness-and-balance.com /disorders/central/movement/psp.htm (4164 words)

	Gale Encyclopedia of Medicine: Progressive supranuclear palsy
		Progressive supranuclear palsy (PSP; also known as Steele-Richardson-Olszewski syndrome) is a rare disease that gradually destroys nerve cells in the parts of the brain that control eye movements, breathing, and muscle coordination.
		Progressive supranuclear palsy is a disease of middle age.
		PSP affects the brainstem, the basal ganglia, and the cerebellum.
	www.findarticles.com /p/articles/mi_g2601/is_0011/ai_2601001117 (1203 words)

	The Society for Progressive Supranuclear Palsy - What is PSP? (Site not responding. Last check: 2007-11-06)
		Progressive supranuclear palsy is an under-recognized brain disease.
		Another characteristic symptom of PSP, and the one for which the disease is named, is weakness (“palsy”) of eye movements, especially in the downward direction.
		PSP is often misdiagnosed as Parkinson’s disease because of the general slowing of movement.
	www.psp.org /what_psp.asp (782 words)

	Progressive Supranuclear Palsy: A Neurophysiological Report
		Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disorder categorized as a form of parkinsonism.
		Progressive damage to multiple brain cells associated with deterioration of the myelin sheath that speeds up nerve impulse conduction, as well as destruction of the entire nerve (2), result in severe and irreversible problems controlling balance, eye movement, breathing, and voluntary muscle movement (3).
		All PSP individuals suffer from some degree of vertical-gaze palsy, in which the ability to move the eyes up-and-down is impaired (4).
	serendip.brynmawr.edu /bb/neuro/neuro02/web1/rdeering.html (1605 words)

	Progressive Supranuclear Palsy Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)
		PSP was first described as a distinct disorder in 1964, when three scientists published a paper that distinguished the condition from Parkinson's disease.
		PSP is often difficult to diagnose because its symptoms can be very much like those of other, more common movement disorders, and because some of the most characteristic symptoms may develop late or not at all.
		We know that the symptoms of PSP are caused by a gradual deterioration of brain cells in a few tiny but important places at the base of the brain, in the region called the brainstem.
	www.ninds.nih.gov /disorders/psp/detail_psp.htm (1697 words)

	Progressive supranuclear palsy - MayoClinic.com
		Progressive supranuclear palsy is a brain disorder that causes serious problems with walking, balance and eye movements.
		Although the cause is unknown, progressive supranuclear palsy results from deterioration of cells in areas of your brain that control movement.
		Progressive supranuclear palsy can be difficult to diagnose because some signs and symptoms — such as stiffness, movement difficulties, and changes in mood or personality — are similar to those of Parkinson's disease and dementia.
	www.mayoclinic.com /health/progressive-supranuclear-palsy/DS00909 (263 words)

	MedlinePlus Medical Encyclopedia: Progressive supranuclear palsy
		Progressive supranuclear palsy is a movement disorder caused by damage to certain nerve cells in the brain.
		Progressive supranuclear palsy is a condition that causes symptoms similar to Parkinson's disease.
		Also, call if progressive supranuclear palsy has been diagnosed and the condition declines to a point when it is not possible to care for the person in the home.
	www.nlm.nih.gov /medlineplus/ency/article/000767.htm (545 words)

	The Parkinson's Institute Movement Disorders
		PSP is considered a rare disorder, yet it is the second most common "neurodegenerative" cause of parkinsonism seen in movement disorder clinics.
		Although the clinical spectrum of PSP is variable, some of the major problems faced by patients and care givers include: visual symptoms, impaired balance leading to falls, speech and swallowing difficulties, personality and mood changes and sleep disturbances.
		The hallmark clinical feature of PSP is a disturbance of eye movement for which the term progressive supranuclear palsy is derived.
	www.parkinsonsinstitute.org /movement_disorders/progressive_supranuclear.html (1907 words)

	Baylor Neurology Case of the Month (Site not responding. Last check: 2007-11-06)
		PSP is characterized by supranuclear disturbance of eye movement function, particularly with saccades, pursuit, vestibuloocular reflex, vertical, and horizontal movements.
		The pathology of progressive supranuclear palsy is characterized by neurofibrillary tangles and granulovacuolar degeneration.
		In PSP, the dopamine deficiency in the putamen is equal to that in the caudate.
	www.bcm.edu /neurol/challeng/pat7/summary.html (1556 words)

	BBC NEWS \| Health \| Medical notes \| Progressive supranuclear palsy
		PSP is a degenerative disease affecting the brain.
		Progressive means it starts slowly and continues to get worse, supranuclear refers to the affected part of the brain - pea-sized structures known as nuclei - and palsy describes the outcome - paralysis.
		Although PSP in itself is not fatal, the disease does get progressively worse, and patients often die from complications such as pneumonia and choking on food.
	news.bbc.co.uk /1/hi/health/medical_notes/461557.stm (566 words)

	Patient Education: Progressive Supranuclear Palsy
		PSP occurs more often in men, and the age at onset is typically in the 60’s, roughly ten years later than the usual onset of classic Parkinson’s disease (PD).
		The cause of PSP is still not fully understood, but pathological changes noted on autopsy examination of the brains of patients with PSP have provided insights into the mechanisms of cell loss in the basal ganglia and some brainstem structures.
		Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration.
	www.bcm.edu /neurol/jankovic/educ_psp.htm (930 words)

	Progressive Supranuclear Palsy
		Progressive supranuclear palsy, or PSP, is a rare neurodegenerative disease that is often misdiagnosed as Parkinson's disease because it carries similar symptoms.
		PSP develops because of the deterioration of brain cells in a few small, but very important areas at the base of the brain.
		Falls experienced by a PSP patient are often described as having a state of dizziness, prior to actually falling.
	www.webmd.com /parkinsons-disease/progressive-supranuclear-palsy (487 words)

	Progressive Supranuclear Palsy
		Progressive supranuclear palsy (PSP) is a rare brain disorder that causes serious and permanent problems with control of gait and balance.
		Another possible cause of PSP is cellular damage caused by free radicals, unstable molecules produced continuously by all cells during normal metabolism.
		The key to establishing the diagnosis of PSP is the identification of early gait instability and difficulty moving the eyes, the hallmark of the disease, as well as ruling out other similar disorders, some of which are treatable.
	healthlink.mcw.edu /article/922569615.html (1444 words)

	Progressive Supranuclear Palsy
		Progressive supranuclear palsy (PSP) is a rare degenerative disease of the brain.
		Palsy means weakness, and it is this characteristic weakness in eye movements for which the disease is named.
		PSP is sometimes called Steele-Richardson-Olszewski syndrome, after the 3 scientists who first described it in 1963.
	www.emedicinehealth.com /progressive_supranuclear_palsy/article_em.htm (281 words)

	Memory and Aging Center: Primary Progressive Aphasia
		In contrast with PSP, in which gait problems and imbalance are among the first symptoms after onset, PD patients don’t experience severe balance dysfunction until later in the course of their disease.
		In PSP the posture is stiff and upright with a tendency to fall backwards, as opposed to the stooped posture seen in PD.
		PSP does not respond to these agents as much as typical PD, and the doses may need to be raised to a relatively high level to see any effect.
	memory.ucsf.edu /Education/Disease/psp.html (1357 words)

	Progressive Supranuclear Palsy
		The symptoms of PSP are caused by a gradual deterioration of brain cells in a few tiny but important places at the base of the brain, in the region called the brainstem.
		The key to establishing the diagnosis of PSP is the identification of early gait instability and difficulty moving the eyes, the hallmark of the disease, as well as ruling out other similar disorders, some of which are treatable.
		In some patients the slowness, stiffness, and balance problems of PSP may respond to antiparkinsonian agents such as levodopa, or levodopa combined with anticholinergic agents, but the effect is usually temporary.
	msainfo.tripod.com /psnp.html (540 words)

	eMedicine - Progressive Supranuclear Palsy : Article by Eric R Eggenberger, DO
		PSP is usually fatal within approximately 6 years of onset, with a range of 2-17 years, based on cohort patients dying under surveillance; life table analysis among Golbe's entire cohort revealed a median disease duration of 9.7 years.
		The primary causes of death in patients with PSP are infections and pulmonary complications (eg, pneumonia) that are frequently related to immobility.
		The cardinal manifestations of PSP are supranuclear ophthalmoplegia (see Physical); pseudobulbar palsy; prominent neck dystonia; parkinsonism; behavioral, cognitive, and gait disturbances that cause imbalance; and frequent falls.
	www.emedicine.com /NEURO/topic328.htm (5561 words)

	PROGRESSIVE SUPRANUCLEAR PALSY
		Progressive Supranuclear Palsy (PSP), also known sometimes as the Mona Lisa disease, is a distinctive and not uncommon cerebral degenerative disease of late adulthood, the cause of which is unknown at present.
		Symptoms begin in the fifth to eighth decade (the range of age of onset of PSP is 45-73).
		PSP is a progressive disorder (familial examples are rare), beginning in middle or old age with supranuclear ophthalmoplegia including down gaze abnormalities and at least 2 or more of the following 5 cardinal features:
	www.mydr.com.au /default.asp?article=3307 (1449 words)

	Progressive Supranuclear Palsy Glossary of Terms with Definitions on MedicineNet.com
		Palsy: Paralysis, generally partial, whereby a local body area is incapable of voluntary movement (motor function).
		For example, Bell's palsy is localized paralysis of the muscles on one side of the face.
		Progressive supranuclear palsy: A neurologic disorder of unknown origin that gradually destroys cells in many areas of the brain, leading to serious and permanent problems with the control of gait and balance.
	www.medicinenet.com /progressive_supranuclear_palsy/glossary.htm (1099 words)

	PROGRESSIVE SUPRANUCLEAR PALSY: Contact a Family - for families with disabled children: information on rare syndromes ...
		PSP, otherwise known as Steele Richardson Olszewski syndrome after the three Canadian Doctors, who first described it in 1962 as a distinct disorder, is a neurodegenerative disease, which involves the progressive death of neurons, mainly in the basal ganglia and brainstem.
		PSP is a very individual disease and can present in different ways making diagnosis very difficult, particularly early in the disease.
		The onset of PSP is mainly in the fifty to seventy age bracket, but patients as young as late thirties have been diagnosed.
	www.cafamily.org.uk /Direct/p49.html (895 words)

	Progressive Supranuclear Palsy (Site not responding. Last check: 2007-11-06)
		The cause of Guamanian PSP is unclear although it has been attributed to unusual dietary factors, possibly interaction with genetic factors.
		It is known that the symptoms of PSP are caused by gradually progressive damage to a group of cells in a part of the brain called the "midbrain".
		The Society for PSP (at Johns Hopkins Hospital), is presently coordinating this effort along with the Mayo Clinic (Jacksonville).
	www.neuro.northwestern.edu /meded/MOVEMENT/psp2.htm (2692 words)

	Progressive Supranuclear Palsy - WrongDiagnosis.com
		Progressive supranuclear palsy (PSP) is a rare brain disorder that causes serious and permanent problems with control of gait and...
		Progressive Supranuclear Palsy is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Progressive Supranuclear Palsy, or a subtype of Progressive Supranuclear Palsy, affects less than 200,000 people in the US population.
	www.wrongdiagnosis.com /p/progressive_supranuclear_palsy/intro.htm (948 words)

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