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Topic: Proteolysis

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	BioMed Central \| Full text \| Limited proteolysis of human histone deacetylase 1
		The linear relationship between trypsin proteolysis and enzymatic activity (see inset in Figure 1D) is consistent with the scenario that HDAC1 degrades to small peptide fragments in the presence of trypsin.
		Limited proteolysis has been used previously to distinguish structurally accessible from inaccessible conformations of proteins, revealing function domains [35,36], and to assess protein stability [37].
		The limited proteolysis provides a secondary assay to confirm that mutagenesis does not result in the global instability and unfolding of the protein [24].
	www.biomedcentral.com /1471-2091/7/22 (6360 words)

	An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ...
		the susceptibility of VWF to proteolysis by ADAMTS13 and that,
		The extent of proteolysis is greater in the case of lanes M and 2:3 both in the presence and absence of ristocetin.
		VWF susceptibility to proteolysis correlates with the Tyr/Cys1584 polymorphism
	www.bloodjournal.org /cgi/content/full/103/3/941 (4806 words)

	Catecholamines inhibit Ca2+-dependent proteolysis in rat skeletal muscle through {beta}2-adrenoceptors and cAMP -- ...
		Overall proteolysis and the activity of skeletal muscle proteolytic systems were investigated in rats 1, 2, or 4 days after
		To measure the intralysosomal proteolysis, muscles from one limb were incubated in the absence of insulin and branched-chain
		To study the maximal activity of the Ca -dependent proteolysis, muscles from one limb were incubated in the presence of insulin
	ajpendo.physiology.org /cgi/content/full/281/3/E449 (3762 words)

	Diabetes: Skeletal muscle proteolysis in rats with acute ... @ HighBeam Research (Site not responding. Last check: )
		In diabetes, the increase in proteolysis was accompanied by reductions in circulating insulin to 25-50% of normal level, whereas food intake did not differ from control.
		Because of the uncertain status of myofibrillar proteolysis in diabetes, the rate of degradation of contractile protein was also estimated from the rate that 3-MH accumulated in plasma.
		This was not unexpected, because in normal rats, fasting per se enhances total and myofibrillar proteolysis in the hemicorpus preparation [23] and perfused hindquarters [34] and also increases total protein breakdown in skeletal muscles of eviscerated preparations [21].
	www.highbeam.com /library/doc0.asp?DOCID=1G1:8136843&refid=holomed_1 (4762 words)

	Welcome to the International Proteolysis Society
		The official website for the International Proteolysis Society: a forum for our members to get access to the latest news and events related to protease research, including meetings, job listings and new research products.
		The International Proteolysis Society was founded in September 1999 to serve as a focus for scientists working on all aspects of proteolytic enzymes, their substrates, and inhibitors.
		Membership in the IPS is open to individuals conducting research in the field of proteolysis, and we currently have an active base of over 300 members worldwide.
	www.protease.org (148 words)

	Proteolysis of Insulin-Like Growth Factor-Binding Protein-3 Is Increased in Urine from Patients with Diabetic ...
		Proteolysis of Insulin-Like Growth Factor-Binding Protein-3 Is Increased in Urine from Patients with Diabetic Nephropathy -- Shinada et al.
		Proteolysis of urinary IGFBP-3 is increased in diabetic nephropathy.
		Proteolysis of urinary IGFBP-3 is increased in patients with NIDDM and diabetic nephropathy.
	jcem.endojournals.org /cgi/content/full/85/3/1163 (4101 words)

	Proteolysis Associated With Insulin Resistance in Cystic Fibrosis -- Hardin et al. 101 (3): 433 -- Pediatrics
		Proteolysis Associated With Insulin Resistance in Cystic Fibrosis -- Hardin et al.
		Proteolysis Associated With Insulin Resistance in Cystic Fibrosis
		Suppression of proteolysis by insulin was less in all CF subgroups
	pediatrics.aappublications.org /cgi/content/abstract/101/3/433 (529 words)

	Ubiquitin-proteasome-dependent muscle proteolysis responds slowly to insulin release and refeeding in starved rats -- ...
		In the present study, the rates of proteolysis were measured in vitro because the incubated muscle technique is the only system where it is possible to simultaneously determine protein synthesis and protein degradation rates, and also at the same time measure the contribution of the different proteolytic pathways to the rates of overall proteolysis.
		Therefore, the lack of elevated plasma AA and/or insulin concentrations to inhibit proteasome-dependent proteolysis at 4 h of refeeding is unlikely to result from the antagonist effect of corticosterone.
		Finally, the delayed inhibition of proteasome-dependent proteolysis measured in vitro is in close agreement with the delayed reduction in both the formation of ubiquitin conjugates and the downregulation of 14-kDa E2 expression upon refeeding.
	jp.physoc.org /cgi/content/full/546/3/765 (7652 words)

	Proteolysis of the Caulobacter McpA Chemoreceptor Is Cell Cycle Regulated by a ClpX-Dependent Pathway -- Tsai and Alley ...
		Proteolysis of the Caulobacter McpA Chemoreceptor Is Cell Cycle Regulated by a ClpX-Dependent Pathway -- Tsai and Alley 183 (17): 5001 -- The Journal of Bacteriology
		Proteolysis is involved in cell differentiation and the progression through the cell cycle in Caulobacter crescentus.
		Proteolysis is an important facet of programmed cellular processes in both eukaryotes and prokaryotes.
	jb.asm.org /cgi/content/full/183/17/5001 (4009 words)

	Procognia Ltd.
		The company's intellectual property, knowledge, expertise, and proprietary platforms, make it a key player in the growing filed of Glycobiology.
		Glycosylation plays an important role in biology, increasing protein conformation and stability in the serum, protecting proteins from proteolysis, and improving protein solubility.
		Fast glycoanalysis of multiple samples throughout the development and manufacturing of glycoprotein drugs is required by the industry, and recommended by the FDA and EMEA.
	www.procognia-il.com (197 words)

	Amino Acids as Regulators of Proteolysis -- Kadowaki and Kanazawa 133 (6): 2052 -- Journal of Nutrition (Site not responding. Last check: )
		to be the main proteolytic pathway for bulk proteolysis (9).
		Proteolysis is a major flux of protein turnover and affects
		Pösö, A. R., Schworer, C. and Mortimore, G. E. (1982) Acceleration of proteolysis in perfused rat liver by deletion of glucogenic amino acids: Regulatory role of glutamine.
	www.nutrition.org /cgi/content/full/133/6/2052S (3571 words)

	Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and ...
		Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity -- Urban and Wolfe 102 (6): 1883 -- Proceedings of the National Academy of Sciences
		Intramembrane proteolysis is a new paradigm in biology that
		Effect of different membrane phospholipid environments on rhomboid intramembrane proteolysis in vitro.(A) Activity of purified rhomboids in DDM micelles (DDM) was compared to activity in various phospholipid environments: lipid extracts from E.
	www.pnas.org /cgi/content/full/102/6/1883 (4295 words)

	Regulation of the Cyclin B Degradation System by an Inhibitor of Mitotic Proteolysis -- Vorlaufer and Peters 9 (7): ...
		APC-dependent proteolysis is prevented by unknown mechanisms in the CSF-induced arrest of vertebrate eggs and in the spindle
		Brandeis, M., and Hunt, T. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S-phase.
		Hunt, T., Luca, F.C., and Ruderman, J.V. The requirements for protein synthesis and degradation, and the control of the destruction of cyclin A and cyclin B in the meiotic and mitotic cell cycles of the clam embryo.
	www.molbiolcell.org /cgi/content/full/9/7/1817 (8281 words)

	RNase L Proteolysis in Chronic Fatigue Syndrome: A Diagnostic Marker?
		In previous sections, the proteolysis of recombinant or endogenous RNase L was monitored by 2-5A probe labeling.
		Whatever the case, RNase L proteolysis removes the Cys-rich region (in the protein kinase homology domain) of RNase L which is believed to be involved in protein-protein interactions.
		It is therefore conceivable that the proteolysis of RNase L might alter its interaction with regulatory proteins or its compartmentalization.
	www.prohealthnetwork.com /library/showarticle.cfm/ID/3767/e/1/T/CFIDS_FM (4509 words)

	Role of adrenoceptors and cAMP on the catecholamine-induced inhibition of proteolysis in rat skeletal muscle -- ...
		Role of adrenoceptors and cAMP on the catecholamine-induced inhibition of proteolysis in rat skeletal muscle -- Navegantes et al.
		proteolysis decreased by 15-20% in the presence of equimolar concentrations
		The rate of proteolysis was determined by measuring the rate of tyrosine release in the incubation medium.
	ajpendo.physiology.org /cgi/content/full/279/3/E663 (3384 words)

	Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in ...
		-toxin-treated hepatocytes was estimated by valine release, previously validated as a reflection of proteolysis (35).
		The route of amino acid signaling for autophagic proteolysis is independent of that for protein synthesis.
		The route of insulin signaling for autophagic proteolysis is the same as that for protein synthesis down to mTOR kinase, although the downstream route after mTOR is unknown.
	www.jbc.org /cgi/content/full/279/9/8452 (5140 words)

	Regulation of B-type cyclin proteolysis by Cdc28[ndash]associated kinases in budding yeast
		Degradation of cyclins is mediated by ubiquitin-dependent proteolysis.
		Cyclin B-specific proteolysis is responsible for the decline in Clb2 levels induced by inactivation of Cln- and Clb-associated kinases.
		Activation of Clb2 proteolysis occurs by inhibition of Cdc28-associated kinases, not by Sic1 binding.
	www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v16/n10/full/7590254a.html (6414 words)

	Phorbol Ester- and Growth Factor-Induced Growth Hormone (GH) Receptor Proteolysis and GH-Binding Protein Shedding: ...
		PMA-induced proteolysis of GHRs and shedding of GHBP in murine preadipocytes and in rabbit GHR-transfected CHO cells is inhibited by IC3
		PMA-induced proteolysis of GHRs in 3T3-F442A cells is sensitive to metalloprotease and PKC inhibitors.
		A, PMA-induced GHR proteolysis is inhibited by IC3.
	endo.endojournals.org /cgi/content/full/142/3/1137 (7573 words)

	Nitric oxide inhibits calpain-mediated proteolysis of talin in skeletal muscle cells -- Koh and Tidball 279 (3): 806 -- ...
		peptide to confirm that talin proteolysis was calpain mediated.
		Proteolysis during isolation of the membrane fraction in
		Oxidation inhibits substrate proteolysis by calpain I but not autolysis.
	ajpcell.physiology.org /cgi/content/full/279/3/C806 (3931 words)

	proteolysis -- Britannica Concise Encyclopedia - The online encyclopedia you can trust!
		Proteolytic enzymes are secreted as zymogens, which are themselves converted by proteolysis to their active forms.
		Many other zymogens or precursors undergo proteolysis to form active enzymes or proteins (e.g., fibrinogen to fibrin).
		The pepsins are enzymes secreted by the stomach in the presence of acid that breaks down proteins (proteolysis).
	www.britannica.com /ebc/article-9376019?tocId=9376019 (364 words)

	Bovine lens epithelial cells have a ubiquitin-dependent proteolysis system. (Site not responding. Last check: )
		Two hallmarks of ubiquitin (Ub) dependent proteolysis have previously been demonstrated in lens cell or tissue supernatants: (1) the presence of ubiquitin conjugates, and (2) ATP-dependent proteolysis.
		Nevertheless, conclusive proof was lacking of a requirement for ubiquitination of substrate proteins for proteolysis.
		Upon reconstitution with purified E1, 100% and 80% of proteolysis was restored in reticulocytes and BLEC supernatant, respectively.
	www.arclab.org /medlineupdates/abstract_8380340.html (226 words)

	Calcium-Regulated Proteolysis of eEF1A -- Ransom-Hodgkins et al. 122 (3): 957 -- PLANT PHYSIOLOGY
		At micromolar Ca concentrations, proteolysis of eEF1A was pH sensitive.
		In summary, we have shown that proteolysis of eEF1A is sensitive to physiologically relevant changes in Ca and pH.
		Wilkinson KD (1995) Roles of ubiquitinylation in proteolysis and cellular regulation.
	www.plantphysiol.org /cgi/content/full/122/3/957 (4770 words)

	RedNova News - Science - Postmortem proteolysis is reduced in transgenic mice overexpressing calpastatin1,2 (Site not responding. Last check: )
		Moreover, the ability to interpret in vivo data gathered from animal models is restricted because it is not possible to conclude with certainty that a particular measured change results directly from a particular treatment or genotype.
		However, autolysis is not obligatory for -calpain proteolysis (Gottin et al., 2001), and the 76-kDa isoform is not always proteolytically active (Geesink and Koohmaraie, 1999a); therefore, the degradation of desmin was used as an indicator of calpain- mediated postmortem proteolysis.
		This transgenic model has p\otential application for experiments investigating the role of calpain and calpastatin in postmortem proteolysis, as well as research seeking to define the role of calpains and calpastatin in muscle growth and protein turnover in the live animal.
	www.rednova.com /news/display?id=50644 (3991 words)

	Proteolysis Associated With Insulin Resistance in Cystic Fibrosis -- Hardin et al. 101 (3): 433 -- Pediatrics
		Measurement of Proteolysis Each participant spent the night in the University of Texas Clinical Research Center the night before the study.
		Basal proteolysis was measured by leucine rate of appearance after 3 hours of isotopic equilibration.
		Insulin suppressibility of proteolysis was measured by step-wise hyperinsulinemic euglycemic clamp.
	pediatrics.aappublications.org /cgi/content/full/101/3/433 (3244 words)

	Chemotherapy Inhibits Skeletal Muscle Ubiquitin-Proteasome-dependent Proteolysis -- Tilignac et al. 62 (10): 2771 -- ...
		proteolysis was measured, one EDL was incubated in a calcium-free
		A, effect of Cyst injection on total muscle proteolysis in healthy and tumor-bearing mice at days 16, 19, and 26, expressed as a percentage of respective saline-injected controls.
		B, effect of Cyst at day 26 on proteasome-dependent proteolysis in muscle from healthy and tumor-bearing mice treated with Cyst (Cyst+) or saline (Cyst-).
	cancerres.aacrjournals.org /cgi/content/full/62/10/2771 (4802 words)

	Three Distinct Phases of Fodrin Proteolysis Induced in Postischemic Hippocampus : Involvement of Calpain and ...
		Three Distinct Phases of Fodrin Proteolysis Induced in Postischemic Hippocampus : Involvement of Calpain and Unidentified Protease -- Yokota et al.
		proteolysis of fodrin induced by global forebrain ischemia in
		Conclusions Calpain induced proteolysis of fodrin in ischemic
	stroke.ahajournals.org /cgi/content/abstract/26/10/1901 (520 words)

	ARS \| Publication request: Polyphenol Oxidase and O-Diphenols Inhibit Post-Harvest Proteolysis in Red Clover and Alfalfa (Site not responding. Last check: )
		Such losses in alfalfa are especially high, with degradation of 44-87% of the forage protein to ammonia, amino acids, and small peptides.
		We assessed post-harvest proteolysis in leaf extracts by measuring the concentration of 5% TCA-soluble amino acids over time.
		Together, these results indicate that PPO and o-diphenols play a major role in post-harvest proteolytic inhibition in red clover, and that this system has the potential to be exploited in the preservation of other forage crops.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=166147 (456 words)

	XVIIth International Congress on Fibrinolysis and Proteolysis (ISFP), Melbourne, Australia
		This meeting is being held under the auspices of the International Society on Fibrinolysis and Proteolysis and will be taking place in Melbourne Australia, from March 21-25, 2004.
		This congress will provide a forum for those who work in the area of Fibrinolysis and Proteolysis to showcase their work, exchange ideas and communicate current developments and advancements.
		This year, we have invited our colleagues from the Asia-Pacific Society on Thrombosis and Haemostasis (APCTH) to participate in the ISFP2004 Congress and we are pleased to announce that a special session has been devoted for this purpose.
	www.icms.com.au /isfp2004 (245 words)

	:: 5th General Meeting of the International Proteolysis Society
		:: 5th General Meeting of the International Proteolysis Society
		5th General Meeting of the International Proteolysis Society
		5th General Meeting of the International Proteolysis Society (IPS2007)
	www.ips2007patras.gr (111 words)

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