
	Where results make sense

Topic: Prostanoid

In the News (Fri 25 Jul 08)

Gordon Brown

Derby County

Mike Huckabee

Lute Olson

Pearl Harbor

Sonia Gandhi

Ricky Hatton

Narendra Modi

Jesus Christ

Rudy Giuliani

	Genomics\|HuGENet\|e-Journal\|Prostanoid DP and asthma
		Models in mice suggest that functional gene variants of the prostanoid DP receptor (PTGDR) are required for the expression of asthma.
		Matsuoka showed mice that do not have a functional prostanoid DP receptor were not able to express asthma (5).
		Role of prostanoid DP receptor variants in susceptibility to asthma.
	www.cdc.gov /genomics/hugenet/ejournal/prostanoid.htm (823 words)

	Prostanoid Receptors: Structures, Properties, and Functions -- Narumiya et al. 79 (4): 1193 -- Physiological Reviews
		prostanoid receptors induced by phorbol esters was examined in
		Phylogenetic tree of prostanoid receptors was constructed by sequence comparison of prostanoid receptors from various species.
		affinities of carboxy methyl esters of prostanoid molecules to
	physrev.physiology.org /cgi/content/full/79/4/1193 (9103 words)

	Cell Membranes, Endothelia, and Atherosclerosis (Site not responding. Last check: 2007-10-15)
		Each prostanoid is also assigned a number subscript that refers to the number of double bonds in the side chain, and sometimes an alpha or beta is also assigned based on the configuration of substituents on the ring.
		Prostanoid principle number one is that prostanoid biochemistry is interwoven, perhaps to the point of being maddeningly labyrinthine.
		Prostanoid principle number two: the 2-series prostanoids (derived from arachidonic acid) are more pro-inflammatory (and potentially more pro-atherosclerotic) than are those of the 1- and the 3-series.20,39 The differences lie mainly in the thromboxanes, the prostanoids that generally stimulate platelets to aggregate and discharge (these are "pro-thrombotic," whence comes their name).
	www.thorne.com /altmedrev/fulltext/fattya1-3.html (6525 words)

	Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy CHEST ... (Site not responding. Last check: 2007-10-15)
		Prostanoids are well established in the medical treatment of this disease.
		Conclusion: Bosentan administered to patients with progressive pulmonary hypertension receiving prostanoids resulted in an increased exercise capacity and an improved RV function.
		Bosentan therefore appears to be well suited for combination therapy with prostanoids in selected patients pending results of ongoing randomized trials.
	www.findarticles.com /p/articles/mi_m0984/is_2_128/ai_n15341239 (846 words)

	Effects of Gestational Age and Labor on Expression of Prostanoid Receptor Genes in Baboon Uterus -- Smith et al. 64 ...
		Densitometric quantitation of ratio of EP to EP receptor genes for prostanoid receptor types in lower uterine segment (LUS) and fundus (FUN) from animals both not in labor (white bars) and in labor (shaded bars).
		Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus.
		Regional variations in contractile responses to prostaglandins and prostanoid receptor messenger ribonucleic acid in pregnant baboon uterus.
	www.biolreprod.org /cgi/content/full/64/4/1131 (4515 words)

	[No title] (Site not responding. Last check: 2007-10-15)
		EP4 receptors are found in high levels in the intestine, and in lower levels in the lung, kidney, thymus, uterus and brain; they are not found in the liver, heart, retina or in skeletal muscle.
		P32240 Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (PGE receptor, EP4 subtype)
		P35408 Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (PGE receptor, EP4 subtype)
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001758 (406 words)

	Central nervous system regulation of reflex responses to hypotension during fetal life -- Wood and Tong 277 (6): 1541 ... (Site not responding. Last check: 2007-10-15)
		Prostanoids are a class of compounds that we proposed could modulate hormonal reflex responses to hypotension in the fetus.
		Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets.
		Prostanoid cascade inhibition prevents cardiovascular and adrenocorticotropic responses to mineral acid infusion.
	ajpregu.physiology.org /cgi/content/full/277/6/R1541 (5838 words)

	GORDON SMITH et al.: Prostanoid receptors in baboon choriodecidua (Journal of Endocrinology) (Site not responding. Last check: 2007-10-15)
		Expression of prostanoid receptor genes in baboon chorion and decidua during pregnancy and parturition.
		The aim of this study was to determine whether expression of prostanoid receptor genes varied with gestational age or labour in the decidua and chorion of baboons.
		Expression of prostanoid receptor genes was determined using Northern blot analysis and the level of expression was related to each of three housekeeping genes.
	journals.endocrinology.org /joe/168/joe1680263.htm (283 words)

	UC Irvine - Department of Pharmacology
		Prostanoid synthesis by cerebral blood vessels from 17b-estradiol-treated and non-treated ovariectomized rats was examined by ELISA.
		Prostanoid synthetic enzymes were examined by immunoblot analysis.
		In conclusion, estrogen influences the biosynthesis and activity of prostanoids that regulate cerebral blood flow and thrombosis.
	www.ucihs.uci.edu /pharmaco/graduate/recent_phd/abst_ospina.html (358 words)

	Endothelial NO and prostanoid involvement in newborn and juvenile pig pial arteriolar vasomotor responses -- Willis and ...
		The mechanism of action of prostanoids and NO in BK, hypercapnia, and acetylcholine cerebrovascular responses were also examined.
		We suggest prostanoids are important mediators of newborn cerebral dilatory responses to BK.
		NO and prostanoids: age dependence of hypercapnia- and histamine-induced dilations of pig pial arterioles.
	ajpheart.physiology.org /cgi/content/full/281/6/H2366 (6145 words)

	[No title] (Site not responding. Last check: 2007-10-15)
		Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [2, 3, 4].
		Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems, and in pain sensation in peripheral systems [5].
		However, identification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue, coupled with poor selectivity of available agonists and antagonists.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001244 (443 words)

	Chemicon - Product #HTS091M - ChemiSCREEN™ Human DP Prostanoid Receptor Membrane Preparation
		Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases.
		Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects (Narumiya and FitzGerald, 2001).
		Genetic and pharmacological analysis of prostanoid receptor function.
	www.chemicon.com /browse/productdetail.asp?ProductID=HTS091M (630 words)

	Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte ...
		Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor -- Clarke et al.
		In the latter case data are expressed as a percentage of the response elicited by 10 µM prostanoid.
		Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: a comparison with the rabbit isolated ear artery.
	ajplung.physiology.org /cgi/content/full/288/2/L238 (7386 words)

	Expression of Cyclooxygenase-2 and Prostanoid Receptors by Human Myometrium -- Erkinheimo et al. 85 (9): 3468 -- ... (Site not responding. Last check: 2007-10-15)
		have the capacity to synthesize prostanoids, and fetal membranes
		Effects of cytokines, phorbol ester, oxytocin, and inhibitors on conversion of arachidonic acid to prostanoids in the cultured myometrial cells.
		prostanoids but also responsiveness to them, may be modulated.
	jcem.endojournals.org /cgi/content/full/85/9/3468 (5446 words)

	Directory - College of Pharmacy - University of Arizona
		Characterization of EP prostanoid receptor subtypes in primary cultures of bovine ciliary epithelial cells by immunofluorescent microscopy and functional studies.
		Differential regulation of FP prostanoid receptor isoforms by protein kinase C. Mol Pharmacol 57:353-358, 2000.
		Activation of FP prostanoid receptor isoforms leads to rho-mediated changes in cell morphology and in the cell cytoskeleton.
	www.pharmacy.arizona.edu /person.php?id=119 (790 words)

	Clinical Trial: Prostanoid Levels After Medication to Prevent Pain Following Third Molar (Wisdom Tooth) Extraction
		At the end of their participation in the study, all patients are given the pain medication flurbiprofen (Ocufen® (Registered Trademark)) to take at home.
		The proposed study will examine prostanoid suppression in the periphery by inhibition of COX-1, -2, and -3, and evaluate the time course of expression of COX isoenzymes in terms of level of mRNA and protein itself.
		Subjects within each group will be further randomized to have a biopsy collected at baseline prior to surgery and either at the time when a subject asks for rescue drug within 3 hours or at 24 hours following surgery.
	www.clinicaltrials.gov /ct/show/NCT00078104 (1513 words)

	Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells -- Hébert ... (Site not responding. Last check: 2007-10-15)
		Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells -- Hébert et al.
		Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells
		International union of pharmacology classification of prostanoid receptors: properties, distribution and structure of prostanoid receptors and their subtypes.
	ajprenal.physiology.org /cgi/content/full/275/6/F904 (5185 words)

	Prostanoid Receptor Gene Expression Profile in Human Trabecular Meshwork: A Quantitative Real-Time PCR Approach -- ...
		the prostanoid receptor genes in parallel with a PCR on ß-actin,
		Mean ± SD contribution of the prostaglandin receptor subtypes to the total expression level of the prostanoid receptors set at 100%.
		or postmortem interval on prostanoid receptor gene expression.
	www.iovs.org /cgi/content/full/42/13/3209 (4433 words)

	Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses -- Baber et al. 285 (6): 2399 ...
		Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses -- Baber et al.
		rat lung, responses to the prostanoid precursor arachidonic
		prostanoids and in the regulation of pressor responses to intravenous
	ajpheart.physiology.org /cgi/content/full/285/6/H2399 (4675 words)

	In Vivo Constriction of the Fetal and Neonatal Ductus Arteriosus by a Prostanoid EP4-Receptor Antagonist in Rats -- ... (Site not responding. Last check: 2007-10-15)
		In Vivo Constriction of the Fetal and Neonatal Ductus Arteriosus by a Prostanoid EP4-Receptor Antagonist in Rats -- MOMMA et al.
		In Vivo Constriction of the Fetal and Neonatal Ductus Arteriosus by a Prostanoid EP4-Receptor Antagonist in Rats
		Smith GC, Coleman RA, McGrath JC 1994 Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus.
	www.pedresearch.org /cgi/content/full/58/5/971 (3304 words)

	Genetic Polymorphisms of Human Flavin Monooxygenase 3 in Sulindac-Mediated Primary Chemoprevention of Familial ...
		The composite prostanoid index for each of the five prostanoids is compared between the sulindac group of patients with genotype combination 1 (n = 6) and the group of patients with all other genotype combinations (non-1; n = 15).
		prostanoid levels was demonstrated by the present study.
		Yang VW, Geiman DE, Hubbard WC, et al Tissue prostanoids as biomarkers for chemoprevention of colorectal neoplasia: correlation between prostanoid synthesis and clinical response in familial adenomatous polyposis.
	clincancerres.aacrjournals.org /cgi/content/full/10/24/8357 (3277 words)

	COX-1 and COX-2 Contributions to Basal and IL-1{beta}-Stimulated Prostanoid Synthesis in Human Neonatal Cerebral ... (Site not responding. Last check: 2007-10-15)
		COX-1 and COX-2 Contributions to Basal and IL-1{beta}-Stimulated Prostanoid Synthesis in Human Neonatal Cerebral Microvascular Endothelial Cells -- PARFENOVA et al.
		prostanoids appear to be major factors that contribute to regulation
		are predominant, whereas in newborn piglets prostanoids are
	www.pedresearch.org /cgi/content/full/52/3/342 (3898 words)

	Expression and Localization of FP and EP Prostanoid Receptor Subtypes in Human Ocular Tissues -- ...
		Expression of EP receptor protein in the pigment epithelium, dilator muscle, individual stromal cells, and stromal vessels (arrow) of the iris (A); labeling of vascular endothelial cells is shown in detail in (B).
		Predominant staining for the EP receptor was seen in the ganglion cell layer and inner nuclear layer (A); (B) labeling of ganglion cells and cells in the inner nuclear layer shown in detail.
		Prostanoid FP and EP receptor subtypes are coupled to different
	www.iovs.org /cgi/content/full/43/5/1475 (6423 words)

	Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways -- Halm and Halm ...
		DP and EP prostanoid receptors in the absence of this inhibitor
		Prostanoid receptors have been classified into eight distinct pharmacological types (10) corresponding with the major prostanoid
		The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
	ajpgi.physiology.org /cgi/content/full/281/4/G984 (6048 words)

	Prostanoid Receptors of Murine NIH 3T3 and RAW 264.7Cells. STRUCTURE AND EXPRESSION OF THE MURINE PROSTAGLANDIN EP4 ...
		Prostanoid Receptors of Murine NIH 3T3 and RAW 264.7Cells.
		to the outside of cells through a prostanoid transporter(s) (4).
		prostanoid responses associated with cell replication and differentiation.
	www.jbc.org /cgi/content/full/271/47/29569 (5502 words)

	The Expression and Activity of Prostaglandin H Synthase-2 Is Enhanced in Trophoblast from Women with Preeclampsia -- ... (Site not responding. Last check: 2007-10-15)
		PGHS is a rate-limiting enzyme in prostanoid biosynthesis from arachidonic
		Cells were allowed to attach 4 h in serum containing media, which was then replaced with serum free M199, containing NS-398 or vehicle.
		Cells were harvested for protein and media assayed for prostanoids at 24 h.
	jcem.endojournals.org /cgi/content/full/82/9/3059 (2127 words)

	Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells -- Parfenova ...
		Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells -- Parfenova et al.
		Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells
		Prostanoid synthesis in response to high CO in newborn pig brain microvascular endothelial cells.
	ajpcell.physiology.org /cgi/content/full/277/4/C728 (6026 words)

	Prostanoid Receptors (Site not responding. Last check: 2007-10-15)
		They are G protein-coupled receptors with seven transmembrane domains, with the domains and amino acid residues conferring the specificities of ligand binding and signal transduction upon the receptor (Kenakin, 1996).
		The tissue and cell distribution of the receptors plus the findings accumulated by pharmacological studies using cyclooxygenase inhibitors and using various prostanoid analogs having agonistic and antagonistic activities have helped to define the actions of each type of receptor.
		IP receptors appear to be most unusual among the prostanoid receptors, and indeed among G protein-coupled receptors, in that the receptor protein requires isoprenylation in order to optimize agonist-induced activation.
	www.10minuteflash.com /sites/sites/34150 (291 words)

	Involvement of TP and EP3 Receptors in Vasoconstrictor Responses to Isoprostanes in Pulmonary Vasculature -- Janssen ...
		Coleman RA, Smith WL and Narumiya S (1994) International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
		Elmhurst JL, Betti PA and Rangachari PK (1997) Intestinal effects of isoprostanes: evidence for the involvement of prostanoid EP and TP receptors.
		Yin K, Halushka PV, Yan YT and Wong PY (1994) Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets.
	jpet.aspetjournals.org /cgi/content/full/301/3/1060 (3461 words)

	Role of Thromboxane A2 in the Induction of Apoptosis of Immature Thymocytes by Lipopolysaccharide -- Rocha et al. 12 ...
		To determine whether this enhanced prostanoid production could be blocked by COX inhibitors, some animals received indomethacin (n = 3) or rofecoxib (n = 3) in the drinking water starting 24 h before the injection.
		At the doses used, both drugs were capable of reducing prostanoid production back to baseline levels (P was not significant for the comparisons between LPS-injected mice treated with indomethacin or rofecoxib and the PBS-injected controls).
		Prostanoids are key regulators of thymocyte physiology (34,
	cvi.asm.org /cgi/content/full/12/8/896 (4738 words)

Try your search on: Qwika (all wikis)