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Topic: Proopiomelanocortin

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	Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate ... (Site not responding. Last check: 2007-10-01)
		Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate Hypothalamic Nucleus -- Huo et al.
		Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate Hypothalamic Nucleus
		Proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC)
	diabetes.diabetesjournals.org /cgi/content/full/55/3/567 (5178 words)

	POMC - proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte ...
		The currently available data suggest that elevated AGRP mRNA along with reduced proopiomelanocortin (POMC) mRNA is associated with many types of obesity and agents antagonizing the effect of AGRP may be a potential therapeutic target in treating obesity and obesity-associated disorders in which endogenous hypothalamic AGRP is elevated.
		This pattern of changes in POMC mRNA is consistent with an inhibitory effect of beta-endorphin on GnRH after the midcycle surge and in the postovulatory phase of the cycle, while low levels of POMC mRNA in the early afternoon of proestrus may permit the release of GnRH, which triggers the LH surge.
		Nucleotide sequences responsible for the cell-specific expression of the human proopiomelanocortin (POMC) gene were analyzed by histochemical staining of beta-galactosidase in culture cells transfected with chimeric genes containing the 5'-flanking regions of the human POMC gene fused to the Escherichia coli lacZ gene.
	www.ihop-net.org /UniPub/iHOP/gg/91180.html (5206 words)

	Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic ...
		Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting -- de Souza et al.
		Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice.
		Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin.
	mcb.asm.org /cgi/content/full/25/8/3076 (8056 words)

	J NEWELL-PRICE: POMC and DNA methylation (Journal of Endocrinology)
		De Smet C, Lurquin C, Lethe B, Martelange V and Boon T. 1999 DNA methylation is the primary silencing mechanism for a set of germ line-specific and tumour-specific genes with a CpG rich promoter.
		Picon A, Bertagna X and de Keyzer Y. 1999 Analysis of the human proopiomelanocortin gene promoter in a small cell lung carcinoma cell line reveals an unusual role for E2F transcription factors.
		Poulin G, Turgeon B and Drouin J. 1997 NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene.
	journals.endocrinology.org /joe/177/0365/joe1770365.htm (1116 words)

	Role of neuropeptide Y and proopiomelanocortin in fluoxetine-induced anorexia.
		Role of neuropeptide Y and proopiomelanocortin in fluoxetine-induced anorexia.
		We examined mRNA expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the brain regions of rats using RT-PCR and in situ hybridization techniques after 2 weeks of administering fluoxetine daily.
		This article was last updated on Thursday, 28th July 2005 at 1:05 am and is filed in the Fluoxetine section.
	counsellingresource.com /medications-research/2005/07/28/role-of-neuropeptide-y-and-proopiomelanocortin-in-fluoxetine-induced-anorexia (466 words)

	Evaluation of ovarian POMC mRNA through quantitative RT-PCR analysis in Rana esculenta -- Nabissi et al. 280 (5): C1038 ...
		Identification of proopiomelanocortin neurons in rat hypothalamus by in situ cDNA-RNA hybridization.
		Hilario, E, Lihrmann I, and Vaudry H. Characterization of the cDNA encoding proopiomelanocortin in the frog Rana ridibunda.
		Proopiomelanocortin gene expression in the ovary of the frog, Rana esculenta.
	ajpcell.physiology.org /cgi/content/full/280/5/C1038 (3551 words)

	BioMed Central \| Full text \| Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct ...
		Adrenalectomy of mice on the high-fat diet significantly reduced plasma corticosterone and strikingly increased both pituitary and hypothalamic POMC mRNA, but failed to reduce body weight, adiposity or leptin, although slight improvements in glucose tolerance and metabolic rate were observed.
		Hypothalamic proopiomelanocortin (POMC) and agouti-related peptide (AGRP) mRNA and pituitary POMC mRNA were measured by Northern blot analysis as previously described [6].
		Bergen HT, Mizuno T, Taylor J, Mobbs CV: Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus.
	www.biomedcentral.com /1472-6793/3/4 (4202 words)

	Human protein: P01189 - Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC) [Contains: NPP; Melanotropin ...
		Reduced expression of a naturally deleted form of human proopiomelanocortin complementary deoxyribonucleic acid after transfection into Chinese hamster ovary cells.
		Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity.
		Molecular screening of the proopiomelanocortin (POMC) gene in Italian obese children: report of three new mutations.
	harvester.embl.de /harvester/P011/P01189.htm (1175 words)

	ARS \| Publication request: Genomic Structure of the Proopiomelanocortin Gene and Expression During Temporal Stress in ...
		Citation: Karsi, A., Waldbieser, G.C., Small, B.C., Wolters, W.R. Genomic structure of the proopiomelanocortin gene and expression during temporal stress in channel catfish, Ictalurus punctatus.
		The proopiomelanocortin (POMC) gene was cloned which provided DNA sequence useful for studying factors which regulate POMC gene activity.
		Technical Abstract: Proopiomelanocortin (POMC) is an important gene involved in the stress response of the hypothalamus-pituitary-adrenal axis (HPA).
	www.ars.usda.gov /research/publications/publications.htm?seq_no_115=173684&pf=1 (353 words)

	Profile
		Dores RM, Sollars C, Danielson P, Lee J, Alrubaian J, Joss JM, Cloning of a proopiomelanocortin cDNA from the pituitary of the Australian lungfish, Neoceratodus forsteri: analyzing trends in the organization of this prohormone precursor.
		Lancha A, Batista M A, Dores R M, An analysis of the proopiomelanocortin systems in the pituitary of the squamate reptile Lacerta galloti.
		Dores R M, Kaneko D J, Sandoval F, An anatomical and biochemical study of the pituitary proopiomelanocortin systems in the polypteriform fish Calamoichthys calabaricus.
	myprofile.cos.com /doresr35 (1992 words)

	Long-term hypoxia enhances proopiomelanocortin processing in the near-term ovine fetus -- Myers et al. 288 (5): R1178 ...
		Long-term hypoxia enhances proopiomelanocortin processing in the near-term ovine fetus -- Myers et al.
		Proopiomelanocortin (POMC) processing to ACTH in the anterior pituitaries of control and long-term hypoxic (LTH) fetal sheep.
		Expression of proopiomelanocortin and prohormone convertase-1 and -2 in the late gestation fetal sheep pituitary.
	ajpregu.physiology.org /cgi/content/full/288/5/R1178 (4453 words)

	ARS \| Publication request: Complementary DNA Cloning, Phylogenetic Analysis, and Expression of Proopiomelanocortin ...
		Interpretive Summary: Channel catfish are subject to a variety of environmental stressors during commercial culture, and establishment of stress responses is important for efficient performance during culture.
		Technical Abstract: Channel catfish (Ictalurus punctatus) proopiomelanocortin (POMC) complementary DNA (cDNA) was cloned to investigate its structure, evolution, and expression in different tissues.
		Overall architecture of channel catfish POMC is highly similar to those from other teleosts.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=152679&pf=1 (434 words)

	Association of Proopiomelanocortin Gene Polymorphisms with Obesity in the IRAS Family Study -- Sutton et al. 13 (9): ...
		Association of Proopiomelanocortin Gene Polymorphisms with Obesity in the IRAS Family Study -- Sutton et al.
		Association of Proopiomelanocortin Gene Polymorphisms with Obesity in the IRAS Family Study
		Proopiomelanocortin (POMC) has been found to be associated with
	www.obesityresearch.org /cgi/content/abstract/13/9/1491 (434 words)

	Endotext.com - The Pineal Gland and Pineal Tumours, Ch 1 Bibliography
		Jin WD, Boutillier AL, Glucksman MJ, Salton SR, Loeffler JP, Roberts JL 1994 Characterization of a corticotropin-releasing hormone-responsive element in the rat proopiomelanocortin gene promoter and molecular cloning of its binding protein.
		Boutillier AL, Monnier D, Koch B, Loeffler JP 1994 Pituitary adenyl cyclase-activating peptide: a hypophysiotropic factor that stimulates proopiomelanocortin gene transcription, and proopiomelanocortin-derived peptide secretion in corticotropic cells.
		Levin N, Blum M, Roberts JL 1989 Modulation of basal and corticotropin-releasing factor-stimulated proopiomelanocortin gene expression by vasopressin in rat anterior pituitary.
	www.mdtext.com /neuroendo/neuroendo1/neuroendobiblio1.htm (5672 words)

	Nur77 Activated by Hypoxia-Inducible Factor-1{alpha} Overproduces Proopiomelanocortin in von Hippel-Lindau-Mutated ...
		Nur77 is necessary and sufficient for hypoxia-induced proopiomelanocortin (POMC) transcription.
		Overproduction of proopiomelanocortin (POMC) and Nur77 in patients with renal cell carcinoma (RCC).
		Braems G. A., Matthews S. G., Challis J. Differential regulation of proopiomelanocortin messenger ribonucleic acid in the pars distalis and pars intermedia of the pituitary gland after prolonged hypoemia in fetal sheep.
	cancerres.aacrjournals.org /cgi/content/full/64/1/35 (3498 words)

	Marcelo Rubinstein, Ph.D.
		His current project involves functional studies of the D2 and the D4 dopamine receptors in the central nervous system, using mouse molecular genetics.
		The proopiomelanocortin (POMC) gene is expressed at significant levels in neurons of the arcuate nucleus of the hypothalamus and in pituitary melanotrophs and corticotrophs.
		Neuronal processing of the POMC prohormone produces melanocortins and beta-endorphin to activate satiety and analgesia, respectively, whereas pituitary ACTH triggers a widespread stress response, stimulating glucocorticoid release.
	www.hhmi.org /research/scholars/rubi.html (485 words)

	Dietary Sodium Intake Modulates Pituitary Proopiomelanocortin mRNA Abundance -- Mayan et al. 28 (2): 244 -- Hypertension
		with a probe to exon 3 of the rat proopiomelanocortin gene,
		The effect of ingestion of hypertonic saline on the melanocyte-stimulating hormone content and histology of the pars intermedia of the rat pituitary gland.
		Acute unilateral nephrectomy elicits a specific increase in plasma of peptides derived from the N-terminal region of proopiomelanocortin.
	hyper.ahajournals.org /cgi/content/full/28/2/244 (3800 words)

	About Us > Faculty & Staff - Department of Behavioral Neuroscience - Portland, Oregon
		Malcolm Low and his associates use a combination of molecular genetic, endocrine, and behavioral approaches to characterize the physiological functions of neuropeptides and G-protein coupled receptors that are highly expressed in the hypothalamus.
		Proopiomelanocortin (POMC) is expressed in the pituitary in addition to hypothalamus and is enzymatically processed into several peptides involved in the stress response and ingestive behaviors.
		We are currently working to extend these types of studies to include conditionally targeted gene mutations that will permit both temporal and spatial control over gene expression.
	www.ohsu.edu /behneuro/about/malcomLow.htm (712 words)

	The CpG Island Promoter of the Human Proopiomelanocortin Gene Is Methylated in Nonexpressing Normal Tissue and Tumors ...
		Therrien M, Drouin J 1993 Cell-specific helix-loop-helix factor required for pituitary expression of the proopiomelanocortin gene.
		Poulin G, Turgeon B, Drouin J 1997 NeuroD1/ß2 contributes to cell-specific transcription of the proopiomelanocortin gene.
		Picon A, Bertagna X, de Keyzer Y 1999 Analysis of proopiomelanocortin gene transcription mechanisms in bronchial tumour cells.
	mend.endojournals.org /cgi/content/full/15/2/338 (5482 words)

	Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain -- ...
		Paxinos G, Watson C (1986) In: The rat brain in stereotaxic coordinates.
		Tatro JF (1990) Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and alpha-melanocyte stimulating hormone.
		Thornton JE, Cheung CC, Clifton DK, Steiner RA (1997) Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice.
	www.jneurosci.org /cgi/content/full/19/18/RC26 (3291 words)

	Effects of tourniquet-induced ischemia on the release of proopiomelanocortin derivatives determined in peripheral blood ...
		Effects of tourniquet-induced ischemia on the release of proopiomelanocortin derivatives determined in peripheral blood plasma -- Matejec et al.
		Articles by Matejec, R. Articles by Teschemacher, H. Effects of tourniquet-induced ischemia on the release of proopiomelanocortin derivatives determined in peripheral blood plasma
		Expression of proopiomelanocortin peptides in human dermal microvascular endothelial cells: evidence for a regulation by ultraviolet light and interleukin-1.
	jap.physiology.org /cgi/content/full/97/3/1040 (3520 words)

	A Fully Functional Proopiomelanocortin/Melanocortin-1 Receptor System Regulates the Differentiation of Human Scalp Hair ...
		Slominski A, Paus R, Mazurkiewicz J 1992 Proopiomelanocortin expression in the skin during induced hair growth in mice.
		Krude H, Gruters A 2000 Implications of proopiomelanocortin (POMC) mutations in humans: the POMC deficiency syndrome.
		Slominski A, Ermak G, Hwang J, Chakraborty A, Mazurkiewicz JE, Mihm M 1995 Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin.
	endo.endojournals.org /cgi/content/full/146/2/532 (7516 words)

	Cloning of Proopiomelanocortin from the Brain of the African Lungfish, Protopterus annectens, and the Brain of ...
		Cloning of Proopiomelanocortin from the Brain of the African Lungfish, Protopterus annectens, and the Brain of the Western Spadefoot Toad, Spea multiplicatus - Karger Publishers
		Cloning of Proopiomelanocortin from the Brain of the African Lungfish, Protopterus annectens, and the Brain of the Western Spadefoot Toad, Spea multiplicatus
		A degenerate primer, specific for the opioid core sequence YGGFM, was used to clone and sequence proopiomelanocortin (POMC) cDNAs from the brain of the African lungfish, Protopterus annectens, and from the brain of the western spadefoot toad, Spea multiplicatus.
	content.karger.com /ProdukteDB/produkte.asp?Doi=54458 (448 words)

	Mechanism of Sorting Proopiomelanocortin and Proenkephalin to the Regulated Secretory Pathway of Neuroendocrine Cells ...
		Mechanism of Sorting Proopiomelanocortin and Proenkephalin to the Regulated Secretory Pathway of Neuroendocrine Cells -- LOH et al.
		Mechanism of Sorting Proopiomelanocortin and Proenkephalin to the Regulated Secretory Pathway of Neuroendocrine Cells
		N-Terminal Proopiomelanocortin Acts as a Mitogen in Adrenocortical Tumor Cells and Decreases Adrenal Steroidogenesis
	www.annalsnyas.org /cgi/content/abstract/971/1/416 (547 words)

	Different Mechanisms for Leukemia Inhibitory Factor-Dependent Activation of Two Proopiomelanocortin Promoter Regions -- ...
		Therrien M, Drouin J 1993 Molecular determinants for cell specificity and glucocorticoid repression of the proopiomelanocortin gene.
		Katahira M, Iwasaki Y, Aoki Y, Oiso Y, Saito H 1998 Cytokine regulation of the rat proopiomelanocortin gene expression in AtT-20 cells.
		Newell-Price J, King P, Clark AJ 2001 The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression.
	endo.endojournals.org /cgi/content/full/143/10/3916 (4962 words)

	Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor ...
		Bousquet, C., Ray, D.W., and Melmed, S. A common proopiomelanocortin element mediates LIF and CRH transcriptional synergy.
		Auernhammer, C.J., Chesnokova, V., Bousquet, C., and Melmed, S. Pituitary corticotroph SOCS-3: novel intracellular regulation of cytokine-mediated proopiomelanocortin gene expression and ACTH secretion.
		Boutillier, A.L., Gaiddon, C., Lorang, D., Roberts, J.L., and Loeffler, J.P. Transcriptional activation of the proopiomelanocortin gene by cyclic AMP-responsive element binding protein.
	www.jci.org /cgi/content/full/104/9/1277 (5551 words)

	Peptide YY3-36 Inhibits Both Anorexigenic Proopiomelanocortin and Orexigenic Neuropeptide Y Neurons: Implications for ...
		Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T (1997) Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in proopiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus.
		Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C (1997) Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations.
		Horvath TL, Diano S, van den Pol AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations.
	www.jneurosci.org /cgi/content/full/25/45/10510 (6062 words)

	Amazon.com: Proopiomelanocortin (Site not responding. Last check: 2007-10-01)
		Cutaneous Neuroimmunomodulation: The Proopiomelanocortin System (Annals of the New York Academy of Sciences) by Thomas A. Luger, Ralf Paus, James M. Lipton, and Andrzej T. Slominski (Hardcover - Dec 1999)
		N-Terminal Fragment of Proopiomelanocortin: Structural Polymorphism & Structure-Bioactivity Characterization (Acta Biomedica Lovaniensia, 269) by Jie Lu (Paperback - Nov 2002)
		Effects of Melanocortins and N-Terminal Proopiomelanocortin on Cardiovascular Function and Autonomic Dynamics (Acta Biomedica Lovaniensia, 194) by Dirk Ramaekers (Paperback - Sep 1999)
	www.amazon.com /s?ie=UTF8&search-alias=aps&keywords=Proopiomelanocortin&page=1 (157 words)

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